Metallothionein over-expression in podocytes reduces adriamycin nephrotoxicity

References

• Muller I, Niethammer D, Bruchelt G. Anthracycline-derived chemotherapeutics in apoptosis and free radical cytotoxicity (Review). Int J Mol Med 1998; 1: 491–494
   PubMed Web of Science ®Google Scholar
• Morgan WA, Kaler B, Bach PH. The role of reactive oxygen species in adriamycin and menadione-induced glomerular toxicity. Toxicol Lett 1998; 94: 209–215
   PubMed Web of Science ®Google Scholar
• Wang Y, Wang YP, Tay YC, Harris DC. Progressive adriamycin nephropathy in mice: sequence of histologic and immunohistochemical events. Kidney Int 2000; 58: 1797–1804
   PubMed Web of Science ®Google Scholar
• Javaid B, Olson JL, Meyer TW. Glomerular injury and tubular loss in adriamycin nephrosis. J Am Soc Nephrol 2001; 12: 1391–1400
   PubMed Web of Science ®Google Scholar
• Qi Z, Fujita H, Jin J, Davis LS, Wang Y, Fogo AB, Breyer MD. Characterization of susceptibility of inbred mouse strains to diabetic nephropathy. Diabetes 2005; 54: 2628–2637
   PubMed Web of Science ®Google Scholar
• Bachur NR, Gordon SL, Gee MV. A general mechanism for microsomal activation of quinone anticancer agents to free radicals. Cancer Res 1978; 38: 1745–1750
   PubMed Web of Science ®Google Scholar
• Mimnaugh EG, Trush MA, Gram TE. A possible role for membrane lipid peroxidation in anthracycline nephrotoxicity. Biochem Pharmacol 1986; 35: 4327–4335
   PubMed Web of Science ®Google Scholar
• Kalyanaraman B, Sealy RC, Sinha BK. An electron spin resonance study of the reduction of peroxides by anthracycline semiquinones. Biochim Biophys Acta 1984; 799: 270–275
   PubMedGoogle Scholar
• Olson RD, Boerth RC, Gerber JG, Nies AS. Mechanism of adriamycin cardiotoxicity: evidence for oxidative stress. Life Sci 1981; 29: 1393–1401
   PubMed Web of Science ®Google Scholar
• Powell SR, McCay PB. Inhibition of doxorubicin-initiated membrane damage by N-acetylcysteine: possible mediation by a thiol-dependent, cytosolic inhibitor of lipid peroxidation. Toxicol Appl Pharmacol 1988; 96: 175–184
   PubMed Web of Science ®Google Scholar
• Hida H, Coudray C, Calop J, Favier A. Effect of antioxidants on adriamycin-induced microsomal lipid peroxidation. Biol Trace Elem Res 1995; 47: 111–116
   PubMed Web of Science ®Google Scholar
• Bertelli R, Ginevri F, Gusmano R, Ghiggeri GM. Cytotoxic effect of adriamycin and agarose-coupled adriamycin on glomerular epithelial cells: role of free radicals. In Vitro Cell Dev Biol 1991; 27A: 799–804
   PubMedGoogle Scholar
• Miner JH, Li C. Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane. Dev Biol 2000; 217: 278–289
   PubMed Web of Science ®Google Scholar
• Natoli TA, Liu J, Eremina V, Hodgens K, Li C, Hamano Y, Mundel P, Kalluri R, Miner JH, Quaggin SE, Kreidberg JA. A mutant form of the Wilms’' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development. J Am Soc Nephrol 2002; 13: 2058–2067
   PubMedGoogle Scholar
• Zheng, S, Carlson, EC, Yang, L, Kralik, PM, Huang, Y, Epstein, PN. Podocyte-specific overexpression of the antioxidant metallothionein reduces diabetic nephropathy. J Am Soc Nephrol 2008;11:2077–2085.
