Dual-ligand modified liposomes provide effective local targeted delivery of lung-cancer drug by antibody and tumor lineage-homing cell-penetrating peptide

References

• Al-Ahmady ZS, Chaloin O, Kostarelos K. (2014). Monoclonal antibody-targeted, temperature-sensitive liposomes: in vivo tumor chemotherapeutics in combination with mild hyperthermia. J Control Release 196:332–43.
   PubMed Web of Science ®Google Scholar
• Bae YH, Park K. (2011). Targeted drug delivery to tumors: Myths, reality and possibility. J Control Release 153:198–205.
   PubMed Web of Science ®Google Scholar
• Cai D, Gao W, He B, et al. (2014a). Hydrophobic penetrating peptide PFVYLI-modified stealth liposomes for doxorubicin delivery in breast cancer therapy. Biomaterials 35:2283–94.
   PubMed Web of Science ®Google Scholar
• Cai DF, Gao W, He B, et al. (2014b). Hydrophobic penetrating peptide PFVYLI-modified stealth liposomes for doxorubicin delivery in breast cancer therapy. Biomaterials 35:2283–94.
   PubMed Web of Science ®Google Scholar
• Chen LM, Liu Q, Huang ZH, et al. (2012a). Tripchlorolide induces cell death in lung cancer cells by autophagy. Int J Oncol 40:1066–70.
   PubMed Web of Science ®Google Scholar
• Chen XY, Huang WH, Wong BCK, et al. (2012b). Liposomes prolong the therapeutic effect of anti-asthmatic medication via pulmonary delivery. Int J Nanomedicine 7:1139–48.
   PubMed Web of Science ®Google Scholar
• Chereddy KK, Her CH, Comune M, et al. (2014). PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing. J Control Release 194:138–47.
   PubMed Web of Science ®Google Scholar
• Dicheva BM, Ten Hagen TL, Schipper D, et al. (2014). Targeted and heat-triggered doxorubicin delivery to tumors by dual targeted cationic thermosensitive liposomes. J Control Release 195:37–48.
   PubMed Web of Science ®Google Scholar
• Fonseca SB, Pereira MP, Kelley SO. (2009). Recent advances in the use of cell-penetrating peptides for medical and biological applications. Adv Drug Deliv Rev 61:953–64.
   PubMed Web of Science ®Google Scholar
• Garbuzenko OB, Saad M, Pozharov VP, et al. (2010). Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance. Proc Natl Acad Sci USA 107:10737–42.
   PubMed Web of Science ®Google Scholar
• Gill KK, Nazzal S, Kaddoumi A. (2011). Paclitaxel loaded PEG(5000)-DSPE micelles as pulmonary delivery platform: formulation characterization, tissue distribution, plasma pharmacokinetics, and toxicological evaluation. Eur J Pharm Biopharm 79:276–84.
   PubMed Web of Science ®Google Scholar
• Kaminskas LM, Mcleod VM, Ryan GM, et al. (2014). Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy. J Control Release 183:18–26.
   PubMed Web of Science ®Google Scholar
• Kondo E, Saito K, Tashiro Y, et al. (2012). Tumour lineage-homing cell-penetrating peptides as anticancer molecular delivery systems. Nat Commun 3:951.
   PubMed Web of Science ®Google Scholar
• Koshkina NV, Waldrep JC, Roberts LE, et al. (2001). Paclitaxel liposome aerosol treatment induces inhibition of pulmonary metastases in murine renal carcinoma model. Clin Cancer Res 7:3258–62.
   PubMed Web of Science ®Google Scholar
• Le QT, Chen E, Salim A, et al. (2006). An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers. Clin Cancer Res 12:1507–14.
   PubMed Web of Science ®Google Scholar
• Li XF, Zang AM, Jia YC, et al. (2016). Triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer cells through PTEN by targeting miR-21. Mol Med Rep 13:2763–8.
   PubMed Web of Science ®Google Scholar
• Liang DS, Su HT, Liu YJ, et al. (2015). Tumor-specific penetrating peptides-functionalized hyaluronic acid-d-alpha-tocopheryl succinate based nanoparticles for multi-task delivery to invasive cancers. Biomaterials 71:11–23.
   PubMed Web of Science ®Google Scholar
• Liao SY, Aurelio ON, Jan K, et al. (1997). Identification of the MN/CA9 protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney. Cancer Res 57:2827–31.
   PubMed Web of Science ®Google Scholar
• Lin C, Wong BCK, Chen H, et al. (2017). Pulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase IX antibody for lung cancer therapy. Sci Rep 7:1097.
   PubMed Web of Science ®Google Scholar
• Liu YY, Ran R, Chen JT, et al. (2014). Paclitaxel loaded liposomes decorated with a multifunctional tandem peptide for glioma targeting. Biomaterials 35:4835–47.
