REFERENCES
- Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. The Writing Group for the PEPI Trial. 1995; JAMA. 273: 199–208
- Abe J, Baines C P, Berk B C.. 2000. Role of mitogen-activated protein kinases in ischemia and reperfusion injury: The good and the bad. Circ Res. 86: 607–609. [PUBMED], [INFOTRIEVE]
- Acs N, Szekacs B, Nadasy G L, Varbiro S, Kakucs R, Monos E.. 1999. The effect of ovariectomy and oestrogen replacement on small artery biomechanics in the rat. Br J Obstet Gynaecol. 106: 148–154. [PUBMED], [INFOTRIEVE]
- Alkayed N J, Narayanan J, Gebremedhin D, Medhora M, Roman R J, Harder D R.. 1996. Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. Stroke. 27: 971–979. [PUBMED], [INFOTRIEVE]
- Anastos K, Charney P, Charon R A, Cohen E, Jones C Y, Marte C, Swiderski D M, Wheat M E, Williams S.. 1991. Hypertension in women: What is really known? The Women's Caucus, Working Group on Women's Health of the Society of General Internal Medicine. Ann Intern Med. 115: 287–293. [PUBMED], [INFOTRIEVE]
- Andjelkovic M, Alessi D R, Meier R, Fernandez A, Lamb N J, Frech M, Cron P, Cohen P, Lucocq J M, Hemmings B A.. 1997. Role of translocation in the activation and function of protein kinase B. J Biol Chem. 272: 31515–31524. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Armstrong S J, Zhang Y, Stewart K G, Davidge S T.. 2002. Estrogen replacement reduces PGHS-2-dependent vasoconstriction in the aged rat. Am J Physiol Heart Circ Physiol. 283: H893–H898. [PUBMED], [INFOTRIEVE]
- Arnal J F, Clamens S, Pechet C, Negre-Salvayre A, Allera C, Girolami J P, Salvayre R, Bayard F.. 1996. Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production. Proc Natl Acad Sci USA. 93: 4108–4113. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Ashton N, Balment R J.. 1991. Sexual dimorphism in renal function and hormonal status of New Zealand genetically hypertensive rats. Acta Endocrinol (Copenh). 124: 91–97
- Barbacanne M A, Rami J, Michel J B, Souchard J P, Philippe M, Besombes J P, Bayard F, Arnal J F.. 1999. Estradiol increases rat aorta endothelium-derived relaxing factor (EDRF) activity without changes in endothelial NO synthase gene expression: Possible role of decreased endothelium-derived superoxide anion production. Cardiovasc Res. 41: 672–681. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Barbagallo M, Dominguez L J, Licata G, Shan J, Bing L, Karpinski E, Pang P K, Resnick L M.. 2001. Vascular effects of progesterone: Role of cellular calcium regulation. Hypertension. 37: 142–147. [PUBMED], [INFOTRIEVE]
- Barrett-Connor E, Grady D.. 1998. Hormone replacement therapy, heart disease, and other considerations. Annu Rev Public Health. 19: 55–72. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Bauersachs J, Popp R, Hecker M, Sauer E, Fleming I, Busse R.. 1996. Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factor. Circulation. 94: 3341–3347. [PUBMED], [INFOTRIEVE]
- Beato M, Chavez S, Truss M.. 1996. Transcriptional regulation by steroid hormones. Steroids. 61: 240–251. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Beato M, Klug J.. 2000. Steroid hormone receptors: An update. Hum Reprod Update. 6: 225–236. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Belcher S M, Zsarnovszky A.. 2001. Estrogenic actions in the brain: Estrogen, phytoestrogens, and rapid intracellular signaling mechanisms. J Pharmacol Exp Ther. 299: 408–414. [PUBMED], [INFOTRIEVE]
- Beske S D, Alvarez G E, Ballard T P, Davy K P.. 2001. Gender difference in cardiovagal baroreflex gain in humans. J Appl Physiol. 91: 2088–2092. [PUBMED], [INFOTRIEVE]
- Beyer M E, Yu G, Hanke H, Hoffmeister H M.. 2001. Acute gender-specific hemodynamic and inotropic effects of 17beta-estradiol on rats. Hypertension. 38: 1003–1010. [PUBMED], [INFOTRIEVE]
- Bilsel A S, Moini H, Tetik E, Aksungar F, Kaynak B, Ozer A.. 2000. 17Beta-estradiol modulates endothelin-1 expression and release in human endothelial cells. Cardiovasc Res. 46: 579–584. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Binko J, Majewski H.. 1998. 17 beta-estradiol reduces vasoconstriction in endothelium-denuded rat aortas through inducible NOS. Am J Physiol. 274: H853–H859. [PUBMED], [INFOTRIEVE]
- Brouchet L, Krust A, Dupont S, Chambon P, Bayard F, Arnal J F.. 2001. Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor-alpha but not estrogen receptor-beta. Circulation. 103: 423–428. [PUBMED], [INFOTRIEVE]
- Brunet A, Bonni A, Zigmond M J, Lin M Z, Juo P, Hu L S, Anderson M J, Arden K C, Blenis J, Greenberg M E.. 1999. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 96: 857–868. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Bueno O F, De, Windt L J, Lim H W, Tymitz K M, Witt S A, Kimball T R, Molkentin J D.. 2001. The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo. Circ Res. 88: 88–96. [PUBMED], [INFOTRIEVE]
- Burt V L, Whelton P, Roccella E J, Brown C, Cutler J A, Higgins M, Horan M J, Labarthe D.. 1995. Prevalence of hypertension in the U.S. adult population. Results from the Third National Health and Nutrition Examination Survey, 1988–1991. Hypertension. 25: 305–313. [PUBMED], [INFOTRIEVE]
- Busse R, Fleming I.. 1998. Pulsatile stretch and shear stress: Physical stimuli determining the production of endothelium-derived relaxing factors. J Vasc Res. 35: 73–84. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Campbell W B, Gebremedhin D, Pratt P F, Harder D R.. 1996. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res. 78: 415–423. [PUBMED], [INFOTRIEVE]
- Campbell W B, Harder D R.. 1999. Endothelium-derived hyperpolarizing factors and vascular cytochrome P450 metabolites of arachidonic acid in the regulation of tone. Circ Res. 84: 484–488. [PUBMED], [INFOTRIEVE]
