Puerarin-loaded PEG-PE micelles with enhanced anti-apoptotic effect and better pharmacokinetic profile

References

• Abouzeid AH, Patel NR, Torchilin VP. (2014). Polyethylene glycol-phosphatidylethanolamine (PEG-PE)/vitamin E micelles for co-delivery of paclitaxel and curcumin to overcome multi-drug resistance in ovarian cancer. Int J Pharm 464:178–84.
   PubMed Web of Science ®Google Scholar
• Chen M, Zhou X, Yu L, et al. (2016). Low-level vagus nerve stimulation attenuates myocardial ischemic reperfusion injury by antioxidative stress and antiapoptosis reactions in canines. J Cardiovasc Electrophysiol 27:224–31.
   PubMed Web of Science ®Google Scholar
• Cui Y, Dong H, Cai X, et al. (2012). Mesoporous silica nanoparticles capped with disulfide-linked PEG gatekeepers for glutathione-mediated controlled release. ACS Appl Mater Interfaces 4:3177–83.
   PubMed Web of Science ®Google Scholar
• Dabholkar RD, Sawant RM, Mongayt DA, et al. (2006). Polyethylene glycol-phosphatidylethanolamine conjugate (PEG-PE)-based mixed micelles: some properties, loading with paclitaxel, and modulation of P-glycoprotein-mediated efflux. Int J Pharm 315:148–57.
   PubMed Web of Science ®Google Scholar
• Demina T, Grozdova I, Krylova O, et al. (2005). Relationship between the structure of amphiphilic copolymers and their ability to disturb lipid bilayers. Biochemistry 44:4042–54.
   PubMed Web of Science ®Google Scholar
• Dong Z, Guo J, Xing X, et al. (2017). RGD modified and PEGylated lipid nanoparticles loaded with puerarin: formulation, characterization and protective effects on acute myocardial ischemia model. Biomed Pharmacother 89:297–304.
   PubMed Web of Science ®Google Scholar
• Endres TK, Beck-Broichsitter M, Samsonova O, et al. (2011). Self-assembled biodegradable amphiphilic PEG-PCL-lPEI triblock copolymers at the borderline between micelles and nanoparticles designed for drug and gene delivery. Biomaterials 32:7721–31.
   PubMed Web of Science ®Google Scholar
• Gill KK, Nazzal S, Kaddoumi A. (2011). Paclitaxel loaded PEG(5000)-DSPE micelles as pulmonary delivery platform: formulation characterization, tissue distribution, plasma pharmacokinetics, and toxicological evaluation. Eur J Pharm Biopharm 79:276–84.
   PubMed Web of Science ®Google Scholar
• Gref R, Minamitake Y, Peracchia MT, et al. (1994). Biodegradable long-circulating polymeric nanospheres. Science 263:1600–3.
   PubMed Web of Science ®Google Scholar
• Hou SZ, Su ZR, Chen SX, et al. (2011). Role of the interaction between puerarin and the erythrocyte membrane in puerarin-induced hemolysis. Chem Biol Interact 192:184–92.
   PubMed Web of Science ®Google Scholar
• Hu X, Yang FF, Liu CY, et al. (2017). In vitro uptake and transport studies of PEG-PLGA polymeric micelles in respiratory epithelial cells. Eur J Pharm Biopharm 114:29–37.
   PubMed Web of Science ®Google Scholar
• Hu X, Yang FF, Quan LH, et al. (2014). Pulmonary delivered polymeric micelles – pharmacokinetic evaluation and biodistribution studies. Eur J Pharm Biopharm 88:1064–75.
   PubMed Web of Science ®Google Scholar
• Huang F, Liu K, Du H, et al. (2012). Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKKbeta/IRS-1-dependent manner. Biochimie 94:1143–50.
   PubMed Web of Science ®Google Scholar
• Kohay H, Sarisozen C, Sawant R, et al. (2017). PEG-PE/clay composite carriers for doxorubicin: effect of composite structure on release, cell interaction and cytotoxicity. Acta Biomater 55:443–54.
   PubMed Web of Science ®Google Scholar
• Lazarjani HA, Vasheghani-Farahani E, Barani L, et al. (2010). Effect of polymer concentration on camouflaging of pancreatic islets with mPEG-succinimidyl carbonate. Artif Cells Blood Substit Immobil Biotechnol 38:250–8.
   PubMed Web of Science ®Google Scholar
• Li JQ, Qi HZ, He ZJ, et al. (2009). Cytoprotective effects of human interleukin-10 gene transfer against necrosis and apoptosis induced by hepatic cold ischemia/reperfusion injury. J Surg Res 157:e71–8.
