2,517
Views
35
CrossRef citations to date
0
Altmetric
Research Article

Toward smart design of retinal drug carriers: a novel bovine retinal explant model to study the barrier role of the vitreoretinal interface

, , , , , & show all
Pages 1384-1394 | Received 28 Jul 2017, Accepted 31 Aug 2017, Published online: 19 Sep 2017

References

  • Apaolaza PS, del Pozo-Rodríguez A, Solinís MA, et al. (2016). Structural recovery of the retina in a retinoschisin-deficient mouse after gene replacement therapy by solid lipid nanoparticles. Biomaterials 90:40–9.
  • Bejjani RA, BenEzra D, Cohen H, et al. (2005). Nanoparticles for gene delivery to retinal pigment epithelial cells. Mol Vis 11:124–32.
  • Bourges JL, Gautier SE, Delie F, et al. (2003). Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles. Investig Ophthalmol Vis Sci 44:3562–9.
  • Boyd RF, Sledge DG, Boye SL, et al. (2016). Photoreceptor-targeted gene delivery using intravitreally administered AAV vectors in dogs. Gene Ther 23:223–30.
  • Boye SE, Boye SL, Lewin AS, Hauswirth WW. (2013). A comprehensive review of retinal gene therapy. Mol Ther 21:509–19.
  • Bu SC, Kuijer R, Van Der Worp RJ, et al. (2015). The ultrastructural localization of type II, IV, and VI collagens at the vitreoretinal interface. PLoS One 10: 1–23.
  • Busskamp V, Picaud S, Sahel JA, Roska B. (2012). Optogenetic therapy for retinitis pigmentosa. Gene Ther 19:169–75.
  • Candiello J, Cole GJ, Halfter W. (2010). Age-dependent changes in the structure, composition and biophysical properties of a human basement membrane. Matrix Biol 29:402–10.
  • Da Costa R, Röger C, Segelken J, et al. (2016). A novel method combining vitreous aspiration and intravitreal AAV2/8 injection results in retina-wide transduction in adult mice. Investig Ophthalmol Vis Sci 57:5326–34.
  • Englander M, Chen TC, Paschalis EI, et al. (2013). Intravitreal injections at the Massachusetts Eye and Ear Infirmary: analysis of treatment indications and postinjection endophthalmitis rates. Br J Ophthalmol 97:460–5.
  • Fradot M, Busskamp V, Forster V, et al. (2011). Gene therapy in ophthalmology: validation on cultured retinal cells and explants from postmortem human eyes. Hum Gene Ther 22:587–93.
  • Gan L, Wang J, Zhao Y, et al. (2013). Hyaluronan-modified core-shell liponanoparticles targeting CD44-positive retinal pigment epithelium cells via intravitreal injection. Biomaterials 34:5978–87.
  • Gauthier R, Joly S, Pernet V, et al. (2005). Brain-derived neurotrophic factor gene delivery to muller glia preserves structure and function of light-damaged photoreceptors. Investig Ophthalmol Vis Sci 46: 3383–92.
  • Le Goff MM, Bishop PN. (2008). Adult vitreous structure and postnatal changes. Eye (London, England) 22:1214–22.
  • Halfter W, Dong S, Dong A, et al. (2008). Origin and turnover of ECM proteins from the inner limiting membrane and vitreous body. Eye (London, England) 22:1207–13.
  • Halfter W, Oertle P, Monnier CA, et al. (2015). New concepts in basement membrane biology. FEBS J 282:4466–79.
  • Hellström M, Ruitenberg MJ, Pollett MA, et al. (2009). Cellular tropism and transduction properties of seven adeno-associated viral vector serotypes in adult retina after intravitreal injection. Gene Ther 16:521–32.
  • Henrich PB, Monnier CA, Halfter W, et al. (2012). Nanoscale topographic and biomechanical studies of the human internal limiting membrane. Investig Ophthalmol Vis Sci 53:2561–70.
  • International AMD Alliance. (2010) The global economic cost of visual impairment.
  • Käsdorf BT, Arends F, Lieleg O. (2015). Diffusion regulation in the vitreous humor. Biophys J 109:2171–81.
  • Kim H, Robinson SB, Csaky KG. (2009). Investigating the movement of intravitreal human serum albumin nanoparticles in the vitreous and retina. Pharm Res 26:329–37.
  • Kobuch K, Herrmann WA, Framme C, et al. (2008). Maintenance of adult porcine retina and retinal pigment epithelium in perfusion culture: characterisation of an organotypic in vitro model. Exp Eye Res 86:661–8.
  • Koo H, Moon H, Han H, et al. (2012). The movement of self-assembled amphiphilic polymeric nanoparticles in the vitreous and retina after intravitreal injection. Biomaterials 33:3485–93.
