Development of dual-targeted nano-dandelion based on an oligomeric hyaluronic acid polymer targeting tumor-associated macrophages for combination therapy of non-small cell lung cancer

References

• Abdallah FM, Helmy MW, Katary MA, Ghoneim AI. (2018). Synergistic antiproliferative effects of curcumin and celecoxib in hepatocellular carcinoma HepG2 cells. Naunyn-Schmiedeberg's Arch Pharmacol 391:1399–410.
   Google Scholar
• Alley SC, Okeley NM, Senter PD. (2010). Antibody–drug conjugates: targeted drug delivery for cancer. Curr Opin Chem Biol 14:529–37.
   PubMed Web of Science ®Google Scholar
• Amaya P-Kg. (2009). Folate receptor beta is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages. Cancer Res 69:9395–403.
   PubMed Web of Science ®Google Scholar
• Assanhou AG, Li W, Zhang L, et al. (2015). Reversal of multidrug resistance by co-delivery of paclitaxel and lonidamine using a TPGS and hyaluronic acid dual-functionalized liposome for cancer treatment. Biomaterials 73:284–95.
   PubMed Web of Science ®Google Scholar
• Barati N, Momtazi-Borojeni AA, Majeed M, Sahebkar A. (2019). Potential therapeutic effects of curcumin in gastric cancer. J Cell Physiol 234:2317–28.
   PubMed Web of Science ®Google Scholar
• Chen D, Dong X, Qi M, et al. (2017a). Dual pH/redox responsive and CD44 receptor targeting hybrid nano-chrysalis based on new oligosaccharides of hyaluronan conjugates. Carbohydr Polym 157:1272–80.
   PubMed Web of Science ®Google Scholar
• Chen D, Lian S, Sun J, et al. (2016). Design of novel multifunctional targeting nano-carrier drug delivery system based on CD44 receptor and tumor microenvironment pH condition. Drug Deliv 23:798–813.
   Web of Science ®Google Scholar
• Chen D, Song X, Wang K, et al. (2017b). Design and evaluation of dual CD44 receptor and folate receptor-targeting double-smart pH-response multifunctional nanocarrier. J Nanopart Res 19:400.
   Web of Science ®Google Scholar
• Chen D, Xie J, Fiskesund R, et al. (2018). Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype. Nat Commun 9:873.
   PubMed Web of Science ®Google Scholar
• Chen D, Yu H, Sun K, et al. (2014). Dual thermoresponsive and pH-responsive self-assembled micellar nanogel for anticancer drug delivery. Drug Deliv 21:258–64.
   PubMed Web of Science ®Google Scholar
• Chen Z, Yu D, Liu C, et al. (2011). Gadolinium-conjugated PLA-PEG nanoparticles as liver targeted molecular MRI contrast agent. J Drug Target 19:657.
   PubMed Web of Science ®Google Scholar
• Cheng R, Feng F, Meng F, et al. (2011). Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery. J Control Release 152:2–12.
   PubMed Web of Science ®Google Scholar
• Desai MP, Labhasetwar V, Amidon GL, et al. (1996). Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm Res 13:1838–45.
   PubMed Web of Science ®Google Scholar
• Dexi Z, Cheng H, Zhen L, et al. (2013). Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways. Cell Signal 26:192–7.
   PubMed Web of Science ®Google Scholar
• Dong X, Zou S, Guo C, et al. (2018). Multifunctional redox-responsive and CD44 receptor targeting polymer–drug nanomedicine based curcumin and alendronate: synthesis, characterization and in vitro evaluation. Artif Cells Nanomed Biotechnol 46:168–77.
   PubMed Web of Science ®Google Scholar
• Farajzadeh Valilou S, Keshavarz-Fathi M, Silvestris N, et al. (2018). The role of inflammatory cytokines and tumor associated macrophages (TAMs) in microenvironment of pancreatic cancer. Cytokine Growth Factor Rev 39:46–61.
