2,220
Views
26
CrossRef citations to date
0
Altmetric
Research Article

Borneol, a messenger agent, improves central nervous system drug delivery through enhancing blood–brain barrier permeability: a preclinical systematic review and meta-analysis

, , , , , ORCID Icon & show all
Pages 1617-1633 | Received 23 Apr 2018, Accepted 05 Jun 2018, Published online: 18 Oct 2018

References

  • Abbott NJ, Patabendige AA, Dolman DE, et al. (2010). Structure and function of the blood-brain barrier. Neurobiol Dis 37:13–25.
  • Abbott NJ, Rönnbäck L, Hansson E. (2006). Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 7:41–53.
  • Abbott NJ. (2013). Blood-brain barrier structure and function and the challenges for CNS drug delivery. J Inherit Metab Dis 36:437–49.
  • Armulik A, Genov G, Mäe M, et al. (2010). Pericytes regulate the blood-brain barrier. Nature 468:557–61.
  • Banks WA. (2016). From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery. Nat Rev Drug Discov 15:275–92.
  • Baoshe Z, Qi de L. (2002). The physiological and pathological opening of the blood-brain barrier by the borneol. Trad Chin Drug Res Clin Pharmacol 13:287–8.
  • Cao Y. (2013). Experimental Study on the effect of borneol for CPT-11 penetrating across BBB in rats [MD dissertation]. Zhejiang, China: Zhejiang Chinese Medical University.
  • Chai G, Pan Y, Li F. (2009). Effect of borneol/mentholum eutectic mixture on nasal-brain delivery of neurotoxin loaded nanoparticles. Zhongguo Zhong Yao Za Zhi 34:698–701.
  • Chen Q. (2005). Study on pharmacokinetics of paeonol influenced by borneol and the distribution of paeonol in mice [MD dissertation]. Zhejiang, Hangzhou: Zhejiang University.
  • Chen RL, Zhao ZG, Zhang XH, et al. (2007). Effect of Borneol on sodium valproate passing blood-brain barrier. Chin J Rehabil Theory Pract 13:151–3.
  • Demeule M, Régina A, Jodoin J, et al. (2002). Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier. Vascul Pharmacol 38:339–48.
  • Diao Y, Liu XN, Wang OY, et al. (2013). The effect of borneol on penetration of MnTBAP through blood brain barrier in rat. Prog Anat Sci 19:410–2.
  • Dong X, Ruan M, Yu B, et al. (2012). Effects of borneol at different doses on concentration of geniposide in rat brains. China Tradit Herb Drugs 43:1366–70.
  • Dong XZ, Tang XA, Gao QH, et al. (2002). Study on the Auxo-action of Borneol assisting the penetration of DDB across BBB. Chin Pharm J 37:275–7.
  • Gao C, Gao M, Shi WZ, et al. (2009). Experimental study on the effect of borneol for methotrexate penetrating across blood brain barrier. Chin J Clin Pharmacol 25:134–7.
  • Garcia E, Andrieux K, Gil S, et al. (2005). Colloidal carriers and Blood-Brain Barrier (Bbb) translocation: a way to deliver drugs to the brain. Int J Pharm 298:274–92.
  • Ge C, Han M, Bai R, et al. (2008). Effect of borneol on the ultrastructure of promoting blood brain barriar open. Chin J Integr Med Cardio-/Cerebrovasc Dis 6:1183–4.
  • Guo JQ, Zhang R, Duan MM, et al. (2015). Effects of natural borneol on methotrexate penetrating across blood-tumor barrier. Trad Chin Drug Res Clin Pharmacol 1:73–7.
  • Guo Y, Yan S, Xu L, et al. (2014). Use of angong niuhuang in treating central nervous system diseases and related research. Evid Based Complement Alternat Med 2014:346918.
  • Hersh DS, Wadajkar AS, Roberts NB, et al. (2016). Evolving drug delivery strategies to overcome the blood brain barrier. Curr Pharm Des 22:1177–93.
  • Holman L, Head ML, Lanfear R, et al. (2015). Evidence of experimental bias in the life sciences: why we need blind data recording. PLoS Biol 13:e1002190.
  • Hou TH, Li XB, Peng CS. (2016). Effects of borneol on the penetration of asiaticoside through the blood brain barrier in rats. Chin Pharm 27:3939–41.
