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Research Article

Preliminary study on fabrication, characterization and synergistic anti-lung cancer effects of self-assembled micelles of covalently conjugated celastrol–polyethylene glycol–ginsenoside Rh2

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Pages 834-845 | Received 03 Apr 2017, Accepted 02 May 2017, Published online: 22 May 2017

References

  • An IS, An S, Kwon KJ, et al. (2013). Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells. Oncol Rep 29:523–8
  • Aqil F, Kausar H, Agrawal AK, et al. (2016). Exosomal formulation enhances therapeutic response of celastrol against lung cancer. Exp Mol Pathol 101:12–21
  • Biswas D, An SY, Li Y, et al. (2017). Intracellular delivery of colloidally stable core-cross-linked triblock copolymer micelles with glutathione-responsive enhanced drug release for cancer therapy. Mol Pharm. [Epub ahead of print]. doi: 10.1021/acs.molpharmaceut.6b01146
  • Chen G, Wang Y, Xie R, Gong S. (2017). Tumor-targeted pH/redox dual-sensitive unimolecular nanoparticles for efficient siRNA delivery. J Control Release. [Epub ahead of print]. doi: 10.1016/j.jconrel.2017.01.042
  • Danson S, Ferry D, Alakhov V, et al. (2004). Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer. Br J Cancer 90:2085–91
  • Desale SS, Cohen SM, Zhao Y, et al. (2013). Biodegradable hybrid polymer micelles for combination drug therapy in ovarian cancer. J Control Release 171:339–48
  • Felber AE, Dufresne MH, Leroux JC. (2012). pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates. Adv Drug Deliv Rev 64:979–92
  • Gao W, Ye G, Duan X, et al. (2017). Transferrin receptor-targeted pH-sensitive micellar system for diminution of drug resistance and targetable delivery in multidrug-resistant breast cancer. Int J Nanomedicine 12:1047–64
  • Gong C, Qi T, Wei X, et al. (2013). Thermosensitive polymeric hydrogels as drug delivery systems. Curr Med Chem 20:79–94
  • Gu Y, Wang GJ, Sun JG, et al. (2006). Quantitative determination of ginsenoside Rh2 in rat biosamples by liquid chromatograph electrospary ionization mass spectrometry. Anal Bioanal Chem 386:2043–53
  • Han X, Sun S, Zhao M, et al. (2014). Celastrol stimulates hypoxia-inducible factor-1 activity in tumor cells by initiating the ROS/Akt/p70S6K signaling pathway and enhancing hypoxia-inducible factor-1α protein synthesis. PLoS One 9:e112470
  • Kang H, Lee M, Jang SW. (2013). Celastrol inhibits TGF-β1-induced epithelial-mesenchymal transition by inhibiting snail and regulating E-cadherin expression. Biochem Biophys Res Commun 437:550–6
  • Kataoka K, Harada A, Nagasaki Y. (2001). Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv Drug Deliv Rev 47:113–31
  • Kim JH, Lee JO, Lee SK, et al. (2013). Celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53-polo like kinase 2 (PLK-2) pathway. Cell Signal 25:805–13
  • Kim SC, Kim DW, Shim YH, et al. (2001). In vivo evaluation of polymeric micellar paclitaxel formulation: toxicity and efficacy. J Control Release 72:191–202
  • Kwon, GS, Okano, T. (1996). Polymeric micelles as new drug carriers. Adv Drug Deliv Rev 21:107–16
  • Li Q, Li Y, Wang X, et al. (2011). Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release. Mol Carcinog 50:760–9
  • Lin WJ, Juang LW, Lin CC. (2003). Stability and release performance of a series of pegylated copolymeric micelles. Pharm Res 20:668–73
  • Lu J, Huang Y, Zhao W, et al. (2013). PEG-derivatized embelin as a nanomicellar carrier for delivery of paclitaxel to breast and prostate cancers. Biomaterials 34:1591–600
  • Lu J, Chuan X, Zhang H, et al. (2014). Free paclitaxel loaded PEGylated-paclitaxel nanoparticles: preparation and comparison with other paclitaxel systems in vitro and in vivo. Int J Pharm 471:525–35