   PubMed Web of Science ®Google Scholar
• Gianfranca C. (2010). Polarization dictates iron handling by inflammatory and alternatively activated macrophages. Haematologica 95:1814–22.
   PubMed Web of Science ®Google Scholar
• Handali S, Moghimipour E, Rezaei M, et al. (2018). A novel 5-fluorouracil targeted delivery to colon cancer using folic acid conjugated liposomes. Biomed Pharmacother 108:1259–73.
   PubMed Web of Science ®Google Scholar
• Harvey TM. (2011). Molecular mechanism and physiological functions of clathrin-mediated endocytosis. Nat Rev Mol Cell Biol 12:517–33.
   PubMed Web of Science ®Google Scholar
• Hayes JD, Wolf CR. (1990). Molecular mechanisms of drug resistance. Biochem J 272:281–95.
   PubMed Web of Science ®Google Scholar
• Hegab AE, Ozaki M, Kagawa S, et al. (2018). Tumor associated macrophages support the growth of FGF9-induced lung adenocarcinoma by multiple mechanisms. Lung Cancer 119:25–35.
   PubMed Web of Science ®Google Scholar
• Herea D, Labusca L, Radu E, et al. (2019). Human adipose-derived stem cells loaded with drug-coated magnetic nanoparticles for in-vitro tumor cells targeting. Mater Sci Eng C Mater Biol Appl 94:666–76.
   PubMed Web of Science ®Google Scholar
• Hong W, Shi H, Qiao M, et al. (2017). pH-sensitive micelles for the intracellular co-delivery of curcumin and Pluronic L61 unimers for synergistic reversal effect of multidrug resistance. Sci Rep 7:42465.
   PubMed Web of Science ®Google Scholar
• Hsiao S, Chung C, Chou Y, et al. (2013). Identification of subgroup patients with stage IIIB/IV non-small cell lung cancer at higher risk for brain metastases. Lung Cancer 82:319–23.
   PubMed Web of Science ®Google Scholar
• Huanan L, Shaoquan B, Yihang H, et al. (2013). High drug loading pH-sensitive pullulan–DOX conjugate nanoparticles for hepatic targeting. J Biomed Mater Res A 102:150–9.
   PubMed Web of Science ®Google Scholar
• Igor M, Yuri M. (2015). Current concept and update of the macrophage plasticity concept: intracellular mechanisms of reprogramming and M3 macrophage “Switch” phenotype. BioMed Res Int 2015:341308.
   PubMed Web of Science ®Google Scholar
• Irannejad R, Tomshine JC, Tomshine JR, et al. (2013). Conformational biosensors reveal GPCR signalling from endosomes. Nature 495:534–8.
   PubMed Web of Science ®Google Scholar
• Jiang F, Yu Q, Chu Y, et al. (2019). MicroRNA-98-5p inhibits proliferation and metastasis in non-small cell lung cancer by targeting TGFBR1. Int J Oncol 54:128–38.
   PubMed Web of Science ®Google Scholar
• Jiang T, Mo R, Bellotti A, et al. (2014). Gel-liposome-mediated co-delivery of anticancer membrane-associated proteins and small-molecule drugs for enhanced therapeutic efficacy. Adv Funct Mater 24:2295–304.
   Web of Science ®Google Scholar
• Kundur S, Prayag A, Selvakumar P, et al. (2019). Synergistic anticancer action of quercetin and curcumin against triple-negative breast cancer cell lines. J Cell Physiol 234:11103–18.
   PubMed Web of Science ®Google Scholar
• Labie H, Perro A, Lapeyre V, et al. (2019). Sealing hyaluronic acid microgels with oppositely-charged polypeptides: a simple strategy for packaging hydrophilic drugs with on-demand release. J Colloid Interface Sci 535:16–27.
   PubMed Web of Science ®Google Scholar
• Lai LF, Guo HX. (2010). Preparation of new 5-fluorouracil-loaded zein nanoparticles for liver targeting. Int J Pharm 404:317–23.
