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Research Article

Improving the topical ocular pharmacokinetics of lyophilized cyclosporine A-loaded micelles: formulation, in vitro and in vivo studies

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Pages 888-899 | Received 14 Feb 2018, Accepted 25 Mar 2018, Published online: 10 Apr 2018

References

  • Adriaens E, Dierckens K, Bauters TGM, et al. (2001). The mucosal toxicity of different benzalkonium chloride analogues evaluated with an alternative test using slugs. Pharm Res 18:937–42.
  • Agarwal P, Rupenthal ID. (2013). Injectable implants for the sustained release of protein and peptide drugs. Drug Discov Today 18:337
  • Agarwal P, Rupenthal ID. (2016). Modern approaches to the ocular delivery of cyclosporine A. Drug Discov Today 21:977–88.
  • Allen C, Maysinger D, Eisenberg A. (1999). Nano-engineering block copolymer aggregates for drug delivery. Colloids Surf B Biointerf 16:3–27.
  • Allergan. 2013. RESTASIS® (cyclosporine ophthalmic emulsion) 0.05%: Highlights of Prescribing Information.
  • Bjerrum KB. (1997). Keratoconjunctivitis sicca and primary Sjogren’s syndrome in a Danish population aged 30-60 years. Acta Ophthalmol Scand 75:281–6.
  • Dash S, Murthy PN, Nath L, Chowdhury P. (2010). Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm 67:217–23.
  • Dou J, Zhang H, Liu X, et al. (2014). Preparation and evaluation in vitro and in vivo of docetaxel loaded mixed micelles for oral administration. Colloids Surf B Biointerf 114:20.
  • Furrer P, Mayer JM, Plazonnet B, Gurny R. (1999). Ocular tolerance of preservatives on the murine cornea. Eur J Pharm Biopharm 47:105.
  • Geethalakshmi A, Karki R, Jha SK, et al. (2012). Sustained ocular delivery of brimonidine tartrate using ion activated in situ gelling system. CDD 9:197–204.
  • Gelderblom H, Verweij J, Nooter K, Sparreboom A. (2001). Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation. Eur J Cancer 37:1590–8.
  • Giannavola C, Bucolo C, Maltese A, et al. (2003). Influence of preparation conditions on Acyclovir-loaded poly-d,l-lactic acid nanospheres and effect of PEG coating on ocular drug bioavailability. Pharma Res 20:584–90.
  • González-Peñas E, Aldana I, Esteras A, et al. (1998). Absorption of sodium diclofenac after ocular administration in rabbit. Eur J Drug Metab Pharmacokinet 48:931.
  • Hancock BC, Parks M. (2000). What is the true solubility advantage for amorphous pharmaceuticals?. Pharma Res 17:397.
  • He P, Davis SS, Illum L. (1998). In vitro evaluation of the mucoadhesive properties of chitosan microspheres. Int J Pharma 166:75–88.
  • Heald CR, Stolnik S, Matteis CD, et al. (2001). Self-consistent field modelling of poly(lactic acid)–poly(ethylene glycol) particles. Colloids Surf A Physicochem Eng Aspects 179:79–91.
  • Hu X, Hao L, Wang H, et al. (2011). Hydrogel contact lens for extended delivery of ophthalmic drugs. Int J Ploym Sci 2011:2341–8.
  • Huang S, Yu X, Yang L, et al. (2014). The efficacy of nimodipine drug delivery using mPEG-PLA micelles and mPEG-PLA/TPGS mixed micelles. Eur J Pharma Sci 63:187–98.
  • Ismailos G, Reppas C, Dressman JB, Macheras P. (2011). Unusual solubility behaviour of cyclosporin A in aqueous media. J Pharm Pharmacol 43:287–9.
  • Jain AK, Mittal A, Jain S. (2011). Enhanced topical delivery of Cyclosporin-A using PLGA nanoparticles as carrier. Cnano 7:524–30.
  • Karn PR, Kim HD, Kang H, et al. (2014). Supercritical fluid-mediated liposomes containing cyclosporin A for the treatment of dry eye syndrome in a rabbit model: comparative study with the conventional cyclosporin A emulsion. Int J Nanomed 9:3791.
  • Koivusalo M, Welch C, Hayashi H, et al. (2010). Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling. J Cell Biol 188:547.
  • Konyushenko EN, Stejskal J, Trchová M, et al. (2006). Multi-wall carbon nanotubes coated with polyaniline. Polymer 47:5715–23.
  • Kwon GS. (2003). Polymeric micelles for delivery of poorly water-soluble compounds. Crit Rev Ther Drug Carrier Syst 20:357.
  • Kymionis GD, Bouzoukis DI, Diakonis VF, Siganos C. (2008). Treatment of chronic dry eye: focus on cyclosporine. Clin Ophthalmol 2:829–36.
  • Lemp MA. (2007). The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocular Surface 5:75.
  • Li X, Zhang Z, Li J, et al. (2012). Diclofenac/biodegradable polymer micelles for ocular applications. Nanoscale 4:4667–73.
