A review of the mechanism and prophylaxis of acetyl salicylic acid-induced injury of the small intestine

References

• Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ. 2002; 324(7329):71–86.
   PubMed Web of Science ®Google Scholar
• Yoshida N, Yoshikawa T, Nakamura Y, et al. Role of neutrophil-mediated inflammation in aspirin-induced gastric mucosal injury. Dig Dis Sci. 1995;40(11):2300–2304.
   PubMed Web of Science ®Google Scholar
• Somasundaram S, Sigthorsson G, Simpson RJ, et al. Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat. Aliment Pharmacol Ther. 2000;14(5):639–650.
   PubMed Web of Science ®Google Scholar
• Bjarnason I, Hayllar J, MacPherson AJ, et al. Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology. 1993;104(6):1832–1847.
   PubMed Web of Science ®Google Scholar
• Leung WK, Bjarnason I, Wong VW, et al. Small bowel enteropathy associated with chronic low-dose aspirin therapy. Lancet. 2007;369(9561):614.
   PubMed Web of Science ®Google Scholar
• Handa O, Naito Y, Okayama T, et al. Endoscopic diagnosis of small intestinal diseases. Clin J Gastroenterol. 2013;6(2):94–98.
   PubMedGoogle Scholar
• Cheng Y, Lin J, Liu J, et al. Decreased vascular endothelial growth factor expression is associated with cell apoptosis in low-dose aspirin-induced gastric mucosal injury. Am J Med Sci. 2015;349(2):110–116.
   PubMed Web of Science ®Google Scholar
• Zeren S, Bayhan Z, Kocak FE, et al. Gastroprotective effects of sulforaphane and thymoquinone against acetylsalicylic acid-induced gastric ulcer in rats. J Surg Res. 2016;203(2):348–359.
   PubMed Web of Science ®Google Scholar
• Hernández C, Barrachina MD, Vallecillo-Hernández J, et al. Aspirin-induced gastrointestinal damage is associated with an inhibition of epithelial cell autophagy. J Gastroenterol. 2016;51(7):691–701.
   PubMed Web of Science ®Google Scholar
• Harusato A, Naito Y, Takagi T, et al. Suppression of indomethacin-induced apoptosis in the small intestine due to Bach1 deficiency. Free Radic Res. 2011;45(6):717–727.
   PubMed Web of Science ®Google Scholar
• Fukumoto K, Naito Y, Takagi T, et al. Role of tumor necrosis factor-alpha in the pathogenesis of indomethacin-induced small intestinal injury in mice. Int J Mol Med. 2011;27(3):353–359.
   PubMed Web of Science ®Google Scholar
• Omatsu T, Naito Y, Handa O, et al. Involvement of reactive oxygen species in indomethacin-induced apoptosis of small intestinal epithelial cells. J Gastroenterol. 2009;44(Suppl19):30–34.
   Web of Science ®Google Scholar
• Omatsu T, Naito Y, Handa O, et al. Reactive oxygen species-quenching and anti-apoptotic effect of polaprezinc on indomethacin-induced small intestinal epithelial cell injury. J Gastroenterol. 2010;45(7):692–702.
   PubMed Web of Science ®Google Scholar
• Pavlidis P, Bjarnason I. Aspirin induced adverse effects on the small and large intestine. Curr Pharm Des. 2015;21(35):5089–5093.
   PubMed Web of Science ®Google Scholar
• Qin Y, Naito Y, Handa O, et al. Heat shock protein 70-dependent protective effect of polaprezinc on acetylsalicylic acid-induced apoptosis of rat intestinal epithelial cells. J Clin Biochem Nutr. 2011;49(3):174–181.
   PubMed Web of Science ®Google Scholar
• Ohkawara T, Nishihira J, Nagashima R, et al. Polaprezinc protects human colon cells from oxidative injury induced by hydrogen peroxide: relevant to cytoprotective heat shock proteins. World J Gastroenterol 2006;12(38):6178–6181.
   PubMed Web of Science ®Google Scholar
• Wada I, Otaka M, Jin M, et al. Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection. Biochem Biophys Res Commun. 2006;349(2):611–618.
   PubMed Web of Science ®Google Scholar
• Smecuol E, Pinto Sanchez MI, Suarez A, et al. Low-dose aspirin affects the small bowel mucosa: results of a pilot study with a multidimensional assessment. Clin Gastroenterol Hepatol. 2009;7(5):524–529.
   PubMed Web of Science ®Google Scholar
• Maiden L, Thjodleifsson B, Seigal A, et al. Long-term effects of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective agents on the small bowel: a cross-sectional capsule enteroscopy study. Clin Gastroenterol Hepatol. 2007;5(9):1040–1045.
   PubMed Web of Science ®Google Scholar
• Fukui A, Naito Y, Handa O, et al. Acetyl salicylic acid induces damage to intestinal epithelial cells by oxidation-related modifications of ZO-1. Am J Physiol Gastrointest Liver Physiol. 2012;303(8):G927–G936.
   PubMed Web of Science ®Google Scholar
• Handa O, Naito Y, Fukui A, et al. The impact of non-steroidal anti-inflammatory drugs on the small intestinal epithelium. J Clin Biochem Nutr. 2014;54(1):2–6.
