Enhanced anti-hepatocarcinoma efficacy by GLUT1 targeting and cellular microenvironment-responsive PAMAM–camptothecin conjugate

References

• Barenholz YC. (2012). Doxil® – the first FDA-approved nano-drug: lessons learned. J Control Release 160:117–34.
   PubMed Web of Science ®Google Scholar
• Chen B, Dai W, He B, et al. (2017). Current multistage drug delivery systems based on the tumor microenvironment. Theranostics 7:538–57.
   PubMed Web of Science ®Google Scholar
• Danhier F. (2016). To exploit the tumor microenvironment: since the EPR effect fails in the clinic, what is the future of nanomedicine. J Control Release 244:108–21.
   PubMed Web of Science ®Google Scholar
• Das SK, Rehman I, Ghosh A, et al. (2016). Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells. Nucleic Acids Res 44:8363–75.
   PubMed Web of Science ®Google Scholar
• Friedrich J, Seidel C, Ebner R, Kunz-Schughart LA. (2008). Spheroid-based drug screen: considerations and practical approach. Nature Protocols 4:309–24.
   Web of Science ®Google Scholar
• Guo Y, Zhang Y, Li J, et al. (2015). Cell microenvironment-controlled antitumor drug releasing nanomicelles for GLUT1-targeting hepatocellular carcinoma therapy. ACS Appl Mater Interfaces 7:5444–53.
   PubMed Web of Science ®Google Scholar
• Hamaguchi T, Doi T, Eguchi-Nakajima T, et al. (2010). Phase I study of NK012, a novel SN-38-incorporating micellar nanoparticle, in adult patients with solid tumors. Clinical Cancer Res 16:5058–66.
   PubMed Web of Science ®Google Scholar
• Hare JI, Lammers T, Ashford MB, et al. (2016). Challenges and strategies in anti-cancer nanomedicine development: an industry perspective. Adv Drug Delivery Rev 1:25–38.
   Google Scholar
• He H, Li Y, Jia XR, et al. (2011). PEGylated Poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors. Biomaterials 32:478–87.
   PubMed Web of Science ®Google Scholar
• Hofmann-Amtenbrink M, Grainger DW, Hofmann H. (2015). Nanoparticles in medicine: current challenges facing inorganic nanoparticle toxicity assessments and standardizations. Nanomedicine 11:1689–94.
   PubMed Web of Science ®Google Scholar
• Hu X, Wu T, Bao Y, Zhang Z. (2017). Nanotechnology based therapeutic modality to boost anti-tumor immunity and collapse tumor defence. J Control Release 256:26–45.
   PubMed Web of Science ®Google Scholar
• Huarte J, Espuelas S, Lai Y, et al. (2016). Oral delivery of camptothecin using cyclodextrin/poly(anhydride) nanoparticles. Int J Pharm 506:116–28.
   PubMed Web of Science ®Google Scholar
• Jadvar H. (2016). PET of glucose metabolism and cellular proliferation in prostate cancer. J Nucl Med 57:25S–9s.
   PubMed Web of Science ®Google Scholar
• Jiang X, Xin H, Gu J, et al. (2014). Enhanced antitumor efficacy by d-glucosamine-functionalized and paclitaxel-loaded poly(ethylene glycol)-co-poly(trimethylene carbonate) polymer nanoparticles. J Pharmaceut Sci 103:1487–96.
   PubMed Web of Science ®Google Scholar
• Jin J, Sui B, Gou J, et al. (2014). PSMA ligand conjugated PCL-PEG polymeric micelles targeted to prostate cancer cells. PLoS One 9:1-12.
   Web of Science ®Google Scholar
• Karimi M, Ghasemi A, Zangabad GS, et al. (2016). Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems. Chem Soc Rev 45:1457–501.
   PubMed Web of Science ®Google Scholar
• Khandare JJ, Jayant S, Singh A, et al. (2006). Dendrimer versus linear conjugate: influence of polymeric architecture on the delivery and anticancer effect of paclitaxel. Bioconjugate Chem 17:1464–72.
   PubMed Web of Science ®Google Scholar
• Kunz-Schughart LA. (1999). Multicellular tumor spheroids_ intermediates between monolayer culture and in vivo tumor. Cell Biol Int 23:157–61.
   PubMed Web of Science ®Google Scholar
• Labak CM, Wang PY, Arora R, et al. (2016). Glucose transport: meeting the metabolic demands of cancer, and applications in glioblastoma treatment. Am J Cancer Res 6:1599–608.
   PubMed Web of Science ®Google Scholar
• Labieniec-Watala M, Watala C. (2014). PAMAM dendrimers: destined for success or doomed to fail? Plain and modified PAMAM dendrimers in the context of biomedical applications. J Pharmaceut Sci 104:2–14.
   PubMed Web of Science ®Google Scholar
• Lacombe D. (2012). Glufosfamide: can we improve the process of anticancer agent development?. Expert Opin Investig Drugs 21:749–54.