   PubMed Web of Science ®Google Scholar
• Li WH, Lu M, Zhang YH, et al. (2017). Puerarin attenuates the daunorubicin-induced apoptosis of H9c2 cells by activating the PI3K/Akt signaling pathway via the inhibition of Ca2+ influx. Int J Mol Med 40:1889–94.
   PubMed Web of Science ®Google Scholar
• Liu B, Wu ZY, Li YP, et al. (2015). Puerarin prevents cardiac hypertrophy induced by pressure overload through activation of autophagy. Biochem Biophys Res Commun 464:908–15.
   PubMed Web of Science ®Google Scholar
• Liu CM, Ma JQ, Sun YZ. (2011). Protective role of puerarin on lead-induced alterations of the hepatic glutathione antioxidant system and hyperlipidemia in rats. Food Chem Toxicol 49:3119–27.
   PubMed Web of Science ®Google Scholar
• Liu CM, Ma JQ, Sun YZ. (2012). Puerarin protects rat kidney from lead-induced apoptosis by modulating the PI3K/Akt/eNOS pathway. Toxicol Appl Pharmacol 258:330–42.
   PubMed Web of Science ®Google Scholar
• Liu LJ, Liu LQ, Bo T, et al. (2013). Puerarin suppress apoptosis of human osteoblasts via ERK signaling pathway. Int J Endocrinol 2013:786574.
   PubMed Web of Science ®Google Scholar
• Liu X, Ding Y, Zhao B, et al. (2016). In vitro and in vivo evaluation of puerarin-loaded PEGylated mesoporous silica nanoparticles. Drug Dev Ind Pharm 42:2031–7.
   PubMed Web of Science ®Google Scholar
• Lu Q, Xiang DX, Yuan HY, et al. (2014). Puerarin attenuates calcification of vascular smooth muscle cells. Am J Chin Med 42:337–47.
   PubMed Web of Science ®Google Scholar
• Lu X, Zhang F, Qin L, et al. (2010). Polymeric micelles as a drug delivery system enhance cytotoxicity of vinorelbine through more intercellular accumulation. Drug Deliv 17:255–62.
   PubMed Web of Science ®Google Scholar
• Lukyanov AN, Hartner WC, Torchilin VP. (2004). Increased accumulation of PEG-PE micelles in the area of experimental myocardial infarction in rabbits. J Control Release 94:187–93.
   PubMed Web of Science ®Google Scholar
• Luo CF, Yuan M, Chen MS, et al. (2011). Determination of puerarin in rat plasma by rapid resolution liquid chromatography tandem mass spectrometry in positive ionization mode. J Chromatogr B Analyt Technol Biomed Life Sci 879:1497–501.
   PubMed Web of Science ®Google Scholar
• Musacchio T, Vaze O, D'souza G, Torchilin VP. (2010). Effective stabilization and delivery of siRNA: reversible siRNA-phospholipid conjugate in nanosized mixed polymeric micelles. Bioconjugate Chem 21:1530–6.
   PubMed Web of Science ®Google Scholar
• Ouyang F, Huang H, Zhang M, et al. (2016). HMGB1 induces apoptosis and EMT in association with increased autophagy following H/R injury in cardiomyocytes. Int J Mol Med 37:679–89.
   PubMed Web of Science ®Google Scholar
• Peng J, Li X, Zhang D, et al. (2015). Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury. Kidney Int 87:137–50.
   PubMed Web of Science ®Google Scholar
• Raza K, Kumar N, Misra C, et al. (2016). Dextran-PLGA-loaded docetaxel micelles with enhanced cytotoxicity and better pharmacokinetic profile. Int J Biol Macromol 88:206–12.
   PubMed Web of Science ®Google Scholar
• Rivolta I, Panariti A, Lettiero B, et al. (2011). Cellular uptake of coumarin-6 as a model drug loaded in solid lipid nanoparticles. J Physiol Pharmacol 62:45–53.
   PubMed Web of Science ®Google Scholar
• Roby A, Erdogan S, Torchilin VP. (2006). Solubilization of poorly soluble PDT agent, meso-tetraphenylporphin, in plain or immunotargeted PEG-PE micelles results in dramatically improved cancer cell killing in vitro. Eur J Pharm Biopharm 62:235–40.
   PubMed Web of Science ®Google Scholar
• Ruan W, Xu JM, Li SB, et al. (2012). Effects of down-regulation of microRNA-23a on TNF-α-induced endothelial cell apoptosis through caspase-dependent pathways. Cardiovasc Res 93:623–32.
