24
Views
22
CrossRef citations to date
0
Altmetric
Original Article

Late onset administration of oral antioxidants prevents age-related loss of motor co-ordination and brain mitochondrial DNA damage

, , , , , & show all
Pages 617-623 | Received 24 Aug 1998, Published online: 07 Jul 2009

References

  • Harman D. Aging: a theory based on free radical and radiation chemistry. Journal of Gerontology 1956; 11: 298–300
  • Harman D. The free radical theory of aging. Proceedings of the National Academy of Sciences of the United States of America 1981; 78: 7124–7128
  • Sies H. Biochemistry of oxidative stress. Angewandte Chemie 1986; 25: 1058–1071
  • Harman D. Free radical theory of aging: Role of free radicals in the origination and evölution of life, aging and disease processes. Free Radicals, Aging and Degenerative Diseases, J.E. Johnson, Jr., R. Walford, D. Harman, J. Miquel. Alan R. Liss, New York 1986; 3–49, In
  • Viña J., Sastre J., Pallardó F.V., Plá R., Estrela J.M., Miquel J. The mitochondrial theory of aging: recent developments. Bulletin of Molecular Biology 1993; 18: 81–87
  • Orr W.C., Sohal R.S. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 1994; 263: 1128–1130
  • Miquel J., Economos A.C., Fleming J., Johnson J.E., Jr. Mitochondrial role in cell aging. Experimental Gerontology 1980; 15: 579–591
  • Miquel J., Fleming J.E. Theoretical and experimental support for an “oxygen radical-mitochondrial injury” hypothesis of cell aging. Free Radicals, Aging and Degenerative Diseases, J.E. Johnson, Jr., R. Walford, D. Harman, J. Miquel. Alan R. Liss, New York 1986; 51–74, In
  • Shigenaga M.K., Hagen T.M., Ames B.N. Oxidative damage and mitochondrial decay in aging. Proceedings of the National Academy of Sciences of the United States of America 1994; 91: 10771–10778
  • Sastre J., Millán A., García de la Asunción J., Plá R., Juan G., Pallardó F.V., O'Connor E., Martin J.A., Droy-Lefaix M.T., Viña J. A Ginkgo biloba extract (EGb 761) prevents mitochondrial aging by protecting against oxidative stress. Free Radical Biology and Medicine 1998; 24(2)298–304
  • Forster M.J., Dubey A., Dawson K.M., Stutts W.A., Lal H., Sohal R.S. Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain. Proceedings of the National Academy of Sciences of the United States of America 1996; 93(10)4765–4769
  • Viña J., Perez C., Furukawa T., Palacín M., Viña J.R. Effect of oral glutathione on hepatic glutathione levels. The British Journal of Nutrition 1989; 62: 683–691
  • Viña J., Sastre J., Anton V., Bruseghini L., Esteras A., Asensi M. Effect of aging on glutathione metabolism. Protection by antioxidants. Free Radicals and Aging, I. Emerit, B. Chance. Birkhauser Verlag, BaselSwitzerland 1992; 136–144, In
  • García de la Asunción J., Millán A., Plá R., Bruseghini L., Esteras A., Pallardó F.V., Sastre J., Viña J. Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA. The FASEB Journal 1996; 10: 333–338
  • Rickwood D., Wilson M.T., Darley-Usmar V.M. Isolation and characteristics of intact mitochondria. Mitochondria: A practical approach, V.M. Darley-Usmar, D. Rickwood, M.T. Wilson. IRL Press Limited, Oxford 1987; 1–16, In
  • Miquel J., Blasco M. A simple technique for evaluation of vitality loss in aging mice by testing their muscular coordination and vigor. Experimental Gerontology 1978; 13: 389–394
  • Yen T.C., Chen Y.S., King K.L., Yeh S.H., Wei Y.H. Liver mitochondrial respiratory functions decline with age. Biochemical and Biophysical Research Communications 1989; 165(3)994–1003
  • Cutler R.G. Antioxidants and aging. American Journal of Clinical Nutrition 1991; 53(Suppl. 1)373S–379S
  • Furukawa T., Meydani S.N., Blumberg J.B. Reversal of age-associated decline in immune responsiveness by dietary glutathione supplementation in mice. Mechanisms of Aging Developments 1987; 38(2)107–117
  • Miquel J., Economos A.C. Favorable effects of the antioxidants sodium and magnesium thiazolidine carboxylate on the vitality and life span of Drosophila and mice. Experimental Gerontology 1979; 14: 279–285
  • Weindruch R., Walford R.L. Dietary restriction in mice begining at one year of age: effects on life span and spontaneous cancer incidence. Science 1982; 215: 1415–1417
  • Alam Z.I., Daniel S.E., lees A.J., marsden D.C., Jenner P., Halliwell B. A generalised increase in protein carbonyls in the brain in Parkinson's but not in incidental Lewy body disease. Journal of Neurochemistry 1997; 69: 1326–1329
  • Alam Z.I., Jenner A., Daniel S.E., Lees A.J., Cairns N., Marsden C.D., Jenner P., Halliwell B. Oxidative DNA damage in the Parkinsonian brain: an apparent selective indrease in 8-hydroxyguanine levels in substantia nigra. Journal of Neurochemistry 1997; 69: 1196–1203
  • Coyle J.T., Puttfarken P. Oxidative stress, glutamate and neurodegenerative disorders. Science 1993; 262: 689–695
  • Sohal R.S., Agarwal S., Candas M., Forster M.J., Lal H. Effect of age and caloric restriction of DNA oxidative damage in different tissues of C57BL/6 mice. Mechanisms of Ageing and Development 1994; 76: 215–224
  • Smith C.D., Carney J.M., Starke-Reed P.E., Oliver C.N., Stadtman E.R., Floyd R.A., Markesbery W.R. Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America 1991; 88: 10540–10543
  • Perrig W.J., Perrig P., Stähelin H.B. The relation between antioxidants and memory performance in the old and very old. The Journal of the American Geriatric Society 1997; 45(6)718–724
  • Smith M.A., Perry G., Richey P.L., Andreson V.E., Beal M.F., Kowall N. Oxidative damage in Alzheimer's. Nature 1996; 382: 120–121
  • Gotz M.E., Freyberger A., Riederer P. Oxidative stress—A role of the pathogenesis of Parkinsons disease. Journal of Neural Transmission 1990; 29: 241–249
  • Sano M., Ernesto C., Thomas R.G., Klauber M.R., Schaffer K., Grundman M., Woodbury P., Growdon J., Cotman C., Pfeiffer E., Schneider L.S., Thal L.J. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The New England Journal of Medicine 1997; 337: 1216–1222

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.