   PubMed Web of Science ®Google Scholar
• Lammers T, Kiessling F, Hennink WE, Storm G. (2012). Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress. J Control Release 161:175–87.
   PubMed Web of Science ®Google Scholar
• Li T, Gao X, Yang L, et al. (2016). Methyl 6-amino-6-deoxy-d-pyranoside-conjugated platinum (II) complexes for glucose transporter (GLUT)-mediated tumor targeting: synthesis, cytotoxicity, and cellular uptake mechanism. Chem Med Chem 11:1069–77.
   Web of Science ®Google Scholar
• Li R, Zheng K, Hu P, et al. (2014). A novel tumor targeting drug carrier for optical imaging and therapy. Theranostics 4:642–59.
   PubMed Web of Science ®Google Scholar
• Louage B, Wever OD, Hennink WE, Geest BGD. (2017). Developments and future clinical outlook of taxane nanomedicines. J Control Release 253:137–52.
   PubMed Web of Science ®Google Scholar
• Luong D, Kesharwani P, Deshmukh R, et al. (2016). PEGylated PAMAM dendrimers: enhancing efficacy and mitigating toxicity for effective anticancer drug and gene delivery. Acta Biomater 14–29.
   PubMed Web of Science ®Google Scholar
• Ma P, Yu H, Zhang X, et al. (2017). Increased active tumor targeting by an αvβ3-targeting and cell-penetrating bifunctional peptide-mediated dendrimer-based conjugate. Pharm Res 34:121–35.
   PubMed Web of Science ®Google Scholar
• Mohamed NK, Hamad MA, Hafez MZE, et al. (2017). Nanomedicine in management of hepatocellular carcinoma: challenges and opportunities. Int J Cancer 140:1475–84.
   PubMed Web of Science ®Google Scholar
• Niu J, Wang A, Ke Z, Zheng Z. (2014). Glucose transporter and folic acid receptor-mediated Pluronic P105 polymeric micelles loaded with doxorubicin for brain tumor treating. J Drug Targeti 22:712–23.
   PubMed Web of Science ®Google Scholar
• Paleos CM, Tsiourvas D, Sideratou Z. (2016). Triphenylphosphonium decorated liposomes and dendritic polymers: prospective second generation drug delivery systems for targeting mitochondria. Mol Pharmaceut 13:2233–41.
   PubMed Web of Science ®Google Scholar
• Sadeghpour ADH. (2015). Surface decorations of poly(amidoamine) dendrimer by various pendant moirties for improved delivery of nucleic acid materials. Colloids Surf B: Biointerfaces 132:85–102.
   PubMed Web of Science ®Google Scholar
• Seymour LW, Ferry DR, Kerr DJ, et al. (2009). Phase II studies of polymer–doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer. Int J Oncol 34:1629–36.
   PubMed Web of Science ®Google Scholar
• Shao K, Ding N, Huang S, et al. (2014). Smart nanodevice combined tumor-specific vector with cellular microenvironment-triggered property for highly effective antiglioma therapy. ACS Nano 8:1191–203.
   PubMed Web of Science ®Google Scholar
• Shi J, Kantoff PW, Wooster R, Farokhzad OC. (2016). Cancer nanomedicine: progress, challenges and opportunities. Nat Rev Cancer 17:20–37.
   PubMed Web of Science ®Google Scholar
• Singh S. (2017). Glucose decorated gold nanoclusters: a membrane potential independent fluorescence probe for rapid identification of cancer cells expressing Glut receptors. Colloids Surf B: Biointerfaces 155:25–34.
   PubMed Web of Science ®Google Scholar
• Stephen ZR, Kievit FM, Veiseh O, et al. (2014). Redox-responsive magnetic nanoparticle for targeted convection-enhanced delivery of O6-benzylguanine to brain tumors. ACS Nano 8:10383–95.
   PubMed Web of Science ®Google Scholar
• Tang Y, Li Y, Wang B, et al. (2012). Efficient in vitro siRNA delivery and Intramuscular Gene Silencing using PEG modified PAMAM dendrimers. Mol Pharmaceut 9:1812–21.
   PubMed Web of Science ®Google Scholar
• Wu M, Li H, Liu R, et al. (2016). Galactose conjugated Platinum(II) complex targeting the Warburg effect for treatment of non-small cell lung cancer and colon cancer. Eur J Med Chem 110:32–42.
   PubMed Web of Science ®Google Scholar
• Yang G, Wang X, Fu S, et al. (2017). pH-triggered chitosan nanogels via an ortho ester-based linkage for efficient chemotherapy. Acta Biomater 60:232–43.
   PubMed Web of Science ®Google Scholar
• You X, Ju X, He F, et al. (2017). Polymersomes with rapid K+-triggered drug release behaviors. ACS Appl Mater Interfaces 9: 19258–68.
   PubMed Web of Science ®Google Scholar
• Zou Y, Meng F, Deng C, Zhong Z. (2016). Robust, tumor-homing and redox-sensitive polymersomal doxorubicin: a superior alternative to doxil and caelys?. J Control Release 10:149–58.
   Web of Science ®Google Scholar