   Google Scholar
• Li X, Chen H, Epstein PN. Metallothionein protects islets from hypoxia and extends islet graft survival by scavenging most kinds of reactive oxygen species. J Biol Chem 2004; 279: 765–771
   PubMed Web of Science ®Google Scholar
• Ye G, Metreveli NS, Ren J, Epstein PN. Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive oxygen species production. Diabetes 2003; 52: 777–783
   PubMed Web of Science ®Google Scholar
• Kang YJ, Chen Y, Yu A, Voss-McCowan M, Epstein PN. Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity. J Clin Invest 1997; 100: 1501–1506
   PubMed Web of Science ®Google Scholar
• Koshikawa M, Mukoyama M, Mori K, Suganami T, Sawai K, Yoshioka T, Nagae T, Yokoi H, Kawachi H, Shimizu F, Sugawara A, Nakao K. Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome. J Am Soc Nephrol 2005; 16: 2690–2701
   PubMed Web of Science ®Google Scholar
• Chen H, Carlson EC, Pellet L, Moritz JT, Epstein PN. Overexpression of metallothionein in pancreatic beta-cells reduces streptozotocin-induced DNA damage and diabetes. Diabetes 2001; 50: 2040–2046
   PubMed Web of Science ®Google Scholar
• Takemoto M, Asker N, Gerhardt H, Lundkvist A, Johansson BR, Saito Y, Betsholtz C. A new method for large scale isolation of kidney glomeruli from mice. Am J Pathol 2002; 161: 799–805
   PubMed Web of Science ®Google Scholar
• Hartner A, Eifert T, Haas CS, Tuysuz C, Hilgers KF, Reinhardt DP, Amann K. Characterization of the renal phenotype in a mouse model of Marfan syndrome. Virchows Arch 2004; 445: 382–388
   PubMed Web of Science ®Google Scholar
• Sanden SK, Wiggins JE, Goyal M, Riggs LK, Wiggins RC. Evaluation of a thick and thin section method for estimation of podocyte number, glomerular volume, and glomerular volume per podocyte in rat kidney with Wilms’ tumor-1 protein used as a podocyte nuclear marker. J Am Soc Nephrol 2003; 14: 2484–2493
   PubMed Web of Science ®Google Scholar
• Huot J, Houle F, Spitz DR, Landry J. HSP27 phosphorylation-mediated resistance against actin fragmentation and cell death induced by oxidative stress. Cancer Res 1996; 56: 273–279
   PubMed Web of Science ®Google Scholar
• Apostolova MD, Chen S, Chakrabarti S, Cherian MG. High-glucose-induced metallothionein expression in endothelial cells: an endothelin-mediated mechanism. Am J Physiol Cell Physiol 2001; 281: C899–C907
   PubMed Web of Science ®Google Scholar
• Mitu GM, Wang S, Hirschberg R. BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury. Am J Physiol Renal Physiol 2007; 293: F1641–F1648
   Web of Science ®Google Scholar
• Liu LL, Li QX, Xia L, Li J, Shao L. Differential effects of dihydropyridine calcium antagonists on doxorubicin-induced nephrotoxicity in rats. Toxicology 2007; 231: 81–90
   PubMed Web of Science ®Google Scholar
• Vielhauer V, Berning E, Eis V, Kretzler M, Segerer S, Strutz F, Horuk R, Grone HJ, Schlondorff D, Anders HJ. CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome. Kidney Int 2004; 66: 2264–2278
   PubMed Web of Science ®Google Scholar
• Miller B, Patel VA, Sorokin A. Cyclooxygenase-2 rescues rat mesangial cells from apoptosis induced by adriamycin via upregulation of multidrug resistance protein 1 (P-glycoprotein). J Am Soc Nephrol 2006; 17: 977–985
   PubMed Web of Science ®Google Scholar
• Li X, Yuan H, Zhang X. Adriamycin increases podocyte permeability: evidence and molecular mechanism. Chin Med J (Engl) 2003; 116: 1831–1835
   PubMed Web of Science ®Google Scholar
• Palmiter RD. Protection against zinc toxicity by metallothionein and zinc transporter 1. Proc Natl Acad Sci USA 2004; 101: 4918–4923
   PubMed Web of Science ®Google Scholar
• Wharram BL, Goyal M, Wiggins JE, Sanden SK, Hussain S, Filipiak WE, Saunders TL, Dysko RC, Kohno K, Holzman LB, Wiggins RC. Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol 2005; 16: 2941–2952
   PubMed Web of Science ®Google Scholar
• Morioka Y, Koike H, Ikezumi Y, Ito Y, Oyanagi A, Gejyo F, Shimizu F, Kawachi H. Podocyte injuries exacerbate mesangial proliferative glomerulonephritis. Kidney Int 2001; 60: 2192–2204
   PubMed Web of Science ®Google Scholar