Active pulmonary targeting against tuberculosis (TB) via triple-encapsulation of Q203, bedaquiline and superparamagnetic iron oxides (SPIOs) in nanoparticle aggregates

References

• Ali ME, McConville JT, Lamprecht A. (2015). Pulmonary delivery of anti-inflammatory agents. Expert Opin Drug Deliv 12:929–45.
   PubMed Web of Science ®Google Scholar
• Arruebo M, Fernández-Pacheco R, Ibarra MR, Santamaría J. (2007). Magnetic nanoparticles for drug delivery. Nano Today 2:22–32.
   Web of Science ®Google Scholar
• Chimote G, Banerjee R. (2010). In vitro evaluation of inhalable isoniazid‐loaded surfactant liposomes as an adjunct therapy in pulmonary tuberculosis. J Biomed Mater Res 94:1–10.
   Web of Science ®Google Scholar
• Chuan J, Li Y, Yang L, et al. (2013). Enhanced rifampicin delivery to alveolar macrophages by solid lipid nanoparticles. J Nanopart Res 15:1634.
   Web of Science ®Google Scholar
• d'Angelo I, Conte C, Miro A, et al. (2015). Pulmonary drug delivery: a role for polymeric nanoparticles?. Curr Topics Med Chem 15:386–400.
   PubMed Web of Science ®Google Scholar
• Gandhimathi C, Venugopal JR, Sundarrajan S, et al. (2015). Breathable medicine: pulmonary mode of drug delivery. J Nanosci Nanotechnol 15:2591–604.
   PubMed Web of Science ®Google Scholar
• Grenha A, Seijo B, Remunán-López C. (2005). Microencapsulated chitosan nanoparticles for lung protein delivery. Eur J Pharm Sci 25:427–37.
   PubMed Web of Science ®Google Scholar
• Heyder J. (2004). Deposition of inhaled particles in the human respiratory tract and consequences for regional targeting in respiratory drug delivery. Proc Am Thorac Soc 1:315–20.
   PubMedGoogle Scholar
• Hirota K, Hasegawa T, Hinata H, et al. (2007). Optimum conditions for efficient phagocytosis of rifampicin-loaded PLGA microspheres by alveolar macrophages. J Control Release 119:69–76.
   PubMed Web of Science ®Google Scholar
• Hirota K, Hasegawa T, Nakajima T, et al. (2010). Delivery of rifampicin–PLGA microspheres into alveolar macrophages is promising for treatment of tuberculosis. J Control Release 142:339–46.
   PubMed Web of Science ®Google Scholar
• Hofemeier P, Koshiyama K, Wada S, Sznitman J. (2018). One (sub-) acinus for all: fate of inhaled aerosols in heterogeneous pulmonary acinar structures. Eur J Pharm Sci 113:53–63.
   PubMed Web of Science ®Google Scholar
• Janer G, Del Molino EM, Fernández-Rosas E, et al. (2014). Cell uptake and oral absorption of titanium dioxide nanoparticles. Toxicol Lett 228:103–10.
   PubMed Web of Science ®Google Scholar
• Kalia NP, Hasenoehrl EJ, Ab Rahman NB, et al. (2017). Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection. Proc Natl Acad Sci USA 114:7426–31.
   PubMed Web of Science ®Google Scholar
• Labiris NR, Dolovich MB. (2003). Pulmonary drug delivery. Part II: the role of inhalant delivery devices and drug formulations in therapeutic effectiveness of aerosolized medications. Br J Clin Pharmacol 56:600–12.
   PubMed Web of Science ®Google Scholar
• Ling Y, Wei K, Zou F, Zhong S. (2012). Temozolomide loaded PLGA-based superparamagnetic nanoparticles for magnetic resonance imaging and treatment of malignant glioma. Int J Pharm 430:266–75.
