Characterization of brusatol self-microemulsifying drug delivery system and its therapeutic effect against dextran sodium sulfate-induced ulcerative colitis in mice

References

• Bolko K , Zvonar A , Gašperlin M. (2014). Mixed lipid phase SMEDDS as an innovative approach to enhance resveratrol solubility. Drug Dev Ind Pharm 40:102–9.
   PubMed Web of Science ®Google Scholar
• Bu T. (2009). Treating Ulcerative Colitis(UC) with Mongolian Medical Therapy. World J Sci Technol 11:75–9.
   Google Scholar
• Chaurasiya A , Singh AK , Jain GK , et al . (2012). Dual approach utilizing self microemulsifying technique and novel P-gp inhibitor for effective delivery of taxanes. J Microencapsul 29:583–95.
   PubMed Web of Science ®Google Scholar
• Chen G , Yang Y , Liu M , et al . (2015a). Banxia xiexin decoction protects against dextran sulfate sodium-induced chronic ulcerative colitis in mice. J Ethnopharmacol 166:149–56.
   PubMed Web of Science ®Google Scholar
• Chen M , Chen R , Wang S , et al . (2013). Chemical components, pharmacological properties, and nanoparticulate delivery systems of Brucea javanica. Int J Nanomedicine 8:85–92.
   PubMed Web of Science ®Google Scholar
• Chen P , Zhou X , Zhang L , et al . (2015b). Anti-inflammatory effects of Huangqin tang extract in mice on ulcerative colitis. J Ethnopharmacol 162:207–14.
   PubMed Web of Science ®Google Scholar
• Chen Y , Zhang H , Yang J , Sun H. (2015c). Improved antioxidant capacity of optimization of a self-microemulsifying drug delivery system for resveratrol. Molecules 20:21167–77.
   PubMed Web of Science ®Google Scholar
• Cui J , Yu B , Zhao Y , et al . (2009). Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems. Int J Pharm 371:148–55.
   PubMed Web of Science ®Google Scholar
• Dangre P , Gilhotra R , Dhole S. (2016). Formulation and statistical optimization of self-microemulsifying drug delivery system of eprosartan mesylate for improvement of oral bioavailability. Drug Deliv and Transl Res 6:610–21.
   PubMed Web of Science ®Google Scholar
• De Faria FM , Luiz-Ferreira A , Socca EA , et al . (2011). Effects of rhizophora mangle on experimental colitis induced by TNBS in rats. Evid Based Complement Alternat Med 2012:753971.
   Web of Science ®Google Scholar
• Doane TL , Chuang CH , Hill RJ , Burda C. (2012). Nanoparticle ζ -potentials. Acc Chem Res 45:317–26.
   PubMed Web of Science ®Google Scholar
• Fang J , Seki T , Tsukamoto T , et al . (2013). Protection from inflammatory bowel disease and colitis-associated carcinogenesis with 4-vinyl-2,6-dimethoxyphenol (canolol) involves suppression of oxidative stress and inflammatory cytokines. Carcinogenesis 34:2833–41.
   PubMed Web of Science ®Google Scholar
• Guan Q , Zhang G , Sun S , et al . (2016). Enhanced oral bioavailability of pueraria flavones by a novel solid self-microemulsifying drug delivery system (SMEDDS) dropping pills. Biol Pharm Bull 39:762–69.
   PubMed Web of Science ®Google Scholar
• Hall IH , Lee KH , Imakura Y , et al . (1983). Anti-inflammatory agents III: structure& activity relationships of brusatol and related quassinoids. J Pharm Sci 72:1282–4.
   PubMed Web of Science ®Google Scholar
• Han F , Zhang H , Xia X , et al . (2015). Porcine β-defensin 2 attenuates inflammation and mucosal lesions in dextran sodium sulfate-induced colitis. J Immunol 194:1882–93.
   PubMed Web of Science ®Google Scholar
• Han S. (2014). Advances in traditional Chinese medicine treatment of ulcerative colitis. Beijing, China: Beijing University of Chinese Medicine.
   Google Scholar
• Harigaya Y , Konda Y , Iguchi M , et al . (2004). Spectroscopic studies of brusatol. J Nat Prod 52:740–748.
   Web of Science ®Google Scholar
• He X , Wei Z , Wang J , et al . (2016). Alpinetin attenuates inflammatory responses by suppressing TLR4 and NLRP3 signaling pathways in DSS-induced acute colitis. Sci Rep 6:28370.
   PubMed Web of Science ®Google Scholar
• Huang YF , Zhou JT , Qu C , et al . (2017). Anti-inflammatory effects of Brucea javanica oil emulsion by suppressing NF-κB activation on dextran sulfate sodium-induced ulcerative colitis in mice. J Ethnopharmacol 198:389–98.
   PubMed Web of Science ®Google Scholar
• Jang JC , Lee KM , Ko SG. (2016). Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis. Mediators Inflamm 2016:1–13.
   Web of Science ®Google Scholar
• Kannan N , Guruvayoorappan C. (2013). Protective effect of Bauhinia tomentosa on acetic acid induced ulcerative colitis by regulating antioxidant and inflammatory mediators. Int J Immunopharmacol 16:57–66.
