Antioxidant therapy for management of oxidative stress induced hypertension

References

• Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet 2005;365:217–223.
   PubMed Web of Science ®Google Scholar
• Touyz RM. Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance? Hypertension 2004;44:248–252.
   PubMed Web of Science ®Google Scholar
• Juranek I, Bezek S. Controversy of free radical hypothesis: reactive oxygen species-cause or consequence of tissue injury? Gen Physiol Biophys 2005;24:263–278.
   PubMed Web of Science ®Google Scholar
• Montezano AC, Touyz RM. Oxidative stress, Noxs, and hypertension: experimental evidence and clinical controversies. Ann Med 2012;44:S2–S16.
   PubMed Web of Science ®Google Scholar
• Rodrigo R, González J, Paoletto F. The role of oxidative stress in the pathophysiology of hypertension. Hypertens Res 2011;34:431–440.
   PubMed Web of Science ®Google Scholar
• Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 2000;87:840–844.
   PubMed Web of Science ®Google Scholar
• Silva BR, Pernomian L, Bendhack LM. Contribution of oxidative stress to endothelial dysfunction in hypertension. Front Physiol 2012;3:441.
   PubMed Web of Science ®Google Scholar
• Tanito M, Nakamura H, Kwon Y-W, Teratani A, Masutani H, Shioji K, et al. Enhanced oxidative stress and impaired thioredoxin expression in spontaneously hypertensive rats. Antioxid Redox Signal 2004;6:89–97.
   PubMed Web of Science ®Google Scholar
• Rodrigo R, Prat H, Passalacqua W, Araya J, Guichard C, Bachler JP. Relationship between oxidative stress and essential hypertension. Hypertens Res 2007;30:1159.
   PubMed Web of Science ®Google Scholar
• Touyz RM, Schiffrin EL. Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients: role of phospholipase D-dependent NAD (P) H oxidase-sensitive pathways. J Hypertens 2001;19:1245–1254.
   PubMed Web of Science ®Google Scholar
• Espinosa O, Jiménez-Almazán J, Chaves FJ, Tormos MC, Clapes S, Iradi A, et al. Urinary 8-oxo-7, 8-dihydro-2′-deoxyguanosine (8-oxo-dG), a reliable oxidative stress marker in hypertension. Free Radic Res 2007;41:546–554.
   PubMed Web of Science ®Google Scholar
• Morrow JD. Quantification of isoprostanes as indices of oxidant stress and the risk of atherosclerosis in humans. Arterioscler Thromb Vasc Biol 2005;25:279–286.
   PubMed Web of Science ®Google Scholar
• Moncada S, Higgs E. Nitric oxide and the vascular endothelium. The vascular endothelium I. Berlin-Heidelberg: Springer; 2006:213–254.
   Google Scholar
• Bredt D, Snyder S. Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem 1994;63:175–195.
   PubMed Web of Science ®Google Scholar
• Moncada S, Palmer R, Higgs E. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109–142.
   PubMed Web of Science ®Google Scholar
• Griffith OW, Stuehr DJ. Nitric oxide synthases: properties and catalytic mechanism. Annu Rev Physiol 1995;57:707–734.
   PubMed Web of Science ®Google Scholar
• Félétou M, Vanhoutte PM. Endothelial dysfunction: a multifaceted disorder (the Wiggers Award Lecture). Am J Physiol-Heart Circul Physiol 2006;291:H985–H1002.
   PubMed Web of Science ®Google Scholar
• Panza JA, Quyyumi AA, Brush JE, Jr, Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 1990;323:22–27.
   PubMed Web of Science ®Google Scholar
• Panza JA, García CE, Kilcoyne CM, Quyyumi AA, Cannon RO. Impaired endothelium-dependent vasodilation in patients with essential hypertension evidence that nitric oxide abnormality is not localized to a single signal transduction pathway. Circulation 1995;91:1732–1738.
   PubMed Web of Science ®Google Scholar
• Higashi Y, Sasaki S, Kurisu S, Yoshimizu A, Sasaki N, Matsuura H, et al. Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide. Circulation 1999;100:1194–1202.
   PubMed Web of Science ®Google Scholar
• Linder L, Kiowski W, Bühler F, Lüscher T. Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension. Circulation 1990;81:1762–1767.