- Campbell W B, Harder D R.. 2001. Prologue: EDHF—what is it?. Am J Physiol Heart Circ Physiol. 280: H2413–H2416. [PUBMED], [INFOTRIEVE]
- Camper-Kirby D, Welch S, Walker A, Shiraishi I, Setchell K D, Schaefer E, Kajstura J, Anversa P, Sussman M A.. 2001. Myocardial Akt activation and gender: Increased nuclear activity in females versus males. Circ Res. 88: 1020–1027. [PUBMED], [INFOTRIEVE]
- Campisi R, Nathan L, Pampaloni M H, Schoder H, Sayre J W, Chaudhuri G, Schelbert H R.. 2002. Noninvasive assessment of coronary microcirculatory function in postmenopausal women and effects of short-term and long-term estrogen administration. Circulation. 105: 425–430. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Carroll J D, Carroll E P, Feldman T, Ward D M, Lang R M, McGaughey D, Karp R B.. 1992. Sex-associated differences in left ventricular function in aortic stenosis of the elderly. Circulation. 86: 1099–1107. [PUBMED], [INFOTRIEVE]
- Caulin-Glaser T, Garcia-Cardena G, Sarrel P, Sessa W C, Bender J R.. 1997. 17 beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization. Circ Res. 81: 885–892. [PUBMED], [INFOTRIEVE]
- Caulin-Glaser T, Watson C A, Pardi R, Bender J R.. 1996. Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression. J Clin Invest. 98: 36–42. [PUBMED], [INFOTRIEVE]
- Chambliss K L, Yuhanna I S, Anderson R G, Mendelsohn M E, Shaul P W.. 2002. ERbeta has nongenomic action in caveolae. Mol Endocrinol. 16: 938–946. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Chambliss K L, Yuhanna I S, Mineo C, Liu P, German Z, Sherman T S, Mendelsohn M E, Anderson R G, Shaul P W.. 2000. Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae. Circ Res. 87: E44–E52. [PUBMED], [INFOTRIEVE]
- Chan H Y, Yao X, Tsang S Y, Bourreau J P, Chan F L, Huang Y.. 2002. Isoproterenol amplifies 17 beta-estradiol-mediated vasorelaxation: Role of endothelium/nitric oxide and cyclic AMP. Cardiovasc Res. 53: 627–633. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Chang W C, Nakao J, Orimo H, Murota S.. 1980. Stimulation of prostacyclin biosynthetic activity by estradiol in rat aortic smooth muscle cells in culture. Biochim Biophys Acta. 619: 107–118. [PUBMED], [INFOTRIEVE]
- Chen L, Haught W H, Yang B, Saldeen T G, Parathasarathy S, Mehta J L.. 1997. Preservation of endogenous antioxidant activity and inhibition of lipid peroxidation as common mechanisms of antiatherosclerotic effects of vitamin E, lovastatin and amlodipine. J Am Coll Cardiol. 30: 569–575. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Chen S J, Li H, Durand J, Oparil S, Chen Y F.. 1996. Estrogen reduces myointimal proliferation after balloon injury of rat carotid artery. Circulation. 93: 577–584. [PUBMED], [INFOTRIEVE]
- Chen Y F, Meng Q C.. 1991. Sexual dimorphism of blood pressure in spontaneously hypertensive rats is androgen dependent. Life Sci. 48: 85–96. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Chen Z, Yuhanna I S, Galcheva-Gargova Z, Karas R H, Mendelsohn M E, Shaul P W.. 1999. Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen. J Clin Invest. 103: 401–406. [PUBMED], [INFOTRIEVE]
- Christ M, Wehling M.. 1998. Cardiovascular steroid actions: Swift swallows or sluggish snails?. Cardiovasc Res. 40: 34–44. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Clarkson T B.. 1998. Effects of estrogens, progestins, and androgens on coronary vasomotion and atherosclerosis. J Reprod Med. 43: 741–745. [PUBMED], [INFOTRIEVE]
- Coats P, Johnston F, MacDonald J, McMurray J J, Hillier C.. 2001. Endothelium-derived hyperpolarizing factor: Identification and mechanisms of action in human subcutaneous resistance arteries. Circulation. 103: 1702–1708. [PUBMED], [INFOTRIEVE]
- Collins P, Rosano G M, Jiang C, Lindsay D, Sarrel P M, Poole-Wilson P A.. 1993. Cardiovascular protection by oestrogen—a calcium antagonist effect?. Lancet. 341: 1264–1265. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Corriu C, Feletou M, Canet E, Vanhoutte P M.. 1996. Inhibitors of the cytochrome P450-mono-oxygenase and endothelium-dependent hyperpolarizations in the guinea-pig isolated carotid artery. Br J Pharmacol. 117: 607–610. [PUBMED], [INFOTRIEVE]
- Couse J F, Curtis S W, Washburn T F, Lindzey J, Golding T S, Lubahn D B, Smithies O, Korach K S.. 1995. Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene. Mol Endocrinol. 9: 1441–1454. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Crews J K, Khalil R A.. 1999. Antagonistic effects of 17 beta-estradiol, progesterone, and testosterone on Ca2+ entry mechanisms of coronary vasoconstriction. Arterioscler Thromb Vasc Biol. 19: 1034–1040. [PUBMED], [INFOTRIEVE]
- Crofton J T, Ota M, Share L.. 1993. Role of vasopressin, the renin-angiotensin system and sex in Dahl salt-sensitive hypertension. J Hypertens. 11: 1031–1038. [PUBMED], [INFOTRIEVE]
- Crofton J T, Share L.. 1997. Gonadal hormones modulate deoxycorticosterone-salt hypertension in male and female rats. Hypertension. 29: 494–499. [PUBMED], [INFOTRIEVE]
- Dantas A P, Scivoletto R, Fortes Z B, Nigro D, Carvalho M H.. 1999. Influence of female sex hormones on endothelium-derived vasoconstrictor prostanoid generation in microvessels of spontaneously hypertensive rats. Hypertension. 34: 914–919. [PUBMED], [INFOTRIEVE]
- Darkow D J, Lu L, White R E.. 1997. Estrogen relaxation of coronary artery smooth muscle is mediated by nitric oxide and cGMP. Am J Physiol. 272: H2765–H2773. [PUBMED], [INFOTRIEVE]
- Davidge S T, Zhang Y.. 1998. Estrogen replacement suppresses a prostaglandin H synthase-dependent vasoconstrictor in rat mesenteric arteries. Circ Res. 83: 388–395. [PUBMED], [INFOTRIEVE]
