Oral delivery of lycopene-loaded microemulsion for brain-targeting: preparation, characterization, pharmacokinetic evaluation and tissue distribution

References

• Acharya SP, Pundarikakshudu K, Panchal A, et al. (2013). Preparation and evaluation of transnasal microemulsion of carbamazepine. AJPS 8:64–70.
   Google Scholar
• Amar I, Aserin A, Garti N. (2003). Solubilization patterns of lutein and lutein esters in food grade nonionic microemulsions. J Agric Food Chem 51:4775–81.
   PubMed Web of Science ®Google Scholar
• Araya H, Tomita M, Hayashi M. (2005). The novel formulation design of O/W microemulsion for improving the gastrointestinal absorption of poorly water soluble compounds. Int J Pharm 305:61–74.
   PubMed Web of Science ®Google Scholar
• Bala V, Rao S, Bateman E, et al. (2016). Enabling oral SN38-based chemotherapy with a combined lipophilic prodrug and self-microemulsifying drug delivery system. Mol Pharmaceutics 13:3518–25.
   PubMed Web of Science ®Google Scholar
• Cai W, Deng W, Yang H, et al. (2012). A propofol microemulsion with low free propofol in the aqueous phase: formulation, physicochemical characterization, stability and pharmacokinetics. Int J Pharm 436:536–44.
   PubMed Web of Science ®Google Scholar
• Cao M, Ren L, Chen G. (2017). Formulation optimization and ex vivo and in vivo evaluation of celecoxib microemulsion-based gel for transdermal delivery. AAPS PharmSciTech 18:1960–71.
   PubMed Web of Science ®Google Scholar
• Chansiri G, Lyons RT, Patel MV, et al. (1999). Effect of surface charge on the stability of oil/water emulsions during steam sterilization. J Pharm Sci 88:454–8.
   PubMed Web of Science ®Google Scholar
• Chen B, Hou M, Zhang B, et al. (2017). Enhancement of the solubility and antioxidant capacity of alpha-linolenic acid using an oil in water microemulsion. Food Funct 8:2792–802.
   PubMed Web of Science ®Google Scholar
• Craparo EF, Ognibene MC, Casaletto MP, et al. (2008). Biocompatible polymeric micelles with polysorbate 80 for use in brain targeting. Nanotechnology 19:485603.
   PubMed Web of Science ®Google Scholar
• des Rieux A, Fievez V, Garinot M, et al. (2006). Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. J Control Release 116:1–27.
   PubMed Web of Science ®Google Scholar
• Faisal W, O’Driscoll CM, Griffin BT. (2010). Bioavailability of lycopene in the rat: the role of intestinal lymphatic transport. J Pharm Pharmacol 62:323–31.
   PubMed Web of Science ®Google Scholar
• Fujita K, Yoshimoto N, Kato T, et al. (2013). Lycopene inhibits ischemia/reperfusion-induced neuronal apoptosis in gerbil hippocampal tissue. Neurochem Res 38:461–9.
   PubMed Web of Science ®Google Scholar
• Gerster H. (1997). The potential role of lycopene for human health. J Am Coll Nutr 16:109–26.
   PubMed Web of Science ®Google Scholar
• Ghosh PK, Majithiya RJ, Umrethia ML, et al. (2006). Design and development of microemulsion drug delivery system of acyclovir for improvement of oral bioavailability. AAPS PharmSciTech 7:77.
   PubMed Web of Science ®Google Scholar
• Guo RX, Fu X, Chen J, et al. (2016). Preparation and characterization of microemulsions of myricetin for improving its antiproliferative and antioxidative activities and oral bioavailability. J Agric Food Chem 64:6286–94.
   PubMed Web of Science ®Google Scholar
• Gupta S, Kesarla R, Omri A. (2013). Formulation strategies to improve the bioavailability of poorly absorbed drugs with special emphasis on self-emulsifying systems. ISRN Pharm 2013:848043
   PubMedGoogle Scholar
• Henderson JT, Piquette-Miller M. (2015). Blood-brain barrier: an impediment to neuropharmaceuticals. Clin Pharmacol Ther 97:308–13.
