Brain targeted oral delivery of doxycycline hydrochloride encapsulated Tween 80 coated chitosan nanoparticles against ketamine induced psychosis: behavioral, biochemical, neurochemical and histological alterations in mice

References

• Angelakis E, Armstrong N, Nappez C, et al. (2015). Doxycycline assay hair samples for testing long-term compliance treatment. J Infect 71:511–7.
   PubMed Web of Science ®Google Scholar
• Antonio RC, Ceron CS, Rizzi E, et al. (2014). Antioxidant effect of doxycycline decreases MMP activity and blood pressure in SHR. Mol Cell Biochem 386:99–105.
   PubMed Web of Science ®Google Scholar
• Arakawa S, Shirayama Y, Fujita Y, et al. (2012). Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline. Pharmacol Biochem Behav 100:601–6.
   PubMed Web of Science ®Google Scholar
• Chatterjee M, Verma R, Ganguly S, Palit G. (2012). Neurochemical and molecular characterization of ketamine-induced experimental psychosis model in mice. Neuropharmacol 63:1161–71.
   PubMed Web of Science ®Google Scholar
• Chatterjee M, Verma P, Maurya R, Palit G. (2011). Evaluation of ethanol leaf extract of ocimum sanctum in experimental models of anxiety and depression. Pharm Biol 49:477–83.
   PubMed Web of Science ®Google Scholar
• Chillar R, Dhingra D. (2013). Antidepressant-like activity of gallic acid in mice subjected to unpredictable chronic mild stress. Fundam Clin Pharmacol 27:409–18.
   PubMed Web of Science ®Google Scholar
• Cho Y, Son HJ, Kim EM, et al. (2009). Doxycycline is neuroprotective against nigral dopaminergic degeneration by a dual mechanism involving MMP-3. Neurotox Res 16:361–71.
   PubMed Web of Science ®Google Scholar
• Corti O, Sanchez-Capelo A, Colin P, et al. (1999). Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinson’s disease. Proc Natl Acad Sci U S A 96:12120–5.
   PubMed Web of Science ®Google Scholar
• Costa P, Lobo JM. (2001). Modeling and comparison of dissolution profiles. Eur J Pharm Sci 13:123–33.
   PubMed Web of Science ®Google Scholar
• da Silva FCC, de Oliveira Cito MDC, da Silva MIG, et al. (2010). Behavioural alterations and pro-oxidant effect of a single ketamine administration to mice. Brain Res Bull 83:9–15.
   PubMed Web of Science ®Google Scholar
• Ellman GL. (1959). Tissue sulfhydryl groups. Arch Biochem Biophys 82:70–7.
   PubMed Web of Science ®Google Scholar
• Elnaggar YS, Etman SM, Abdelmonsif DA, Abdallah OY. (2015). Intranasal piperine-loaded chitosan nanoparticles as brain-targeted therapy in Alzheimr’s disease: optimization, biological efficacy, and potential toxicity. J Pharm Sci 104:3544–56.
   PubMed Web of Science ®Google Scholar
• Fazil M, Md S, Haque S, et al. (2012). Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting. Eur J Pharm Sci 47:6–15.
   PubMed Web of Science ®Google Scholar
• Frye LJ, Chong E, Winikoff B. NCT01799252 Trial Investigators. (2015). What happens when we routinely give doxycycline to medical abortion patients? Contraception 91:19–24.
   PubMed Web of Science ®Google Scholar
• Guo F, Zhang M, Gao Y, et al. (2016). Modified nanoparticles with cell-penetrating peptide and amphipathic chitosan derivative for enhanced oral colon absorption of insulin: preparation and evaluation. Drug Deliv 23:2003–14.
   PubMed Web of Science ®Google Scholar
• Hansraj GP, Singh SK, Kumar P. (2015). Sumatriptan succinate loaded chitosan solid lipid nanoparticles for enhanced anti-migraine potential. Int J Biol Macromol 81:467–76.
   PubMed Web of Science ®Google Scholar
• Hunter R. (2014). Developing tomorrow’s antipsychotics: the need for a more personalised approach. Adv Psychiatr Treat 20:3–12.
   Google Scholar
• Kandi P, Hayslett RL. (2011). Nicotine and 17β-estradiol produce an antidepressant-like effect in female ovariectomized rats. Brain Res Bull 84:224–8.
