High-power bipolar multilevel pulsed electroporator

References

• Talele, S. Drug Delivery by Electroporation: Review. Springer: New York, 2013; pp. 567–575.
   Google Scholar
• Frey, W.; White, J.A.; Price, R.O.; Blackmore, P.F.; Joshi, R.P.; Nuccitelli, R.; Beebe, S.J.; Schoenbach, K.H.; Kolb, J.F. Plasma Membrane Voltage Changes during Nanosecond Pulsed Electric Field Exposure. Biophys. J. 2006, 90(10), 3608–3615.
   PubMed Web of Science ®Google Scholar
• Neumann, E.; Kakorin, S.; Toensing, K. Fundamentals of Electroporative Delivery of Drugs and Genes. Bioelectrochem Bioenerg. 1999, 48(1), 3–16.
   PubMed Web of Science ®Google Scholar
• Teissié, J.; Escoffre, J.; Rols, M.; Golzio, M. Time Dependence of Electric Field Effects on Cell Membranes. A Review for a Critical Selection of Pulse Duration for Therapeutical Applications. Radiol. Oncol. 2008, 42(4), 196–206.
   Web of Science ®Google Scholar
• Schoenbach, K.H.; Peterkin, F.E.; Alden, R.W.; Beebe, S.J. The Effect of Pulsed Electric Fields on Biological Cells: Experiments and Applications. IEEE Trans. Plasma Sci. 1997, 25(2), 284–292.
   Web of Science ®Google Scholar
• Tsong, T.Y. Electroporation of Cell Membranes. Biophys. J. 1991, 60(2), 297–306.
   PubMed Web of Science ®Google Scholar
• Orlowski, S.; Mir, L.M. Cell Electropermeabilization: A New Tool for Biochemical and Pharmacological Studies. Biochimica et Biophysica Acta (BBA) – Rev. Biomembr. 1993, 1154(1), 51–63.
   PubMed Web of Science ®Google Scholar
• Huang, Y.; Rubinsky, B. Micro-Electroporation: Improving the Efficiency and Understanding of Electrical Permeabilization of Cells. Biomed. Microdev. 1999, 2(2), 145–150.
   Web of Science ®Google Scholar
• Granot, Y.; Rubinsky, B. Methods of optimization of electrical impedance tomography for imaging tissue electroporation. Physiological Measurement. 2007, 28 (10), 1135–47.
   PubMed Web of Science ®Google Scholar
• Mir, L.M.; Glass, L.F.; Sersa, G.; Teissie, J.; Domenge, C.; Miklavcic, D.; Jaroszeski, M.J.; Orlowski, S.; Reintgen, D.S.; Rudolf, Z. Effective Treatment of Cutaneous and Subcutaneous Malignant Tumours by Electrochemotherapy. Brit. J. Cancer 1998, 77(12), 2336–2342.
   PubMed Web of Science ®Google Scholar
• Davalos, R.V.; Mir, L.M.; Rubinsky, B. Tissue Ablation with Irreversible Electroporation. Ann. Biomed. Eng. 2005, 33(2), 223–231.
   PubMed Web of Science ®Google Scholar
• Gehl, J. Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research. Acta Physiologica Scandinavica 2003, 177(4), 437–47.
   PubMedGoogle Scholar
• Heller, R.; Gilbert, R.; Jaroszeski, M.J. Clinical Applications of Electrochemotherapy. Adv. Drug Deliv. Rev. 1999, 35(1), 119–129.
   PubMed Web of Science ®Google Scholar
• Reberšek, M.; Miklavčič, D. Advantages and Disadvantages of Different Concepts of Electroporation Pulse Generation. Automatika-J. Control Measure. Electron. Comput. Commun. 2011, 52(1), 12–19.
   Google Scholar
• Pavlin, M.; Kandušer, M.; Reberšek, M.; Pucihar, G.; Hart, F.X.; Magjarevićcacute; Ratko; Miklavčič, D. Effect of Cell Electroporation on the Conductivity of a Cell Suspension. Biophys. J. 2005, 88(6), 4378–4390.
   PubMed Web of Science ®Google Scholar
• Staal, L.; Gilbert, R. Generators and Applicators: Equipment for Electroporation. Springer: New York, 2011; pp. 45–65.
   Google Scholar
• Reberšek, M.; Miklavčič, D. Concepts of Electroporation Pulse Generation and Overview of Electric Pulse Generators for Cell and Tissue Electroporation. In Advanced Electroporation Techniques in Biology and Medicine. Pakhomov, A.G., Maklavčič, D., Markov, M.S., eds., CRC Press: Boca Raton, FL, 2010; pp. 323–339.
