Nano-engineered microcapsules boost the treatment of persistent pain

References

• Antipina MN, Sukhorukov GB. (2011). Remote control over guidance and release properties of composite polyelectrolyte based capsules. Adv Drug Deliv Rev 63:716–29.
   PubMed Web of Science ®Google Scholar
• Binshtok AM, Bean BP, Woolf CJ. (2007). Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature 449:607–10.
   PubMed Web of Science ®Google Scholar
• Brenneis C, Kistner K, Puopolo M, et al. (2014). Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block. Br J Pharmacol 171:438–51.
   PubMed Web of Science ®Google Scholar
• Chiappini C, De Rosa E, Martinez JO, et al. (2015). Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization. Nat Mater 14:532–9.
   PubMed Web of Science ®Google Scholar
• De Cock LJ, De Koker S, De Geest BG, et al. (2010). Polymeric multilayer capsules in drug delivery. Angew Chem Int Ed Engl 49:6954–73.
   PubMed Web of Science ®Google Scholar
• Decher G. (1997). Fuzzy nanoassemblies: toward layered polymeric multicomposites. Science 277:1232–7.
   Web of Science ®Google Scholar
• Delcea M, Mohwald H, Skirtach AG. (2011). Stimuli-responsive LbL capsules and nanoshells for drug delivery. Adv Drug Deliv Rev 63:730–47.
   PubMed Web of Science ®Google Scholar
• Ermolyuk YS, Alder FG, Surges R, et al. (2013). Differential triggering of spontaneous glutamate release by P/Q-, N- and R-type Ca2+ channels. Nat Neurosci 16:1754–63.
   PubMed Web of Science ®Google Scholar
• Frias B, Merighi A. (2016). Capsaicin, nociception and pain. Molecules 21:pii:E797.
   PubMed Web of Science ®Google Scholar
• Gao H, Goriacheva OA, Tarakina NV, et al. (2016). Intracellularly biodegradable polyelectrolyte/silica composite microcapsules as carriers for small molecules. ACS Appl Mater Interfaces 8:9651–61.
   PubMed Web of Science ®Google Scholar
• Hofmann ME, Largent-Milnes TM, Fawley JA, et al. (2014). External QX-314 inhibits evoked cranial primary afferent synaptic transmission independent of TRPV1. J Neurophysiol 112:2697–706.
   PubMed Web of Science ®Google Scholar
• Hua S, Cabot PJ. (2013). Targeted nanoparticles that mimic immune cells in pain control inducing analgesic and anti-inflammatory actions: a potential novel treatment of acute and chronic pain condition. Pain Physician 16:E199–216.
   PubMed Web of Science ®Google Scholar
• Kopach O, Krotov V, Belan P, et al. (2015). Inflammatory-induced changes in synaptic drive and postsynaptic AMPARs in lamina II dorsal horn neurons are cell-type specific. Pain 156:428–38.
   PubMed Web of Science ®Google Scholar
• Kopach O, Krotov V, Goncharenko J, et al. (2016). Inhibition of Spinal Ca2+-permeable AMPA receptors with dicationic compounds alleviates persistent inflammatory pain without adverse effects. Front Cell Neurosci 10:50.
   PubMed Web of Science ®Google Scholar
• Kopach O, Viatchenko-Karpinski V, Atianjoh FE, et al. (2013). PKCalpha is required for inflammation-induced trafficking of extrasynaptic AMPA receptors in tonically firing lamina II dorsal horn neurons during the maintenance of persistent inflammatory pain. J Pain 14:182–92.
   PubMed Web of Science ®Google Scholar
• Kopach O, Viatchenko-Karpinski V, Belan P, et al. (2012). Development of inflammation-induced hyperalgesia and allodynia is associated with the upregulation of extrasynaptic AMPA receptors in tonically firing lamina II dorsal horn neurons. Front Physiol 3:391.
   PubMed Web of Science ®Google Scholar
• Leffler A, Lattrell A, Kronewald S, et al. (2011). Activation of TRPA1 by membrane permeable local anesthetics. Mol Pain 7:62.
   PubMed Web of Science ®Google Scholar
• Lim TK, Macleod BA, Ries CR, et al. (2007). The quaternary lidocaine derivative, QX-314, produces long-lasting local anesthesia in animal models in vivo. Anesthesiology 107:305–11.
