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Drug Delivery Volume 15, 2008 - Issue 2
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Research Article

Design of Cationic Microspheres Based on Aminated Gelatin for Controlled Release of Peptide and Protein Drugs

Kazuhiro Morimoto Hokkaido Phamaceutical University, School of Pharmacy, Hokkaido, Japan
,
Sumio Chono Hokkaido Phamaceutical University, School of Pharmacy, Hokkaido, Japan
,
Tadashi Kosai Hokkaido Phamaceutical University, School of Pharmacy, Hokkaido, Japan
,
Toshinobu Seki Hokkaido Phamaceutical University, School of Pharmacy, Hokkaido, Japan
&
Yasuhiko Tabata Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
Pages 113-117 | Received 30 Apr 2007, Accepted 20 Jun 2007, Published online: 10 Oct 2008

REFERENCES

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  • Leitner V. M., Guggi D., Krauland A. H., Bernkop-Schnurch A., Andreas B. S. Nasal delivery of human growth hormone: in vitro and in vivo evaluation of a thiomer/glutathione microparticulate delivery system. J. Control. Rel. 2004; 100: 87–95
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  • Morimoto K., Chono S., Kosai T., Seki T., Tabata Y. Design of novel injectable cationic microspheres based on aminated gelatin for prolonged action of insulin. J. Pharm. Pharmacol. 2005; 57: 839–844
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  • Tabata Y., Ikada Morimoto K., Kstsumata H., Yabuta T., Iwanaga K., Kakemi T. Surfactant-free preparation of biodegradable hydrogel micro-spheres for protein release. J. Bioact. Compat. Polymers 1999; 14: 371–384
  • Tabata Y., Ikada Y. Synthesis of gelatin microspheres containing interferon. Pharm. Res. 1989; 6: 422–427
  • Wang J., Tauchi Y., Deguchi Y., Morimoto K., Tabata Y. Positively charged gelatin microsphere as gastric mucoadhesive drug delivery system for clearance of H. pylori. Drug Deliv. 2000; 7: 237–243
  • Wang J., Tabata Y., Morimoto K. Aminated gelatin microspheres as a nasal delivery system for peptide drugs: evaluation of in vitro release and in vivo insulin absorption in rats. J. Control. Rel. 2006; 113: 31–37

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