   PubMed Web of Science ®Google Scholar
• Tsutsui M, Shimokawa H, Otsuji Y, Yanagihara N. Pathophysiological relevance of NO signaling in the cardiovascular system: novel insight from mice lacking all NO synthases. Pharmacol Ther 2010;128:499–508.
   PubMed Web of Science ®Google Scholar
• Higashi Y, Kihara Y, Noma K. Endothelial dysfunction and hypertension in aging. Hypertens Res 2012;35:1039–1047.
   PubMed Web of Science ®Google Scholar
• Dijkhorst-Oei L, Stroes E, Koomans H, Rabelink T. Acute simultaneous stimulation of nitric oxide and oxygen radicals by angiotensin II in humans in vivo. J Cardiovasc Pharmacol 1999;33:420–424.
   PubMed Web of Science ®Google Scholar
• Irani K. Oxidant signaling in vascular cell growth, death, and survival a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling. Circul Res 2000;87:179–183.
   PubMed Web of Science ®Google Scholar
• Kumar KV, Das U. Are free radicals involved in the pathobiology of human essential hypertension? Free Radic Res Commun 1993;19:59–66.
   PubMed Web of Science ®Google Scholar
• Redón J, Oliva MR, Tormos C, Giner V, Chaves J, Iradi A, Sáez GT. Antioxidant activities and oxidative stress byproducts in human hypertension. Hypertension 2003;41:1096–1101.
   PubMed Web of Science ®Google Scholar
• Rajagopalan S, Kurz S, Münzel T, Tarpey M, Freeman BA, Griendling KK, Harrison DG. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. J Clin Invest 1996;97:1916.
   PubMed Web of Science ®Google Scholar
• Hegde L, Srivastava P, Kumari R, Dikshit M. Alterations in the vasoreactivity of hypertensive rat aortic rings: role of nitric oxide and superoxide radicals. Clin Exp Hypertens 1998;20:885–901.
   PubMed Web of Science ®Google Scholar
• Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 1998;97:2222–2229.
   PubMed Web of Science ®Google Scholar
• Dohi Y, Thiel MA, Bühler F, Lüscher T. Activation of endothelial l-arginine pathway in resistance arteries. Effect of age and hypertension. Hypertension 1990;16:170–179.
   PubMed Web of Science ®Google Scholar
• Majzunova M, Dovinova I, Barancik M, Chan JY. Redox signaling in pathophysiology of hypertension. J Biomed Sci 2013;20:1.
   PubMed Web of Science ®Google Scholar
• Touyz RM, Briones AM. Reactive oxygen species and vascular biology: implications in human hypertension. Hypertens Res 2011;34:5–14.
   PubMed Web of Science ®Google Scholar
• Rochette L, Lorin J, Zeller M, Guilland J-C, Lorgis L, Cottin Y, Vergely C. Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets? Pharmacol Ther 2013;140:239–257.
   PubMed Web of Science ®Google Scholar
• Moens AL, Kass DA. Tetrahydrobiopterin and cardiovascular disease. Arterioscler Thromb Vasc Biol 2006;26:2439–2444.
   PubMed Web of Science ®Google Scholar
• Roe ND, Ren J. Nitric oxide synthase uncoupling: a therapeutic target in cardiovascular diseases. Vascul Pharmacol 2012;57:168–172.
   PubMed Web of Science ®Google Scholar
• Finkel T. Signal transduction by reactive oxygen species. J Cell Biol 2011;194:7–15.
   PubMed Web of Science ®Google Scholar
• Balakumar P, Jagadeesh G. Multifarious molecular signaling cascades of cardiac hypertrophy: can the muddy waters be cleared? Pharmacol Res 2010;62:365–383.
   PubMed Web of Science ®Google Scholar
• Griendling KK, Sorescu D, Lassègue B, Ushio-Fukai M. Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology. Arterioscler Thromb Vasc Biol 2000;20:2175–2183.
   PubMed Web of Science ®Google Scholar
• Schmidt HH, Stocker R, Vollbracht C, Paulsen G, Riley D, Daiber A, Cuadrado A. Antioxidants in translational medicine. Antioxid Redox Signal 2015;23:1130–1143.
   PubMed Web of Science ®Google Scholar
• Ülker S, McKeown PP, Bayraktutan U. Vitamins reverse endothelial dysfunction through regulation of eNOS and NAD(P)H oxidase activities. Hypertension 2003;41:534–539.
