Antitumor efficacy of liposome-encapsulated NVP-BEZ 235 in combination with irreversible electroporation

References

• Al-Sakere B, André F, Bernat C, et al. (2007). Tumor ablation with irreversible electroporation. PLoS One 2:e1135.
   PubMed Web of Science ®Google Scholar
• Allen TM, Cullis PR. (2013). Liposomal drug delivery systems: from concept to clinical applications. Adv Drug Deliv Rev 65:36–48.
   PubMed Web of Science ®Google Scholar
• Belehradek M, Domenge C, Luboinski B, et al. (1993). Electrochemotherapy, a new antitumor treatment. First clinical phase I-II trial. Cancer 72:3694–700.
   PubMed Web of Science ®Google Scholar
• Bhende PM, Park SI, Lim MS, et al. (2010). The dual PI3K/mTOR inhibitor, NVP-BEZ235, is efficacious against non-hodgkin lymphoma. Leukemia 24:1781.
   PubMed Web of Science ®Google Scholar
• Blanco E, Shen H, Ferrari M. (2015). Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat Biotechnol 33:941–51.
   PubMed Web of Science ®Google Scholar
• Campbell RB, Balasubramanian SV, Straubinger RM. (2001). Influence of cationic lipids on the stability and membrane properties of paclitaxel-containing liposomes. J. Pharm Sci 90:1091–105.
   PubMed Web of Science ®Google Scholar
• Cao P, Maira S-M, Garcia-Echeverria C, Hedley D. (2009). Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts. Br J Cancer 100:1267–76.
   PubMed Web of Science ®Google Scholar
• Chakraborty S, Shukla D, Mishra B, Singh S. (2009). Lipid-an emerging platform for oral delivery of drugs with poor bioavailability. Eur J Pharm Biopharm 73:1–15.
   PubMed Web of Science ®Google Scholar
• Cho DC, Cohen MB, Panka DJ, et al. (2010). The efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 compared with rapamycin in renal cell carcinoma. Clin Cancer Res 16:3628–38.
   PubMed Web of Science ®Google Scholar
• Dahiru T. (2008). P-value, a true test of statistical significance? A cautionary note. Ann Ib Postgrad Med 6:21–6.
   PubMedGoogle Scholar
• Davalos RV, Mir L, Rubinsky B. (2005). Tissue ablation with irreversible electroporation. Ann Biomed Eng 33:223.
   PubMed Web of Science ®Google Scholar
• Edwards K, Johnsson M, Karlsson G, Silvander M. (1997). Effect of polyethyleneglycol-phospholipids on aggregate structure in preparations of small unilamellar liposomes. Biophys Jl 73:258–66.
   PubMed Web of Science ®Google Scholar
• Gehl J. (2003). Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research. Acta Physiol Scand 177:437–47.
   PubMedGoogle Scholar
• Gelperina S, Kisich K, Iseman MD, Heifets L. (2005). The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis. Am J Respir Crit Care Med 172:1487–90.
   PubMed Web of Science ®Google Scholar
• Golberg A, Bruinsma BG, Uygun BE, Yarmush ML. (2015). Tissue heterogeneity in structure and conductivity contribute to cell survival during irreversible electroporation ablation by “electric field sinks”. Sci Rep 5:8485.
   PubMed Web of Science ®Google Scholar
• Jarm T, Cemazar M, Miklavcic D, Sersa G. (2010). Antivascular effects of electrochemotherapy: implications in treatment of bleeding metastases. Expert Rev Anticancer Ther 10:729–46.
   PubMed Web of Science ®Google Scholar
• Krech RL, Walsh D. (1991). Symptoms of pancreatic cancer. J Pain Symptom Manage 6:360–7.
   PubMed Web of Science ®Google Scholar
• Liu TJ, Koul D, Lafortune T, et al. (2009). NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas. Mol Cancer Ther 8:2204–10.
   PubMed Web of Science ®Google Scholar
• Maira SM, Stauffer F, Brueggen J, et al. (2008). Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther 7:1851–63.
   PubMed Web of Science ®Google Scholar
• Miklavcic D, Davalos RV. (2015). Electrochemotherapy (ECT) and irreversible electroporation (IRE)-advanced techniques for treating deep-seated tumors based on electroporation. Biomed Eng Online 14:I1.
   PubMed Web of Science ®Google Scholar
• Pabst G, Rappolt M, Amenitsch H, Laggner P. (2000). Structural information from multilamellar liposomes at full hydration: full q-range fitting with high quality x-ray data. Phys Rev E 62:4000.
   PubMed Web of Science ®Google Scholar
• Philips P, Hays D, Martin RC. (2013). Irreversible electroporation ablation (IRE) of unresectable soft tissue tumors: learning curve evaluation in the first 150 patients treated. PloS One 8:e76260.
   PubMed Web of Science ®Google Scholar
• Polk HC, Camp FA, Walker AW. (1967). Dysphagia and esophageal stenosis. Manifestation of metastatic mammary cancer. Cancer 20:2002–7.
   PubMed Web of Science ®Google Scholar
• Saczko J, Kamińska I, Kotulska M, et al. (2014). Combination of therapy with 5-fluorouracil and cisplatin with electroporation in human ovarian carcinoma model in vitro. ‎Biomed Pharmacother 68:573–80.
   PubMed Web of Science ®Google Scholar
• Samad A, Sultana Y, Aqil M. (2007). Liposomal drug delivery systems: an update review. Curr Drug Deliv 4:297–305.
   PubMedGoogle Scholar
• Seront E, Rottey S, Filleul B, et al. (2016). Phase II study of dual phosphoinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR) inhibitor BEZ235 in patients with locally advanced or metastatic transitional cell carcinoma. BJU Int 118:408–15.
   PubMed Web of Science ®Google Scholar
• Silve A, Leray I, Poignard C, Mir LM. (2016). Impact of external medium conductivity on cell membrane electropermeabilization by microsecond and nanosecond electric pulses. Sci Rep 6:19957.
   PubMed Web of Science ®Google Scholar
• Tian L, Lu L, Qiao Y, et al. (2016). Stimuli-responsive gold nanoparticles for cancer diagnosis and therapy. J Funct Biomater 7:19.
   Web of Science ®Google Scholar
• West DL, White SB, Zhang Z, et al. (2013). Assessment and optimization of electroporation-assisted tumoral nanoparticle uptake in a nude mouse model of pancreatic ductal adenocarcinoma. Int J Nanomed 9:4169–76.
   Web of Science ®Google Scholar
• Xu C-X, Li Y, Yue P, et al. (2011). The combination of RAD001 and NVP-BEZ235 exerts synergistic anticancer activity against non-small cell lung cancer in vitro and in vivo. PloS One 6:e20899.
   PubMed Web of Science ®Google Scholar
• Yang T, Cui FD, Choi MK, et al. (2007). Liposome formulation of paclitaxel with enhanced solubility and stability. Drug Deliv 14:301–8.
   PubMed Web of Science ®Google Scholar
• Zhao J, Qiao Y, Zhou M, et al. (2015). Antitumor efficacy of irreversible electroporation and doxorubicin-loaded polymeric micelles. ACS Macro Lett 4:1081–4.
   PubMed Web of Science ®Google Scholar
• Zimm S, Collins JM, O'neill D, et al. (1983). Inhibition of first-pass metabolism in cancer chemotherapy: interaction of 6-mercaptopurine mercaptopurine and allopurinol. Clin Pharmacol Ther 34:810–7.
   PubMed Web of Science ®Google Scholar