  • Lebrun-Julien F, Duplan L, Pernet V, et al. (2009). Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism. J Neurosci 29:5536–45.
  • Mains J, Tan LE, Wilson C, Urquhart A. (2012). A pharmacokinetic study of a combination of beta adrenoreceptor antagonists - In the isolated perfused ovine eye. Eur J Pharm Biopharm 80:393–401.
  • Mains J, Wilson CG, Urquhart A. (2011). ToF-SIMS analysis of dexamethasone distribution in the isolated perfused eye. Investig Ophthalmol Vis Sci 52:8413–9.
  • Martens TF, Remaut K, Deschout H, et al. (2015). Coating nanocarriers with hyaluronic acid facilitates intravitreal drug delivery for retinal gene therapy. J Control Release 202:83–92.
  • Martens TF, Vercauteren D, Forier K, et al. (2013). Measuring the intravitreal mobility of nanomedicines with single-particle tracking microscopy. Nanomedicine 8:1955–68.
  • Martens TF, Vercauteren D, Forier K, et al. (2013). Measuring the intravitreal mobility of nanomedicines with single-particle tracking microscopy. Nanomedicine (Lond) 8:1955–68.
  • Mowat FM, Gornik KR, Dinculescu A, et al. (2014). Tyrosine capsid-mutant AAV vectors for gene delivery to the canine retina from a subretinal or intravitreal approach. Gene Ther 21:96–105.
  • Nickerson CS, Park J, Kornfield JA, Karageozian H. (2008). Rheological properties of the vitreous and the role of hyaluronic acid. J Biomech 41:1840–6.
  • Ochakovski GA, Bartz-Schmidt KU, Fischer MD. (2017). Retinal gene therapy: surgical vector delivery in the translation to clinical trials. Front Neurosci 11:1–7.
  • Peeters L, Sanders NN, Braeckmans K, et al. (2005). Vitreous: a barrier to nonviral ocular gene therapy. Investig Ophthalmol Vis Sci 46:3553–61.
  • Pitkänen L, Pelkonen J, Ruponen M, et al. (2004). Neural retina limits the nonviral gene transfer to retinal pigment epithelium in an in vitro bovine eye model. AAPS J 6:e25.
  • Pitkänen L, Ruponen M, Nieminen J, Urtti A. (2003). Vitreous is a barrier in nonviral gene transfer by cationic lipids and polymers. Pharm Res 20:576–83.
  • Russell SR. (2012). What we know (and do not know) about vitreoretinal adhesion. Retina 32:S181–S6.
  • Russell WMS, Burch RL. (1959). The principles of humane experimental technique. London: Methuen & Co. Ltd.
  • Sakurai E, Ozeki H, Kunou N, Ogura Y. (2001). Effect of particle size of polymeric nanospheres on intravitreal kinetics. Ophthalm Res 33:31–6.
  • Schimmer J, Breazzano S. (2015). Investor outlook: focus on upcoming LCA2 gene therapy phase III results. Hum Gene Ther Clin Dev 26:144–9.
  • Skeie JM, Mahajan VB. (2013). Proteomic interactions in the mouse vitreous-retina complex. PLoS One 8:1–14.
  • Spark Therapeutics Press Release. (2016). Spark Therapeutics Announces New Positive Data from Continuation of Phase 3 Trial of Voretigene Neparvovec. Available at: http://ir.sparktx.com/phoenix.zhtml?c=253900&p=irol-newsArticle&ID=2194535 [last accessed 21 Mar 2017].
  • Takahashi K, Igarashi T, Miyake K, et al. (2017). Improved intravitreal AAV-mediated inner retinal gene transduction after surgical internal limiting membrane peeling in Cynomolgus Monkeys. Mol Ther 25:296–302.
  • The Lasker/IRRF Initiative for Innovation in Vision Science. (2014). Restoring vision to the blind: gene therapy for vision loss: the road ahead. Association for Research in Vision and Ophthalmology. Transl Vis Sci Technol 3:5.
  • Trapani I, Banfi S, Simonelli F, et al. (2015). Gene therapy of inherited retinal degenerations: prospects and challenges. Hum Gene Ther 26:193–200.
  • Uckermann O, Iandiev I, Francke M, et al. (2004). Selective staining by vital dyes of Müller Glial cells in retinal whole mounts. Glia 45:59–66.
  • Wassmer SJ, Carvalho LS, György B, et al. (2017). Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection. Sci Rep 7:45329.
  • Xu J, Heys JJ, Barocas VH, Randolph TW. (2000). Permeability and diffusion in vitreous humor: implications for drug delivery. Pharm Res 17:664–9.
  • Xu Q, Boylan NJ, Suk JS, et al. (2013). Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo. J Control Release 167:76–84.