   PubMed Web of Science ®Google Scholar
• Kawakami K , Yoshikawa T , Hayashi T , et al . (2002). Microemulsion formulation for enhanced absorption of poorly soluble drugs. II. In vivo study. J Control Release 81:65–74.
   PubMed Web of Science ®Google Scholar
• Lei Y. (2013). Evaluation of the efficacy of Brucea javanica king and medicine herbal compound in TNBS induced ulcerative colitis. Zhejiang, China: Zhejiang University.
   Google Scholar
• Li F , Song S , Guo Y , et al . (2014a). Preparation and pharmacokinetics evaluation of oral self-emulsifying system for poorly water-soluble drug Lornoxicam. Drug Deliv 22:1–11.
   PubMed Web of Science ®Google Scholar
• Li J , Zhong W , Wang W , et al . (2014b). Ginsenoside metabolite compound K promotes recovery of dextran sulfate sodium-induced colitis and inhibits inflammatory responses by suppressing NF-κB activation. PLoS One 9:e87810.
   PubMed Web of Science ®Google Scholar
• Li Q , Zhai W , Jiang Q , et al . (2015). Curcumin–piperine mixtures in self-microemulsifying drug delivery system for ulcerative colitis therapy. Int J Pharm 490:22–31.
   PubMed Web of Science ®Google Scholar
• Liu X , Wang J. (2011). Anti-inflammatory effects of iridoid glycosides fraction of folium syringae leaves on TNBS-induced colitis in rats. J Ethnopharmacol 133:780–7.
   PubMed Web of Science ®Google Scholar
• Lombardi VRM , Etcheverría I , Carrera I , et al . (2011). Prevention of chronic experimental colitis induced by dextran sulphate sodium (DSS) in mice treated with FR91. BioMed Res Int 2012:826178.
   Google Scholar
• Ma S , Chen F , Ye X , et al . (2013). Intravenous microemulsion of docetaxel containing an anti-tumor synergistic ingredient (Brucea javanica oil): formulation and pharmacokinetics. Int J Nanomedicine 8:4045–52.
   PubMed Web of Science ®Google Scholar
• Mao J , Li Y. (2002). Clinical observation on retention enema treatment with Brucea javanica Sanhuang decoction of ulcerative colitis. Zhejiang J Integr Tradit Chin West Med 12:764–764.
   Google Scholar
• Nagib MM , Tadros MG , Elsayed MI , Khalifa AE. (2013). Anti-inflammatory and anti-oxidant activities of olmesartan medoxomil ameliorate experimental colitis in rats. Toxicol Appl Pharmacol 271:106–13.
   PubMed Web of Science ®Google Scholar
• National Pharmacopoeia Committee . (2010). Pharmacopoeia of People’s Republic of China. Beijing, China: China Medical Science Press.
   Google Scholar
• Niu YT , Zhao YP , Jiao YF , et al . (2016). Protective effect of gentiopicroside against dextran sodium sulfate induced colitis in mice. Int J Immunopharmacol 39:16–22.
   Web of Science ®Google Scholar
• Noorshahida A , Wong TW , Choo CY. (2009). Hypoglycemic effect of quassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds. J Ethnopharmacol 124:586–91.
   PubMed Web of Science ®Google Scholar
• Pandurangan AK , Ismail S , Saadatdoust Z , Esa NM. (2015). Allicin alleviates dextran sodium sulfate- (DSS-) induced ulcerative colitis in BALB/c mice. Oxid Med Cell Longev 2015:605208.
   PubMed Web of Science ®Google Scholar
• Pervin M , Hasnat MA , Lim JH , et al . (2015). Preventive and therapeutic effects of blueberry (Vaccinium corymbosum) extract against DSS-induced ulcerative colitis by regulation of antioxidant and inflammatory mediators. J Nutr Biochem 28:103–113.
   PubMed Web of Science ®Google Scholar
• Rashidian A , Muhammadnejad A , Dehpour AR , et al . (2016). Atorvastatin attenuates TNBS-induced rat colitis: the involvement of the TLR4/NF-kB signaling pathway. Inflammopharmacol 24:1-10.
   PubMed Web of Science ®Google Scholar
• Seo YG , Kim DH , Ramasamy T , et al . (2013). Development of docetaxel-loaded solid self-nanoemulsifying drug delivery system (SNEDDS) for enhanced chemotherapeutic effect. INT J PHARMACEUT 452:412–420.
   PubMed Web of Science ®Google Scholar
• Setthacheewakul S , Mahattanadul S , Phadoongsombut N , et al . (2010). Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rats. Eur J Pharm Biopharm 76:475–485.
   PubMed Web of Science ®Google Scholar
• Sha X , Yan G , Wu Y , et al . (2005). Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells. Eur J Pharm Sci 24:477–486.
   PubMed Web of Science ®Google Scholar
• Sheng Y. (2012). Observation on the effect of retention enema with Brucea javanica oil emulsion in the treatment of 75 patients with ulcerative colitis. Journal of Qilu Nursing 18:12–14.
