Uniform-sized insulin-loaded PLGA microspheres for improved early-stage peri-implant bone regeneration

References

• Abtahi J, Agholme F, Sandberg O, Aspenberg P. (2013). Effect of local vs systemic bisphosphonate delivery on dental implant fixation in a model of osteonecrosis of the Jaw. J Dent Res 92:279–83.
   PubMed Web of Science ®Google Scholar
• Anderson J, Patterson J, Vines J, et al. (2011). Biphasic peptide amphiphile nanomatrix embedded with hydroxyapatite nanoparticles for stimulated osteoinductive response. ACS Nano 5:9463–79.
   PubMed Web of Science ®Google Scholar
• Andreas K, Zehbe R, Kazubek M, et al. (2011). Biodegradable insulin-loaded PLGA microspheres fabricated by three different emulsification techniques: investigation for cartilage tissue engineering. Acta Biomater 7:1485–95.
   PubMed Web of Science ®Google Scholar
• Brånemark P, Adell R, Albrektsson T, et al. (1983). Osseointegrated titanium fixtures in the treatment of edentulousness. Biomaterials 4:25–8.
   PubMed Web of Science ®Google Scholar
• Coelho P, Jimbo R, Tovar N, Bonfante E. (2015). Osseointegration: hierarchical designing encompassing the macrometer, micrometer, and nanometer length scales. Dent Mater 31:37–52.
   PubMed Web of Science ®Google Scholar
• Contaldo C, Myers T, Zucchini C, et al. (2014). Expression levels of insulin receptor substrate-1 modulate the osteoblastic differentiation of mesenchymal stem cells and osteosarcoma cells. Growth Factors 32:41–52.
   PubMed Web of Science ®Google Scholar
• Deschaseaux F, Sensébé L, Heymann D. (2009). Mechanisms of bone repair and regeneration. Trends Mol Med 15:417–29.
   PubMed Web of Science ®Google Scholar
• Fournier SB, D’Errico JN, Stapleton PA. (2018). Engineered nanomaterial applications in perinatal therapeutics. Pharmacol Res 130:36–43.
   PubMed Web of Science ®Google Scholar
• Gerstenfeld L, Sacks D, Pelis M, et al. (2009). Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing. J Bone Miner Res 24:196–208.
   PubMed Web of Science ®Google Scholar
• Goodman W, Hori M. (1984). Diminished bone formation in experimental diabetes. Relationship to osteoid maturation and mineralization. Diabetes 33:825–31.
   PubMed Web of Science ®Google Scholar
• Goriainov V, Cook R, Latham J, et al. (2014). Bone and metal: an orthopaedic perspective on osseointegration of metals. Acta Biomater 10:4043–57.
   PubMed Web of Science ®Google Scholar
• Gundersen H, Bendtsen T, Korbo L, et al. (1988). Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. Apmis 96:379–94.
   PubMed Web of Science ®Google Scholar
• Haggag Y, Faheem A, Tambuwala M, et al. (2018). Effect of poly(ethylene glycol) content and formulation parameters on particulate properties and intraperitoneal delivery of insulin from PLGA nanoparticles prepared using the double-emulsion evaporation procedure. Pharm Dev Technol 23:370–81.
   PubMed Web of Science ®Google Scholar
• Han Y, Zeng Q, E L, et al. (2012). Sustained topical delivery of insulin from fibrin gel loaded with poly(lactic-co-glycolic Acid) microspheres improves the biomechanical retention of titanium implants in type 1 diabetic rats. J Oral Maxillofac Surg 70:2299–308.
   PubMed Web of Science ®Google Scholar
• Hu C, Feng H, Zhu C. (2012). Preparation and characterization of rifampicin-PLGA microspheres/sodium alginate in situ gel combination delivery system. Colloids Surface B 95:162–9.
   PubMed Web of Science ®Google Scholar
• Kang F, Singh J. (2005). Preparation, in vitro release, in vivo absorption and biocompatibility studies of insulin-loaded microspheres in rabbits. AapsPharmscitech 6:E487–494.
   PubMed Web of Science ®Google Scholar
• Kayal R, Alblowi J, Mckenzie E, et al. (2009). Diabetes causes the accelerated loss of cartilage during fracture repair which is reversed by insulin treatment. Bone 44:357–63.
   PubMed Web of Science ®Google Scholar
• Kazazi-Hyseni F, Landin M, Lathuile A, et al. (2014). Computer modeling assisted design of monodisperse PLGA microspheres with controlled porosity affords zero order release of an encapsulated macromolecule for 3 months. Pharm Res 31:2844–56.