   Google Scholar
• Novickij, V.; Grainys, A.; Novickij, J.; Tolvaisiene, S.; Markovskaja, S. Compact Electro-Permeabilization System for Controlled Treatment of Biological Cells and Cell Medium Conductivity Change Measurement. Measure. Sci. Rev. 2014, 14(5), 279–284.
   Web of Science ®Google Scholar
• Flisar, K.; Meglic, S.H.; Morelj, J.; Golob, J.; Miklavcic, D. Testing a Prototype Pulse Generator for a Continuous Flow System and its Use for E. coli Inactivation and Microalgae Lipid Extraction. Bioelectrochemistry 2014, 100, 44–51.
   PubMed Web of Science ®Google Scholar
• Flaxer, E. Note: High Resolution Ultra Fast High-Power Pulse Generator for Inductive Load using Digital Signal Processor. Rev. Sci. Instrum. 2014, 85(8), 086108.
   Web of Science ®Google Scholar
• Arena, C.B.; Sano, M.B.; Rylander, M.N.; Davalos, R.V. Theoretical Considerations of Tissue Electroporation With High-Frequency Bipolar Pulses. IEEE Trans. Biomed. Eng. 2011, 58(5), 1474–1482.
   PubMed Web of Science ®Google Scholar
• Sungwoo, B.; Kwasinski, A.; Flynn, M.M.; Hebner, R.E. High-Power Pulse Generator With Flexible Output Pattern. IEEE Trans. Power Electron. 2010, 25(7), 1675–1684.
   Web of Science ®Google Scholar
• Kotnik, T.; Mir, L.M.; Flisar, K.; Puc, M.; Miklavcic, D. Cell Membrane Electropermeabilization by Symmetrical Bipolar Rectangular Pulses. Part I. Increased Efficiency of Permeabilization. Bioelectrochemistry 2001, 54(1), 83–90.
   PubMed Web of Science ®Google Scholar
• Sano, M.B.; Arena, C.B.; DeWitt, M.R.; Saur, D.; Davalos, R.V. In-vitro Bipolar Nano- and Microsecond Electro-Pulse Bursts for Irreversible Electroporation Therapies. Bioelectrochemistry 2014, 100, 69–79.
   PubMed Web of Science ®Google Scholar
• Dymek, K.; Dejmek, P.; Galindo, F.G. Influence of Pulsed Electric Field Protocols on the Reversible Permeabilization of Rucola Leaves. Food Bioprocess Technol. 2013, 7(3), 761–773.
   Web of Science ®Google Scholar
• Arena, C.B.; Sano, M.B.; Rossmeisl, J.H.; Caldwell, J.L.; Garcia, P.A.; Rylander, M.N.; Davalos, R.V. High-Frequency Irreversible Electroporation (H-FIRE) for Non-Thermal Ablation without Muscle Contraction. Biomed. Eng. Online 2011, 10, 102.
   PubMed Web of Science ®Google Scholar
• Esser, A.T.; Smith, K.C.; Gowrishankar, T.R.; Weaver, J.C. Towards Solid Tumor Treatment by Nanosecond Pulsed Electric Fields. Technol. Cancer Res. Treat. 2009, 8(4), 289–306.
   PubMed Web of Science ®Google Scholar
• Rebersek, M.; Miklavcic, D.; Bertacchini, C.; Sack, M. Cell Membrane Electroporation-Part 3: The Equipment. IEEE Electr. Insul. Mag. 2014, 30(3), 8–18.
   Web of Science ®Google Scholar
• Bertacchini, C.; Margotti, P.M.; Bergamini, E.; Lodi, A.; Ronchetti, M.; Cadossi, R. Design of an Irreversible Electroporation System for Clinical Use. Technol. Cancer Res. Treat. 2007, (4), 313–320.
   PubMed Web of Science ®Google Scholar
• http://ixapps.ixys.com. Datasheet 40PG1200DHGLB. Accessed online 2015–04-24.
   Google Scholar
• Davari, P.; Zare, F.; Ghosh, A.; Akiyama, H. High-Voltage Modular Power Supply Using Parallel and Series Configurations of Flyback Converter for Pulsed Power Applications. IEEE Trans. Plasma Sci. 2012, 40(10), 2578–2587.
   Web of Science ®Google Scholar