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Research Article

Novel compounds protect auditory hair cells against gentamycin-induced apoptosis by maintaining the expression level of H3K4me2

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Pages 1033-1043 | Received 03 Feb 2018, Accepted 02 Apr 2018, Published online: 24 Apr 2018

References

  • Bedford MT, Clarke SG. (2009). Protein arginine methylation in mammals: who, what, and why. Mol Cell 33:1–13.
  • Berger SL. (2007). The complex language of chromatin regulation during transcription. Nature 447:407–12.
  • Borg E, Viberg A. (2002). Extra inner hair cells in the developing rabbit cochlea. Hear Res 172:10–3.
  • Chai R, Kuo B, Wang T, et al. (2012). Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. Proc Natl Acad Sci USA 109:8167–72.
  • Chai R, Xia A, Wang T, et al. (2011). Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea. J Assoc Res Otolaryngol 12:455–69.
  • Chang J, Jung HH, Yang JY, et al. (2011). Protective role of antidiabetic drug metformin against gentamicin induced apoptosis in auditory cell line. Hear Res 282:92–6.
  • Chen J, Hill K, Sha SH. (2016). Inhibitors of histone deacetylases attenuate noise-induced hearing loss. J Assoc Res Otolaryngol 17:289–302.
  • Cheng C, Guo L, Lu L, et al. (2017). Characterization of the transcriptomes of Lgr5+ hair cell progenitors and Lgr5- supporting cells in the mouse cochlea. Front Mol Neurosci 10:122.
  • Cunningham LL, Cheng AG, Rubel EW. (2002). Caspase activation in hair cells of the mouse utricle exposed to neomycin. J Neurosci 22:8532–40.
  • Doetzlhofer A, Avraham KB. (2017). Insights into inner ear-specific gene regulation: epigenetics and non-coding RNAs in inner ear development and regeneration. Semin Cell Dev Biol 65:69–79.
  • Dong Y, Liu D, Hu Y, Ma X. (2015). NaHS protects cochlear hair cells from gentamicin-induced ototoxicity by inhibiting the mitochondrial apoptosis pathway. PLoS One 10:e0136051.
  • Durante-Mangoni E, Grammatikos A, Utili R, Falagas ME. (2009). Do we still need the aminoglycosides?. Int J Antimicrob Agents 33:201–5.
  • Faucher D, Wellinger RJ. (2010). Methylated H3K4, a transcription-associated histone modification, is involved in the DNA damage response pathway. PLoS Genet 6(8):e1001082.
  • Gale JE, Marcotti W, Kennedy HJ, et al. (2001). FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel. J Neurosci 21:7013–25.
  • Glutz A, Leitmeyer K, Setz C, et al. (2015). Metformin protects auditory hair cells from gentamicin-induced toxicity in vitro. Audiol Neurotol 20:360–9.
  • Greer EL, Shi Y. (2012). Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet 13:343–57.
  • Gupta S, Kim SY, Artis S, et al. (2010). Histone methylation regulates memory formation. J Neurosci 30:3589–99.
  • He Y, Cai C, Tang D, et al. (2014a). Effect of histone deacetylase inhibitors trichostatin A and valproic acid on hair cell regeneration in zebrafish lateral line neuromasts. Front Cell Neurosci 8:382.
  • He Y, Mei H, Yu H, et al. (2014b). Role of histone deacetylase activity in the developing lateral line neuromast of zebrafish larvae. Exp Mol Med 46:e94
  • Henley CM, Rybak LP. (1995). Ototoxicity in developing mammals. Brain Res Brain Res Rev 20:68–90.
  • He Y, Tang D, Li W, et al. (2016a). Histone deacetylase 1 is required for the development of the zebrafish inner ear. Sci Rep 6:16535
  • He Y, Wang Z, Sun S, et al. (2016b). HDAC3 is required for posterior lateral line development in zebrafish. Mol Neurobiol 53:5103–17.
  • He Y, Yu H, Cai C, et al. (2015). Inhibition of H3K4me2 demethylation protects auditory hair cells from neomycin-induced apoptosis. Mol Neurobiol 52:196–205.
  • Huth ME, Ricci AJ, Cheng AG. (2011). Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection. Int J Otolaryngol 2011:937861
  • Kim T, Buratowski S. (2009). Dimethylation of H3K4 by Set1 recruits the Set3 histone deacetylase complex to 5' transcribed regions. Cell 137:259–72.
  • Layman WS, Zuo J. (2014). Epigenetic regulation in the inner ear and its potential roles in development, protection, and regeneration. Front Cell Neurosci 8:446.
  • Lei ZJ, Wang J, Xiao HL, et al. (2015). Lysine-specific demethylase 1 promotes the stemness and chemoresistance of Lgr5+ liver cancer initiating cells by suppressing negative regulators of beta-catenin signaling. Oncogene 34:3214.
  • Li A, He Y, Sun S, et al. (2015a). Lysine-specific demethylase 1 inhibitors protect cochlear spiral ganglion neurons against cisplatin-induced damage. Neuroreport 26:539–47.
  • Li Y, Li A, Wu J, et al. (2016). MiR-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a. Cell Death Dis 7:e2362.
  • Li W, Wu J, Yang J, et al. (2015b). Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. Proc Natl Acad Sci USA 112:166–71.
  • Lu X, Sun S, Qi J, et al. (2017). Bmi1 regulates the proliferation of cochlear supporting cells via the canonical Wnt signaling pathway. Mol Neurobiol 54:1326–39.
