2,282
Views
22
CrossRef citations to date
0
Altmetric
Research Article

Nasal administration of metoclopramide from different dosage forms: in vitro, ex vivo, and in vivo evaluation

, , , , &
Pages 167-175 | Published online: 01 Apr 2009

References

  • Martindale (2002). The complete drug reference. In: Sweetman SC, ed. (2002). Martindale: The complete drug reference, thirty-fifth edition, London: Pharmaceutical Press, 1235–7.
  • Gavini E, Rassu G, Sanna V, Cossu M, Giunchedi P. (2004). Mucoadhesive microspheres for nasal administration of an antiemetic drug, metoclopramide: in-vitro/ex-vivo studies. J Pharm Pharmacol, 57, 287–94.
  • Chien YW. (1992). Nasal drug delivery systems. In: Swacbrick, J, ed. Novel drug delivery systems. New York: Marcel Dekker, 139–96.
  • Zaki NM, Award GA, Mortada ND, Elhady SS. (2006). Rapid onset intranasal delivery of metoclopramide hydrochloride. Part II: safety of various absorption enhancers and pharmacokinetic evaluation. Int J Pharm, 327, 97–103.
  • Chavanpatil MD, Vavia PR. (2004). The influence of absorption enhancers on nasal absorption of acyclovir. Eur J Pharm Biopharm, 57, 483–7.
  • Dondeti P, Zia H, Needham TE. (1996). Bioadhesive and formulation parameters affecting nasal absorption. Int J Pharm, 127, 115–33.
  • Merkus FWHM, Verhoef JC, Marttin E, Romeijn SG, Van der Kuy PHM, Hermens WAJJ, Schipper NGM. (1999). Cyclodextrins in nasal drug delivery. Adv Drug Del Rev, 36, 41–57.
  • Ugwoke MI, Agu RU, Vanbilloen H, Baetens J, Augustijns P, Verbeke N, Mortelmans L, Verbruggen A, Kinget R, Bormans G. (2000). Scintigraphic evaluation in rabbits of nasal drug delivery systems based on carbopol 971p® and carboxymethylcellulose. J Contr Rel, 6, 207–14.
  • Tas C, Ozkan Y, Savas¸er A, Baykara T. (2003). In vitro release studies of chlorpheniramine maleate gels prepared by different cellulose derivatives. II Farmaco, 58, 605–11.
  • Osth K, Paulsson M, Björk E, Edsman K. (2002). Evaluation of drug release from gels on pig nasal mucosa in a horizontal Ussing chamber. J Contr Rel, 83, 377–88.
  • Cheng Y-H, Watts P, Hinchcliffe M, Hotchkiss R, Nankervis R, Faraj NF, Smith A, Davis SS, Illum L. (2002). Development of a nasal nicotine formulation comprising an optimal pulsatile and sustained plasma nicotine profile for smoking cessation. J Contr Rel, 79, 243–54.
  • Shargel L, Yu ABC. (1985). Applied biopharmaceutics and pharmacokinetics, 2nd ed. Norwalk: Appleton-Century-Crofts, 231–43.
  • Tas C, Ozkan CK, Savaser A, Ozkan Y, Tasdemir U, Altunay H. (2006). Nasal absorption of metoclopramide from different carbopol® 981 based formulations: in vitro, ex vivo and in vivo evaluation. Eur J Pharm Biopharm, 64, 246–54.
  • Escudero JJ, Ferrero C, Jimenez-Castellanos MR. (2008). Compaction properties, drug release kinetics and fronts movement studies from matrices combining mixtures of swellable and inert polymers: effect of HPMC of different viscosity grades. Int J Pharm, 351, 61–73.
  • Ma WD, Xu H, Wang C, Nie S-F, Pan W-S. (2008). Pluronic F127-g-poly(acrylic acid) copolymers as in situ gelling vehicle for opthalmic drug delivery system. Int J Pharm, 350, 247–56.
  • Rajinikanth PS, Mishra B. (2008). Floating in situ gelling system for stomach site-spesific delivery of claritromycin to eradicate H.pylori. J Contr Rel, 125, 33–41.
  • Fang J-Y, Hwang T-L, Leu Y-L. (2003). Effect of enhancers and retarders on percutaneous absorption of flurbiprofen from hydrogels. Int J Pharm, 250, 313–25.
  • D’Souza R, Mutalik S, Venkatesh M, Vidyasagar S, Udupa N. (2005). Nasal insulin gel as an alternate to parenteral insulin: formulation, preclinical, and clinical studies. AAPS Pharm Sci Tech, 6, 184–9.
  • Charlton ST, Davis SS, Illum L. (2007). Evaluation of bioadhesive polymers as delivery systems for nose to brain delivery: in vitro characterisation studies. J Contr Rel, 118, 225–34.
