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Research Article

A novel matrix dispersion based on phospholipid complex for improving oral bioavailability of baicalein: preparation, in vitro and in vivo evaluations

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Pages 720-728 | Received 08 Feb 2017, Accepted 23 Mar 2017, Published online: 24 Apr 2017

References

  • Ahmad H, Arya A, Agrawal S, et al. (2016). Phospholipid complexation of NMITLI118RT+: way to a prudent therapeutic approach for beneficial outcomes in ischemic stroke in rats. Drug Deliv 23:3606–18
  • Alexander A, Ajazuddin Patel RJ, et al. (2016). Recent expansion of pharmaceutical nanotechnologies and targeting strategies in the field of phytopharmaceuticals for the delivery of herbal extracts and bioactives. J Control Release 241:110–24
  • Chen L, Dou J, Su Z, et al. (2011). Synergistic activity of baicalein with ribavirin against influenza A (H1N1) virus infections in cell culture and in mice. Antiviral Res 91:314–20
  • Cheng Y, He G, Mu X, et al. (2008). Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile. Neurosci Lett 441:16–20
  • Cong W, Shen L, Xu D, et al. (2014). Solid dispersion tablets of breviscapine with polyvinylpyrrolidone K30 for improved dissolution and bioavailability to commercial breviscapine tablets in beagle dogs. Eur J Drug Metab Pharmacokinet 39:203–10
  • Evers DL, Chao CF, Wang X, et al. (2005). Human cytomegalovirus-inhibitory flavonoids: studies on antiviral activity and mechanism of action. Antiviral Res 68:124–34
  • Jiang Q, Yang X, Du P, et al. (2016). Dual strategies to improve oral bioavailability of oleanolic acid: Enhancing water-solubility, permeability and inhibiting cytochrome P450 isozymes. Eur J Pharm Biopharm 99:65–72
  • Kanaze FI, Kokkalou E, Niopas I, et al. (2010). Dissolution rate and stability study of flavanone aglycones, naringenin and hesperetin, by drug delivery systems based on polyvinylpyrrolidone (PVP) nanodispersions. Drug Dev Ind Pharm 36:292–301
  • Kawakami K. (2016). Supersaturation and crystallization: non-equilibrium dynamics of amorphous solid dispersions for oral drug delivery. Expert Opin Drug Deliv [Epub ahead of print]. doi: 10.1080/17425247.2017.1230099
  • Khan J, Alexander A, Ajazuddin, et al. (2013). Recent advances and future prospects of phyto-phospholipid complexation technique for improving pharmacokinetic profile of plant actives. J Control Release 168:50–60
  • Kimata M, Shichijo M, Miura T, et al. (2000). Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells. Clin Exp Allergy 30:501–8
  • Li F, Yang X, Yang Y, et al. (2015). Phospholipid complex as an approach for bioavailability enhancement of echinacoside. Drug Dev Ind Pharm 41:1777–84
  • Liang J, Wu W, Liu Q, et al. (2013). Long-circulating nanoliposomes (LCNs) sustained delivery of baicalein (BAI) with desired oral bioavailability in vivo. Drug Deliv 20:319–23
  • Lipinski CA, Lombardo F, Dominy BW, et al. (2001). Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 46:3–26
  • Liu J, Qiu L, Gao J, et al. (2006). Preparation, characterization and in vivo evaluation of formulation of baicalein with hydroxypropyl-beta-cyclodextrin. Int J Pharm 312:137–43
  • Liu W, Tian R, Hu W, et al. (2012). Preparation and evaluation of self-microemulsifying drug delivery system of baicalein. Fitoterapia 83:1532–9
  • Luo J, Kong JL, Dong BY, et al. (2016). Baicalein attenuates the quorum sensing-controlled virulence factors of Pseudomonas aeruginosa and relieves the inflammatory response in P. aeruginosa-infected macrophages by downregulating the MAPK and NFkappaB signal-transduction pathways. Drug Des Devel Ther 10:183–203
  • Moon JH, Park SY. (2015). Baicalein prevents human prion protein-induced neuronal cell death by regulating JNK activation. Int J Mol Med 35:439–45
  • Saoji SD, Dave VS, Dhore PW, et al. (2016). The role of phospholipid as a solubility- and permeability-enhancing excipient for the improved delivery of the bioactive phytoconstituents of Bacopa monnieri. Eur J Pharm Sci. [Epub ahead of print]. doi: 10.1016/j.ejps.2016.08.056
  • Shao ZH, Vanden HT, Qin Y, et al. (2002). Baicalein attenuates oxidant stress in cardiomyocytes. Am J Physiol Heart Circ Physiol 282:H999–1006
  • Sharma A, Jain CP. (2010). Preparation and characterization of solid dispersions of carvedilol with PVP K30. Res Pharm Sci 5:49–56
  • Singh C, Bhatt TD, Gill MS, et al. (2014). Novel rifampicin-phospholipid complex for tubercular therapy: synthesis, physicochemical characterization and in-vivo evaluation. Int J Pharm 460:220–7
  • Tian S, He G, Song J, et al. (2012). Pharmacokinetic study of baicalein after oral administration in monkeys. Fitoterapia 83:532–40
  • Wang L, Ling Y, Chen Y, et al. (2010). Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells. Cancer Lett 297:42–8
  • Wei Q, Keck CM, Muller RH. (2017). Preparation and tableting of long-term stable amorphous rutin using porous silica. Eur J Pharm Biopharm 113:97–107
  • Xing J, Chen X, Zhong D. (2005). Absorption and enterohepatic circulation of baicalin in rats. Life Sci 78:140–6
  • Yan F, Ke X, Ping QN, et al. (2008). Preparation of baicalein solid dispersions and oral bioavailability in rats. J China Pharm Univ 39:406–11
  • Yang D, Hu H, Huang S, et al. (2000). Study on the inhibitory activity, in vitro, of baicalein and baicalin against skin fungi and bacteria. Zhong Yao Cai 23:272–4
  • Yanyu X, Yunmei S, Zhipeng C, et al. (2006). The preparation of silybin-phospholipid complex and the study on its pharmacokinetics in rats. Int J Pharm 307:77–82
  • Yue PF, Yuan HL, Li XY, et al. (2010). Process optimization, characterization and evaluation in vivo of oxymatrine-phospholipid complex. Int J Pharm 387:139–46
  • Zhang J, Lv H, Jiang K, et al. (2011). Enhanced bioavailability after oral and pulmonary administration of baicalein nanocrystal. Int J Pharm 420:180–8
  • Zhang Y, Luo R, Chen Y, et al. (2014). Application of carrier and plasticizer to improve the dissolution and bioavailability of poorly water-soluble baicalein by hot melt extrusion. AAPS PharmSciTech 15:560–8
  • Zhang Z, Chen Y, Deng J, et al. (2014). Solid dispersion of berberine-phospholipid complex/TPGS 1000/SiO(2): preparation, characterization and in vivo studies. Int J Pharm 465:306–16
  • Zheng YH, Yin LH, Grahn TH, et al. (2014). Anticancer effects of baicalein on hepatocellular carcinoma cells. Phytother Res 28:1342–8