Docosahexaenoic acid–mediated, targeted and sustained brain delivery of curcumin microemulsion

References

• Aggarwal BB, Shishodia S. (2006). Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71:1397–421
   PubMed Web of Science ®Google Scholar
• Ahmad N, Ahmad I, Umar S, et al. (2014). PNIPAM nanoparticles for targeted and enhanced nose-to-brain delivery of curcuminoids: UPLC/ESI-Q-ToF-MS/MS-based pharmacokinetics and pharmacodynamic evaluation in cerebral ischemia model. Drug Deliv 1–20. doi:10.3109/10717544.2014.941076
   Web of Science ®Google Scholar
• Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. (2007). Bioavailability of curcumin: problems and promises. Mol Pharm 4:807–18
   PubMed Web of Science ®Google Scholar
• Baumgartner M, Sturlan S, Roth E, et al. (2004). Enhancement of arsenic trioxide‐mediated apoptosis using docosahexaenoic acid in arsenic trioxide‐resistant solid tumor cells. Int J Can 112:707–12
   PubMed Web of Science ®Google Scholar
• Berquin IM, Min Y, Wu R, et al. (2007). Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. J. Clin. Invest 117:1866–75
   PubMed Web of Science ®Google Scholar
• Bock TK, Müller BW. (1994). A novel assay to determine the hemolytic activity of drugs incorporated in colloidal carrier systems. Pharm Res 11:589–91
   PubMed Web of Science ®Google Scholar
• Chen X, Zhi F, Jia X, et al. (2013). Enhanced brain targeting of curcumin by intranasal administration of a thermosensitive poloxamer hydrogel. J Pharm Pharmacol 65:807–16
   PubMed Web of Science ®Google Scholar
• Chen CT, Ouellet Z, Liu M, Calon F, et al. (2009). Rapid β-oxidation of eicosapentaenoic acid in mouse brain: an in situ study. Prostaglandins, Leukot Essent Fatty Acids 80:157–63
   PubMed Web of Science ®Google Scholar
• Devarajan PV, Shinde RL. 2011. Advances in microemulsions and nanoemulsions for improved therapy in brain cancer. In: Souto E, ed. Advanced anticancer approaches with multifunctional lipid nanocarriers. UK: i Smithers-Creative Publishing Solutions, 347–94
   Google Scholar
• Dobrovolskaia MA, Clogston JD, Neun BW, et al. (2008). Method for analysis of nanoparticle hemolytic properties in vitro. Nano Lett 8:2180–7
   PubMed Web of Science ®Google Scholar
• Dong Z, Katsumi H, Sakane T, Yamamoto A. (2010). Effects of polyamidoamine (PAMAM) dendrimers on the nasal absorption of poorly absorbable drugs in rats. Int J Pharm 393:245–53
   Web of Science ®Google Scholar
• Ganta S, Amiji M. (2009). Coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells. Mol Pharm 6:928–39
   PubMed Web of Science ®Google Scholar
• Goppert TM, Müller RH. (2005). Polysorbate-stabilized solid lipid nanoparticles as colloidal carriers for intravenous targeting of drugs to the brain: comparison of plasma protein adsorption patterns. J Drug Target 13:179–87
   PubMed Web of Science ®Google Scholar
• Han HD, Shin BC, Choi HS. (2006). Doxorubicin-encapsulated thermosensitive liposomes modified with poly (N-isopropylacrylamide-co-acrylamide): drug release behavior and stability in the presence of serum. Eur J Pharm Biopharm 62:110–16
   PubMed Web of Science ®Google Scholar
• Harvey KA, Xu Z, Saaddatzadeh MR, et al. (2015). Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines. J Neurosurg 122:547–56
   PubMed Web of Science ®Google Scholar
• Ikushima S, Fujiwara F, Todo S, Imashuku S. (1990). Effects of polyunsaturated fatty acids on vincristine-resistance in human neuroblastoma cells. Anticancer Res 11:1215–20
   Web of Science ®Google Scholar
• Jain R, Nabar S, Dandekar P, et al. (2010). Formulation and evaluation of novel micellar nanocarrier for nasal delivery of sumatriptan. Nanomedicine (Lond) 5:575–87
