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Free Radical Research Volume 52, 2018 - Issue 7
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Original Article

Dunnione protects against experimental cisplatin-induced nephrotoxicity by modulating NQO1 and NAD+ levels

Saeed Nazari Soltan AhmadDepartment of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; ORCID Iconhttp://orcid.org/0000-0002-6831-7624View further author information
ORCID Icon,
Nadereh RashtchizadehBiotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-2878-3847View further author information
ORCID Icon,
Hassan ArganiUrology and Nephrology Research Center, Beheshti University of Medical Sciences, Tehran, Iran; View further author information
,
Leila RoshangarStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; View further author information
,
Amir Ghorbani HaghjoBiotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; View further author information
,
Davoud SanajouDepartment of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; View further author information
,
Fatemeh PanahDepartment of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; View further author information
,
Zahra Ashrafi JighehDepartment of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; View further author information
,
Siavoush DastmalchiBiotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; View further author information
&
Mehran Mesgari-AbbasiDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IranView further author information
 show all
Pages 808-817 | Received 16 Mar 2018, Accepted 07 May 2018, Published online: 04 Jun 2018

References

  • Pabla N, Dong Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int. 2008;73(9):994–1007.
  • Miller RP, Tadagavadi RK, Ramesh G, et al. Mechanisms of cisplatin nephrotoxicity. Toxins. 2010;2(11):2490–2518.
  • Chirino YI, Pedraza-Chaverri J. Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity. Exp Toxicol Pathol. 2009;61(3):223–242.
  • Jung YJ, Lee JE, Lee AS, et al. SIRT1 overexpression decreases cisplatin-induced acetylation of NF-κB p65 subunit and cytotoxicity in renal proximal tubule cells. Biochem Biophys Res Commun. 2012;419(2):206–210.
  • Kobayashi EH, Suzuki T, Funayama R, et al. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nat Commun. 2016;7:11624.
  • Vaziri H, Dessain SK, Ng Eaton E, et al. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell. 2001;107(2):149–159.
  • Loboda A, Damulewicz M, Pyza E, et al. Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism. Cell Mol Life Sci. 2016;73(17):3221–3247.
  • Tanigawa S, Fujii M, Hou DX. Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin. Free Radic Biol Med. 2007;42(11):1690–1703.
  • Oh GS, Kim HJ, Choi JH, et al. Pharmacological activation of NQO1 increases NAD+ levels and attenuates cisplatin-mediated acute kidney injury in mice. Kidney Int. 2014;85(3):547–560.
  • Park JS, Lee YY, Kim J, et al. β-Lapachone increases phase II antioxidant enzyme expression via NQO1-AMPK/PI3K-Nrf2/ARE signaling in rat primary astrocytes. Free Radic Biol Med. 2016;97:168–178.
  • Bian J, Xu L, Deng B, et al. Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD (P) H: quinone oxidoreductase 1 (NQO1). Bioorg Med Chem Lett. 2015;25(6):1244–1248.
  • Park D, Jo IG, Jang JY, et al. A dunnione compound MB12662 improves cisplatin-induced tissue injury and emesis. Biomol Ther. 2015;23(5):449–457.
  • Lee S, Kim W, Moon SO, et al. Rosiglitazone ameliorates cisplatin-induced renal injury in mice. Nephrol Dial Transplant. 2006;21(8):2096–2105.
  • Poljsak B, Milisav I. NAD+as the link between oxidative stress, inflammation, caloric restriction, exercise, DNA repair, longevity, and health span. Rejuvenation Res. 2016;19(5):406–413.
  • Imai S-I, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 2014;24(8):464–471.
  • Pandit A, Kim HJ, Oh GS, et al. Dunnione ameliorates cisplatin-induced small intestinal damage by modulating NAD+ metabolism. Biochem Biophys Res Commun. 2015;467(4):697–703.
  • Caito S, Rajendrasozhan S, Cook S, et al. SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. FASEB J. 2010;24(9):3145–3159.
  • Arunachalam G, Yao H, Sundar IK, et al. SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: role of resveratrol. Biochem Biophys Res Commun. 2010;393(1):66–72.
  • Hassan HA, Edrees GM, El-Gamel EM, et al. Amelioration of cisplatin-induced nephrotoxicity by grape seed extract and fish oil is mediated by lowering oxidative stress and DNA damage. Cytotechnology. 2014;66(3):419–429.
  • Chaitanya GV, Steven AJ, Babu PP. PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration. Cell Commun Signal. 2010;8(1):31.
  • Liu M, Grigoryev DN, Crow MT, et al. Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice. Kidney Int. 2009;76(3):277–285.
  • Wild AC, Moinova HR, Mulcahy RT. Regulation of γ-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2. J Biol Chem. 1999;274(47):33627–33636.
  • Ozkok A, Edelstein CL. Pathophysiology of cisplatin-induced acute kidney injury. BioMed Res Int. 2014;2014:967826.
  • Oh GS, Kim HJ, Shen A, et al. Cisplatin-induced kidney dysfunction and perspectives on improving treatment strategies. Electrolyte Blood Press. 2014;12(2):55–65.
  • Boutaud A, Borza DB, Bondar O, et al. Type IV collagen of the glomerular basement membrane. Evidence that the chain specificity of network assembly is encoded by the noncollagenous NC1 domains. J Biol Chem. 2000;275(39):30716–30724.
  • Sekulic M, Pichler Sekulic S. A compendium of urinary biomarkers indicative of glomerular podocytopathy. Pathol Res Int. 2013;2013:782395.
  • Vaidya VS, Ferguson MA, Bonventre JV. Biomarkers of acute kidney injury. Annu Rev Pharmacol Toxicol. 2008;48:463–493.

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