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Original

Encapsulation of Human Islets in Novel Inhomogeneous Alginate-Ca2+/Ba2+ Microbeads: In Vitro and In Vivo Function

, , , , , , , , , , , , , , & , MD show all
Pages 403-420 | Published online: 11 Jul 2009

References

  • Alejandro R., Lehmann R., Ricordi C., Kenyon N. S., Angelico M. C., Burke G., Esquenazi V., Nery J., Betancourt A. E., Kong S. S., Miller J., Mintz D. H. Long-term function (6 years) of islet allografts in type 1 diabetes. Diabetes 1997; 46: 1983–1989
  • Avila J. G., Tsujimura T., Oberholzer J., Churchill T., Salehi P., Shapiro A. M., Lakey J. R. Improvement of pancreatic islet isolation outcomes using glutamine perfusion during isolation procedure. Cell Transplant 2003; 12: 877–881
  • Calafiore R., Basta G., Luca G., Lemmi A., Montanucci M. P., Calabrese G., Racanicchi L., Mancuso F., Brunetti P. Microencapsulated pancreatic islet allografts into nonimmunosuppressed patients with type 1 diabetes: first two cases. Diabetes Care 2006; 29: 137–138
  • De Vos P., Van Straaten J. F., Nieuwenhuizen A. G., de Groot M., Ploeg R. J., De Haan B. J., Van Schilfgaarde R. Why do microencapsulated islet grafts fail in the absence of fibrotic overgrowth?. Diabetes 1999; 48: 1381–1388
  • Duvivier-Kali V. F., Omer A., Parent R. J., O'Neil J. J., Weir G. C. Complete protection of islets against allorejection and autoimmunity by a simple barium-alginate membrane. Diabetes 2001; 50: 1698–1705
  • Elliott R. B., Escobar L., Calafiore R., Basta G., Garkavenko O., Vasconcellos A., Bambra C. Transplantation of micro- and macroencapsulated piglet islets into mice and monkeys. Transplant Proc 2005; 37: 466–469
  • Fridell J. A., Agarwal A., Milgrom M. L., Goggins W. C., Murdock P., Pescovitz M. D. Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution for organ preservation in clinical pancreas transplantation. Transplantation 2004; 77: 1304–1306
  • Kobayashi T., Aomatsu Y., Iwata H., Kin T., Kanehiro H., Hisanga M., Ko S., Nagao M., Harb G., Nakajima Y. Survival of microencapsulated islets at 400 days posttransplantation in the omental pouch of NOD mice. Cell Transplant 2006; 15: 359–365
  • Kobayashi T., Harb G., Rayat G. R. Prolonged survival of microencapsulated neonatal porcine islets in mice treated with a combination of anti-CD154 and anti-LFA-1 monoclonal antibodies. Transplantation 2005; 80: 821–827
  • Korbutt G. S., Mallett A. G., Ao Z., Flashner M., Rajotte R. V. Improved survival of microencapsulated islets during in vitro culture and enhanced metabolic function following transplantation. Diabetologia 2004; 47: 1810–1818
  • Lakey J. R., Rajotte R. V., Warnock G. L., Kneteman N. M. Human pancreas preservation prior to islet isolation. Cold ischemic tolerance. Transplantation 1995; 59: 689–694
  • Leu F. J., Chen C. F., Chiang W. E., Chern H. T., Shian L. R., Chung T. M., Wang J., Sun A. M. Microencapsulated pancreatic islets: a pathologic study. J Formos Med Assoc 1992; 91: 849–858
  • Lim F., Sun A. M. Microencapsulated islets as bioartificial endocrine pancreas. Science 1980; 210: 908–910
  • Morch Y. A., Donati I., Strand B. L., Skjak-Braek G. Effect of Ca2+, Ba2+, and Sr2+ on alginate microbeads. Biomacromolecules 2006; 7: 1471–1480
  • O'Shea G. M., Goosen M. F., Sun A. M. Prolonged survival of transplanted islets of Langerhans encapsulated in a biocompatible membrane. Biochim Biophys Acta 1984; 804: 133–136