  • Huang P, Xia HL, Jia F, et al. (2013). Effect of Benzoinum and Borneo Camphor in different proportion on the mice of cerebral ischemia, anoxia and blood-brain barrier. Pharmacol Clin Chin Mater Clin Med 29:75–8.
  • Jia YM, Ding Z, Zeng LY, et al. (2004). Borneol on facilitating permeation for cisplatin through blood brain barrier. Sichuan Med J 25:156–7.
  • Kroll RA, Neuwelt EA. (1998). Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means. Neurosurgery 42:1083–99.
  • Landis SC, Amara SG, Asadullah K, et al. (2012). A call for transparent reporting to optimize the predictive value of preclinical research. Nature 490:187–91.
  • Li H, Huang J, Shi W, et al. (2008). The pharmacokinetics of temozolomide in rabbits after intragastric administration of Borneol. Proceedings of the Eighth Chinese Conference on Pharmacoepidemiology; Beijing Tiantan Hospital Affiliated to Capital Medical University; Beijing.
  • Li WR, Chen RW, Yang L, et al. (2012). Pharmacokinetics of natural borneol after oral administration in mice brain and its effect on excitation ratio. Eur J Drug Metab Pharm 7:39–44.
  • Liang MR, Ye SM, Zhang YQ, et al. (1993). The effect of borneol on Evan’s blue staining of rabbit and rat brain tissue. Guangzhou Zhong Yi Xue Yuan Xue Bao 10:211–3.
  • Lin XM, Chen HD, Yan JW, et al. (2003). Effect of acupoint injection of camphol-fluid on the permeability of blood-brain barrier in rats. Zhen Ci Yan Jiu 28:99–101.
  • Lin ZZ, Yao MC, Lan MX, et al. (2008). Effects of borneol on distribution of sodium ferulate in plasma and brain regions of mice. Chin Tradit Herb Drugs 39:551–6.
  • Liu BL. (2015). Study of borneol on nasal absorption of ligustrazine and on nasal mucosal mucin expression level influence [MD dissertation]. Guangdong, China: Guangzhou University of Chinese Medicine;.
  • Liu J, Li X, Hu SS, et al. (2016). Studies on the effects of Baras Camphor on the tissue distribution of Salvia miltiorrhiza Bge. In complex Danshen prescription in rabbits. Anal Methods 8:3171–1615.
  • Liu N, Gao XC. (2007). The study of blood-brain barrier opening by Borneol. Acta Acad Med Weifang 29:398–400.
  • Liu Q, Liang M, Chen Z, et al. (1994). The influence of borneol on the passing of gentamycin through blood-brain barrier. J Guangzhou Univ Tradit Chin Med 11:37–40.
  • Liu YD, Sun HJ, Li R, et al. (2008). Influence of borneol on nasal absorption of Ligustrazinee. Zhongguo Zhong Yao Za Zhi 33:259–61.
  • Lu Y, Du SY, Chen XL, et al. (2011). Enhancing effect of natural borneol on the absorption of geniposide in rat via intranasal administration. J Zhejiang Univ Sci B 12:143–8.
  • Macleod MR, O’Collins T, Howells DW, et al. (2004). Pooling of animal experimental data reveals influence of study design and publication bias. Stroke 35:1203–8.
  • Pardridge WM. (2005). The blood-brain barrier: bottleneck in brain drug development. NeuroRx 2:3–14.
  • Ren ZY, 2016. Research on the impact of borneol on blood brain barrier and pglycoprotein [MD dissertation]. Shandong, China: Shandong University of Traditional Chinese Medicine.
  • Robinson MA, Baumgardner JE, Otto CM. (2011). Oxygen-dependent regulation of nitric oxide production by inducible nitric oxide synthase. Free Radic Biol Med 51:1952–65.
  • Shi WZ, Zhao ZG. (2008). Pharmacokinetics study of nimustine (ACNU) through blood brain barrier after intragastric administration of borneol. Chin J Hosp Pharm 28:1933–6.
  • State Pharmacopoeia Committee. (2010). The pharmacopoeia of people’s republic of China. Beijing: Chemical Industry Press. 56–136 p.
  • Tang DD, Zhang J, Wang JR, et al. (2016). Borneol promotes oral absorption and penetration into brain of puerarin and catalpol. Chin J Chin Mater Med 41:2720–6.