   PubMed Web of Science ®Google Scholar
• Luo T, Loira-Pastoriza C, Patil HP, et al. (2016). PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma. J Control Release 239:62–71.
   PubMed Web of Science ®Google Scholar
• Maeda H, Nakamura H, Fang J. (2013). The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo. Adv Drug Deliv Rev 65:71–9.
   PubMed Web of Science ®Google Scholar
• Mahmoud W, Rousserie G, Reveil B, et al. (2011). Advanced procedures for labeling of antibodies with quantum dots. Anal Biochem 416:180–5.
   PubMed Web of Science ®Google Scholar
• Mcdonald PC, Winum JY, Supuran CT, Dedhar S. (2012). Recent developments in targeting carbonic anhydrase IX for cancer therapeutics. Oncotarget 3:84–97.
   PubMed Web of Science ®Google Scholar
• Mehta G, Hsiao AY, Ingram M, et al. (2012). Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy. J Control Release 164:192–204.
   PubMed Web of Science ®Google Scholar
• Minchinton AI, Tannock IF. (2006). Drug penetration in solid tumours. Nat Rev Cancer 6:583–92.
   PubMed Web of Science ®Google Scholar
• Pastorek J, Pastorekova S. (2015). Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: From biology to clinical use. Sem Cancer Biol 31:52–64.
   PubMed Web of Science ®Google Scholar
• Raghunand N, Gatenby RA, Gillies RJ. (2003). Microenvironmental and cellular consequences of altered blood flow in tumours. Br J Radiol 76: S11–S22.
   PubMed Web of Science ®Google Scholar
• Reno TA, Kim JY, Raz DJ. (2015). Triptolide inhibits lung cancer cell migration, invasion, and metastasis. Ann Thorac Surg 100:1817–25.
   PubMed Web of Science ®Google Scholar
• Saarnio J, Parkkila S, Parkkila AK, et al. (1998). Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation. Am J Pathol 153:279–85.
   PubMed Web of Science ®Google Scholar
• She Z, Zhang T, Wang X, et al. (2014). The anticancer efficacy of pixantrone-loaded liposomes decorated with sialic acid-octadecylamine conjugate. Biomaterials 35:5216–25.
   PubMed Web of Science ®Google Scholar
• Swinson DEB, Jones JL, Richardson D, et al. (2003). Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer. J Clin Oncol 21:473–82.
   PubMed Web of Science ®Google Scholar
• Vermylen P, Roufosse C, Burny A, et al. (1999). Carbonic anhydrase IX antigen differentiates between preneoplastic malignant lesions in non-small cell lung carcinoma. Eur Respir J 14:806–11.
   PubMed Web of Science ®Google Scholar
• Wang FH, Wang Y, Zhang X, et al. (2014). Recent progress of cell-penetrating peptides as new carriers for intracellular cargo delivery. J Control Release 174:126–36.
   PubMed Web of Science ®Google Scholar
• Wauthoz N, Deleuze P, Hecq J, et al. (2010). In vivo assessment of temozolomide local delivery for lung cancer inhalation therapy. Eur J Pharm Sci 39:402–11.
   PubMed Web of Science ®Google Scholar
• Wong BCK, Zhang HQ, Qin L, et al. (2014). Carbonic anhydrase IX-directed immunoliposomes for targeted drug delivery to human lung cancer cells in vitro. Drug Des Devel Ther 8:993–1001.
   PubMed Web of Science ®Google Scholar
• Wykoff CC, Beasley N, Watson PH, et al. (2001). Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast. Am J Pathol 158:1011–19.
   PubMed Web of Science ®Google Scholar
• Xue M, Zhao Y, Li XJ, et al. (2012). Comparison of toxicokinetic and tissue distribution of triptolide-loaded solid lipid nanoparticles vs. free triptolide in rats. Eur J Pharm Sci 47:713–17.
   PubMed Web of Science ®Google Scholar
• Yang YF, Yang Y, Xie XY, et al. (2014). PEGylated liposomes with NGR ligand and heat-activable cell-penetrating peptide-doxorubicin conjugate for tumor-specific therapy. Biomaterials 35:4368–81.
   PubMed Web of Science ®Google Scholar
• Yao VJ, D'angelo S, Butler KS, et al. (2016). Ligand-targeted theranostic nanomedicines against cancer. J Control Release 240:267–86.
   PubMed Web of Science ®Google Scholar
• Zhuang XM, Liu PX, Zhang YJ, et al. (2013). Simultaneous determination of triptolide and its prodrug MC002 in dog blood by LC-MS/MS and its application in pharmacokinetic studies. J Ethnopharmacol 150:131–7.
   PubMed Web of Science ®Google Scholar