  • Oberholzer J., Triponez F., Mage R., Andereggen E., Buhler L., Cretin N., Fournier B., Goumaz C., Lou J., Philippe J., Morel P. Human islet transplantation: lessons from 13 autologous and 13 allogeneic transplantations. Transplantation 2000; 69: 1115–1123
  • Omer A., Duvivier-Kali V., Fernandes J., Tchipashvili V., Colton C. K., Weir G. C. Long-term normoglycemia in rats receiving transplants with encapsulated islets. Transplantation 2005; 79: 52–58
  • Potdar S., Malek S., Eghtesad B., Shapiro R., Basu A., Patel K., Broznick B., Fung J. Initial experience using histidine-tryptophan-ketoglutarate solution in clinical pancreas transplantation. Clin Transplant 2004; 18: 661–665
  • Ricordi C., Gray D. W., Hering B. J., Kaufman D. B., Warnock G. L., Kneteman N. M., Lake S. P., London N. J., Socci C., Alejandro R., et al. Islet isolation assessment in man and large animals. Acta Diabetol Lat 1990; 27: 185–195
  • Ricordi C., Lacy P. E., Scharp D. W. Automated islet isolation from human pancreas. Diabetes 1989; 38 Suppl 1: 140–142
  • Roe, M. W., Worley, J. F., 3rd, Mittal, A. A., \Kuznetsov, A., DasGupta, S., Mertz, R. J., Witherspoon, S. M., 3rd, Blair, N., Lancaster, M. E., McIntyre, M. S., Shehee, W. R., Dukes, I. D. and Philipson, L. H. 1996. Expression and function of pancreatic beta-cell delayed rectifier K+ channels. Role in stimulus-secretion coupling. J Biol Chem 271: 32241–32246.
  • Roe, M. W., Worley, J. F., 3rd, Tokuyama, Y., Philipson, L. H., Sturis, J., Tang, J., Dukes, I. D., Bell, G. I. and Polonsky, K. S. 1996. NIDDM is associated with loss of pancreatic beta-cell L-type Ca2+ channel activity. Am J Physiol 270: EE133–140.
  • Sandler S., Andersson A., Eizirik D. L., Hellerstrom C., Espevik T., Kulseng B., Thu B., Pipeleers D. G., Skjak-Braek G. Assessment of insulin secretion in vitro from microencapsulated fetal porcine islet-like cell clusters and rat, mouse, and human pancreatic islets. Transplantation 1997; 63: 1712–1718
  • Schneider S., Feilen P. J., Brunnenmeier F., Minnemann T., Zimmermann H., Zimmermann U., Weber M. M. Long-term graft function of adult rat and human islets encapsulated in novel alginate-based microcapsules after transplantation in immunocompetent diabetic mice. Diabetes 2005; 54: 687–693
  • Shapiro A. M., Ricordi C., Hering B. J., Auchincloss H., Lindblad R., Robertson R. P., Secchi A., Brendel M. D., Berney T., Brennan D. C., Cagliero E., Alejandro R., Ryan E. A., DiMercurio B., Morel P., Polonsky K. S., Reems J. A., Bretzel R. G., Bertuzzi F., Froud T., Kandaswamy R., Sutherland D. E., Eisenbarth G., Segal M., Preiksaitis J., Korbutt G. S., Barton F. B., Viviano L., Seyfert-Margolis V., Bluestone J., Lakey J. R. International trial of the Edmonton protocol for islet transplantation. N Engl J Med 2006; 355: 1318–1330
  • Soon-Shiong P., Feldman E., Nelson R., Heintz R., Yao Q., Yao Z., Zheng T., Merideth N., Skjak-Braek G., Espevik T., et al. Long-term reversal of diabetes by the injection of immunoprotected islets. Proc Natl Acad Sci U S A 1993; 90: 5843–5847
  • Soon-Shiong P., Heintz R. E., Merideth N., Yao Q. X., Yao Z., Zheng T., Murphy M., Moloney M. K., Schmehl M., Harris M., et al. Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation. Lancet 1994; 343: 950–951
  • Soria, B. , Roche, E. , Reig, J. A. and Martin, F. 2005. Generation of insulin-producing cells from stem cells. Novartis Found Symp 265: 158–167; discussion 167-173, 204-111.
  • Strand B. L., Gaserod O., Kulseng B., Espevik T., Skjak-Baek G. Alginate-polylysine-alginate microcapsules: effect of size reduction on capsule properties. J Microencapsul 2002; 19: 615–630