  • Tosi G, Costantino L, Ruozi B, et al. (2008). Polymeric nanoparticles for the drug delivery to the central nervous system. Expert Opin Drug Deliv 5:155–74.
  • Wang G, Zeng N, Wang J, et al. (2012). Study on the effect of borneol influence on BBB opening for promoting the cerebral absorption of quercetin. Pharmacol Clin Chin Mater Clin Med 28:65–8.
  • Wang LP, Feng JF, Hu KL, et al. (2014). Progress in regulation effect of aromatic refreshing traditional Chinese medicine on BBB permeability and its mechanism. Zhongguo Zhong Yao Za Zhi 39:949–54.
  • Wang NS, Xie D, Liang MR, et al. (1992). Effect of borneol on rabbit blood brain barrier function by CT dynamic scanning observation. Tradit Chin Drug Res Pharmacol 8:28–31.
  • Wang P, Wang C, Lou Y. (2011). Borneol and rhizome of chuanxiong on facilitating permeation for compound Shuyu Jiannao decoction through blood brain barrier. J Hubei Univ Chin Med 13:21–3.
  • Wang SX, Miao WL, Fang MF, et al. (2009). Effect of borneol on the tissue distribution of notoginseng R1, ginsenoside Rg1 and Rein rabbits. J Fourth Mil Med Univ 30:2750–2.
  • Wang W. (2006). Study on the auxo-action of borneol accelerating transportation of drug through the BBB [MD dissertation]. Zhejiang, China: Zhejiang University.
  • Wang Y, Zhang ZY, Xu F, et al. (2006). Effects of borneol on concentration of tetramethylpyrazine in blood and distribution in brain of rat. Zhongguo Yaoye 15:30–1.
  • Wei SJ. (2016). Effect of borneol and quercetin on the penetration of erlotinib across the blood-brain barrier in mice [MD dissertation]. Fujian, China: Fujian Medical University.
  • Wei Y, Liu P, He X, et al. (2010). Microdialysis and HPLC method for determination of concentration of pantoprazole in rat striatum after combined administration with borneol. Zhongguo Zhong Yao Za Zhi 35:2605–8.
  • Wu HB, Wang SN, Shi L, et al. (2009). Effects of borneol on the distribution of azidothymidine palmitate liposomes in mice. Chin Pharmacol J 44:590–3.
  • Wu JB. (2016). The role of chloride channels in the enhanced transport of adiamycin and rhodamine across the blood brain barrier induced by borneol [MD dissertation]. Guangdong, China: Jinan University.
  • Wu QD. (2011). The studies on the synthesis and pharmacokinetics of borneol derivates [PhD dissertation]. Guangdong, China: Guangzhou University of Chinese Medicine.
  • Wu SR, Cheng G, He YX, et al. (2004). Studies on the effects of borneol on the distribution of rifampicin in mice. Chin Pharmacol J 39:289–91.
  • Wu X, Ouyang L, Xiang D, et al. (2011). Enhancing effect of borneolum syntheticum and acori talarinowii rhizoma on penetrating blood-brain barrier of hydroxysafflor yellow A. China Tradit Herb Drugs 42:734–7.
  • Xiao YQ, Zhang LY, Tang HT, et al. (2007). Study on the role of borneol in improving permeability of arsenic through blood brain barrier. Chin J Neurosurg Dis Res 6:244–6.
  • Xiao YY, Ping QN. (2009). Effects of Borneol-β-cyclodextrin inclusion complex on the plasma and brain concentrations of tetramethylpyrazine phosphate in mice. J Chin Pharm Univ 40:412–5.
  • Xin HL, He XR, Li W, et al. (2014). The effect of borneol on the concentration of meropenem in rat brain and blood. J Asian Nat Prod Res 16:648–57.
  • Xu JY, Zhu LT, Yu YZ, et al. (2016). The effect of Borneol on serum and cerebrospinal fluid sodium valproate concentration in children with intractable epilepsy. Chin J Integr Trad West Med 36:1138–40.
  • Xu W, Wang ZR. (1995). Effect of menthol and borneol on the distribution of sulfadiazine sodium and Evan’s blue in the rat and mouse brain. Pharmacol Clin Chin Mater Clin Med 6:31–3.