   PubMed Web of Science ®Google Scholar
• Jogani VV, Shah PJ, Mishra P, et al. (2008). Intranasal mucoadhesive microemulsion of tacrine to improve brain targeting. Alzheimer Dis Assoc Disord 22:116–24
   PubMed Web of Science ®Google Scholar
• Kozlovskaya L, Abou-Kaoud M, Stepensky D. (2014). Quantitative analysis of drug delivery to the brain via nasal route. J Control Release 189:133–40
   PubMed Web of Science ®Google Scholar
• Kreuter J, Ramge P, Petrov V, et al. (2003). Direct evidence that polysorbate-80-coated poly (butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles. Pharm Res 20:409–16
   PubMed Web of Science ®Google Scholar
• Kumar M, Misra A, Mishra AK, et al. (2008a). Mucoadhesive nanoemulsion-based intranasal drug delivery system of olanzapine for brain targeting. J Drug Target 16:806–14
   PubMed Web of Science ®Google Scholar
• Kumar M, Misra A, Babbar AK, Mishra AK, et al. (2008b). Intranasal nanoemulsion based brain targeting drug delivery system of risperidone. Int J Pharm 358:285–91
   PubMed Web of Science ®Google Scholar
• Laquintana V, Trapani A, Denora N, et al. (2009). New strategies to deliver anticancer drugs to brain tumors. Expert Opin Drug Deliv 6:1017–32
   PubMed Web of Science ®Google Scholar
• Lukiw WJ, Bazan NG. (2008). Docosahexaenoic acid and the aging brain. J. Nutr 138:2510–14
   PubMed Web of Science ®Google Scholar
• Madane RG, Mahajan HS. (2016). Curcumin-loaded nanostructured lipid carriers (NLCs) for nasal administration: design, characterization, and in vivo study. Drug Deliv 23:1326–1334
   PubMed Web of Science ®Google Scholar
• Mathew A, Fukuda T, Nagaoka Y, et al. (2012). Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease. PLoS One 7:e32616
   PubMed Web of Science ®Google Scholar
• Menendez JA, Lupu R, Colomer R. (2005). Exogenous supplementation with ω-3 polyunsaturated fatty acid docosahexaenoic acid (DHA; 22: 6n-3) synergistically enhances taxane cytotoxicity and downregulates Her-2/neu (c-erbB-2) oncogene expression in human breast cancer cells. Eur J Cancer Prev 14:263–70
   PubMed Web of Science ®Google Scholar
• Mukerjee A, Vishwanatha JK. (2009). Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. Anticancer Res 29:3867–75
   PubMed Web of Science ®Google Scholar
• Mulik RS, Mönkkönen J, Juvonen RO, et al. (2010). Transferrin mediated solid lipid nanoparticles containing curcumin: enhanced in vitro anticancer activity by induction of apoptosis. Int J Pharm 398:190–203
   PubMed Web of Science ®Google Scholar
• Nasrollahzadeh J, Siassi F, Doosti M, et al. (2008). The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mRNA expression. Lipids Health Dis 7:1
   PubMed Web of Science ®Google Scholar
• Nguyen LN, Ma D, Shui G, et al. (2014). Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature 509:503–6
   PubMed Web of Science ®Google Scholar
• Pastoriza-Gallego MJ, Lugo L, Legido JL, Piñeiro MM. (2011). Rheological non-Newtonian behavior of ethylene glycol-based Fe2O3 nanofluids. Nanoscale Res Lett 6:1–7
   Web of Science ®Google Scholar
• Patel MJ, Patel NM, Patel RB, Patel RP. (2010). Formulation and evaluation of self-microemulsifying drug delivery system of lovastatin. Asian J Pharm Sci 5:266–75
   Google Scholar
• Picq M, Chen P, Perez M, et al. (2010). DHA metabolism: targeting the brain and lipoxygenation. Mol Neurobiol 42:48–51
   PubMed Web of Science ®Google Scholar
• Schouten LJ, Rutten J, Huveneers HA, Twijnstra A. (2002). Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma. Cancer 94:2698–705
   PubMed Web of Science ®Google Scholar
• Setthacheewakul S, Mahattanadul S, Phadoongsombut N, et al. (2010). Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rats. Eur J Pharm Biopharm 76:475–85