   PubMed Web of Science ®Google Scholar
• Liu Q, Zhan C, Barhoumi A, et al. (2016). A supramolecular shear-thinning anti-inflammatory steroid hydrogel. Adv Mater Weinheim 28:6680–6.
   PubMed Web of Science ®Google Scholar
• Mishra A, Reynolds JP, Chen Y, et al. (2016). Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles. Nat Neurosci 19:1619–27.
   PubMed Web of Science ®Google Scholar
• Munoz Javier A, Del Pino P, Bedard MF, et al. (2008). Photoactivated release of cargo from the cavity of polyelectrolyte capsules to the cytosol of cells. Langmuir 24:12517–20.
   PubMed Web of Science ®Google Scholar
• Park JH, Gu L, Von Maltzahn G, et al. (2009a). Biodegradable luminescent porous silicon nanoparticles for in vivo applications. Nat Mater 8:331–6.
   PubMed Web of Science ®Google Scholar
• Park JS, Voitenko N, Petralia RS, et al. (2009b). Persistent inflammation induces GluR2 internalization via NMDA receptor-triggered PKC activation in dorsal horn neurons. J Neurosci 29:3206–19.
   PubMed Web of Science ®Google Scholar
• Pavlov AM, De Geest BG, Louage B, et al. (2013). Magnetically engineered microcapsules as intracellular anchors for remote control over cellular mobility. Adv Mater Weinheim 25:6945–50.
   PubMed Web of Science ®Google Scholar
• Pavlov AM, Sapelkin AV, Huang X, et al. (2011). Neuron cells uptake of polymeric microcapsules and subsequent intracellular release. Macromol Biosci 11:848–54.
   PubMed Web of Science ®Google Scholar
• Peters CM, Ririe D, Houle TT, et al. (2014). Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats. Anesthesiology 120:976–86.
   PubMed Web of Science ®Google Scholar
• Roberson DP, Binshtok AM, Blasl F, et al. (2011). Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review. Br J Pharmacol 164:48–58.
   PubMed Web of Science ®Google Scholar
• Rwei AY, Lee JJ, Zhan C, et al. (2015). Repeatable and adjustable on-demand sciatic nerve block with phototriggerable liposomes. Proc Natl Acad Sci USA 112:15719–24.
   PubMed Web of Science ®Google Scholar
• Stuart MA, Huck WT, Genzer J, et al. (2010). Emerging applications of stimuli-responsive polymer materials. Nat Mater 9:101–13.
   PubMed Web of Science ®Google Scholar
• Stueber T, Eberhardt MJ, Hadamitzky C, et al. (2016). Quaternary lidocaine derivative QX-314 activates and permeates human TRPV1 and TRPA1 to produce inhibition of sodium channels and cytotoxicity. Anesthesiology 124:1153–65.
   PubMed Web of Science ®Google Scholar
• Sukhorukov GB, Mohwald H. (2007). Multifunctional cargo systems for biotechnology. Trends Biotechnol 25:93–8.
   PubMed Web of Science ®Google Scholar
• Sukhorukov GB, Rogach AL, Zebli B, et al. (2005). Nanoengineered polymer capsules: tools for detection, controlled delivery, and site-specific manipulation. Small 1:194–200.
   PubMed Web of Science ®Google Scholar
• Tanbour R, Martins AM, Pitt WG, et al. (2016). Drug delivery systems based on polymeric micelles and ultrasound: a review. Curr Pharm Des 22:2796–807.
   PubMed Web of Science ®Google Scholar
• Xu ZZ, Kim YH, Bang S, et al. (2015). Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. Nat Med 21:1326–31.
   PubMed Web of Science ®Google Scholar
• Zhan C, Wang W, Mcalvin JB, et al. (2016). Phototriggered local anesthesia. Nano Lett 16:177–81.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Chan HF, Leong KW. (2013). Advanced materials and processing for drug delivery: the past and the future. Adv Drug Deliv Rev 65:104–20.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Zhou C, Liu J, et al. (2014). The quaternary lidocaine derivative QX-314 produces long-lasting intravenous regional anesthesia in rats. PLoS One 9:e99704.
   PubMed Web of Science ®Google Scholar
• Zheng K, Bard L, Reynolds JP, et al. (2015). Time-resolved imaging reveals heterogeneous landscapes of nanomolar Ca2+ in neurons and astroglia. Neuron 88:277–88.
   PubMed Web of Science ®Google Scholar