   PubMed Web of Science ®Google Scholar
• Sarisozen C, Vural I, Levchenko T, et al. (2012a). Long-circulating PEG-PE micelles co-loaded with paclitaxel and elacridar (GG918) overcome multidrug resistance. Drug Deliv 19:363–70.
   PubMed Web of Science ®Google Scholar
• Sarisozen C, Vural I, Levchenko T, et al. (2012b). PEG-PE-based micelles co-loaded with paclitaxel and cyclosporine A or loaded with paclitaxel and targeted by anticancer antibody overcome drug resistance in cancer cells. Drug Deliv 19:169–76.
   PubMed Web of Science ®Google Scholar
• Sawant RR, Sawant RM, Torchilin VP. (2008). Mixed PEG-PE/vitamin E tumor-targeted immunomicelles as carriers for poorly soluble anti-cancer drugs: improved drug solubilization and enhanced in vitro cytotoxicity. Eur J Pharm Biopharm 70:51–7.
   PubMed Web of Science ®Google Scholar
• Sawant RR, Torchilin VP. (2010). Multifunctionality of lipid-core micelles for drug delivery and tumour targeting. Mol Membr Biol 27:232–46.
   PubMed Web of Science ®Google Scholar
• Shao K, Huang R, Li J, et al. (2010). Angiopep-2 modified PE-PEG based polymeric micelles for amphotericin B delivery targeted to the brain. J Control Release 147:118–26.
   PubMed Web of Science ®Google Scholar
• Szilagyi I, Trefalt G, Tiraferri A, et al. (2014). Polyelectrolyte adsorption, interparticle forces, and colloidal aggregation. Soft Matter 10:2479–502.
   PubMed Web of Science ®Google Scholar
• Tang J, Wang X, Wang T, et al. (2014). In vivo pharmacokinetics, biodistribution and antitumor effect of amphiphilic poly(L-amino acids) micelles loaded with a novel all-trans retinoic acid derivative. Eur J Pharm Sci 51:157–64.
   PubMed Web of Science ®Google Scholar
• Tong S, Hou S, Ren B, et al. (2011). Self-assembly of phospholipid-PEG coating on nanoparticles through dual solvent exchange. Nano Lett 11:3720–6.
   PubMed Web of Science ®Google Scholar
• Torchilin VP. (2005). Lipid-core micelles for targeted drug delivery. Curr Drug Deliv 2:319–27.
   PubMedGoogle Scholar
• Wang J, Wang Y, Liang W. (2012). Delivery of drugs to cell membranes by encapsulation in PEG-PE micelles. J Control Release 160:637–51.
   PubMed Web of Science ®Google Scholar
• Wang Q, Jiang J, Chen W, et al. (2016). Targeted delivery of low-dose dexamethasone using PCL-PEG micelles for effective treatment of rheumatoid arthritis. J Control Release 230:64–72.
   PubMed Web of Science ®Google Scholar
• Wang Y, Fan W, Dai X, et al. (2014). Enhanced tumor delivery of gemcitabine via PEG-PE/TPGS mixed micelles. Mol Pharm 11:1140–50.
   PubMed Web of Science ®Google Scholar
• Wong KH, Li GQ, Li KM, et al. (2011). Kudzu root: traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases. J Ethnopharmacol 134:584–607.
   PubMed Web of Science ®Google Scholar
• Wu J, Zhang X, Zhang B. (2014). Efficacy and safety of puerarin injection in treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis of randomized controlled trials. J Tradit Chin Med 34:401–10.
   PubMed Web of Science ®Google Scholar
• Xu Y, Wang S, Chan HF, et al. (2017). Triphenylphosphonium-modified poly(ethylene glycol)-poly(epsilon-caprolactone) micelles for mitochondria- targeted gambogic acid delivery. Int J Pharm 522:21–33.
   PubMed Web of Science ®Google Scholar
• Yassin MA, Appelhans D, Wiedemuth R, et al. (2015). Overcoming concealment effects of targeting moieties in the PEG corona: controlled permeable polymersomes decorated with folate-antennae for selective targeting of tumor cells. Small 11:1580–91.
   PubMed Web of Science ®Google Scholar
• Yuan Y, Zong J, Zhou H, et al. (2014). Puerarin attenuates pressure overload-induced cardiac hypertrophy. J Cardiol 63:73–81.
   PubMed Web of Science ®Google Scholar
• Zhang H, Zhang L, Zhang Q, et al. (2011). Puerarin: a novel antagonist to inward rectifier potassium channel (IK1). Mol Cell Biochem 352:117–23.
   PubMed Web of Science ®Google Scholar