   PubMed Web of Science ®Google Scholar
• Duffy SJ, Gokce N, Holbrook M, Hunter LM, Biegelsen ES, Huang A, et al. Effect of ascorbic acid treatment on conduit vessel endothelial dysfunction in patients with hypertension. Am J Physiol-Heart Circul Physiol 2001;280:H528–HH34.
   Web of Science ®Google Scholar
• Nishikawa Y, Tatsumi K, Matsuura T, Yamamoto A, Nadamoto T, Urabe K. Effects of vitamin C on high blood pressure induced by salt in spontaneously hypertensive rats. J Nutr Sci Vitaminol 2003;49:301–309.
   PubMed Web of Science ®Google Scholar
• Chen X, Touyz RM, Park JB, Schiffrin EL. Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR. Hypertension 2001;38:606–611.
   PubMed Web of Science ®Google Scholar
• Reckelhoff JF, Kanji V, Racusen LC, Schmidt AM, Du Yan S, Morrow J, et al. Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys. Am J Physiol-Regul Integr Comp Physiol 1998;274:R767–RR74.
   Google Scholar
• Atarashi K, Ishiyama A, Takagi M, Minami M, Kimura K, Goto A, Omata M. Vitamin E ameliorates the renal injury of Dahl salt-sensitive rats. Am J Hypertens 1997;10:116S–119S.
   PubMed Web of Science ®Google Scholar
• Jackson TS, Xu A, Vita JA, Keaney JF. Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations. Circ Res 1998;83:916–922.
   PubMed Web of Science ®Google Scholar
• Vita JA, Frei B, Holbrook M, Gokce N, Leaf C, Keaney JF. Jr. l-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease. J Clin Invest 1998;101:1408.
   PubMed Web of Science ®Google Scholar
• Duffy S, Gokce N, Holbrook M, Huang A, Frei B, Keaney JF, Vita JA. Treatment of hypertension with ascorbic acid. Lancet 1999;354:2048–2049.
   PubMed Web of Science ®Google Scholar
• Fotherby MD, Williams JC, Forster LA, Craner P, Ferns GA. Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons. J Hypertens 2000;18:411–415.
   PubMed Web of Science ®Google Scholar
• Block G, Mangels AR, Norkus EP, Patterson BH, Levander OA, Taylor PR. Ascorbic acid status and subsequent diastolic and systolic blood pressure. Hypertension 2001;37:261–267.
   PubMed Web of Science ®Google Scholar
• Ghosh S, Ekpo E, Shah I, Girling A, Jenkins C, Sinclair A. A double-blind, placebo-controlled parallel trial of vitamin C treatment in elderly patients with hypertension. Gerontology 1994;40:268–272.
   PubMed Web of Science ®Google Scholar
• Mullan BA, Young IS, Fee H, McCance DR. Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes. Hypertension 2002;40:804–809.
   PubMed Web of Science ®Google Scholar
• Galley HF, Thornton J, Howdle PD, Walker BE, Webster NR. Combination oral antioxidant supplementation reduces blood pressure. Clin Sci 1997;92:361–365.
   PubMed Web of Science ®Google Scholar
• Steinbrenner H, Sies H. Protection against reactive oxygen species by selenoproteins. Biochim Biophys Acta (BBA)-Gen Subj 2009;1790:1478–1485.
   PubMed Web of Science ®Google Scholar
• Padayatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee J-H, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr 2003;22:18–35.
   PubMed Web of Science ®Google Scholar
• Malyszko J. Mechanism of endothelial dysfunction in chronic kidney disease. Clin Chim Acta 2010;411:1412–1420.
   PubMed Web of Science ®Google Scholar
• Bauersachs J, Fleming I, Fraccarollo D, Busse R, Ertl G. Prevention of endothelial dysfunction in heart failure by vitamin E: attenuation of vascular superoxide anion formation and increase in soluble guanylyl cyclase expression. Cardiovasc Res 2001;51:344–350.
   PubMed Web of Science ®Google Scholar
• Çınar M, Ülker S, Alper G, Linnaz U, Evinc A. Effect of dietary vitamin E supplementation on vascular reactivity of thoracic aorta in streptozotocin-diabetic rats. Pharmacology 2001;62:56–64.