- Deenadayalu V P, White R E, Stallone J N, Gao X, Garcia A J.. 2001. Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel. Am J Physiol Heart Circ Physiol. 281: H1720–H1727. [PUBMED], [INFOTRIEVE]
- Dimmeler S, Assmus B, Hermann C, Haendeler J, Zeiher A M.. 1998. Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: Involvement in suppression of apoptosis. Circ Res. 83: 334–341. [PUBMED], [INFOTRIEVE]
- Dimmeler S, Zeiher A M.. 2000. Akt takes center stage in angiogenesis signaling. Circ Res. 86: 4–5. [PUBMED], [INFOTRIEVE]
- Ding A Q, Stallone J N.. 2001. Testosterone-induced relaxation of rat aorta is androgen structure specific and involves K+ channel activation. J Appl Physiol. 91: 2742–2750. [PUBMED], [INFOTRIEVE]
- Dube S, Canty J M, Jr.. 2001. Shear stress-induced vasodilation in porcine coronary conduit arteries is independent of nitric oxide release. Am J Physiol Heart Circ Physiol. 280: H2581–H2590. [PUBMED], [INFOTRIEVE]
- Dubey R K, Gillespie D G, Mi Z, Rosselli M, Keller P J, Jackson E K.. 2000. Estradiol inhibits smooth muscle cell growth in part by activating the cAMP-adenosine pathway. Hypertension. 35: 262–266. [PUBMED], [INFOTRIEVE]
- Dubey R K, Jackson E K.. 2001. Cardiovascular protective effects of 17beta-estradiol metabolites. J Appl Physiol. 91: 1868–1983. [PUBMED], [INFOTRIEVE]
- Dubey R K, Jackson E K.. 2001. Estrogen-induced cardiorenal protection: Potential cellular, biochemical, and molecular mechanisms. Am J Physiol Renal Physiol. 280: F365–F388. [PUBMED], [INFOTRIEVE]
- Dubey R K, Jackson E K, Keller P J, Imthurn B, Rosselli M.. 2001. Estradiol metabolites inhibit endothelin synthesis by an estrogen receptor-independent mechanism. Hypertension. 37: 640–644. [PUBMED], [INFOTRIEVE]
- Dubey R K, Tyurina Y Y, Tyurin V A, Gillespie D G, Branch R A, Jackson E K, Kagan V E.. 1999. Estrogen and tamoxifen metabolites protect smooth muscle cell membrane phospholipids against peroxidation and inhibit cell growth. Circ Res. 84: 229–239. [PUBMED], [INFOTRIEVE]
- Dupont S, Krust A, Gansmuller A, Dierich A, Chambon P, Mark M.. 2000. Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development. 127: 4277–4291. [PUBMED], [INFOTRIEVE]
- Duran M G, Galvez G G, De, Frutos T, Diaz R J, Casado S, Lopez F A.. 2000. 17Beta-estradiol-stimulated nitric oxide production by neutrophils: Effect on platelet activation. Obstet Gynecol. 95: 284–290. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Edwards G, Dora K A, Gardener M J, Garland C J, Weston A H.. 1998. K+ is an endothelium-derived hyperpolarizing factor in rat arteries. Nature. 396: 269–272. [PUBMED], [INFOTRIEVE], [CROSSREF]
- Evans M J, Eckert A, Lai K, Adelman S J, Harnish D C.. 2001. Reciprocal antagonism between estrogen receptor and NF-kappaB activity in vivo. Circ Res. 89: 823–830. [PUBMED], [INFOTRIEVE]
- Falkenstein E, Tillmann H C, Christ M, Feuring M, Wehling M.. 2000. Multiple actions of steroid hormones—a focus on rapid, nongenomic effects. Pharmacol Rev. 52: 513–556. [PUBMED], [INFOTRIEVE]
- Farhat M Y, Abi-Younes S, Dingaan B, Vargas R, Ramwell P W.. 1996. Estradiol increases cyclic adenosine monophosphate in rat pulmonary vascular smooth muscle cells by a nongenomic mechanism. J Pharmacol Exp Ther. 276: 652–657. [PUBMED], [INFOTRIEVE]
- Feletou M, Vanhoutte P M.. 1999. The alternative: EDHF. J Mol Cell Cardiol. 31: 15–22. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Fimiani C, Magazine H, Welters I D, Bilfinger T V, Salsano F, Tonnesen E, Stefano G B.. 2000. Antagonism of LPS and IFN-gamma induced iNOS expression in human atrial endothelia by morphine, anandamide, and estrogen. Acta Pharmacol Sin. 21: 405–409. [PUBMED], [INFOTRIEVE]
- Fisslthaler B, Popp R, Kiss L, Potente M, Harder D R, Fleming I, Busse R.. 1999. Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature. 401: 493–497. [PUBMED], [INFOTRIEVE], [CROSSREF]
- Fleming I, Schermer B, Popp R, Busse R.. 1999. Inhibition of the production of endothelium-derived hyperpolarizing factor by cannabinoid receptor agonists. Br J Pharmacol. 126: 949–960. [PUBMED], [INFOTRIEVE]
- Fraser H, Davidge S T, Clanachan A S.. 2000. Activation of Ca(2+)-independent nitric oxide synthase by 17beta-estradiol in post-ischemic rat heart. Cardiovasc Res. 46: 111–118. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Fujio Y, Guo K, Mano T, Mitsuuchi Y, Testa J R, Walsh K.. 1999. Cell cycle withdrawal promotes myogenic induction of Akt, a positive modulator of myocyte survival. Mol Cell Biol. 19: 5073–5082. [PUBMED], [INFOTRIEVE]
- Fujio Y, Nguyen T, Wencker D, Kitsis R N, Walsh K.. 2000. Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation. 101: 660–667. [PUBMED], [INFOTRIEVE]
- Fulton D, Gratton J P, McCabe T J, Fontana J, Fujio Y, Walsh K, Franke T F, Papapetropoulos A, Sessa W C.. 1999. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. 399: 597–601. [PUBMED], [INFOTRIEVE], [CROSSREF]
- Fulton D, McGiff J C, Quilley J.. 1992. Contribution of NO and cytochrome P450 to the vasodilator effect of bradykinin in the rat kidney. Br J Pharmacol. 107: 722–725. [PUBMED], [INFOTRIEVE]
- Gafter U, Ben, Bassat M, Levi J.. 1990. Castration inhibits glomerular hypertrophy and proteinuria in uninephrectomized male rats. Eur J Clin Invest. 20: 360–365. [PUBMED], [INFOTRIEVE]
- Gallagher P E, Li P, Lenhart J R, Chappell M C, Brosnihan K B.. 1999. Estrogen regulation of angiotensin-converting enzyme mRNA. Hypertension. 33: 323–328. [PUBMED], [INFOTRIEVE]
- Ganten U, Schroder G, Witt M, Zimmermann F, Ganten D, Stock G.. 1989. Sexual dimorphism of blood pressure in spontaneously hypertensive rats: Effects of anti-androgen treatment. J Hypertens. 7: 721–726. [PUBMED], [INFOTRIEVE]