   PubMed Web of Science ®Google Scholar
• Handa O, Majima A, Onozawa Y, et al. The role of mitochondria-derived reactive oxygen species in the pathogenesis of non-steroidal anti-inflammatory drug-induced small intestinal injury. Free Radic Res. 2014;48(9):1095–1099.
   PubMed Web of Science ®Google Scholar
• Taylor Nordgård C, Draget KI. Dynamic responses in small intestinal mucus: relevance for the maintenance of an intact barrier. Eur J Pharm Biopharm. 2015;95(A):144–150.
   Web of Science ®Google Scholar
• Chassaing B, Koren O, Goodrich JK, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015;519(7541):92–96.
   PubMed Web of Science ®Google Scholar
• Nonoyama K, Nakagawa K, Amagase K, et al. New method of inducing intestinal lesions in rats by intraduodenal administration of aspirin. J Gastroenterol Hepatol. 2010;25(Suppl1):S15–S22.
   Web of Science ®Google Scholar
• Yasuda-Onozawa Y, Handa O, Naito Y, et al. Rebamipide upregulates mucin secretion of intestinal goblet cells via Akt phosphorylation. Mol Med Rep. 2017;16(6):8216–8222.
   PubMed Web of Science ®Google Scholar
• Suyama Y, Handa O, Naito Y, et al. Mucus reduction promotes acetyl salicylic acid-induced small intestinal mucosal injury in rats. Biochem Biophys Res Commun. 2018 28;498(1):228–233.
   PubMed Web of Science ®Google Scholar
• Endo H, Higurashi T, Hosono K, et al. Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study. J Gastroenterol. 2011;46(7):894–905.
   PubMed Web of Science ®Google Scholar
• Mizukami K, Murakami K, Abe T, et al. Aspirin-induced small bowel injuries and the preventive effect of rebamipide. World J Gastroenterol. 2011;17(46):5117–5122.
   PubMed Web of Science ®Google Scholar
• Watari I, Oka S, Tanaka S, et al. Effectiveness of polaprezinc for low-dose aspirin-induced small-bowel mucosal injuries as evaluated by capsule endoscopy: a pilot randomized controlled study. BMC Gastroenterol. 2013;13:108.
   PubMed Web of Science ®Google Scholar
• Watanabe T, Takeuchi T, Handa O, et al. A multicenter, randomized, double-blind, placebo-controlled trial of high-dose rebamipide treatment for low-dose aspirin-induced moderate-to-severe small intestinal damage. PLoS ONE. 2015;10(4):e0122330.
   PubMed Web of Science ®Google Scholar
• Naito Y, Yoshikawa T. Rebamipide: a gastrointestinal protective drug with pleiotropic activities. Expert Rev Gastroenterol Hepatol. 2010;4(3):261–270.
   PubMed Web of Science ®Google Scholar
• Iijima K, Ichikawa T, Okada S, et al. Rebamipide, a cytoprotective drug, increases gastric mucus secretion in human: evaluations with endoscopic gastrin test. Dig Dis Sci. 2009;54(7):1500–1507.
   PubMed Web of Science ®Google Scholar
• Suetsugu H, Ishihara S, Moriyama N, et al. Effect of rebamipide on prostaglandin EP4 receptor gene expression in rat gastric mucosa. J Lab Clin Med. 2000;136(1):50–57.
   PubMed Web of Science ®Google Scholar
• Yoshikawa T, Naito Y, Tanigawa T, et al. Free radical scavenging activity of the novel anti-ulcer agent rebamipide studied by electron spin resonance. Arzneimittelforschung. 1993;43(3):363–366.
   PubMed Web of Science ®Google Scholar
• Murakami K, Okajima K, Uchiba M, et al. Rebamipide attenuates indomethacin-induced gastric mucosal lesion formation by inhibiting activation of leukocytes in rats. Dig Dis Sci. 1997;42(2):319–325.
   PubMed Web of Science ®Google Scholar
• Nagano Y, Matsui H, Shimokawa O, et al. Rebamipide attenuates nonsteroidal anti-inflammatory drugs (NSAID) induced lipid peroxidation by the manganese superoxide dismutase (MnSOD) overexpression in gastrointestinal epithelial cells. J Physiol Pharmacol. 2012;63(2):137–142.
   PubMed Web of Science ®Google Scholar
• Suzuki H, Masaoka T, Minegishi Y, et al. Lansoprazole promotes gastric mucosal cell proliferation and migration by activating p44/p42 mitogen-activated protein kinase. Wound Repair Regen. 2004;12(1):93–99.
   PubMed Web of Science ®Google Scholar
• Endo H, Sakai E, Taniguchi L, et al. Risk factors for small-bowel mucosal breaks in chronic low-dose aspirin users: data from a prospective multicenter capsule endoscopy registry. Gastrointest Endosc. 2014;80(5):826–834.
   PubMed Web of Science ®Google Scholar
• Wallace JL, Syer S, Denou E, et al. Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. Gastroenterology. 2011;141(4):1314–22, 1322.e1.
   PubMed Web of Science ®Google Scholar
• Kuroda M, Yoshida N, Ichikawa H, et al. Lansoprazole, a proton pump inhibitor, reduces the severity of indomethacin-induced rat enteritis. Int J Mol Med. 2006;17(1):89–93.
   PubMed Web of Science ®Google Scholar