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Drug Delivery Volume 24, 2017 - Issue 1
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Research Article

Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of periodontitis

Maha M. A. Nasra1 Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt and
,
Heba M. Khiri1 Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt and
,
Heba A. Hazzah2 Department of Pharmaceutics, Faculty of Pharmacy and Drug Manufacturing, Pharos university in Alexandria, Alexandria, EgyptCorrespondence[email protected]
&
Ossama Y. Abdallah1 Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt and
Pages 133-142 | Received 19 Jul 2016, Accepted 04 Sep 2016, Published online: 03 Feb 2017

References

  • Association. WM (2001). World medical association declaration of helsinki, ethical principles for medical research involving human subjects. Bull World Health Organ 79:373–4
  • Babu J, Ayyappan T, Vetrichelvan T. (2011). Novel site specific delivery system containing ofloxacin for the treatment of periodontal infection. Res J Pharm Biol Chem Sci 2:590–602
  • Bilensoy E, Rouf MA, Vural I, et al. (2006). Mucoadhesive, thermosensitive, prolonged-release vaginal gel for clotrimazole: β-cyclodextrin complex. PharmSciTech 7:E54–60
  • Checchi L, Montevecchi M, Checchi V, Zappulla F. (2009). The relationship between bleeding on probing and subgingival deposits. An endoscopical evaluation. Open Dentistry J 3:154
  • Dumortier G, Grossiord JL, Agnely F, Chaumeil JC. (2006). A review of poloxamer 407 pharmaceutical and pharmacological characteristics. Pharm Res 23:2709–28
  • Garala K, Joshi P, Shah M, et al. (2013). Formulation and evaluation of periodontal in situ gel. Int J Pharm Investigation 3:29
  • Gilbert JC, Richardson JL, Davies MC, et al. (1987). The effect of solutes and polymers on the gelation properties of pluronic F-127 solutions for controlled drug delivery. J Control Release 5:113–18
  • Glavind L, Löe H. (1967). Errors in the clinical assessment of periodontal destruction. J Periodontal Res 2:180–4
  • Guimarães MR, Coimbra LS, de Aquino SG, et al. (2011). Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo. J Periodontal Res 46:269–79
  • Hazzah HA, Farid RM, Nasra MM, et al. (2016). A new approach for treatment of precancerous lesions with curcumin solid-lipid nanoparticle-loaded gels: in vitro and clinical evaluation. Drug Deliv 23:1409–19
  • Jagetia GC, Aggarwal BB. (2007). “Spicing up” of the immune system by curcumin. J Clin Immunol 27:19–35
  • Kirkpatrick LA, Feeney BC. (2012). A simple guide to IBM SPSS: for version 20.0. Nelson Education. USA: Jon David Hogue
  • Löe H, Silness J. (1963). Periodontal disease in pregnancy I. Prevalence and Severity. Acta Odontol Scand 21:533–51
  • Maheshwari M, Miglani G, Mali A, et al. (2006). Development of tetracycline-serratiopeptidase-containing periodontal gel: formulation and preliminary clinical study. American Association of Pharmaceutical Scientists. PharmSciTech 7:E162–E71
  • Mandeville J-S, Froehlich E, Tajmir-Riahi H. (2009). Study of curcumin and genistein interactions with human serum albumin. J Pharm Biomed Anal 49:468–74
  • Nagpal M, Sood S. (2013). Role of curcumin in systemic and oral health: an overview. J Nat Sci Biol Med 4:3
  • Peppas N. (1985). Analysis of Fickian and non-Fickian drug release from polymers. Pharm Acta Helvetiae 60:110
  • Pihlstrom BL, Michalowicz BS, Johnson NW. (2005). Periodontal diseases. Lancet 366:1809–20
  • Quitschke WW. (2012). Bioavailability and metabolism of curcuminoids. In: M. Diederich, K. Noworyta, eds. Natural compounds as inducers of cell death. Netherlands: Springer, 95–124
  • Rastogi P, Anand V, Minkle Gulati N, et al. (2012). A review of curcumin in reference to its use in oral diseases. Ann Ayurvedic Med 2:11
  • Schmolka IR. (1972). Artificial skin. I. Preparation and properties of pluronic F-127 gels for treatment of burns. J Biomed Mater Res 6:571–82
  • Siepmann J, Siepmann F. (2008). Mathematical modeling of drug delivery. Int J Pharm 364:328–43
  • Silness J, Löe H. (1964). Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condtion. Acta Odontol Scand 22:121–35
  • Song J, Choi B, Jin E-J, et al. (2012). Curcumin suppresses Streptococcus mutans adherence to human tooth surfaces and extracellular matrix proteins. Eur J Clin Microbiol Infect Dis 31:1347–52
  • Sun Y, Lee C-C, Hung W-C, et al. (2008). The bound states of amphipathic drugs in lipid bilayers: study of curcumin. Biophys J 95:2318–24
  • Tirnaksiz F, Robinson J. (2005). Rheological, mucoadhesive and release properties of pluronic F-127 gel and pluronic F-127/polycarbophil mixed gel systems. Die Pharmazie 60:518–23
  • Vadnere M, Amidon G, Lindenbaum S, Haslam JL. (1984). Thermodynamic studies on the gel–sol transition of some pluronic polyols. Int J Pharm 22:207–18
  • Zhongfa L, Chiu M, Wang J, et al. (2012). Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice. Cancer Chemother Pharmacol 69:679–89

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