Targeting murine alveolar macrophages by the intratracheal administration of locked nucleic acid containing antisense oligonucleotides

References

• Atri C, Guerfali FZ, Laouini D. (2018). Role of human macrophage polarization in inflammation during infectious diseases. IJMS 19:1801.
   Web of Science ®Google Scholar
• Bennett CF. (2019). Therapeutic antisense oligonucleotides are coming of age. Annu Rev Med 70:307–21.
   PubMed Web of Science ®Google Scholar
• Chan J, Cheng-Lai A. (2017). Inhaled insulin: a clinical and historical review. Cardiol Rev 25:140–6.
   PubMed Web of Science ®Google Scholar
• Crooke ST, Wang S, Vickers TA, et al. (2017). Cellular uptake and trafficking of antisense oligonucleotides. Nat Biotechnol. 35:230–7.
   PubMed Web of Science ®Google Scholar
• Delgado E, Okabe H, Preziosi M, et al. (2015). Complete response of Ctnnb1-mutated tumours to β-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model. J Hepatol 62:380–7.
   PubMed Web of Science ®Google Scholar
• Donner AJ, Yeh ST, Hung G, et al. (2015). CD40 generation 2.5 antisense oligonucleotide treatment attenuates doxorubicin-induced nephropathy and kidney inflammation. Mol Ther Nucleic Acids 4:e265.
   PubMedGoogle Scholar
• Frazier KS. (2015). Antisense oligonucleotide therapies: the promise and the challenges from a toxicologic pathologist's perspective. Toxicol Pathol 43:78–89.
   PubMed Web of Science ®Google Scholar
• Gupta N, Fisker N, Asselin MC, et al. (2010). A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo. PLoS One 17:e10682.
   Web of Science ®Google Scholar
• Hagedorn PH, Persson R, Funder ED, et al. (2018). Locked nucleic acid: modality, diversity, and drug discovery. Drug Discov Today 23:101–14.
   PubMed Web of Science ®Google Scholar
• Hussell T, Bell TJ. (2014). Alveolar macrophages: plasticity in a tissue-specific context. Nat Rev Immunol 14:81–93.
   PubMed Web of Science ®Google Scholar
• Kauppinen S, Vester B, Wengel J. (2005). Locked nucleic acid (LNA): high affinity targeting of RNA for diagnostics and therapeutics. Drug Discov Today Technol 2:287–90.
   PubMedGoogle Scholar
• Kim ES, Plosker GL. (2015). AFREZZA® (insulin human) inhalation powder: a review in diabetes mellitus. Drugs 75:1679–86.
   PubMed Web of Science ®Google Scholar
• Kopf M, Schneider C, Nobs SP. (2015). The development and function of lung-resident macrophages and dendritic cells. Nat Immunol 16:36–44.
   PubMed Web of Science ®Google Scholar
• Kurotaki D, Osato N, Nishiyama A, et al. (2013). Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation. Blood 121:1839–49.
   PubMed Web of Science ®Google Scholar
• Lafferty EI, Qureshi ST, Schnare M. (2010). The role of toll-like receptors in acute and chronic lung inflammation. J Inflamm 7:57.
   Google Scholar
• Morales-Nebreda L, Misharin AV, Perlman H, et al. (2015). The heterogeneity of lung macrophages in the susceptibility to disease. Eur Respir Rev 24:505–9.
   PubMed Web of Science ®Google Scholar
• Morihara H, Yamamoto T, Oiwa H, et al. (2017). Phospholamban inhibition by a single dose of locked nucleic acid antisense oligonucleotide improves cardiac contractility in pressure overload-induced systolic dysfunction in mice. J Cardiovasc Pharmacol Ther 22:273–82.
   PubMed Web of Science ®Google Scholar
• Murray S, Ittig D, Koller E, et al. (2012). TricycloDNA-modified oligo-2′-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues – a comparative study of oligonucleotide length, design and chemistry. Nucleic Acids Res 40:6135–43.
   PubMed Web of Science ®Google Scholar
• Opitz B, van Laak V, Eitel J, et al. (2010). Innate immune recognition in infectious and noninfectious diseases of the lung. Am J Respir Crit Care Med 181:1294–309.
   PubMed Web of Science ®Google Scholar
• Park MK, Ngo V, Kwon YM, et al. (2013). Lactobacillus plantarum DK119 as a probiotic confers protection against influenza virus by modulating innate immunity. PLoS One 8:e75368.
   PubMed Web of Science ®Google Scholar
• Patton JS, Fishburn CS, Weers JG. (2004). The lungs as a portal of entry for systemic drug delivery. Proc Am Thorac Soc 1:338–44.
   PubMedGoogle Scholar
• Prakash TP, Graham MJ, Yu J, et al. (2014). Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice. Nucleic Acids Res 42:8796–807.
   PubMed Web of Science ®Google Scholar
• Shen X, Corey DR. (2018). Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs. Nucleic Acids Res 46:1584–600.
   PubMed Web of Science ®Google Scholar
• Smola M, Vandamme T, Sokolowski A. (2008). Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases. Int J Nanomedicine 3:1–19.
   PubMed Web of Science ®Google Scholar
• Straarup EM, Fisker N, Hedtjärn M, et al. (2010). Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates. Nucleic Acids Res 38:7100–11.
   PubMed Web of Science ®Google Scholar
• Sugo T, Terada M, Oikawa T, et al. (2016). Development of antibody-siRNA conjugate targeted to cardiac and skeletal muscles. J Control Release 237:1–13.
   PubMed Web of Science ®Google Scholar
• Swayze EE, Siwkowski AM, Wancewicz EV, et al. (2007). Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals. Nucleic Acids Res 35:687–700.
   PubMed Web of Science ®Google Scholar
• Uemura Y, Hagiwara K, Kobayashi K. (2017). The intratracheal administration of locked nucleic acid containing antisense oligonucleotides induced gene silencing and an immune-stimulatory effect in the murine lung. PLoS One 12:e0187286.
   PubMed Web of Science ®Google Scholar
• Uemura Y, Naoi T, Kanai Y, et al. (2019). The efficiency of lipid nanoparticles with an original cationic lipid as a siRNA delivery system for macrophages and dendritic cells. Pharm Dev Technol 24:263–8.
   PubMed Web of Science ®Google Scholar
• Veedu RN, Wengel J. (2010). Locked nucleic acids: promising nucleic acid analogs for therapeutic applications. C&B 7:536–42.
   Web of Science ®Google Scholar
• Weiss G, Schaible UE. (2015). Macrophage defense mechanisms against intracellular bacteria. Immunol Rev 264:182–203.
   PubMed Web of Science ®Google Scholar