- Garcia-Cardena G, Fan R, Shah V, Sorrentino R, Cirino G, Papapetropoulos A, Sessa W C.. 1998. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature. 392: 821–824. [PUBMED], [INFOTRIEVE], [CROSSREF]
- Garcia-Cardena G, Oh P, Liu J, Schnitzer J E, Sessa W C.. 1996. Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: Implications for nitric oxide signaling. Proc Natl Acad Sci USA. 93: 6448–6453. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Garcia-Duran M, De, Frutos T, Diaz-Recasens J, Garcia-Galvez G, Jimenez A, Monton M, Farre J, Sanchez dM, Gonzalez-Fernandez F, Arriero M D, Rico L, Garcia R, Casado S, Lopez-Farre A.. 1999. Estrogen stimulates neuronal nitric oxide synthase protein expression in human neutrophils. Circ Res. 85: 1020–1026. [PUBMED], [INFOTRIEVE]
- Ge T, Hughes H, Junquero D C, Wu K K, Vanhoutte P M, Boulanger C M.. 1995. Endothelium-dependent contractions are associated with both augmented expression of prostaglandin H synthase-1 and hypersensitivity to prostaglandin H2 in the SHR aorta. Circ Res. 76: 1003–1010. [PUBMED], [INFOTRIEVE]
- Geary G G, Krause D N, Duckles S P.. 1998. Estrogen reduces myogenic tone through a nitric oxide-dependent mechanism in rat cerebral arteries. Am J Physiol. 275: H292–H300. [PUBMED], [INFOTRIEVE]
- Geary G G, Krause D N, Duckles S P.. 2000. Gonadal hormones affect diameter of male rat cerebral arteries through endothelium-dependent mechanisms. Am J Physiol Heart Circ Physiol. 279: H610–H618. [PUBMED], [INFOTRIEVE]
- Geary G G, McNeill A M, Ospina J A, Krause D N, Korach K S, Duckles S P.. 2001. Selected contribution: Cerebrovascular NOS and cyclooxygenase are unaffected by estrogen in mice lacking estrogen receptor-alpha. J Appl Physiol. 91: 2391–2399. [PUBMED], [INFOTRIEVE]
- Gerber H P, McMurtrey A, Kowalski J, Yan M, Keyt B A, Dixit V, Ferrara N.. 1998. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway: Requirement for Flk-1/KDR activation. J Biol Chem. 273: 30336–30343. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Gerber R T, Anwar M A, Poston L.. 1998. Enhanced acetylcholine induced relaxation in small mesenteric arteries from pregnant rats: An important role for endothelium-derived hyperpolarizing factor (EDHF). Br J Pharmacol. 125: 455–460. [PUBMED], [INFOTRIEVE]
- Gerhard M, Walsh B W, Tawakol A, Haley E A, Creager S J, Seely E W, Ganz P, Creager M A.. 1998. Estradiol therapy combined with progesterone and endothelium-dependent vasodilation in postmenopausal women. Circulation. 98: 1158–1163. [PUBMED], [INFOTRIEVE]
- Ghanam K, Javellaud J, Ea-Kim L, Oudart N.. 1998. The protective effect of 17 beta-estradiol on vasomotor responses of aorta from cholesterol-fed rabbit is reduced by inhibitors of superoxide dismutase and catalase. Biochem Biophys Res Commun. 249: 858–864. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Ghanam K, Lavagna C, Burgaud J L, Javellaud J, Ea-Kim L, Oudart N.. 2000. Involvement of cyclooxygenase 2 in the protective effect of 17beta-estradiol on hypercholesterolemic rabbit aorta. Biochem Biophys Res Commun. 275: 696–703. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Gilligan D M, Badar D M, Panza J A, Quyyumi A A, Cannon R O, III. 1994. Acute vascular effects of estrogen in postmenopausal women. Circulation. 90: 786–791. [PUBMED], [INFOTRIEVE]
- Go Y M, Boo Y C, Park H, Maland M C, Patel R, Pritchard K A, Jr., Fujio Y, Walsh K, Darley-Usmar V, Jo H.. 2001. Protein kinase B/Akt activates c-Jun NH(2)-terminal kinase by increasing NO production in response to shear stress. J Appl Physiol. 91: 1574–1581. [PUBMED], [INFOTRIEVE]
- Go Y M, Levonen A L, Moellering D, Ramachandran A, Patel R P, Jo H, Darley-Usmar V M.. 2001. Endothelial NOS-dependent activation of c-Jun NH(2)- terminal kinase by oxidized low-density lipoprotein. Am J Physiol Heart Circ Physiol. 281: H2705–H2713. [PUBMED], [INFOTRIEVE]
- Goetz R M, Thatte H S, Prabhakar P, Cho M R, Michel T, Golan D E.. 1999. Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase. Proc Natl Acad Sci USA. 96: 2788–2793. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Golding E M, Kepler T E.. 2001. Role of estrogen in modulating EDHF-mediated dilations in the female rat middle cerebral artery. Am J Physiol Heart Circ Physiol. 280: H2417–H2423. [PUBMED], [INFOTRIEVE]
- Grady D, Hulley S B.. 2000. Hormones to prevent coronary disease in women: When are observational studies adequate evidence?. Ann Intern Med. 133: 999–1001. [PUBMED], [INFOTRIEVE]
- Grady D, Rubin S M, Petitti D B, Fox C S, Black D, Ettinger B, Ernster V L, Cummings S R.. 1992. Hormone therapy to prevent disease and prolong life in postmenopausal women. Ann Intern Med. 117: 1016–1037. [PUBMED], [INFOTRIEVE]
- Grodstein F, Manson J E, Colditz G A, Willett W C, Speizer F E, Stampfer M J.. 2000. A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease. Ann Intern Med. 133: 933–941. [PUBMED], [INFOTRIEVE]
- Grodstein F, Stampfer M J, Colditz G A, Willett W C, Manson J E, Joffe M, Rosner B, Fuchs C, Hankinson S E, Hunter D J, Hennekens C H, Speizer F E.. 1997. Postmenopausal hormone therapy and mortality. N Engl J Med. 336: 1769–1775. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Grodstein F, Stampfer M J, Manson J E, Colditz G A, Willett W C, Rosner B, Speizer F E, Hennekens C H.. 1996. Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med. 335: 453–461. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Guerra S, Leri A, Wang X, Finato N, Di, Loreto C, Beltrami C A, Kajstura J, Anversa P.. 1999. Myocyte death in the failing human heart is gender dependent. Circ Res. 85: 856–866. [PUBMED], [INFOTRIEVE]