   Google Scholar
• Socca EA , Luizferreira A , De Faria FM , et al . (2013). Inhibition of tumor necrosis factor-alpha and cyclooxigenase-2 by isatin: a molecular mechanism of protection against TNBS-induced colitis in rats. Chem Biol Interact 209:48–55.
   PubMed Web of Science ®Google Scholar
• Tang W , Xie J , Xu S , et al . (2014). Novel nitric oxide-releasing derivatives of brusatol as anti-inflammatory agents: design, synthesis, biological evaluation and nitric oxide release studies. J Med Chem 57:7600–7612.
   PubMed Web of Science ®Google Scholar
• Ting Y , Jiang Y , Ho CT , Huang Q. (2014). Common delivery systems for enhancing in vivo bioavailability and biological efficacy of nutraceuticals. J Funct Foods 7:112–128.
   Web of Science ®Google Scholar
• Turpaev K , Welsh N. (2015). Brusatol inhibits the response of cultured beta-cells to pro-inflammatory cytokines invitro. Biochem Biophys Res Commun 460:868–72.
   PubMed Web of Science ®Google Scholar
• Vrečer F. (2014). Development of a solid self-microemulsifying drug delivery system (SMEDDS) for solubility enhancement of naproxen. Drug Dev Ind Pharm 41:1–10.
   Web of Science ®Google Scholar
• Wu X , Xu J , Huang X , Wen C. (2010). Self-microemulsifying drug delivery system improves curcumin dissolution and bioavailability. Drug Dev Ind Pharm 37:15–23.
   PubMed Web of Science ®Google Scholar
• Xing J , You C , Dong K , et al . (2013). Ameliorative effects of 3,4-oxo-isopropylidene-shikimic acid on experimental colitis and their mechanisms in rats. Int J Immunopharmacol 15:524–31.
   Web of Science ®Google Scholar
• Xiong J , Lin YH , Bi LH , et al . (2013). Effects of Interleukin-4 or Interleukin-10 gene therapy on trinitrobenzenesulfonic acid-induced murine colitis. BMC Gastroenterol 13:1–7.
   PubMed Web of Science ®Google Scholar
• Yang X , Yan Y , Li J , et al . (2016). Protective effects of ethanol extract from Portulaca oleracea L on dextran sulphate sodium-induced mice ulcerative colitis involving anti-inflammatory and antioxidant. Am J Transl Res 8:2138–48.
   PubMed Web of Science ®Google Scholar
• Yun J , Xu CT , Pan BR (2009). Epidemiology and gene markers of ulcerative colitis in the Chinese. World J Gastroenterol 15:788–803.
   PubMed Web of Science ®Google Scholar
• Yuan Z , Jiajia Z , Qianfeng Z , et al . (2014). In vitro and in vivo evaluation of capsaicin-loaded microemulsion for enhanced oral bioavailability. J Sci Food Agric 95:2678–85.
   PubMed Web of Science ®Google Scholar
• Zhang H , Deng A , Zhang Z , et al . (2016a). The protective effect of epicatechin on experimental ulcerative colitis in mice is mediated by increasing antioxidation and by the inhibition of NF-κB pathway. Pharmacological Reports Pr 68:514–520.
   PubMed Web of Science ®Google Scholar
• Zhang L , Feng X , Ma D , et al . (2013). Brusatol isolated from Brucea javanica (L.) Merr. induces apoptotic death of insect cell lines. Pest Biochem Physiol 107:18–24.
   PubMed Web of Science ®Google Scholar
• Zhang L , Zhu W , Yang C , et al . (2012). A novel folate-modified self-microemulsifying drug delivery system of curcumin for colon targeting. Int J Nanomedicine 7:151–162.
   PubMed Web of Science ®Google Scholar
• Zhang Q , Yuan Y , Cui J , et al . (2016b). Determination of a potential antitumor quassinoid in rat plasma by UPLC-MS/MS and its application in a pharmacokinetic study. J Pharm Biomed Anal 124:143–148.
   PubMed Web of Science ®Google Scholar
• Zhao J , Hong T , Dong M , et al . (2013a). Protective effect of myricetin in dextran sulphate sodium-induced murine ulcerative colitis. Mol Med Rep 7:565–570.
   PubMed Web of Science ®Google Scholar
• Zhao L , Wei Y , Huang Y , et al . (2013b). Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation. Int J Nanomedicine 8:3769–3779.
   PubMed Web of Science ®Google Scholar
• Zhou HY , Yan J , Fang L , et al . (2014). Change and significance of IL-8, IL-4, and IL-10 in the pathogenesis of terminal Ileitis in SD rat. Cell Biochem Biophys 69:327–31.
   PubMed Web of Science ®Google Scholar
• Zhu JX , Tang D , Feng L , et al . (2013). Development of self-microemulsifying drug delivery system for oral bioavailability enhancement of berberine hydrochloride. Drug Dev Ind Pharm 39:499–506.
   PubMed Web of Science ®Google Scholar