Non-toxicity of IV Injected Perfluorocarbon Oxygen Carrier in an Animal Model of Liver Regeneration Following Surgical Injury

References

• Moolman, F.S. 2004. Oxygen carriers for a novel bio-artificial liver support system. PHD thesis, University of Pretoria, http://upetd.up.ac.za #etd-09092004-162043.
   Google Scholar
• Moolman F.S., Rolfes H., van der Merwe S.W., Focke W.W. Optimization of Perfluorocarbon emulsion properties for enhancing oxygen mass transfer in a bio-artificial liver support system. Biochem Eng J 2004; 19: 237–250
   Google Scholar
• Nieuwoudt M., Moolman F.S., Van Wyk A.J., Kreft E., Olivier B., Laurens J.B., Stegman F., Vosloo J., Bond R., van der Merwe S.W. Hepatocyte function in a radial-flow bioreactor using a perfluorocarbon oxygen xarrier. J Artif Org 2005; 29(11)915–918
   Google Scholar
• Riess J.G. Perfluorocarbon-based oxygen delivery. Artif Cell Blood Substit. Biotechnol 2006; 34: 567–80
   Google Scholar
• Krafft M.P., Riess J.G. Perfluorocarbons: Life sciences and medical uses. J Polym Sci Part A: Polym Chem 2007; 45: 1185–98
   Web of Science ®Google Scholar
• Spahn D.R., Kocian R. The place of artificial oxygen carriers in reducing allogenic blood transfusions and augmenting tissue oxygenation. Canadian Jnl Anaesthesia 2003; 50(6)41–7
   Google Scholar
• Kim H.W., Greenburg A.G. Toward 21st century blood component replacement therapeutics: Artificial O2 carriers. Artif Cells, Bl subs. Biotechnol 2006; 34: 537–50
   Google Scholar
• Kuznetsova I.N. Perfluorocarbon emulsions: Stability in vitro and in vivo. Pharm Chem Jnl 2003; 37(8)415–20
   Google Scholar
• Ingram D.A., Forman M.B., Murray J.J. Activation of complement by Fluosol attributable to the pluronic detergent micelle structure. J Cardiovasc Pharmacol 1993; 22: 456–61
   PubMed Web of Science ®Google Scholar
• Noveck R.J., Shanon E.J., Leese P.T. Randomized safety studies of IV perflubron emulsion. II. Effects on immune function in healthy volunteers. Anesth Analg 2000; 91: 812–22
   PubMed Web of Science ®Google Scholar
• Noveck R.J., Shanon E.J., Shor J.S. Randomized safety studies of IV perflubron emulsion. I. Effects on coagulation function in healthy volunteers. Anesth Analg 2000; 91: 804–11
   PubMedGoogle Scholar
• Burgan A.R., Herrick W.C., Long D.M. Acute and subacute toxicity of 100% PFOB emulsion. Biomat Art Cells Art Org 1988; 16(1-3)681–2
   Web of Science ®Google Scholar
• Sedova L.A., Kochetygov N.I., Berkos M.V. Side reaction caused by the PFC emulsions in IV infusion to experimental animals. Art Cells. Blood Subs Immob Biotech 1998; 26(2)149–57
   PubMed Web of Science ®Google Scholar
• Sloviter H.A., Yamada H., Ogoshi S. Some effects of IV administered dispersed fluorochemicals in animals. Federation Proceedings 1970; 29(5)1755–7
   PubMedGoogle Scholar
• Mattrey R.F., Hilpert P.L., Long C.D. Hemodynamic effects of IV lecithin-based PFC emulsions in dogs. Crit Care Med 1989; 17(7)652–6
   PubMedGoogle Scholar
• Peck W., Mattrey R.F., Slutsky R.A. Perfluorooctyl bromide: acute hemodynamic effects in pigs of IV administration compared with standard ionic contrast media. Investigative Radiology 1984; 2: 129–32
   Google Scholar
• Nieuwoudt M., Kunneke R., Smuts M., Becker J., Stegmann G.F., Van der Walt C., Neser J., Van der Merwe S. Standardization criteria for an ischemic surgical model of acute hepatic failure in pigs. Biomaterials 2006; 27(20)3836–45
   PubMedGoogle Scholar
• Higgins G.M., Anderson R.M. Experimental pathology of the liver. Arch Pathol 1931; 12: 186–202
   Google Scholar
• Emond J., Capron-Laudereau M., Meriggi F., Bernau J., Reynes M., Houssin D. Extent of hepatectomy in the rat. Eur Surg Res 1989; 21: 251–59
   PubMedGoogle Scholar
• Kubota T., Takabe K., Yang M., Sekido H., Endo I., Ichikawa Y. Minimum sizes for remnant and transplanted livers in rats. J Hep Bil Pancr Surg 1997; 4: 398–404
   Google Scholar
• Topaglu S., Izci E., Ozel H., Topaglu E., Avsar F., Saygun O. Effects of TVE application during 70% hepatectomy on regeration capacity of rats. J Surg Res 2005; 124: 139–45
   PubMedGoogle Scholar
• Ijichi H., Taketomi A., Yoshizumi T., Uchiyama H., Yonemura Y., Soejima Y. Hyperbaric oxygen induces endothelial growth factor and reduces liver injury in regenerating rat liver after partial hepatectomy. J Hepatol 2006; 45: 28–34
   PubMed Web of Science ®Google Scholar
• Urakami H., Abe Y., Grisham M.B. Role of reactive metabolites of oxygen and nitrogen in partial liver transplantation. Clin Exp Pharmacol Physiol 2007; 34: 912–9
   PubMedGoogle Scholar
• Vd Kerkhove M.P., Hoekstra R., van Gulik T.M., Chamuleau R. Large animal models of fulminant hepatic failure in artificial and Bioartificial liver support research. Biomaterials 2004; 25: 1613–25
   PubMedGoogle Scholar
• Seleverstov O., Bader A. Evaluation of liver support systems for preclinical testing by animal trials. Artificial Organs 2006; 30(10)815–21
   PubMedGoogle Scholar