Microencapsulated macrophages releases conditioned medium able to prevent epithelial to mesenchymal transition

References

• Acarregui A, Herran E, Igartua M, et al. (2014). Multifunctional hydrogel-based scaffold for improving the functionality of encapsulated therapeutic cells and reducing inflammatory response. Acta Biomater 10:4206–16.
   PubMed Web of Science ®Google Scholar
• Baer PC, Bereiter-Hahn J, Missler C, et al. (2009). Conditioned medium from renal tubular epithelial cells initiates differentiation of human mesenchymal stem cells. Cell Prolif 42:29–37.
   PubMed Web of Science ®Google Scholar
• Baer PC, Doring C, Hansmann ML, et al. (2013). New insights into epithelial differentiation of human adipose-derived stem cells. J Tissue Eng Regen Med 7:271–8.
   PubMed Web of Science ®Google Scholar
• Brzoska M, Geiger H, Gauer S, Baer P. (2005). Epithelial differentiation of human adipose tissue-derived adult stem cells. Biochem Biophys Res Commun 330:142–50.
   PubMed Web of Science ®Google Scholar
• Cao Q, Harris DCH, Wang Y. (2015). Macrophages in kidney injury, inflammation, and fibrosis. Physiology (Bethesda) 30:183–94.
   PubMed Web of Science ®Google Scholar
• Ciriza J, Saenz del Burgo L, Virumbrales-Munoz M, et al. (2015). Graphene oxide increases the viability of C2C12 myoblasts microencapsulated in alginate. Int J Pharm 493:260–70.
   PubMed Web of Science ®Google Scholar
• de Vos P, Wolters GH, van SR. (1994). Possible relationship between fibrotic overgrowth of alginate-polylysine-alginate microencapsulated pancreatic islets and the microcapsule integrity. Transplant Proc 26:782–3.
   PubMed Web of Science ®Google Scholar
• Grande MT, Lopez-Novoa JM. (2009). Fibroblast activation and myofibroblast generation in obstructive nephropathy. Nat Rev Nephrol 5:319–28.
   PubMed Web of Science ®Google Scholar
• Gurruchaga H, Ciriza J, Saenz del Burgo L, et al. (2015). Cryopreservation of microencapsulated murine mesenchymal stem cells genetically engineered to secrete erythropoietin. Int J Pharm 485:15–24.
   PubMed Web of Science ®Google Scholar
• Iwano M, Plieth D, Danoff TM, et al. (2002). Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 110:341–50.
   PubMed Web of Science ®Google Scholar
• Jung M, Sola A, Hughes J, et al. (2012). Infusion of IL-10-expressing cells protects against renal ischemia through induction of lipocalin-2. Kidney Int 81:969–82.
   PubMed Web of Science ®Google Scholar
• Kalluri R, Neilson EG. (2003). Epithelial–mesenchymal transition and its implications for fibrosis. J Clin Invest 112:1776–84.
   PubMed Web of Science ®Google Scholar
• Kushiyama T, Oda T, Yamada M, et al. (2011). Alteration in the phenotype of macrophages in the repair of renal interstitial fibrosis in mice. Nephrology (Carlton) 16:522–35.
   PubMed Web of Science ®Google Scholar
• Li K, Han Q, Yan X, Liao L, Zhao RC. (2010). Not a process of simple vicariousness, the differentiation of human adipose-derived mesenchymal stem cells to renal tubular epithelial cells plays an important role in acute kidney injury repairing. Stem Cells Dev 19:1267–75.
   PubMed Web of Science ®Google Scholar
• Liu Y. (2004). Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 15:1–12.
   PubMed Web of Science ®Google Scholar
• López-Guisa JM, Cai X, Collins SJ, et al. (2012). Mannose receptor 2 attenuates renal fibrosis. J Am Soc Nephrol 23:236–51.
   PubMed Web of Science ®Google Scholar
• Orive G, Hernández RM, Murua A, Pedraz JL. (2010). Recent advances in the use of encapsulated cells for effective delivery of therapeutics. Ther Deliv 1:387–96.
   PubMedGoogle Scholar
• Pan B, Liu G, Jiang Z, Zheng D. (2015). Regulation of renal fibrosis by macrophage polarization. Cell Physiol Biochem 35:1062–9.
   PubMed Web of Science ®Google Scholar
• Ponce S, Orive G, Hernández R, et al. (2006). Chemistry and the biological response against immunoisolating alginate-polycation capsules of different composition. Biomaterials 27:4831–9.
   PubMed Web of Science ®Google Scholar
• Saenz del Burgo L, Compte M, Aceves M, et al. (2015). Microencapsulation of therapeutic bispecific antibodies producing cells: immunotherapeutic organoids for cancer management. J Drug Target 23:170–9.
   PubMed Web of Science ®Google Scholar
• Saenz del Burgo L, Ciriza J, Acarregui A, et al. (2017). Hybrid alginate-protein-coated graphene oxide microcapsules enhance the functionality of erythropoietin secreting C2C12 myoblasts. Mol Pharm 14:885–98.
   PubMed Web of Science ®Google Scholar
• Shen B, Liu X, Fan Y, et al. (2014). Macrophages regulate renal fibrosis through modulating TGFβ superfamily signaling. Inflammation 37:2076–84.
   PubMed Web of Science ®Google Scholar
• Stout RD, Jiang C, Matta B, et al. (2005). Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences. J. Immunol 175:342–9.
   PubMed Web of Science ®Google Scholar
• Sugiura S, Oda T, Izumida Y, et al. (2005). Size control of calcium alginate beads containing living cells using micro-nozzle array. Biomaterials 26:3327–31.
   PubMed Web of Science ®Google Scholar
• Ventayol M, Viñas JL, Sola A, et al. (2014). miRNA let-7e targeting MMP9 is involved in adipose derived stem cell differentiation toward epithelia. Cell Death Dis 5:e1048.
   PubMed Web of Science ®Google Scholar
• Wang Y, Wang YP, Zheng G, et al. (2007). Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease. Kidney Int 72:290–9.
   PubMed Web of Science ®Google Scholar
• Wang N, Liang H, Zen K. (2014). Molecular mechanisms that influence the macrophage m1-m2 polarization balance. Front Immunol 5:614–20.
   PubMed Web of Science ®Google Scholar
• Zeisberg M, Kalluri R. (2004). The role of epithelial-to-mesenchymal transition in renal fibrosis. J Mol Med 82:175–81.
   PubMed Web of Science ®Google Scholar