   PubMed Web of Science ®Google Scholar
• Kim Y-S, Kang K-S, Park S-U, Jung W-S, Moon S-K, Park J-M, et al. Antihyperlipidemic and antioxidant effects of Insamsansa-eum (Renshenshanzha-yin) in hypercholesterolemic rats. Korean J Orient Med 2006;27:96–104.
   Google Scholar
• Lee I-M, Cook NR, Gaziano JM, Gordon D, Ridker PM, Manson JE, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA 2005;294:56–65.
   PubMed Web of Science ®Google Scholar
• Walsh PC. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. J Urol 2005;174:1823–1824.
   PubMedGoogle Scholar
• Investigators G-P. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 1999;354:447–455.
   PubMed Web of Science ®Google Scholar
• Rapola JM, Virtamo J, Ripatti S, Huttunen JK, Albanes D, Taylor PR, Heinonen OP. Randomised trial of α-tocopherol and β-carotene supplements on incidence of major coronary events in men with previous myocardial infarction. Lancet 1997;349:1715–1720.
   PubMed Web of Science ®Google Scholar
• Ward NC, Wu JH, Clarke MW, Puddey IB, Burke V, Croft KD, Hodgson JM. The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. J Hypertens 2007;25:227–234.
   PubMed Web of Science ®Google Scholar
• Sherman DL, Keaney JF, Biegelsen ES, Duffy SJ, Coffman JD, Vita JA. Pharmacological concentrations of ascorbic acid are required for the beneficial effect on endothelial vasomotor function in hypertension. Hypertension 2000;35:936–941.
   PubMed Web of Science ®Google Scholar
• Vera R, Sánchez M, Galisteo M, Villar IC, Jimenez R, Zarzuelo A, et al. Chronic administration of genistein improves endothelial dysfunction in spontaneously hypertensive rats: involvement of eNOS, caveolin and calmodulin expression and NADPH oxidase activity. Clin Sci 2007;112:183–191.
   PubMed Web of Science ®Google Scholar
• Si H, Liu D. Genistein, a soy phytoestrogen, upregulates the expression of human endothelial nitric oxide synthase and lowers blood pressure in spontaneously hypertensive rats. J Nutr 2008;138:297–304.
   PubMed Web of Science ®Google Scholar
• Cho HY, Park CM, Kim MJ, Chinzorig R, Cho CW, Song YS. Comparative effect of genistein and daidzein on the expression of MCP-1, eNOS, and cell adhesion molecules in TNF-α-stimulated HUVECs. Nutr Res Pract 2011;5:381–388.
   PubMed Web of Science ®Google Scholar
• Zhen P, Zhao Q, Hou D, Liu T, Jiang D, Duan J, et al. Genistein attenuates vascular endothelial impairment in ovariectomized hyperhomocysteinemic rats. BioMed Res Int 2012;2012:730462.
   Google Scholar
• Squadrito F, Altavilla D, Morabito N, Crisafulli A, D'Anna R, Corrado F, et al. The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women. Atherosclerosis 2002;163:339–347.
   PubMed Web of Science ®Google Scholar
• Rodrigo R, Gil D, Miranda-Merchak A, Kalantzidis G. Antihypertensive role of polyphenols. Adv Clin Chem 2012;58:225.
   PubMed Web of Science ®Google Scholar
• Ward NC, Hodgson JM, Croft KD, Burke V, Beilin LJ, Puddey IB. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427–434.
   PubMed Web of Science ®Google Scholar
• Pecháňová O, Zicha J, Kojšová S, Dobešová Z, Jendeková L, Kuneš J. Effect of chronic N-acetylcysteine treatment on the development of spontaneous hypertension. Clin Sci 2006;110:235–242.
   PubMed Web of Science ®Google Scholar
• Zembowicz A, Hatchett RJ, Radziszewski W, Gryglewski RJ. Inhibition of endothelial nitric oxide synthase by ebselen. Prevention by thiols suggests the inactivation by ebselen of a critical thiol essential for the catalytic activity of nitric oxide synthase. J Pharmacol Exp Ther 1993;267:1112–1118.
   PubMed Web of Science ®Google Scholar
• Barrios V, Calderón A, Navarro-Cid J, Lahera V, Ruilope LM. N-Acetylcysteine potentiates the antihypertensive effect of ACE inhibitors in hypertensive patients. Blood Press 2002;11:235–239.