   PubMed Web of Science ®Google Scholar
• Liu J, Ding D, Jiang Z, et al. (2019). Long non-coding RNA CCAT1/miR-148a/PKCζ prevents cell migration of prostate cancer by altering macrophage polarization. Prostate 79:105–12.
   PubMed Web of Science ®Google Scholar
• Liu Q, Das M, Liu Y, Huang L. (2018a). Targeted drug delivery to melanoma. Adv Drug Deliv Rev 127:208–21.
   PubMed Web of Science ®Google Scholar
• Liu Y, Kim Y, Siriwon N, et al. (2018b). Combination drug delivery via multilamellar vesicles enables targeting of tumor cells and tumor vasculature. Biotechnol Bioeng 115:1403–15.
   PubMed Web of Science ®Google Scholar
• Lv Y, Hao L, Hu W, et al. (2016). Novel multifunctional pH-sensitive nanoparticles loaded into microbubbles as drug delivery vehicles for enhanced tumor targeting. Sci Rep 6:29321.
   PubMed Web of Science ®Google Scholar
• Murray PJ, Allen JE, Biswas SK, et al. (2014). Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 41:14–20.
   PubMed Web of Science ®Google Scholar
• Ngambenjawong C, Gustafson HH, Pun SH. (2017). Progress in tumor-associated macrophage (TAM)-targeted therapeutics. Adv Drug Deliv Rev 114:206–21.
   PubMed Web of Science ®Google Scholar
• Ostuni R, Kratochvill F, Murray PJ, Natoli G. (2015). Macrophages and cancer: from mechanisms to therapeutic implications. Trends Immunol 36:229.
   PubMed Web of Science ®Google Scholar
• Qiu SQ, Waaijer SJH, Zwager MC, et al. (2018). Tumor-associated macrophages in breast cancer: innocent bystander or important player? Cancer Treat Rev 70:178–89.
   PubMed Web of Science ®Google Scholar
• Quail DF, Joyce JA. (2017). Molecular pathways: deciphering mechanisms of resistance to macrophage-targeted therapies. Clin Cancer Res 23:876–84.
   PubMed Web of Science ®Google Scholar
• Räihä MR, Puolakkainen PA. (2018). Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: a review. Chron Dis Transl Med 4:156–63.
   PubMedGoogle Scholar
• Raina S, Missiakas D. (1997). Making and breaking disulfide bonds. Annu Rev Microbiol 51:179–202.
   PubMed Web of Science ®Google Scholar
• Raza A, Hayat U, Rasheed T, et al. (2018). Redox-responsive nano-carriers as tumor-targeted drug delivery systems. Eur J Med Chem 157:705–15.
   PubMed Web of Science ®Google Scholar
• Rehman A, Omran Z, Anton H, et al. (2018). Development of doxorubicin hydrochloride loaded pH-sensitive liposomes: investigation on the impact of chemical nature of lipids and liposome composition on pH-sensitivity. Eur J Pharm Biopharm 133:331–8.
   PubMed Web of Science ®Google Scholar
• Saijie Z, Mengmeng N, Hannah OM, Zhengrong C. (2013). Targeting of tumor-associated macrophages made possible by PEG-sheddable, mannose-modified nanoparticles. Mol Pharm 10:3525–30.
   PubMed Web of Science ®Google Scholar
• Santoni M, Cheng L, Conti A, et al. (2017). Activity and functions of tumor-associated macrophages in prostate carcinogenesis. Eur Urol Suppl 16:301–8.
   Web of Science ®Google Scholar
• Singh S, Mehta N, Lilan J, et al. (2017). Initiative action of tumor-associated macrophage during tumor metastasis. Biochim Open 4:8–18.
   PubMedGoogle Scholar
• Suhaas A, Janib SM, Andrew Mackay J. (2009). Environmentally responsive peptides as anticancer drug carriers. Adv Drug Deliv Rev 61:940–952.
