The involvement of perivascular spaces or tissues in the facial intradermal brain-targeted delivery

References

• Adeeb N, Mortazavi MM, Deep A, et al. (2013). The pia mater: a comprehensive review of literature. Childs Nerv Syst 29:1803–10.
   PubMed Web of Science ®Google Scholar
• Aspelund A, Antila S, Proulx ST, et al. (2015). A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med 212:991–9.
   PubMed Web of Science ®Google Scholar
• Dhuria SV, Hanson LR, Frey WH. 2nd (2010). Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J Pharm Sci 99:1654–73.
   PubMed Web of Science ®Google Scholar
• Dobson H, Sharp MM, Cumpsty R, et al. (2017). The perivascular pathways for influx of cerebrospinal fluid are most efficient in the midbrain. Clin Sci 131:2745–52.
   PubMed Web of Science ®Google Scholar
• Durant PA, Yaksh TL. (1986). Distribution in cerebrospinal fluid, blood, and lymph of epidurally injected morphine and inulin in dogs. Anesth Analg 65:583–92.
   PubMed Web of Science ®Google Scholar
• Furukawa M, Shimoda H, Kajiwara T, et al. (2008). Topographic study on nerve-associated lymphatic vessels in the murine craniofacial region by immunohistochemistry and electron microscopy. Biomed Res 29:289–96. [In eng].
   PubMed Web of Science ®Google Scholar
• Gallina P, Scollato A, Conti R, et al. (2015). Abeta clearance, "hub" of multiple deficiencies leading to Alzheimer disease. Front Aging Neurosci 7:200.
   PubMed Web of Science ®Google Scholar
• Griffin WS. (2008). Perispinal etanercept: potential as an Alzheimer therapeutic. J Neuroinflamm 5:3.
   PubMed Web of Science ®Google Scholar
• Hanson LR, Frey WH. 2nd (2007). Strategies for intranasal delivery of therapeutics for the prevention and treatment of neuroAIDS. J Neuroimmune Pharmacol 2:81–6. [In eng].
   PubMed Web of Science ®Google Scholar
• Harvey AJ, Kaestner SA, Sutter DE, et al. (2011). Microneedle-based intradermal delivery enables rapid lymphatic uptake and distribution of protein drugs. Pharm Res 28:107–16.
   PubMed Web of Science ®Google Scholar
• He G, Lu T, Lu B, et al. (2012). Perivascular and perineural extension of formed and soluble blood elements in an intracerebral hemorrhage rat model. Brain Res 1451:10–8.
   PubMed Web of Science ®Google Scholar
• Heinle H, Lindner V. (1984). The binding of Evans blue to collagen and elastin in elastic tissue. Arch Int Physiol Biochim 92:13–7.
   PubMed Web of Science ®Google Scholar
• Iliff JJ, Nedergaard M. (2013). Is there a cerebral lymphatic system? Stroke 44:S93–S5. [In eng].
   PubMed Web of Science ®Google Scholar
• Jain S, Tiwary AK, Jain NK. (2008). PEGylated elastic liposomal formulation for lymphatic targeting of zidovudine. Curr Drug Deliv 5:275–81.
   PubMedGoogle Scholar
• Johnston M, Armstrong D, Koh L. (2007). Possible role of the cavernous sinus veins in cerebrospinal fluid absorption. Cerebrospinal Fluid Res 4:3.
   PubMedGoogle Scholar
• Kim H, Moore SA, Johnston MG. (2014). Potential for intranasal drug delivery to alter cerebrospinal fluid outflow via the nasal turbinate lymphatics. Fluids Barriers CNS 11:4. [In eng].
   PubMedGoogle Scholar
• Lochhead JJ, Wolak DJ, Pizzo ME, et al. (2015). Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration. J Cereb Blood Flow Metab 35:371–81.
   PubMed Web of Science ®Google Scholar
• Maloveska M, Danko J, Petrovova E, et al. (2018). Dynamics of Evans blue clearance from cerebrospinal fluid into meningeal lymphatic vessels and deep cervical lymph nodes. Neurol Res 40:372–80.
   PubMed Web of Science ®Google Scholar
• Marchi N, Teng Q, Nguyen MT, et al. (2010). Multimodal investigations of trans-endothelial cell trafficking under condition of disrupted blood-brain barrier integrity. BMC Neurosci 11:34.
   PubMed Web of Science ®Google Scholar
• Mestre H, Kostrikov S, Mehta RI, et al. (2017). Perivascular spaces, glymphatic dysfunction, and small vessel disease. Clin Sci 131:2257–74.
   PubMed Web of Science ®Google Scholar
• Miyake MM, Bleier BS. (2015). The blood-brain barrier and nasal drug delivery to the central nervous system. Am J Rhinol Allergy 29:124–7.
   PubMed Web of Science ®Google Scholar
• Mohan S, Verma A, Sitoh YY, et al. (2009). Virchow-robin spaces in health and disease. Neuroradiol J 22:518–24.