   PubMed Web of Science ®Google Scholar
• Ilic D, Misso M. (2012). Lycopene for the prevention and treatment of benign prostatic hyperplasia and prostate cancer: a systematic review. Maturitas 72:269–76.
   PubMed Web of Science ®Google Scholar
• Karasulu HY. (2008). Microemulsions as novel drug carriers: the formation, stability, applications and toxicity. Expert Opin Drug Deliv 5:119–35.
   PubMed Web of Science ®Google Scholar
• Kaur H, Chauhan S, Sandhir R. (2011). Protective effect of lycopene on oxidative stress and cognitive decline in rotenone induced model of Parkinson’s disease. Neurochem Res 36:1435–43.
   PubMed Web of Science ®Google Scholar
• Kawakami K, Yoshikawa T, Hayashi T, et al. (2002a). Microemulsion formulation for enhanced absorption of poorly soluble drugs. II. In vivo study. J Control Release 81:75–82.
   PubMed Web of Science ®Google Scholar
• Kawakami K, Yoshikawa T, Moroto Y, et al. (2002b). Microemulsion formulation for enhanced absorption of poorly soluble drugs. I. Prescription design. J Control Release 81:65–74.
   PubMed Web of Science ®Google Scholar
• Kreuter J. (2001). Nanoparticulate systems for brain delivery of drugs. Adv Drug Deliv Rev 47:65–81.
   PubMed Web of Science ®Google Scholar
• Lawrence MJ, Rees GD. (2000). Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev 45:89–121.
   PubMed Web of Science ®Google Scholar
• Lee MT, Chen BH. (2002). Stability of lycopene during heating and illumination in a model system. Food Chem 78:425–32.
   Web of Science ®Google Scholar
• Liu CB, Wang R, Yi YF, et al. (2018). Lycopene mitigates beta-amyloid induced inflammatory response and inhibits NF-kappaB signaling at the choroid plexus in early stages of Alzheimer’s disease rats. J Nutr Biochem 53:66–71.
   PubMed Web of Science ®Google Scholar
• Liu CH, Chang FY, Hung DK. (2011). Terpene microemulsions for transdermal curcumin delivery: effects of terpenes and cosurfactants. Colloids Surf B Biointerfaces 82:63–70.
   PubMed Web of Science ®Google Scholar
• Ma L, Fan Y, Wu H, et al. (2013). Tissue distribution and targeting evaluation of TMP after oral administration of TMP-loaded microemulsion to mice. Drug Dev Ind Pharm 39:1951–8.
   PubMed Web of Science ®Google Scholar
• Meresse S, Delbart C, Fruchart JC, et al. (1989). Low-density lipoprotein receptor on endothelium of brain capillaries. J Neurochem 53:340–5.
   PubMed Web of Science ®Google Scholar
• Miller KW, Lorr NA, Yang CS. (1984). Simultaneous determination of plasma retinol, alpha-tocopherol, lycopene, alpha-carotene, and beta-carotene by high-performance liquid chromatography. Anal Biochem 138:340–5.
   PubMed Web of Science ®Google Scholar
• Milne DB, Botnen J. (1986). Retinol, alpha-tocopherol, lycopene, and alpha- and beta-carotene simultaneously determined in plasma by isocratic liquid chromatography. Clin Chem 32:874–6.
   PubMed Web of Science ®Google Scholar
• Mohsin K, Alamri R, Ahmad A, et al. (2016). Development of self-nanoemulsifying drug delivery systems for the enhancement of solubility and oral bioavailability of fenofibrate, a poorly water-soluble drug. Int J Nanomed 11:2829–38.
   PubMed Web of Science ®Google Scholar
• Palozza P, Simone R, Catalano A, et al. (2011). Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-kappaB nuclear binding and increase in PPARgamma expression. J Nutr Biochem 22:259–68.