  • Mahato RI. (2004). Pharmaceutical delivery systems and dosage forms. New York: Castle Connoly, 37–64.
  • Zhang Y, Zhang Q, Sun Y, Sun J, Wang X, Chen M. (2005). Nasal recombinant hirudin-2 delivery: absorption and its mechanism in vivo and in vitro studies. Bio Pharm Bull, 28, 2263–7.
  • Zaki NM, Awad GA, Mortada ND, Elhady SSA. (2007). Enhanced bioavailability of metoclopramide HCI by intranasal administration of a mucoadhesive in situ gel with modulated rheological and mucociliary transport properties. Eur J Pharm Sci, 32, 296–307.
  • Behl CR, Pimplaskar HK, Sileno AP, deMeireles J, Romeo VD. (1998). Effects of physicochemical and other factors on systemic nasal drug delivery. Adv Drug Del Rev, 29, 89–116.
  • Aurora J. (2002). Development of nasal delivery systems. A Review. Drug Deliv Technol, 2(7), 70–3.
  • Martin E, Romeijn SG, Verhoef JC, Merkus FWHM. (1997). Nasal absorption of dihydroergotamine from liquid and powder forrmulations in rabbits. J Pharm Sci, 86, 802–7.
  • Asai K, Morishita M, Katsuta H, Hosoda S, Shinomiya K, Noro M, Nagai T, Takayama K. (2002). The effects of water-soluble cyclodextrins on the histological integrity of the rat nasal mucosa. Int J Pharm, 246, 25–35.
  • Arora P, Sharma S, Garg S. (2002). Permeability issues in nasal drug delivery. Drug Discov Today, 7, 967–75.
  • Najafabadi AR, Moslemi P, Tajerzadeh H. (2004). Intranasal bioavailability of insulin from carbopol-based gel spray in rabbits. Drug Del, 11, 295–300.
  • Morimoto K, Tabata H, Morisaka K. (1987). Nasal absorption of nifedipine from gel preparations in rats. Chem Pharm Bull, 35, 3041–4.
  • Tuncel T, Otuk G, Kuscu I, Ates S. (1994). Nasal absorption of roxitromycin from gel preparations in rabbits. Eur J Pharm Biopharm, 40, 24–6.
  • Yetkin G, çelebi N, Agabeyoglu I, Gokcora N. (1999). The effect of dimethyl-β-cyclodextrin and sodium taurocholate on the nasal bioavailability of salmon calcitonin in rabbits. STP Pharm Sci, 9, 249–52.
  • Ozsoy Y, Tuncel T, Can A, Akev N, Birteksoz S, Gerceker A. (2000). In vivo nasal studies on nasal preparations of ciprofloxacin hydrochloride. Pharmazie, 55, 607–9.
  • Leitner VM, Guggi D, Bernkop-Schnurch A. (2004). Thiomers in noninvasive poypeptide delivery: in vitro and in vivo characterization of a polycarbophil-cysteine/glutathione gel formulation for human growth hormone. J Pharm Sci, 93, 1682–91.
  • Ishikawa F, Katsura M, Tamai I, Tsuji A. (2001). Improved nasal bioavailability of elcatonin by insoluble powder formulation. Int J Pharm, 224, 105–14.
  • Leitner VM, Guggi D, Krauland AH, Bernkop-Schnürch A. (2004). Nasal delivery of human growth hormone: in vitro and in vivo evaluation of a thiomer/glutathione microparticulate delivery system. J Contr Rel, 100, 87–95.
  • Ugwoke MI, Exaud S, Mooter GVD, Verbeke N, Kinget R. (1999). Bioavailability of apomorphine following intranasal administration of mucoadhesive drug delivery systems in rabbits. Eur J Pharm Sci, 9, 213–9.
  • Nakamura K, Maitani Y, Takayama K. (2002). The enhancing effect of nasal absorption of FITC-Dextran 4,400 by β-Sitosterol β-D-Glucoside in rabbits. J Contr Rel, 79, 147–55.
  • Gu F, Cui F, Gao Y. (2005). Preparation of prostaglandin E1-hydroxypropyl-β-cyclodextrin complex and its nasal delivery in rats. Int J Pharm, 290, 101–8.
  • Irie T, Wakamatsu K, Arima H, Aritomi H, Uekama K. (1992). Enhancing effects of cyclodextrins on nasal absorption of insulin in rats. Int J Pharm, 84, 129–39.
  • Sinswat P, Temgamnuay P. (2003). Enhancing effect of chitosan on nasal absorption of salmon calcitonin in rats: comparison with hydroxypropyl- and dimethyl-β-cyclodextrins. Int J Pharm, 257, 15–22.
  • Yang T, Hussain A, Paulson J, Abbruscato TJ, Ahsan F. (2004). Cyclodextrins in nasal delivery of low-molecular-weight heparins: in vivo and in vitro studies. Pharm Res, 21, 1127–36.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.