  • Yang H, Xun Y, Li Z, et al. (2009). Influence of borneol on in vitro corneal permeability and on in vivo and in vitro corneal toxicity. J Int Med Res 37:791–802.
  • Yin Y, Cao L, Ge HF, et al. (2017). L-Borneol induces transient opening of the blood-brain barrier and enhances the therapeutic effect of cisplatin. Cell Mol Dev Neurosci 28:506–13.
  • Yu B, Lv GH, Sun Y, et al. (2011). Effect of electroacupuncture combined with intragastric administration of borneol on the permeability of blood-brain barrier in the mouse. Zhen Ci Yan Jiu 36:335–40.
  • Yu B, Ruan M, Dong X, et al. (2012). The influence of borneol treatment interval on the concentration of geniposide in rat brains. Chin Pharmacol Bull 28:862–6.
  • Yu B, Ruan M, Dong X, et al. (2013). The mechanism of the opening of the blood-brain barrier by borneol: a pharmacodynamics and pharmacokinetics combination study. J Ethnopharmacol 150:1096–1108.
  • Yu H, Zhou GL, Mao BB. (2015). Effect of borneol on the function of P-glycoprotein in blood brain barrier. J Anhui Sci Technol Univ 29:34–8.
  • Zhang HY, Wu WK, Lu Q, et al. (2012). Effect of borneol on promoting absorption of oral drugs. Chin J Exp Trad Med Formulae 18:294–7.
  • Zhang JQ, Wei YH, Duan HG, et al. (2011). Effects of borneol on the pharmacokinetics and brain tissue distribution of carbamazepine. Chin J Hosp Pharm 31:747–50.
  • Zhang L. 2011. Aprotinin-conjugated nanoparticles drug delivery system unite with promete penentration-action of borneol for brain targeting [PhD dissertation]. Shanghai, China: Fudan University.
  • Zhang N, Liu P, He XR. (2012). Effect of borneol, moschus, storax, and acorus tatarinowii on expression levels of four amino acid neurotransmitters in the rat corpus striatum. Neural Regen Res 7:440–4.
  • Zhang Q, Wu D, Wu J, et al. (2015). Improved blood-brain barrier distribution: effect of borneol on the brain pharmacokinetics of kaempferol in rats by in vivo microdialysis sampling. J Ethnopharmacol 162:270–7.
  • Zhang Q. (2014). The enhancing effect of borneol on the blood-brain barrier penetration of neuroprotective kaempferol based on blood and cerebral microdialysis [MD dissertation]. Anhui, China: Anhui Medical University.
  • Zhang QL, Fu BM, Zhang ZJ. (2017). Borneol, a novel agent that improves central nervous system drug delivery by enhancing blood-brain barrier permeability. Drug Deliv 24:1037–44.
  • Zhang RT, Wang H, Chen L, et al. (2005). Study on the effect of borneol nasal drops on the vasopermeability of nasal mucosa and cerebral vessel of guinea pigs. J Chin Pharm 16:1291–3.
  • Zhang XH, Liu FQ, Zhao ZG. (2007). The opening effect on the blood-cerebrospinal fluid barrier induced by borneol (Bn, Bingpian) and its improvement of antibiotic treatment in rabbits with experimental bacterial meningitis. Chin J Neuroimmunol Neurol 14:93–6.
  • Zhao TJ, Zhang PL, Zhou Y, et al. (2015). Influences of borneol and muscone on blood-brain barrier permeability of nerve growth factor. Chin J New Clin Med 8:728–31.
  • Zheng XH, Zhao X, Fang M, et al. (2007). Pharmacokinetic effects of shi herb-borneol on jun herb-Salvia miltiorrhiza. J Xi’an Jiaotong Univ Med Sci 28:170–3.
  • Zhou HY, Chen XY, Huang CK, et al. (2008). Effect of borneol on the distribution of carbamazepine in mice. Wenzhou Yi Xue Yuan Xue Bao 38:300–5.
  • Zhou HY, Wang P, Lin D, et al. (2005). Studies on the effects of borneol on the pharmacokinetics of carbamazepine in rabbits. Chin Pharmacol Bull 21:1263–6.
  • Zhu GD. (2009). Study on the auxo-action of borneol accelerating the penetration of BBB and P-glycoprotein-mediated mechanism [MD dissertation]. Guangdong, China: Guangzhou Medical University.
  • Zlokovic BV. (2008). The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 57:178–201.