   PubMed Web of Science ®Google Scholar
• Parikh A, Kathawala K, Tan CC, et al. (2017). Lipid-based nanosystem of edaravone: development, optimization, characterization and in vitro/in vivo evaluation. Drug Deliv 24:962–78.
   PubMed Web of Science ®Google Scholar
• Prabhakar K, Afzal SM, Surender G, et al. (2013). Tween 80 containing lipid nanoemulsions for delivery of indinavir to brain. Acta Pharma Sinica B 3:345–53.
   Web of Science ®Google Scholar
• Ren J, Zou M, Gao P, et al. (2013). Tissue distribution of borneol-modified ganciclovir-loaded solid lipid nanoparticles in mice after intravenous administration. Eur J Pharm Biopharm 83:141–8.
   PubMed Web of Science ®Google Scholar
• Rowe R, Sheskey P, Quinn M. (2009). Handbook of pharmaceutical excipient. UK and USA: Pharmaceutical Press and American Pharmacists Association, 1–917.
   Google Scholar
• Salem HF, Kharshoum RM, Abou-Taleb HA, et al. (2019). Nanosized transferosome-based intranasal in situ gel for brain targeting of resveratrol: formulation, optimization, in vitro evaluation, and in vivo pharmacokinetic study. AAPS PharmSciTech 20:181.
   PubMed Web of Science ®Google Scholar
• Sane R, Mittapalli RK, Elmquist WF. (2013). Development and evaluation of a novel microemulsion formulation of elacridar to improve its bioavailability. J Pharm Sci 102:1343–54.
   PubMed Web of Science ®Google Scholar
• Sangsen Y, Wiwattanawongsa K, Likhitwitayawuid K, et al. (2016). Influence of surfactants in self-microemulsifying formulations on enhancing oral bioavailability of oxyresveratrol: studies in Caco-2 cells and in vivo. Int J Pharm 498:294–303.
   PubMed Web of Science ®Google Scholar
• Schinkel AH. (1999). P-Glycoprotein, a gatekeeper in the blood-brain barrier. Adv Drug Deliv Rev 36:179–94.
   PubMed Web of Science ®Google Scholar
• Shah B, Khunt D, Misra M, et al. (2016). Non-invasive intranasal delivery of quetiapine fumarate loaded microemulsion for brain targeting: formulation, physicochemical and pharmacokinetic consideration. Eur J Pharm Sci 91:196–207.
   PubMed Web of Science ®Google Scholar
• Shah B, Khunt D, Misra M, et al. (2018). Formulation and in-vivo pharmacokinetic consideration of intranasal microemulsion and mucoadhesive microemulsion of rivastigmine for brain targeting. Pharm Res 35:8.
   PubMed Web of Science ®Google Scholar
• Shinde RL, Devarajan PV. (2017). Docosahexaenoic acid-mediated, targeted and sustained brain delivery of curcumin microemulsion. Drug Deliv 24:152–61.
   PubMed Web of Science ®Google Scholar
• Spernath A, Yaghmur A, Aserin A, et al. (2002). Food-grade microemulsions based on nonionic emulsifiers: media to enhance lycopene solubilization. J Agric Food Chem 50:6917–22.
   PubMed Web of Science ®Google Scholar
• Subongkot T, Ngawhirunpat T. (2017). Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid. Int J Nanomed 12:5585–99.
   Google Scholar
• Sun D, Xue A, Zhang B, et al. (2015). Polysorbate 80-coated PLGA nanoparticles improve the permeability of acetylpuerarin and enhance its brain-protective effects in rats. J Pharm Pharmacol 67:1650–62.
   PubMed Web of Science ®Google Scholar
• Sun D, Xue A, Zhang B, et al. (2016). Enhanced oral bioavailability of acetylpuerarin by poly(lactide-co-glycolide) nanoparticles optimized using uniform design combined with response surface methodology. Drug Des Devel Ther 10:2029–39.