  • Mangiardi DA, Mclaughlin-Williamson K, May KE, et al. (2004). Progression of hair cell ejection and molecular markers of apoptosis in the avian cochlea following gentamicin treatment. J Comp Neurol 475:1–18.
  • Mclean WJ, Yin X, Lu L, et al. (2017). Clonal expansion of Lgr5-positive cells from mammalian cochlea and high-purity generation of sensory hair cells. Cell Rep 18:1917–29.
  • Mosammaparast N, Shi Y. (2010). Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases. Annu Rev Biochem 79:155–79.
  • Ni W, Lin C, Guo L, et al. (2016a). Extensive supporting cell proliferation and mitotic hair cell generation by in vivo genetic reprogramming in the neonatal mouse cochlea. J Neurosci 36:8734–45.
  • Ni W, Zeng S, Li W, et al. (2016b). Wnt activation followed by Notch inhibition promotes mitotic hair cell regeneration in the postnatal mouse cochlea. Oncotarget 7:66754–68.
  • Orford K, Kharchenko P, Lai W, et al. (2008). Differential H3K4 methylation identifies developmentally poised hematopoietic genes. Dev Cell 14:798–809.
  • Popova EY, Xu X, Dewan AT, et al. (2012). Stage and gene specific signatures defined by histones H3K4me2 and H3K27me3 accompany mammalian retina maturation in vivo. PLoS One 7:e46867.
  • Reik W. (2007). Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447:425–32.
  • Richardson GP, Russell IJ. (1991). Cochlear cultures as a model system for studying aminoglycoside induced ototoxicity. Hear Res 53:293–311.
  • Rizzi R, DI Pasquale E, Portararo P, et al. (2012). Post-natal cardiomyocytes can generate iPS cells with an enhanced capacity toward cardiomyogenic re-differentation. Cell Death Differ 19:1162–74.
  • Roidl D, Hacker C. (2014). Histone methylation during neural development. Cell Tissue Res 356:539–52.
  • Rugg-Gunn PJ, Cox BJ, Ralston A, Rossant J. (2010). Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo. Proc Natl Acad Sci USA 107:10783–90.
  • Santos-Rosa H, Schneider R, Bannister AJ, et al. (2002). Active genes are tri-methylated at K4 of histone H3. Nature 419:407–11.
  • Schatz A, Bugie E, Waksman SA. (2005). Streptomycin, a substance exhibiting antibiotic activity against gram-positive and gram-negative bacteria. 1944. Clin Orthop Relat Res 437:3–6.
  • Selimoglu E. (2007). Aminoglycoside-induced ototoxicity. Curr Pharm Des 13:119–26.
  • Shi Y, Lan F, Matson C, et al. (2004). Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119:941–53.
  • Strahl BD, Allis CD. (2000). The language of covalent histone modifications. Nature 403:41–5.
  • Suva ML, Riggi N, Bernstein BE. (2013). Epigenetic reprogramming in cancer. Science 339:1567–70.
  • Tang D, Lin Q, He Y, et al. (2016). Inhibition of H3K9me2 reduces hair cell regeneration after hair cell loss in the zebrafish lateral line by down-regulating the Wnt and Fgf signaling pathways. Front Mol Neurosci 9:39.
  • Taverna SD, Li H, Ruthenburg AJ, et al. (2007). How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol 14:1025–40.
  • Taylor RR, Nevill G, Forge A. (2008). Rapid hair cell loss: a mouse model for cochlear lesions. J Assoc Res Otolaryngol 9:44–64.
  • Tyagi S, Herr W. (2009). E2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferases. EMBO J 28:3185–95.
  • Walter D, Matter A, Fahrenkrog B. (2014). Loss of histone H3 methylation at lysine 4 triggers apoptosis in Saccharomyces cerevisiae. PLoS Genet 10:e1004095.
  • Wang T, Chai R, Kim GS, et al. (2015). Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatal mouse utricle. Nat Commun 6:6613.
  • Wang J, Lu F, Ren Q, et al. (2011). Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties. Cancer Res 71:7238–49.
  • Wang Y, Zhang H, Chen Y, et al. (2009). LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell 138:660–72.
  • Waqas M, Guo L, Zhang S, et al. (2016). Characterization of Lgr5+ progenitor cell transcriptomes in the apical and basal turns of the mouse cochlea. Oncotarget 7:41123–41.
  • Waqas M, Sun S, Xuan C, et al. (2017). Bone morphogenetic protein 4 promotes the survival and preserves the structure of flow-sorted Bhlhb5+ cochlear spiral ganglion neurons in vitro. Sci Rep 7:3506.
  • Weaver IC, Cervoni N, Champagne FA, et al. (2004). Epigenetic programming by maternal behavior. Nat Neurosci 7:847–54.
  • Wood A, Schneider J, Shilatifard A. (2005). Cross-talking histones: implications for the regulation of gene expression and DNA repair. Biochem Cell Biol 83:460–7.
  • Wu J, Li W, Lin C, et al. (2016). Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles. Sci Rep 6:29418.
  • Yang M, Culhane JC, Szewczuk LM, et al. (2007). Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nat Struct Mol Biol 14:535–9.
  • Yu H, Lin Q, Wang Y, et al. (2013). Inhibition of H3K9 methyltransferases G9a/GLP prevents ototoxicity and ongoing hair cell death. Cell Death Dis 4:e506
  • Zhang J, Parvin J, Huang K. (2012). Redistribution of H3K4me2 on neural tissue specific genes during mouse brain development. BMC Genomics 13:S5.