- Guo S, Rena G, Cichy S, He X, Cohen P, Unterman T.. 1999. Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. J Biol Chem. 274: 17184–17192. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Gura T.. 1995. Estrogen: Key player in heart disease among women. Science. 269: 771–773. [PUBMED], [INFOTRIEVE]
- Halcox J P, Narayanan S, Cramer-Joyce L, Mincemoyer R, Quyyumi A A.. 2001. Characterization of endothelium-derived hyperpolarizing factor in the human forearm microcirculation. Am J Physiol Heart Circ Physiol. 280: H2470–H2477. [PUBMED], [INFOTRIEVE]
- Hall J E, Mizelle H L, Hildebrandt D A, Brands M W.. 1990. Abnormal pressure natriuresis: A cause or a consequence of hypertension?. Hypertension. 15: 547–559. [PUBMED], [INFOTRIEVE]
- Hanke H, Lenz C, Hess B, Spindler K D, Weidemann W.. 2001. Effect of testosterone on plaque development and androgen receptor expression in the arterial vessel wall. Circulation. 103: 1382–1385. [PUBMED], [INFOTRIEVE]
- Haq S, Choukroun G, Lim H, Tymitz K M, del, Monte F, Gwathmey J, Grazette L, Michael A, Hajjar R, Force T, Molkentin J D.. 2001. Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure. Circulation. 103: 670–677. [PUBMED], [INFOTRIEVE]
- Harder D R, Campbell W B, Roman R J.. 1995. Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone. J Vasc Res. 32: 79–92. [PUBMED], [INFOTRIEVE]
- Harshfield G A, Alpert B S, Pulliam D A, Somes G W, Wilson D K.. 1994. Ambulatory blood pressure recordings in children and adolescents. Pediatrics. 94: 180–184. [PUBMED], [INFOTRIEVE]
- Hayashi K, Miyamoto A, Berisha B, Kosmann M R, Okuda K, Schams D.. 2000. Regulation of angiotensin II production and angiotensin receptors in microvascular endothelial cells from bovine corpus luteum. Biol Reprod. 62: 162–167. [PUBMED], [INFOTRIEVE]
- Hayashi T, Yamada K, Esaki T, Muto E, Chaudhuri G, Iguchi A.. 1998. Physiological concentrations of 17beta-estradiol inhibit the synthesis of nitric oxide synthase in macrophages via a receptor-mediated system. J Cardiovasc Pharmacol. 31: 292–298. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Haynes M P, Sinha D, Russell K S, Collinge M, Fulton D, Morales-Ruiz M, Sessa W C, Bender J R.. 2000. Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells. Circ Res. 87: 677–682. [PUBMED], [INFOTRIEVE]
- Heckbert S R, Weiss N S, Psaty B M.. 1999. Hormone replacement therapy for secondary prevention of coronary heart disease. JAMA. 281: 795–796. [PUBMED], [INFOTRIEVE]
- Hecker M.. 2000. Endothelium-derived hyperpolarizing factor-fact or fiction?. News Physiol Sci. 15: 1–5. [PUBMED], [INFOTRIEVE]
- Henrion D, Dechaux E, Dowell F J, Maclour J, Samuel J L, Levy B I, Michel J B.. 1997. Alteration of flow-induced dilatation in mesenteric resistance arteries of L-NAME treated rats and its partial association with induction of cyclo-oxygenase-2. Br J Pharmacol. 121: 83–90. [PUBMED], [INFOTRIEVE]
- Hisamoto K, Ohmichi M, Kurachi H, Hayakawa J, Kanda Y, Nishio Y, Adachi K, Tasaka K, Miyoshi E, Fujiwara N, Taniguchi N, Murata Y.. 2001. Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells. J Biol Chem. 276: 3459–3467. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Hodges Y K, Tung L, Yan X D, Graham J D, Horwitz K B, Horwitz L D.. 2000. Estrogen receptors alpha and beta: Prevalence of estrogen receptor beta mRNA in human vascular smooth muscle and transcriptional effects. Circulation. 101: 1792–1798. [PUBMED], [INFOTRIEVE]
- Hodgin J B, Krege J H, Reddick R L, Korach K S, Smithies O, Maeda N.. 2001. Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/-mice. J Clin Invest. 107: 333–340. [PUBMED], [INFOTRIEVE]
- Huang A, Koller A.. 1996. Both nitric oxide and prostaglandin-mediated responses are impaired in skeletal muscle arterioles of hypertensive rats. J Hypertens. 14: 887–895. [PUBMED], [INFOTRIEVE]
- Huang A, Koller A.. 1997. Endothelin and prostaglandin H2 enhance arteriolar myogenic tone in hypertension. Hypertension. 30: 1210–1215. [PUBMED], [INFOTRIEVE]
- Huang A, Sun D, Carroll M A, Jiang H, Smith C J, Connetta J A, Falck J R, Shesely E G, Koller A, Kaley G.. 2001. EDHF mediates flow-induced dilation in skeletal muscle arterioles of female eNOS-KO mice. Am J Physiol Heart Circ Physiol. 280: H2462–H2469. [PUBMED], [INFOTRIEVE]
- Huang A, Sun D, Kaley G, Koller A.. 1997. Estrogen maintains nitric oxide synthesis in arterioles of female hypertensive rats. Hypertension. 29: 1351–1356. [PUBMED], [INFOTRIEVE]
- Huang A, Sun D, Kaley G, Koller A.. 1998. Estrogen preserves regulation of shear stress by nitric oxide in arterioles of female hypertensive rats. Hypertension. 31: 309–314. [PUBMED], [INFOTRIEVE]
- Huang A, Sun D, Koller A.. 1993. Endothelial dysfunction augments myogenic arteriolar constriction in hypertension. Hypertension. 22: 913–921. [PUBMED], [INFOTRIEVE]
- Huang A, Sun D, Koller A, Kaley G.. 1997. Gender difference in myogenic tone of rat arterioles is due to estrogen-induced, enhanced release of NO. Am J Physiol. 272: H1804–H1809. [PUBMED], [INFOTRIEVE]
- Huang A, Sun D, Koller A, Kaley G.. 1998. Gender difference in flow-induced dilation and regulation of shear stress: Role of estrogen and nitric oxide. Am J Physiol. 275: R1571–R1577. [PUBMED], [INFOTRIEVE]
- Huang A, Sun D, Koller A, Kaley G.. 2000. 17beta-estradiol restores endothelial nitric oxide release to shear stress in arterioles of male hypertensive rats. Circulation. 101: 94–100. [PUBMED], [INFOTRIEVE]
- Huang A, Sun D, Wu F, Yan C, Carroll M A, Jiang H, Falck J R, Kaley G.. 2003. Estrogen elicits cytochrome P450-mediated flow-induced dilation of arterioles in NO deficiency: Role of PI3K-Akt phosphorylation in genomic regulation. Circ Res, (in press).