   PubMed Web of Science ®Google Scholar
• Sun W, Xie C, Wang H, et al. (2004). Specific role of polysorbate 80 coating on the targeting of nanoparticles to the brain. Biomaterials 25:3065–71.
   PubMed Web of Science ®Google Scholar
• Syed HK, Peh KK. (2014). Identification of phases of various oil, surfactant/ co-surfactants and water system by ternary phase diagram. Acta Pol Pharm 71:301–9.
   PubMed Web of Science ®Google Scholar
• Takahashi Y, Kondo H, Yasuda T, et al. (2002). Common solubilizers to estimate the Caco-2 transport of poorly water-soluble drugs. Int J Pharm 246:85–94.
   PubMed Web of Science ®Google Scholar
• Talwar D, Ha TK, Cooney J, et al. (1998). A routine method for the simultaneous measurement of retinol, alpha-tocopherol and five carotenoids in human plasma by reverse phase HPLC. Clin Chim Acta 270:85–100.
   PubMed Web of Science ®Google Scholar
• Tang G, Ferreira AL, Grusak MA, et al. (2005). Bioavailability of synthetic and biosynthetic deuterated lycopene in humans. J Nutr Biochem 16:229–35.
   PubMed Web of Science ®Google Scholar
• Tang TT, Hu XB, Liao DH, et al. (2013). Mechanisms of microemulsion enhancing the oral bioavailability of puerarin: comparison between oil-in-water and water-in-oil microemulsions using the single-pass intestinal perfusion method and a chylomicron flow blocking approach. Int J Nanomed 8:4415–26.
   PubMed Web of Science ®Google Scholar
• Tao J, Zhu Q, Qin F, et al. (2017). Preparation of steppogenin and ascorbic acid, vitamin E, butylated hydroxytoluene oil-in-water microemulsions: characterization, stability, and antibrowning effects for fresh apple juice. Food Chem 224:11–8.
   PubMed Web of Science ®Google Scholar
• Wang LS, Shi ZF, Zhang YF, et al. (2012). Effect of Xiongbing compound on the pharmacokinetics and brain targeting of tetramethylpyrazine. J Pharm Pharmacol 64:1688–94.
   PubMed Web of Science ®Google Scholar
• Wilson B, Samanta MK, Santhi K, et al. (2008). Targeted delivery of tacrine into the brain with polysorbate 80-coated poly(n-butylcyanoacrylate) nanoparticles. Eur J Pharm Biopharm 70:75–84.
   PubMed Web of Science ®Google Scholar
• Wu L, Qiao Y, Wang L, et al. (2015). A self-microemulsifying drug delivery system (SMEDDS) for a novel medicative compound against depression: a preparation and bioavailability study in rats. AAPS PharmSciTech 16:1051–8.
   PubMed Web of Science ®Google Scholar
• Yeom DW, Song YS, Kim SR, et al. (2015). Development and optimization of a self-microemulsifying drug delivery system for atorvastatin calcium by using D-optimal mixture design. Int J Nanomed 10:3865–77.
   PubMed Web of Science ®Google Scholar
• Yi T, Tang D, Wang F, et al. (2017). Enhancing both oral bioavailability and brain penetration of puerarin using borneol in combination with preparation technologies. Drug Deliv 24:422–9.
   PubMed Web of Science ®Google Scholar
• Yin YM, Cui FD, Mu CF, et al. (2009). Docetaxel microemulsion for enhanced oral bioavailability: preparation and in vitro and in vivo evaluation. J Control Release 140:86–94.
   PubMed Web of Science ®Google Scholar
• Zakeri-Milani P, Valizadeh H. (2014). Intestinal transporters: enhanced absorption through P-glycoprotein-related drug interactions. Expert Opin Drug Metab Toxicol 10:859–71.
   PubMed Web of Science ®Google Scholar