  • Lin H, Yiu SC. (2014). Dry eye disease: a review of diagnostic approaches and treatments. Saudi J Ophthalmol 28:173–81.
  • Mondon K, Zeisserlabouèbe M, Gurny R, Möller M. (2011). Novel cyclosporin A formulations using MPEG-hexyl-substituted polylactide micelles: a suitability study. Eur J Pharm Biopharm 77:56–65.
  • Monti D, Chetoni P, Burgalassi S, et al. (2002). Increased corneal hydration induced by potential ocular penetration enhancers: assessment by differential scanning calorimetry (DSC) and by desiccation. Int J Pharm 232:139–47.
  • Moscovici BK, Holzchuh R, Chiacchio BB, et al. (2012). Clinical treatment of dry eye using 0.03% tacrolimus eye drops. Cornea 31:945–9.
  • Moynihan H, Crean AM. 2009. The physicochemical basis of pharmaceuticals. Oxford (UK): Oxford University Press, 156–92.
  • Mundargi RC, Babu VR, Rangaswamy V, et al. (2008). Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives. J Control Release 125:193–209.
  • Navale ST, Mane AT, Ghanwat AA, et al. (2014). Camphor sulfonic acid (CSA) doped polypyrrole (PPy) films: measurement of microstructural and optoelectronic properties. Measurement 50:363–9.
  • Nikoofal S, Mohajeri SA, Banaee T, et al. (2013). Evaluation of cyclosporine A eye absorption after administration of liposomal or conventional forms in animal model. Nanomed J 1:48–54.
  • Nussenblatt RB, Palestine AG. (1986). Cyclosporine: immunology, pharmacology and therapeutic uses. Surv Ophthalmol 31:159–69.
  • Ouahab A, Cheraga N, Onoja V, et al. (2014). Novel pH-sensitive charge-reversal cell penetrating peptide conjugated PEG-PLA micelles for docetaxel delivery: in vitro study. Int J Pharm 466:233–45.
  • Panahi FH, Peighambardoust SJ, Davaran S, Salehi R. (2017). Development and characterization of PLA-mPEG copolymer containing iron nanoparticle-coated carbon nanotubes for controlled delivery of docetaxel. Polymer 117:117–31.
  • Perry JW, Wobus CE. (2010). Endocytosis of murine norovirus 1 into murine macrophages is dependent on dynamin II and cholesterol. J Virol 84:6163
  • Phan QT, Le MH, Le TT, et al. (2016). Characteristics and cytotoxicity of folate-modified curcumin-loaded PLA-PEG micellar nano systems with various PLA:PEG ratios. Int J Pharma 507:32.
  • Power WJ, Mullaney P, Farrell M, Collum LM. (1993). Effect of topical cyclosporin A on conjunctival T cells in patients with secondary Sjögren’s syndrome. Cornea 12:507–11.
  • Rodriguez-Aller M, Kaufmann B, Guillarme D, et al. (2012). In vivo characterisation of a novel water-soluble Cyclosporine A prodrug for the treatment of dry eye disease. Eur J Pharma Biopharma 80:544–52.
  • Seda Tığlı Aydın R, Pulat M. (2012). 5-Fluorouracil encapsulated chitosan nanoparticles for pH-Stimulated drug delivery: evaluation of controlled release kinetics. J Nanomater 2012:2817–27.
  • Sharma A, Khanna R, Reiter G. (1999). A thin film analog of the corneal mucus layer of the tear film: an enigmatic long range non-classical DLVO interaction in the breakup of thin polymer films. Colloids Surf B Biointerf 14:223–35.
  • Shoji J, Sakimoto T, Muromoto K, et al. (2005). Comparison of topical dexamethasone and topical FK506 treatment for the experimental allergic conjunctivitis model in Balb/c mice. Jpn J Ophthalmol 49:205–10.
  • Siepmann J, Peppas NA. (2001). Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev 48:139.
  • Smith JA, Albeitz J, Begley C, et al. (2007). The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye Workshop (2007). Ocular Surface 5:93–107.
  • Suksiriworapong J, Rungvimolsin T, Agomol A, Chantasart D. (2014). Development and characterization of lyophilized diazepam-loaded polymeric micelles. Aaps PharmScitech 15:52–64.
  • Utine CA, Stern M, Akpek EK. (2010). Clinical review: topical ophthalmic use of cyclosporin A. Ocul Immunol Inflamm 18:352–61.
  • Vandervoort J, Ludwig A. (2004). Preparation and evaluation of drug-loaded gelatin nanoparticles for topical ophthalmic use. Eur J Pharm Biopharm 57:251–61.
  • Wan KH, Chen LJ, Young AL. (2015). Efficacy and safety of topical 0.05% cyclosporine eye drops in the treatment of dry eye syndrome: a systematic review and meta-analysis. Ocul Surf 13:213–25.
  • Wang Y, Huang L, Shen Y, et al. (2017). Electrostatic interactions between polyglutamic acid and polylysine yields stable polyion complex micelles for deoxypodophyllotoxin delivery. IJN 12:7963–77.
  • Zheng X, Kan B, Gou M, et al. (2010). Preparation of MPEG-PLA nanoparticle for honokiol delivery in vitro. Int J Pharm 386:262.