   PubMed Web of Science ®Google Scholar
• Shinde RL, Bharkad GP, Devarajan PV. (2015). Intranasal microemulsion for targeted nose to brain delivery in neurocysticercosis: role of docosahexaenoic acid. Eur J Pharm Biopharm 96:363–79
   PubMed Web of Science ®Google Scholar
• Shinde RL, Jindal AB, Devarajan PV. (2011). Microemulsions and nanoemulsions for targeted drug delivery to the brain. Curr. Nanosci 7:119–33
   Web of Science ®Google Scholar
• Siddiqui RA, Harvey KA, Walker C, et al. (2013a). Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on DMBA-induced mammary tumorigenesis in mice. BMC Cancer 13:1
   PubMed Web of Science ®Google Scholar
• Siddiqui RA, Harvey K, Bammerlin E, Ikhlaque N. (2013b). Docosahexaenoic acid: a potential modulator of brain tumors and metastasis. J Biomol Res Ther 2:3
   Google Scholar
• Tamilvanan S. (2009). Formulation of multifunctional oil-in-water nanosized emulsions for active and passive targeting of drugs to otherwise inaccessible internal organs of the human body. Int J Pharm 381:62–76
   PubMed Web of Science ®Google Scholar
• Thirawong N, Nunthanid J, Puttipipatkhachorn S, Sriamornsak P. (2007). Mucoadhesive properties of various pectins on gastrointestinal mucosa: an in vitro evaluation using texture analyzer. Eur J Pharm Biopharm 67:132–40
   PubMed Web of Science ®Google Scholar
• Tiwari S, Yi-Meng T, Amiji M. (2006). Preparation and in vitro characterization of multifunctional nanoemulsions for simultaneous MR imaging and targeted drug delivery. J. Biomed. Nanotech 2:217–24
   Web of Science ®Google Scholar
• Trebelhorn CH, Dennis JC, Pondugula SR, et al. (2014). Plant-based omega-3 stearidonic acid enhance s antitumor activity of doxorubicin in human prostate cancer cell lines. J Cancer Res Ther 2:132–43
   Google Scholar
• Vyas TK, Babbar AK, Sharma RK, Misra A. (2005). Intranasal mucoadhesive microemulsions of zolmitriptan: preliminary studies on brain-targeting. J Drug Target 13:317–24
   PubMed Web of Science ®Google Scholar
• Vyas TK, Babbar AK, Sharma RK, et al. (2006a). Preliminary brain-targeting studies on intranasal mucoadhesive microemulsions of sumatriptan. AAPS PharmSciTech 7:E49–57
   PubMed Web of Science ®Google Scholar
• Vyas TK, Babbar AK, Sharma RK, et al. (2006b). Intranasal mucoadhesive microemulsions of clonazepam: preliminary studies on brain targeting. J Pharm Sci 95:570–80
   PubMed Web of Science ®Google Scholar
• Vyas TK, Shahiwala A, Amiji MM. (2008). Improved oral bioavailability and brain transport of saquinavir upon administration in novel nanoemulsion formulations. Int J Pharm 347:93–101
   PubMed Web of Science ®Google Scholar
• Wang S, Chen P, Zhang L, et al. (2012). Formulation and evaluation of microemulsion-based in situ ion-sensitive gelling systems for intranasal administration of curcumin. J Drug Target 20:831–40
   PubMed Web of Science ®Google Scholar
• Washington N, Steele RJC, Jackson SJ, et al. (2000). Determination of baseline human nasal pH and the effect of intranasally administered buffers. Int J Pharm 198:139–46
   PubMed Web of Science ®Google Scholar
• Zhang Q, Jiang X, Jiang W, et al. (2004). Preparation of nimodipine-loaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain. Int J Pharm 275:85–96
   PubMed Web of Science ®Google Scholar
• Zhuo Z, Zhang L, Mu Q, et al. (2009). The effect of combination treatment with docosahexaenoic acid and 5-fluorouracil on the mRNA expression of apoptosis-related genes, including the novel gene BCL2L12, in gastric cancer cells. In Vitro Cell Dev Biol Anim 5:69–74
   Web of Science ®Google Scholar