   PubMedGoogle Scholar
• Morris AW, Sharp MM, Albargothy NJ, et al. (2016). Vascular basement membranes as pathways for the passage of fluid into and out of the brain. Acta Neuropathol 131:725–36.
   PubMed Web of Science ®Google Scholar
• Papisov MI, Belov VV, Gannon KS. (2013). Physiology of the intrathecal bolus: the leptomeningeal route for macromolecule and particle delivery to CNS. Mol Pharmaceutics 10:1522–32.
   PubMed Web of Science ®Google Scholar
• Pathan SA, Iqbal Z, Zaidi SM, et al. (2009). CNS drug delivery systems: novel approaches. Recent Pat Drug Deliv Formul 3:71–89.
   PubMedGoogle Scholar
• Paul G, Zachrisson O, Varrone A, et al. (2015). Safety and tolerability of intracerebroventricular PDGF-BB in Parkinson's disease patients. J Clin Invest 125:1339–46.
   PubMed Web of Science ®Google Scholar
• Plog BA, Nedergaard M. (2018). The glymphatic system in central nervous system health and disease: past, present, and future. Annu Rev Pathol 13:379–94.
   PubMed Web of Science ®Google Scholar
• Rangroo Thrane V, Thrane AS, Plog BA, et al. (2013). Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain. Sci Rep 3:2582. [In eng].
   PubMed Web of Science ®Google Scholar
• Reiter RJ, Tan DX, Kim SJ, et al. (2014). Delivery of pineal melatonin to the brain and SCN: role of canaliculi, cerebrospinal fluid, tanycytes and Virchow-Robin perivascular spaces. Brain Struct Funct 219:1873–87.
   PubMed Web of Science ®Google Scholar
• Rennels ML, Gregory TF, Blaumanis OR, et al. (1985). Evidence for a 'paravascular' fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space. Brain Res 326:47–63. [In eng].
   PubMed Web of Science ®Google Scholar
• Shi JQ, Wang BR, Jiang WW, et al. (2011). Cognitive improvement with intrathecal administration of infliximab in a woman with Alzheimer's disease. J Am Geriatr Soc 59:1142–4.
   PubMed Web of Science ®Google Scholar
• Smoliar E, Smoliar A, Sorkin L, et al. (1998). Microcirculatory bed of the human trigeminal nerve. Anat Rec 250:245–9. [In eng].
   PubMedGoogle Scholar
• Thorne RG, Frey WH. 2nd, (2001). Delivery of neurotrophic factors to the central nervous system. Pharmacokinetic considerations. Clin Pharmacokinet 40:907–46. [In eng].
   PubMed Web of Science ®Google Scholar
• Thorne RG, Pronk GJ, Padmanabhan V, et al. (2004). Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 127:481–96. [In eng].
   PubMed Web of Science ®Google Scholar
• Weiser T, Herrmann A, Wienrich M. (1996). Interactions of the dye Evans Blue and GYKI 52466, a 2,3-benzodiazepine, with (S)- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in cultured rat cortical neurons: electrophysiological evidence for at least two different binding sites for non-competitive antagonists. Neurosci Lett 216:29–32. [In eng].
   PubMed Web of Science ®Google Scholar
• Wong KH, Riaz MK, Xie Y, et al. (2019). Review of current strategies for delivering Alzheimer's disease drugs across the blood-brain barrier. Int J Mol Sci 20:E381.
   Web of Science ®Google Scholar
• Yang L, Kress BT, Weber HJ, et al. (2013). Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer. J Transl Med 11:107.
   PubMed Web of Science ®Google Scholar
• Yin J, Lu TM, Qiu G, et al. (2013). Intracerebral hematoma extends via perivascular spaces and perineurium. Tohoku J Exp Med 230:133–9.
   PubMed Web of Science ®Google Scholar
• Yu XC, Yang JJ, Jin BH, et al. (2017). A strategy for bypassing the blood-brain barrier: facial intradermal brain-targeted delivery via the trigeminal nerve. J Control Release 258:22–33.
   PubMed Web of Science ®Google Scholar
• Zakharov A, Papaiconomou C, Djenic J, et al. (2003). Lymphatic cerebrospinal fluid absorption pathways in neonatal sheep revealed by subarachnoid injection of Microfil. Neuropathol Appl Neurobiol 29:563–73. [In eng].
   PubMed Web of Science ®Google Scholar
• Zeiadeh I, Najjar A, Karaman R. (2018). Strategies for enhancing the permeation of CNS-active drugs through the blood-brain barrier: a review. Molecules 23:1289.
   Web of Science ®Google Scholar
• Zhang ET, Inman CB, Weller RO. (1990). Interrelationships of the pia mater and the perivascular (Virchow-Robin) spaces in the human cerebrum. J Anat 170:111–23.
   PubMed Web of Science ®Google Scholar