  • Strand B. L., Ryan T. L., In't Veld P., Kulseng B., Rokstad A. M., Skjak-Brek G., Espevik T. Poly-L-Lysine induces fibrosis on alginate microcapsules via the induction of cytokines. Cell Transplant 2001; 10: 263–275
  • Sun Y., Chen L., Hou X. G., Hou W. K., Dong J. J., Sun L., Tang K. X., Wang B., Song J., Li H., Wang K. X. Differentiation of bone marrow-derived mesenchymal stem cells from diabetic patients into insulin-producing cells in vitro. Chin Med J (Engl) 2007; 120: 771–776
  • Sun Y., Ma X., Zhou D., Vacek I., Sun A. M. Normalization of diabetes in spontaneously diabetic cynomologus monkeys by xenografts of microencapsulated porcine islets without immunosuppression. J Clin Invest 1996; 98: 1417–1422
  • Ta M., Choi Y., Atouf F., Park C. H., Lumelsky N. The defined combination of growth factors controls generation of long-term-replicating islet progenitor-like cells from cultures of adult mouse pancreas. Stem Cells 2006; 24: 1738–1749
  • Tamarina N. A., Wang Y., Mariotto L., Kuznetsov A., Bond C., Adelman J., Philipson L. H. Small-conductance calcium-activated K+ channels are expressed in pancreatic islets and regulate glucose responses. Diabetes 2003; 52: 2000–2006
  • Thompson, D. M., Fung, M. A. and Warnock, G. L. 2007. Islet transplantation. N Engl J Med 356: 964; author reply 964–965.
  • Thu B., Gaserod O., Paus D., Mikkelsen A., Skjak-Braek G., Toffanin R., Vittur F., Rizzo R. Inhomogeneous alginate gel spheres: an assessment of the polymer gradients by synchrotron radiation-induced X-ray emission, magnetic resonance microimaging, and mathematical modeling. Biopolymers 2000; 53: 60–71
  • Trivedi N., Keegan M., Steil G. M., Hollister-Lock J., Hasenkamp W. M., Colton C. K., Bonner-Weir S., Weir G. C. Islets in alginate macrobeads reverse diabetes despite minimal acute insulin secretory responses. Transplantation 2001; 71: 203–211
  • Tsujimura T., Kuroda Y., Kin T., Avila J. G., Rajotte R. V., Korbutt G. S., Ryan E. A., Shapiro A. M., Lakey J. R. Human islet transplantation from pancreases with prolonged cold ischemia using additional preservation by the two-layer (UW solution/perfluorochemical) cold-storage method. Transplantation 2002; 74: 1687–1691
  • van de Linde P., Boog P. J., Tysma O. M., Elliott J. F., Roelen D. L., Claas F. H., de Fijter J. W., Roep B. O. Selective unresponsiveness to beta cell autoantigens after induction immunosuppression in pancreas transplantation with anti-interleukin-2 receptor antibody versus anti-thymocyte globulin. Clin Exp Immunol 2007; 149: 56–62
  • Vandenbossche G. M., Bracke M. E., Cuvelier C. A., Bortier H. E., Mareel M. M., Remon J. P. Host reaction against alginate-polylysine microcapsules containing living cells. J Pharm Pharmacol 1993; 45: 121–125
  • Weber C., Ayres-Price J., Costanzo M., Becker A., Stall A. NOD mouse peritoneal cellular response to poly-L-lysine-alginate microencapsulated rat islets. Transplant Proc 1994; 26: 1116–1119
  • Xu, B. Y., Yang, H., Serreze, D. V., MacIntosh, R., Yu, W. and Wright, J. R., Jr. 2005. Rapid destruction of encapsulated islet xenografts by NOD mice is CD4-dependent and facilitated by B-cells: innate immunity and autoimmunity do not play significant roles. Transplantation 80: 402–409.
  • Yang H., Acker J., Chen A., McGann L. In situ assessment of cell viability. Cell Transplant 1998; 7: 443–451

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