   PubMed Web of Science ®Google Scholar
• Kellendonk C, Simpson EH, Polan HJ, et al. (2006). Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning. Neuron 49:603–15.
   PubMed Web of Science ®Google Scholar
• Kreuter J. (2001). Nanoparticulate systems for brain delivery of drugs. Adv Drug Deliv Rev 47:65–81.
   PubMed Web of Science ®Google Scholar
• Kreuter J. (2002). Transport of drugs across the blood-brain barrier by nanoparticles. Curr Med Chem Cent Nerv Syst Agents 2:241–9.
   Google Scholar
• Kumar A, Yadav M, Parle P, et al. (2017). Potential drug targets and treatment of schizophrenia. Inflammopharmacology 25:277–92.
   PubMed Web of Science ®Google Scholar
• Lowe IP, Robins E, Eyerman GS. (1958). The fluorimetric measurement of glutamic, decarboxylase measurement and its distributionin brain. J Neurochem 3:8–18.
   PubMed Web of Science ®Google Scholar
• Mandala Rayabandla SK, Aithal K, Anandam A, et al. (2010). Preparation, in vitro characterization, pharmacokinetic, and pharmacodynamic evaluation of chitosan-based plumbagin microspheres in mice bearing B16F1 melanoma. Drug Deliv 17:103–13.
   PubMed Web of Science ®Google Scholar
• Nagpal K, Singh SK, Mishra DN. (2013). Evaluation of safety and efficacy of brain targeted chitosan nanoparticles of minocycline. Int J Biol Macromol 59:20–8.
   PubMed Web of Science ®Google Scholar
• Omolu A, Bailly M, Day RM. (2017). Assessment of solid microneedle rollers to enhance transmembrane delivery of doxycycline and inhibition of MMP activity. Drug Deliv 24:942–51.
   PubMed Web of Science ®Google Scholar
• Pae CU, Marks DM, Han C, Patkar AA. (2008). Does minocycline have antidepressant effect? Biomed Pharmacother 62:308–11.
   PubMed Web of Science ®Google Scholar
• Rao NP, Remington G. (2013). Investigational drugs for schizophrenia targeting the dopamine receptor: phase II trials. Expert Opin Investig Drugs 22:881–94.
   PubMed Web of Science ®Google Scholar
• Sarısozen C, Arıca B, Orman MN, et al. (2010). Optimization of prednisolone acetate-loaded chitosan microspheres using a 2(3) factorial design for preventing restenosis. Drug Deliv 17:178–86.
   PubMed Web of Science ®Google Scholar
• Sarvaiya J, Agrawal YK. (2015). Chitosan as a suitable nanocarrier material foranti-Alzheimer drug delivery. Int J Biol Macromol 72:454–65.
   PubMed Web of Science ®Google Scholar
• Schlumpf M, Lichtensteiger W, Langemann H, et al. (1974). A fluorimetricmicromethod for the simultaneous determination of serotonin, noradrenaline and dopamine in milligram amount of brain tissue. Biochem Pharmacol 23:2437–46.
   PubMed Web of Science ®Google Scholar
• Soni K, Parle M. (2017). Trachyspermum ammi seeds supplementation helps reverse scopolamine, alprazolam and electroshock induced amnesia. Neurochem Res 42:1333–44.
   PubMed Web of Science ®Google Scholar
• Tilakaratne A, Soory M. (2014). Antioxidant response of osteoblasts to doxycycline in an inflammatory model induced by C-reactive protein and interleukin-6. Infect Disord Drug Targets 14:14–22.
   PubMedGoogle Scholar
• Wills ED. (1964). The effect of inorganic iron on the thiobarbituric acid method for the determination of lipid peroxides. Biochim Biophys Acta 84:475–7.
   PubMed Web of Science ®Google Scholar
• Yadav M, Jindal DK, Dhingra MS, et al. (2017). Protective effect of gallic acid in experimental model of ketamine-induced psychosis: possible behaviour, biochemical, neurochemical and cellular alterations. Inflammopharmacology. doi:10.1007/s10787-017-0366-8
   Web of Science ®Google Scholar
• Zugno AI, Chipindo HL, Volpato AM, et al. (2014). Omega-3 prevents behaviour response and brain oxidative damage in the ketamine model of schizophrenia. Neurosci 259:223–31.
   PubMed Web of Science ®Google Scholar