   PubMed Web of Science ®Google Scholar
• Zaslavskaia R, Shcherban E, Lilitsa G, Logvinenko S. Melatonin in the combined treatment of cardiovascular diseases. Klin Med (Mosk) 2009;88:26–30.
   Google Scholar
• Feig DI, Soletsky B, Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA 2008;300:924–932.
   PubMed Web of Science ®Google Scholar
• Mazzali M, Hughes J, Kim Y-G, Jefferson JA, Kang D-H, Gordon KL, et al. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension 2001;38:1101–1106.
   PubMed Web of Science ®Google Scholar
• Kuzkaya N, Weissmann N, Harrison DG, Dikalov S. Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. J Biol Chem 2003;278:22546–22554.
   PubMed Web of Science ®Google Scholar
• Suzuki H, DeLano FA, Parks DA, Jamshidi N, Granger DN, Ishii H, et al. Xanthine oxidase activity associated with arterial blood pressure in spontaneously hypertensive rats. Proc Natl Acad Sci 1998;95:4754–4759.
   PubMed Web of Science ®Google Scholar
• George J, Struthers A. The role of urate and xanthine oxidase in vascular oxidative stress: future directions. Ther Clin Risk Manag 2009;5:799–803.
   PubMedGoogle Scholar
• Savica V, Bellinghieri G, Kopple JD. The effect of nutrition on blood pressure. Annu Rev Nutr 2010;30:365–401.
   PubMed Web of Science ®Google Scholar
• Storniolo CE, Casillas R, Bullo M, Castaner O, Ros E, Saez GT, et al. A Mediterranean diet supplemented with extra virgin olive oil or nuts improves endothelial markers involved in blood pressure control in hypertensive women. Eur J Nutr 2017;56:89–97.
   PubMed Web of Science ®Google Scholar
• Estruch R, Ros E, Salas-Salvado J, Covas MI, Corella D, Aros F, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013;368:1279–1290.
   PubMed Web of Science ®Google Scholar
• Toledo E, Hu F, Estruch R, Buil-Cosiales P, Corella D, Salas-Salvad ÓJ, et al. Effect of the Mediterranean diet on blood pressure in the PREDIMED trial: results from a randomized controlled trial. BMC Med 2013;11:207.
   PubMed Web of Science ®Google Scholar
• Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, et al. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med 1997;336:1117–1124.
   PubMed Web of Science ®Google Scholar
• Nowson CA, Wattanapenpaiboon N, Pachett A. Low-sodium dietary approaches to stop hypertension – type diet including lean red meat lowers blood pressure in postmenopausal women. Nutr Res 2009;29:8–18.
   PubMed Web of Science ®Google Scholar
• Sáez GT, Tormos C, Giner V, Chaves J, Lozano JV, Iradi A, Redón J. Factors related to the impact of antihypertensive treatment in antioxidant activities and oxidative stress by-products in human hypertension. Am J Hypertens 2004;17:809–816.
   PubMed Web of Science ®Google Scholar
• Griendling KK, Sorescu D, Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 2000;86:494–501.
   PubMed Web of Science ®Google Scholar
• Wenzel P, Schulz E, Oelze M, Müller J, Schuhmacher S, Alhamdani MS, et al. AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats. Free Radic Biol Med 2008;45:619–626.
   PubMed Web of Science ®Google Scholar
• Hornig B, Landmesser U, Kohler C, Ahlersmann D, Spiekermann S, Christoph A, et al. Comparative effect of ACE inhibition and angiotensin II type 1 receptor antagonism on bioavailability of nitric oxide in patients with coronary artery disease: role of superoxide dismutase. Circulation 2001;103:799–805.
   PubMed Web of Science ®Google Scholar
• Dandona P, Karne R, Ghanim H, Hamouda W, Aljada A, Magsino CH. Carvedilol inhibits reactive oxygen species generation by leukocytes and oxidative damage to amino acids. Circulation 2000;101:122–124.
   PubMed Web of Science ®Google Scholar
• Dahlöf B, Devereux RB, Kjeldsen SE, Julius S, Beevers G, de Faire U, et al. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002;359:995–1003.
   PubMed Web of Science ®Google Scholar
• Garg R, Yusuf S, Bussmann W, Sleight P, Uprichard A, Massie B, et al. Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. JAMA 1995;273:1450–1456.
   PubMed Web of Science ®Google Scholar
• Ball S. The Acute Infarction Ramipril Efficacy (AIRE) Study Investigators. Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. Lancet 1993;342:821–828.