   PubMed Web of Science ®Google Scholar
• Makino K, Nakajima T, Shikamura M, et al. (2004). Efficient intracellular delivery of rifampicin to alveolar macrophages using rifampicin-loaded PLGA microspheres: effects of molecular weight and composition of PLGA on release of rifampicin. Colloids Surf B Biointerfaces 36:35–42.
   PubMed Web of Science ®Google Scholar
• Mehanna MM, Mohyeldin SM, Elgindy NA. (2014). Respirable nanocarriers as a promising strategy for antitubercular drug delivery. J Control Release 187:183–97.
   PubMed Web of Science ®Google Scholar
• O'callaghan C, Barry PW. (1997). The science of nebulised drug delivery. Thorax 52:S31.
   PubMed Web of Science ®Google Scholar
• Ohashi K, Kabasawa T, Ozeki T, Okada H. (2009). One-step preparation of rifampicin/poly (lactic-co-glycolic acid) nanoparticle-containing mannitol microspheres using a four-fluid nozzle spray drier for inhalation therapy of tuberculosis. J Control Release 135:19–24.
   PubMed Web of Science ®Google Scholar
• Ostrovski Y, Dorfman S, Mezhericher M, et al. (2019). Targeted drug delivery to upper airways using a pulsed aerosol bolus and inhaled volume tracking method. Flow Turbul Combust 102:73–87.
   PubMed Web of Science ®Google Scholar
• Ostrovski Y, Hofemeier P, Sznitman J. (2016). Augmenting regional and targeted delivery in the pulmonary acinus using magnetic particles. Int J Nanomed 11:3385.
   PubMed Web of Science ®Google Scholar
• Pethe K, Bifani P, Jang J, et al. (2013). Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat Med 19:1157–60.
   PubMed Web of Science ®Google Scholar
• Pham D-D, Fattal E, Tsapis N. (2015). Pulmonary drug delivery systems for tuberculosis treatment. Int J Pharm 478:517–29.
   PubMed Web of Science ®Google Scholar
• Pitance L, Vecellio L, Leal T, et al. (2010). Delivery efficacy of a vibrating mesh nebulizer and a jet nebulizer under different configurations. J Aerosol Med Pulmon Drug Deliv 23:389–96.
   PubMed Web of Science ®Google Scholar
• Rashid J, Absar S, Nahar K, et al. (2015). Newer devices and improved formulations of inhaled insulin. Expert Opin Drug Deliv 12:917–28.
   PubMed Web of Science ®Google Scholar
• Schleich N, Sibret P, Danhier P, et al. (2013). Dual anticancer drug/superparamagnetic iron oxide-loaded PLGA-based nanoparticles for cancer therapy and magnetic resonance imaging. Int J Pharm 447:94–101.
   PubMed Web of Science ®Google Scholar
• Suarez S, O'hara P, Kazantseva M, et al. (2001). Respirable PLGA microspheres containing rifampicin for the treatment of tuberculosis: screening in an infectious disease model. Pharm Res 18:1315–9.
   PubMed Web of Science ®Google Scholar
• Sznitman J. (2013). Respiratory microflows in the pulmonary acinus. J Biomech 46:284–98.
   PubMed Web of Science ®Google Scholar
• Tripathi A, Gupta R, Saraf SA. (2010). PLGA nanoparticles of anti tubercular drug: drug loading and release studies of a water in-soluble drug. Int J Pharm Tech Res 2:2116–23.
   Google Scholar
• Ungaro F, d'Angelo I, Coletta C, et al. (2012). Dry powders based on PLGA nanoparticles for pulmonary delivery of antibiotics: modulation of encapsulation efficiency, release rate and lung deposition pattern by hydrophilic polymers. J Control Release 157:149–59.
   PubMed Web of Science ®Google Scholar
• W. H. Organization. (2018). Global tuberculosis report 2018. World Health Organization.
   Google Scholar
• Xie Y, Longest P, Xu YH, et al. (2010). In vitro and in vivo lung deposition of coated magnetic aerosol particles. J Pharm Sci 99:4658–68.
   PubMed Web of Science ®Google Scholar