   PubMed Web of Science ®Google Scholar
• Lai P, Daear W, Lobenberg R, Prenner E. (2014). Overview of the preparation of organic polymeric nanoparticles for drug delivery based on gelatine, chitosan, poly(D,L-lactide-co-glycolic acid) and polyalkylcyanoacrylate. Colloid Surface B 118:154–63.
   PubMed Web of Science ®Google Scholar
• Lauzon M, Bergeron É, Marcos B, Faucheux N. (2012). Bone repair: new developments in growth factor delivery systems and their mathematical modeling. J Control Release 162:502–20.
   PubMed Web of Science ®Google Scholar
• Lock J, Nguyen T, Liu H. (2012). Hydroxyapatite and poly (lactide-co-glycolide) composites promote human mesenchymal stem cell adhesion and osteogenic differentiation in vitro. J Mater Sci Mater Med 23:2543–452.
   PubMed Web of Science ®Google Scholar
• Malekzadeh B, Tengvall P, Ohrnell L, et al. (2013). Effects of locally administered insulin on bone formation in non-diabetic rats. J Biomed Mater Res 101:132–7.
   Web of Science ®Google Scholar
• Masuzaki T, Ayukawa Y, Moriyama Y, et al. (2010). The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia. Biomaterials 31:3327–34.
   PubMed Web of Science ®Google Scholar
• Pramojanee S, Phimphilai M, Chattipakorn N, Chattipakorn S. (2014). Possible roles of insulin signaling in osteoblasts. Endocr Res 39:144–51.
   PubMed Web of Science ®Google Scholar
• Qi F, Wu J, Fan Q, et al. (2013). Preparation of uniform-sized exenatide-loaded PLGA microspheres as long-effective release system with high encapsulation efficiency and bio-stability. Collid Surface B 112:492–8.
   PubMed Web of Science ®Google Scholar
• Qi F, Wu J, Yang T, et al. (2014). Mechanistic studies for monodisperse exenatide-loaded PLGA microspheres prepared by different methods based on SPG membrane emulsification. Acta Biomater 10:4247–56.
   PubMed Web of Science ®Google Scholar
• Qian S, Qiao Y, Liu X. (2014). Selective biofunctional modification of titanium implants for osteogenic and antibacterial applications. J Mater Chem 2:7475–87.
   Web of Science ®Google Scholar
• Smeets R, Stadlinger B, Schwarz F, et al. (2016). Impact of dental implant surface modifications on osseointegration. BioMed Res Int 2:6285620.
   Google Scholar
• Tang W, Lin D, Yu Y, et al. (2016). Bioinspired trimodal macro/micro/nano-porous scaffolds loading rhBMP-2 for complete regeneration of critical size bone defect. Acta Biomater 32:309–23.
   PubMed Web of Science ®Google Scholar
• Thomas D, Udagawa N, Hards D, et al. (1998). Insulin receptor expression in primary and cultured osteoclast-like cells. Bone 23:181–6.
   PubMed Web of Science ®Google Scholar
• Thrailkill K, Liu L, Wah E, et al. (2005). Bone formation is impaired in a model of type 1 diabetes. Diabetes 54:2875–81.
   PubMed Web of Science ®Google Scholar
• Uribe R, Peñarrocha M, Balaguer J, Fulgueiras N. (2005). Immediate loading in oral implants. present situation. Med Oral Patol Oral 10:E143–E153.
   PubMedGoogle Scholar
• Wang B, Song Y, Wang F, et al. (2011). Effects of local infiltration of insulin around titanium implants in diabetic rats. Br J Oral Maxillofac Surg 49:225–9.
   PubMed Web of Science ®Google Scholar
• Wang L, Xu X, Huo N, et al. (2013). A combination of insulin and ubiquitin A20 promotes osteocalcin expression in adipose-derived stem cells. Biochem Cell Biol 91:513–8.
   PubMedGoogle Scholar
• Wang X, Wu X, Xing H, et al. (2017). Porous nano-hydroxyapatite/collagen scaffolds loading insulin PLGA particles for restoration of critical size bone defect. ACS Appl Mater Interfaces 13:11380–91.
   Google Scholar
• Wang X, Zhang G, Qi F, et al. (2017). Enhanced bone regeneration using an insulin-loaded nano-hydroxyapatite/collagen/plga composite scaffold. IJN 13:117–27.
   Google Scholar
• Wang X, Zou X, Zhao J, et al. (2016). Site-specific characteristics of bone marrow mesenchymal stromal cells modify the effect of aging on the skeleton. Rejuv Res 5:351–61.
   Google Scholar
• Yushu H, Venkatraman S. (2006). The effect of process variables on the morphology and release characteristics of protein-loaded PLGA particles. J Appl Polym Sci 101:3053–61.
   Web of Science ®Google Scholar