   PubMed Web of Science ®Google Scholar
• Williams HC, Griendling KK. NADPH oxidase inhibitors: new antihypertensive agents? J Cardiovasc Pharmacol 2007;50:9–16.
   PubMed Web of Science ®Google Scholar
• Mancini GJ, Henry GC, Macaya C, O'Neill BJ, Pucillo AL, Carere RG, et al. Angiotensin-converting enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease: The TREND (Trial on Reversing ENdothelial Dysfunction) Study. Circulation 1996;94:258–265.
   PubMed Web of Science ®Google Scholar
• Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P. Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 2000;342:154–160.
   PubMed Web of Science ®Google Scholar
• Zepeda RJ, Castillo R, Rodrigo R, Prieto JC, Aramburu I, Brugere S, et al. Effect of carvedilol and nebivolol on oxidative stress-related parameters and endothelial function in patients with essential hypertension. Basic Clin Pharmacol Toxicol 2012;111:309–316.
   PubMed Web of Science ®Google Scholar
• Kelly AS, Gonzalez-Campoy JM, Rudser KD, Katz H, Metzig AM, Thalin M, Bank AJ. Carvedilol-Lisinopril combination therapy and endothelial function in obese individuals with hypertension. J Clin Hypertens 2012;14:85–91.
   Web of Science ®Google Scholar
• Tzemos N, Lim PO, MacDonald TM. Nebivolol reverses endothelial dysfunction in essential hypertension: a randomized, double-blind, crossover study. Circulation 2001;104:511–514.
   PubMed Web of Science ®Google Scholar
• Perros F, Ranchoux B, Izikki M, Bentebbal S, Happé C, Antigny F, et al. Nebivolol for improving endothelial dysfunction, pulmonary vascular remodeling, and right heart function in pulmonary hypertension. J Am Coll Cardiol 2015;65:668–680.
   PubMed Web of Science ®Google Scholar
• Mollnau H, Schulz E, Daiber A, Baldus S, Oelze M, August M, et al. Nebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflammatory cells. Arterioscler Thromb Vasc Biol 2003;23:615–621.
   PubMed Web of Science ®Google Scholar
• Münzel T, Gori T. Nebivolol: the somewhat-different beta-adrenergic receptor blocker. J Am Coll Cardiol 2009;54:1491–1499.
   PubMed Web of Science ®Google Scholar
• Mak IT, Boehme P, Weglicki WB. Antioxidant effects of calcium channel blockers against free radical injury in endothelial cells. Correlation of protection with preservation of glutathione levels. Circul Res 1992;70:1099–1103.
   PubMed Web of Science ®Google Scholar
• Matsubara M, Hasegawa K. Benidipine, a dihydropyridine-calcium channel blocker, prevents lysophosphatidylcholine-induced injury and reactive oxygen species production in human aortic endothelial cells. Atherosclerosis 2005;178:57–66.
   PubMed Web of Science ®Google Scholar
• Napoli C, Salomone S, Godfraind T, Palinski W, Capuzzi DM, Palumbo G, et al. 1, 4-Dihydropyridine calcium channel blockers inhibit plasma and LDL oxidation and formation of oxidation-specific epitopes in the arterial wall and prolong survival in stroke-prone spontaneously hypertensive rats. Stroke 1999;30:1907–1915.
   PubMed Web of Science ®Google Scholar
• Champagne S, Hittinger L, Héloire F, Suto Y, Sambin L, Crozatier B, Su JB. Reduced coronary vasodilator responses to amlodipine in pacing-induced heart failure in conscious dogs: role of nitric oxide. Br J Pharmacol 2002;136:264–270.
   PubMed Web of Science ®Google Scholar
• Celık T, Balta S, Karaman M, Ahmet Ay S, Demırkol S, Ozturk C, et al. Endocan, a novel marker of endothelial dysfunction in patients with essential hypertension: comparative effects of amlodipine and valsartan. Blood Press 2015;24:55–60.
   PubMed Web of Science ®Google Scholar
• Chen X-n, Xu J, Feng Z, Fan M, Han J-y, Yang Z. Simvastatin combined with nifedipine enhances endothelial cell protection by inhibiting ROS generation and activating Akt phosphorylation. Acta Pharmacol Sin 2010;31:813–820.
   PubMed Web of Science ®Google Scholar