  • Matsumura Y. (2008). Poly (amino acid) micelle nanocarriers in preclinical and clinical studies. Adv Drug Deliv Rev 60:899–914
  • Mi C, Shi H, Ma J, et al. (2014). Celastrol induces the apoptosis of breast cancer cells and inhibits their invasion via downregulation of MMP-9. Oncol Rep 32:2527–32
  • Negishi T, Koizumi F, Uchino H, et al. (2006). NK105, a paclitaxel-incorporating micellar nanoparticle, is a more potent radiosensitising agent compared to free paclitaxel. Br J Cancer 95:601–6
  • Niemelä E, Desai D, Nkizinkiko Y, et al. (2015). Sugar-decorated mesoporous silica nanoparticles as delivery vehicles for the poorly soluble drug celastrol enables targeted induction of apoptosis in cancer cells. Eur J Pharm Biopharm 96:11–21
  • Peng Q, Mu H. (2016). The potential of protein-nanomaterial interaction for advanced drug delivery. J Control Release 225:121–32
  • Qu D, Wang L, Liu M, et al. (2017). Oral nanomedicine based on multicomponent microemulsions for drug-resistant breast cancer treatment. Biomacromolecules 18:1268–80
  • Qu D, Lin H, Zhang N, et al. (2013). In vitro evaluation on novel modified chitosan for targeted antitumor drug delivery. Carbohydr Polym 92:545–54
  • Qu G, Zhu X, Zhang C, Ping Q. (2009). Modified chitosan derivative micelle system for natural anti-tumor product gambogic acid delivery. Drug Deliv 16:363–70
  • Su P, Cheng Q, Wang X, et al. (2014a). Characterization of eight terpenoids from tissue cultures of the Chinese herbal plant, Tripterygium wilfordii, by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Biomed Chromatogr 28:1183–92
  • Su Z, Xing L, Chen Y, et al. (2014b). Lactoferrin-modified poly(ethylene glycol)-grafted BSA nanoparticles as dual targeting carrier for treating brain gliomas. Mol Pharm 11:1823–34
  • Tan YF, Mundargi RC, Chen MH, et al. (2014). Layer-by-layer nanoparticles as an efficient siRNA delivery vehicle for SPARC silencing. Small 10:1790–8
  • Torchilin VP, Leychenko TS, Lukyanoy AN, et al. (2001a). p-Nitrophenylcarbonyl-PEG-PE liposomes: fast and simple attachment of specific ligands, including monoclonal antibodies, to distal ends of PEG chains via p-nitrophenylcarbonyl groups. Biochim Biophys Acta 1511:397–411
  • Torchilin VP, Rammohan R, Weissig V, et al. (2001b). TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors. Proc Natl Acad Sci USA 98:8786–91
  • Valle JW, Armstrong A, Newman C, et al. (2011). A phase 2 study of SP1049C, doxorubicin in P-glycoprotein-targeting pluronics, in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction. Invest New Drugs 29:1029–37
  • van Nostrum CF. (2004). Polymeric micelles to deliver photosensitizers for photodynamic therapy. Adv Drug Deliv Rev 56:9–16
  • Wang DK, Varanasi S, Strounina E, et al. (2014). Synthesis and characterization of a POSS-PEG macromonomer and POSS-PEG-PLA hydrogels for periodontal applications. Biomacromolecules 15:666–79
  • Wong HL, Chattopadhyay N, Wu XY, Bendayan R. (2010). Nanotechnology applications for improved delivery of antiretroviral drugs to the brain. Adv Drug Deliv Rev 62:503–17
  • Wu S, Yang X, Lu Y, et al. (2017). A green approach to dual-drug nanoformulations with targeting and synergistic effects for cancer therapy. Drug Deliv 24:51–60
  • Xu X, Li J, Han S, et al. (2016). A novel doxorubicin loaded folic acid conjugated PAMAM modified with borneol, a nature dual-functional product of reducing PAMAM toxicity and boosting BBB penetration. Eur J Pharm Sci 88:178–90
  • Zhao H, Li Q, Hong Z. (2016). Paclitaxel-loaded mixed micelles enhance Ovarian cancer therapy through extracellular pH-Triggered PEG detachment and endosomal escape. Mol Pharm 13:2411–22