   PubMed Web of Science ®Google Scholar
• Sun YQ, Dai CM, Zheng Y, et al. (2017). Binding effect of fluorescence labeled glycyrrhetinic acid with GA receptors in hepatocellular carcinoma cells. Life Sci 188:186–91.
   PubMed Web of Science ®Google Scholar
• Tan HY, Wang N, Man K, et al. (2015). Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin. Cell Death Dis 6:e1942.
   PubMed Web of Science ®Google Scholar
• Tian Q, Wang XH, Wang W, et al. (2012). Self-assembly and liver targeting of sulfated chitosan nanoparticles functionalized with glycyrrhetinic acid. Nanomedicine 8:870–9.
   PubMed Web of Science ®Google Scholar
• Wang K, Guo C, Dong X, et al. (2018a). In vivo evaluation of reduction-responsive alendronate–hyaluronan–curcumin polymer–drug conjugates for targeted therapy of bone metastatic breast cancer. Mol Pharm 15:2764–9.
   PubMed Web of Science ®Google Scholar
• Wang K, Guo C, Zou S, et al. (2018b). Synthesis, characterization and in vitro/in vivo evaluation of novel reduction-sensitive hybrid nano-echinus-like nanomedicine. Artif Cells Nanomed Biotechnol 46:659–67.
   PubMed Web of Science ®Google Scholar
• Wang K, Qi M, Guo C, et al. (2018c). Novel dual mitochondrial and CD44 receptor targeting nanoparticles for redox stimuli-triggered release. Nanoscale Res Lett 13:32.
   PubMed Web of Science ®Google Scholar
• Wenyuan W. (2006). Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms. Cancer Res 66:970–80.
   PubMed Web of Science ®Google Scholar
• Yan T, Cheng J, Liu Z, et al. (2018). Acid-sensitive polymeric vector targeting to hepatocarcinoma cells via glycyrrhetinic acid receptor-mediated endocytosis. Mater Sci Eng C Mater Biol Appl 87:32–40.
   PubMed Web of Science ®Google Scholar
• Yang R, Xu J, Xu L, et al. (2018). Cancer cell membrane-coated adjuvant nanoparticles with mannose modification for effective anticancer vaccination. ACS Nano 12:5121–9.
   PubMed Web of Science ®Google Scholar
• Yang Y, Xing R, Liu S, et al. (2019). Hydroxypropyltrimethyl ammonium chloride chitosan activates RAW 264.7 macrophages through the MAPK and JAK-STAT signaling pathways. Carbohydr Polym 205:401–9.
   PubMed Web of Science ®Google Scholar
• Yoshiyuki H, Jun Y, Chisato S, et al. (2015). Evaluation of antitumor effect of zoledronic acid entrapped in folate-linked liposome for targeting to tumor-associated macrophages. J Liposome Res 25:131–40.
   PubMed Web of Science ®Google Scholar
• Yuan R, Li S, Geng H, et al. (2017). Reversing the polarization of tumor-associated macrophages inhibits tumor metastasis. Int Immunopharmacol 49:30–7.
   PubMed Web of Science ®Google Scholar
• Zarogoulidis K, Zarogoulidis P, Darwiche K, et al. (2013). Treatment of non-small cell lung cancer (NSCLC). J Thorac Dis 5:S389–S96.
   PubMed Web of Science ®Google Scholar
• Zhang C, Hao Y, Wu L, et al. (2018). Curcumin induces apoptosis and inhibits angiogenesis in murine malignant mesothelioma. Int J Oncol 53:2531–41.
   PubMed Web of Science ®Google Scholar
• Zhao P, Wang Y, Kang X, et al. (2018). Dual-targeting biomimetic delivery for anti-glioma activity via remodeling the tumor microenvironment and directing macrophage-mediated immunotherapy. Chem Sci 9:2674–89.
   PubMed Web of Science ®Google Scholar