- Huang A, Sun D, Smith C J, Connetta J A, Shesely E G, Koller A, Kaley G.. 2000. In eNOS knockout mice skeletal muscle arteriolar dilation to acetylcholine is mediated by EDHF. Am J Physiol Heart Circ Physiol. 278: H762–H768. [PUBMED], [INFOTRIEVE]
- Huang A, Wu Y, Sun D, Koller A, Kaley G.. 2001. Effect of estrogen on flow-induced dilation in NO deficiency: Roles of prostaglandins and EDHF. J Appl Physiol. 91: 2561–2566. [PUBMED], [INFOTRIEVE]
- Huang P L.. 1999. Neuronal and endothelial nitric oxide synthase gene knockout mice. Braz J Med Biol Res. 32: 1353–1359. [PUBMED], [INFOTRIEVE]
- Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinghoff E.. 1998. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA. 280: 605–613. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Iafrati M D, Karas R H, Aronovitz M, Kim S, Sullivan T R, Jr., Lubahn D B, O'Donnell T F, Jr., Korach K S, Mendelsohn M E.. 1997. Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice. Nat Med. 3: 545–548. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Iams S G, Wexler B C.. 1977. Retardation in the development of spontaneous hypertension in SH rats by gonadectomy. J Lab Clin Med. 90: 997–1003. [PUBMED], [INFOTRIEVE]
- Iruela-Arispe M L, Porter P, Bornstein P, Sage E H.. 1996. Thrombospondin-1, an inhibitor of angiogenesis, is regulated by progesterone in the human endometrium. J Clin Invest. 97: 403–412. [PUBMED], [INFOTRIEVE]
- Isles C G, Hole D J, Hawthorne V M, Lever A F.. 1992. Relation between coronary risk and coronary mortality in women of the Renfrew and Paisley survey: Comparison with men. Lancet. 339: 702–706. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Jiang C, Sarrel P M, Poole-Wilson P A, Collins P.. 1992. Acute effect of 17 beta-estradiol on rabbit coronary artery contractile responses to endothelin-1. Am J Physiol. 263: H271–H275. [PUBMED], [INFOTRIEVE]
- Johnson P C.. 1980. The myogenic response. In: Handbook of Physiology: The Cardiovascular System: Vascular Smooth Muscle. Am. Physiol. Soc.. Bethesda, MD, 409–442
- Jun S S, Chen Z, Pace M C, Shaul P W.. 1998. Estrogen upregulates cyclooxygenase-1 gene expression in ovine fetal pulmonary artery endothelium. J Clin Invest. 102: 176–183. [PUBMED], [INFOTRIEVE]
- Karas R H, Hodgin J B, Kwoun M, Krege J H, Aronovitz M, Mackey W, Gustafsson J A, Korach K S, Smithies O, Mendelsohn M E.. 1999. Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice. Proc Natl Acad Sci USA. 96: 15133–15136. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Karas R H, Schulten H, Pare G, Aronovitz M J, Ohlsson C, Gustafsson J A, Mendelsohn M E.. 2001. Effects of estrogen on the vascular injury response in estrogen receptor alpha, beta (double) knockout mice. Circ Res. 89: 534–539. [PUBMED], [INFOTRIEVE]
- Karas R H, van, Eickels M, Lydon J P, Roddy S, Kwoun M, Aronovitz M, Baur W E, Conneely O, O'Malley B W, Mendelsohn M E.. 2001. A complex role for the progesterone receptor in the response to vascular injury. J Clin Invest. 108: 611–618. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Kauser K, Rubanyi G M.. 1997. Potential cellular signaling mechanisms mediating upregulation of endothelial nitric oxide production by estrogen. J Vasc Res. 34: 229–236. [PUBMED], [INFOTRIEVE]
- Kauser K, Sonnenberg D, Tse J, Rubanyi G M.. 1997. 17 beta-estradiol attenuates endotoxin-induced excessive nitric oxide production in ovariectomized rats in vivo. Am J Physiol. 273: H506–H509. [PUBMED], [INFOTRIEVE]
- Kelly M J, Wagner E J.. 1999. Estrogen modulation of G-protein-coupled receptors. Trends Endocrinol Metab. 10: 369–374. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Khatsenko O G, Gross S S, Rifkind A B, Vane J R.. 1993. Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants. Proc Natl Acad Sci USA. 90: 11147–11151. [PUBMED], [INFOTRIEVE]
- Khaw K T, Barrett-Connor E.. 1988. Blood pressure and endogenous testosterone in men: An inverse relationship. J Hypertens. 6: 329–332. [PUBMED], [INFOTRIEVE]
- Kim H P, Lee J Y, Jeong J K, Bae S W, Lee H K, Jo I.. 1999. Nongenomic stimulation of nitric oxide release by estrogen is mediated by estrogen receptor alpha localized in caveolae. Biochem Biophys Res Commun. 263: 257–262. [PUBMED], [INFOTRIEVE], [CROSSREF]
- Koller A.. 2002. Signaling pathways of mechanotransduction in arteriolar endothelium and smooth muscle cells in hypertension. Microcirculation. 9: 277–294. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Koller A, Kaley G.. 1990. Endothelium regulates skeletal muscle microcirculation by a blood flow velocity-sensing mechanism. Am J Physiol. 258: H916–H920. [PUBMED], [INFOTRIEVE]
- Koller A, Sun D, Huang A, Kaley G.. 1994. Corelease of nitric oxide and prostaglandins mediates flow-dependent dilation of rat gracilis muscle arterioles. Am J Physiol. 267: H326–H332. [PUBMED], [INFOTRIEVE]
- Krumholz H M, Larson M, Levy D.. 1993. Sex differences in cardiac adaptation to isolated systolic hypertension. Am J Cardiol. 72: 310–313. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Kuiper G G, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson J A.. 1996. Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA. 93: 5925–5930. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Kuiper G G, Lemmen J G, Carlsson B, Corton J C, Safe S H, van der, Saag P T, van der, B B, Gustafsson J A.. 1998. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology. 139: 4252–4263. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Kuo L, Chilian W M, Davis M J.. 1991. Interaction of pressure- and flow-induced responses in porcine coronary resistance vessels. Am J Physiol. 261: H1706–H1715. [PUBMED], [INFOTRIEVE]
- Lantin-Hermoso R L, Rosenfeld C R, Yuhanna I S, German Z, Chen Z, Shaul P W.. 1997. Estrogen acutely stimulates nitric oxide synthase activity in fetal pulmonary artery endothelium. Am J Physiol. 273: L119–L126. [PUBMED], [INFOTRIEVE]
- Levine R L, Chen S J, Durand J, Chen Y F, Oparil S.. 1996. Medroxyprogesterone attenuates estrogen-mediated inhibition of neointima formation after balloon injury of the rat carotid artery. Circulation. 94: 2221–2227. [PUBMED], [INFOTRIEVE]
- Levy D, Kannel W B.. 1988. Cardiovascular risks: New insights from Framingham. Am Heart J. 116: 266–272. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Li Q, Li B, Wang X, Leri A, Jana K P, Liu Y, Kajstura J, Baserga R, Anversa P.. 1997. Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest. 100: 1991–1999. [PUBMED], [INFOTRIEVE]
- Lim-Tio S S, Keightley M C, Fuller P J.. 1997. Determinants of specificity of transactivation by the mineralocorticoid or glucocorticoid receptor. Endocrinology. 138: 2537–2543. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Lindner V, Kim S K, Karas R H, Kuiper G G, Gustafsson J A, Mendelsohn M E.. 1998. Increased expression of estrogen receptor-beta mRNA in male blood vessels after vascular injury. Circ Res. 83: 224–229. [PUBMED], [INFOTRIEVE]
- Liu M Y, Hattori Y, Fukao M, Sato A, Sakuma I, Kanno M.. 2001. Alterations in EDHF-mediated hyperpolarization and relaxation in mesenteric arteries of female rats in long-term deficiency of oestrogen and during oestrus cycle. Br J Pharmacol. 132: 1035–1046. [PUBMED], [INFOTRIEVE]
- London B.. 2001. Taking the gender gap to heart. Circ Res. 89: 378–379. [PUBMED], [INFOTRIEVE]
- Lottering M L, Haag M, Seegers J C.. 1992. Effects of 17 beta-estradiol metabolites on cell cycle events in MCF-7 cells. Cancer Res. 52: 5926–5932. [PUBMED], [INFOTRIEVE]
- Luscher T F, Vanhoutte P M.. 1986. Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Hypertension. 8: 344–348. [PUBMED], [INFOTRIEVE]
- Machelon V, Nome F, Grosse B, Lieberherr M.. 1996. Progesterone triggers rapid transmembrane calcium influx and/or calcium mobilization from endoplasmic reticulum, via a pertussis-insensitive G-protein in granulosa cells in relation to luteinization process. J Cell Biochem. 61: 619–628. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Makela S, Savolainen H, Aavik E, Myllarniemi M, Strauss L, Taskinen E, Gustafsson J A, Hayry P.. 1999. Differentiation between vasculoprotective and uterotrophic effects of ligands with different binding affinities to estrogen receptors alpha and beta. Proc Natl Acad Sci USA. 96: 7077–7082. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Malyusz M, Ehrens H J, Wrigge P.. 1985. Effect of castration on the experimental renal hypertension of the rat: Blood pressure, nephrosclerosis, long-chain fatty acids, and N-acetylation of PAH in the kidney. Nephron. 40: 96–99. [PUBMED], [INFOTRIEVE]
- Manson J E, Martin K A.. 2001. Clinical practice: Postmenopausal hormone-replacement therapy. N Engl J Med. 345: 34–40. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Markaverich B M, Roberts R R, Alejandro M A, Johnson G A, Middleditch B S, Clark J H.. 1988. Bioflavonoid interaction with rat uterine type II binding sites and cell growth inhibition. J Steroid Biochem. 30: 71–78. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Markides C S, Roy D, Liehr J G.. 1998. Concentration dependence of prooxidant and antioxidant properties of catecholestrogens. Arch Biochem Biophys. 360: 105–112. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Martucci C P, Fishman J.. 1993. P450 enzymes of estrogen metabolism. Pharmacol Ther. 57: 237–257. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Masubuchi Y, Kumai T, Uematsu A, Komoriyama K, Hirai M.. 1982. Gonadectomy-induced reduction of blood pressure in adult spontaneously hypertensive rats. Acta Endocrinol (Copenh). 101: 154–160
- Matoba T, Shimokawa H, Nakashima M, Hirakawa Y, Mukai Y, Hirano K, Kanaide H, Takeshita A.. 2000. Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice. J Clin Invest. 106: 1521–1530. [PUBMED], [INFOTRIEVE]
- Matsui T, Li L, del M, Fukui Y, Franke T F, Hajjar R J, Rosenzweig A.. 1999. Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation. 100: 2373–2379. [PUBMED], [INFOTRIEVE]
- McCabe T J, Fulton D, Roman L J, Sessa W C.. 2000. Enhanced electron flux and reduced calmodulin dissociation may explain “calcium-independent” eNOS activation by phosphorylation. J Biol Chem. 275: 6123–6128. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- McConnaughey M M, Iams S G.. 1993. Sex hormones change adrenoceptors in blood vessels of the spontaneously hypertensive rat. Clin Exp Hypertens. 15: 153–170. [PUBMED], [INFOTRIEVE]
- McCulloch A I, Randall M D.. 1998. Sex differences in the relative contributions of nitric oxide and EDHF to agonist-stimulated endothelium-dependent relaxations in the rat isolated mesenteric arterial bed. Br J Pharmacol. 123: 1700–1706. [PUBMED], [INFOTRIEVE]
- Meier R, Alessi D R, Cron P, Andjelkovic M, Hemmings B A.. 1997. Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta. J Biol Chem. 272: 30491–30497. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Mendelsohn M E, Karas R H.. 1999. The protective effects of estrogen on the cardiovascular system. N Engl J Med. 340: 1801–1811. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Mercuro G, Pitzalis L, Podda A, Zoncu S, Pilia I, Melis G B, Cherchi A.. 1999. Effects of acute administration of natural progesterone on peripheral vascular responsiveness in healthy postmenopausal women. Am J Cardiol. 84: 214–218. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Mershon J L, Baker R S, Clark K E.. 2002. Estrogen increases iNOS expression in the ovine coronary artery. Am J Physiol Heart Circ Physiol. 283: H1169–H1180. [PUBMED], [INFOTRIEVE]
- Messerli F H, Garavaglia G E, Schmieder R E, Sundgaard-Riise K, Nunez B D, Amodeo C.. 1987. Disparate cardiovascular findings in men and women with essential hypertension. Ann Intern Med. 107: 158–161. [PUBMED], [INFOTRIEVE]
- Meyer M C, Cummings K, Osol G.. 1997. Estrogen replacement attenuates resistance artery adrenergic sensitivity via endothelial vasodilators. Am J Physiol. 272: H2264–H2270. [PUBMED], [INFOTRIEVE]
- Migliaccio A, Castoria G, Di, Domenico M, De, Falco A, Bilancio A, Lombardi M, Barone M V, Ametrano D, Zannini M S, Abbondanza C, Auricchio F.. 2000. Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation. EMBO J. 19: 5406–5417. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Mikkola T, Viinikka L, Ylikorkala O.. 2000. Administration of transdermal estrogen without progestin increases the capacity of plasma and serum to stimulate prostacyclin production in human vascular endothelial cells. Fertil Steril. 73: 72–74. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Minshall R D, Pavcnik D, Browne D L, Hermsmeyer K.. 2002. Nongenomic vasodilator action of progesterone on primate coronary arteries. J Appl Physiol. 92: 701–708. [PUBMED], [INFOTRIEVE]
- Miura H, Gutterman D D.. 1998. Human coronary arteriolar dilation to arachidonic acid depends on cytochrome P-450 monooxygenase and Ca2+-activated K+ channels. Circ Res. 83: 501–507. [PUBMED], [INFOTRIEVE]
- Miura H, Liu Y, Gutterman D D.. 1999. Human coronary arteriolar dilation to bradykinin depends on membrane hyperpolarization: Contribution of nitric oxide and Ca2+-activated K+ channels. Circulation. 99: 3132–3138. [PUBMED], [INFOTRIEVE]
- Miura H, Wachtel R E, Liu Y, Loberiza F R, Jr., Saito T, Miura M, Gutterman D D.. 2001. Flow-induced dilation of human coronary arterioles: Important role of Ca(2+)-activated K(+) channels. Circulation. 103: 1992–1998. [PUBMED], [INFOTRIEVE]
- Morey A K, Pedram A, Razandi M, Prins B A, Hu R M, Biesiada E, Levin E R.. 1997. Estrogen and progesterone inhibit vascular smooth muscle proliferation. Endocrinology. 138: 3330–3339. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Morey A K, Razandi M, Pedram A, Hu R M, Prins B A, Levin E R.. 1998. Oestrogen and progesterone inhibit the stimulated production of endothelin-1. Biochem J. 330(Pt 3)1097–1105. [PUBMED], [INFOTRIEVE]
- Morisset S, Patry C, Lora M, Brum-Fernandes A J.. 1998. Regulation of cyclooxygenase-2 expression in bovine chondrocytes in culture by interleukin 1alpha, tumor necrosis factor-alpha, glucocorticoids, and 17beta-estradiol. J Rheumatol. 25: 1146–1153. [PUBMED], [INFOTRIEVE]
- Morley P, Whitfield J F, Vanderhyden B C, Tsang B K, Schwartz J L.. 1992. A new, nongenomic estrogen action: The rapid release of intracellular calcium. Endocrinology. 131: 1305–1312. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Moroi M, Zhang L, Yasuda T, Virmani R, Gold H K, Fishman M C, Huang P L.. 1998. Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice. J Clin Invest. 101: 1225–1232. [PUBMED], [INFOTRIEVE]
- Mugge A, Barton M, Fieguth H G, Riedel M.. 1997. Contractile responses to histamine, serotonin, and angiotensin II are impaired by 17 beta-estradiol in human internal mammary arteries in vitro. Pharmacology. 54: 162–168. [PUBMED], [INFOTRIEVE]
- Mugge A, Riedel M, Barton M, Kuhn M, Lichtlen P R.. 1993. Endothelium independent relaxation of human coronary arteries by 17 beta-oestradiol in vitro. Cardiovasc Res. 27: 1939–1942. [PUBMED], [INFOTRIEVE]
- Myers S I, Turnage R H, Bartula L, Kalley B, Meng Y.. 1996. Estrogen increases male rat aortic endothelial cell (RAEC) PGI2 release. Prostaglandins Leukot Essent Fatty Acids. 54: 403–409. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Nadal A, Ropero A B, Laribi O, Maillet M, Fuentes E, Soria B.. 2000. Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor alpha and estrogen receptor beta. Proc Natl Acad Sci USA. 97: 11603–11608. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Neugarten J, Medve I, Lei J, Silbiger S R.. 1999. Estradiol suppresses mesangial cell type I collagen synthesis via activation of the MAP kinase cascade. Am J Physiol. 277: F875–F881. [PUBMED], [INFOTRIEVE]
- Nishigaki I, Sasaguri Y, Yagi K.. 1995. Anti-proliferative effect of 2-methoxyestradiol on cultured smooth muscle cells from rabbit aorta. Atherosclerosis. 113: 167–170. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Nishikawa Y, Stepp D W, Chilian W M.. 2000. Nitric oxide exerts feedback inhibition on EDHF-induced coronary arteriolar dilation in vivo. Am J Physiol Heart Circ Physiol. 279: H459–H465. [PUBMED], [INFOTRIEVE]
- Node K, Kitakaze M, Kosaka H, Minamino T, Funaya H, Hori M.. 1997. Amelioration of ischemia- and reperfusion-induced myocardial injury by 17beta-estradiol: Role of nitric oxide and calcium-activated potassium channels. Circulation. 96: 1953–1963. [PUBMED], [INFOTRIEVE]
- Node K, Kitakaze M, Kosaka H, Minamino T, Sato H, Kuzuya T, Hori M.. 1997. Roles of NO and Ca2+-activated K+ channels in coronary vasodilation induced by 17beta-estradiol in ischemic heart failure. FASEB J. 11: 793–799. [PUBMED], [INFOTRIEVE]
- Nordeen S K, Moyer M L, Bona B J.. 1994. The coupling of multiple signal transduction pathways with steroid response mechanisms. Endocrinology. 134: 1723–1732. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Nuedling S, Karas R H, Mendelsohn M E, Katzenellenbogen J A, Katzenellenbogen B S, Meyer R, Vetter H, Grohe C.. 2001. Activation of estrogen receptor beta is a prerequisite for estrogen-dependent upregulation of nitric oxide synthases in neonatal rat cardiac myocytes. FEBS Lett. 502: 103–108. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Ogata R, Inoue Y, Nakano H, Ito Y, Kitamura K.. 1996. Oestradiol-induced relaxation of rabbit basilar artery by inhibition of voltage-dependent Ca channels through GTP-binding protein. Br J Pharmacol. 117: 351–359. [PUBMED], [INFOTRIEVE]
- Ogawa S, Inoue S, Watanabe T, Hiroi H, Orimo A, Hosoi T, Ouchi Y, Muramatsu M.. 1998. The complete primary structure of human estrogen receptor beta (hER beta) and its heterodimerization with ER alpha in vivo and in vitro. Biochem Biophys Res Commun. 243: 122–126. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Ospina J A, Krause D N, Duckles S P.. 2002. 17beta-estradiol increases rat cerebrovascular prostacyclin synthesis by elevating cyclooxygenase-1 and prostacyclin synthase. Stroke. 33: 600–605. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Ouchi Y, Share L, Crofton J T, Iitake K, Brooks D P.. 1987. Sex difference in the development of deoxycorticosterone-salt hypertension in the rat. Hypertension. 9: 172–177. [PUBMED], [INFOTRIEVE]
- Pak K J, Geary G G, Duckles S P, Krause D N.. 2002. Male-female differences in the relative contribution of endothelial vasodilators released by rat tail artery. Life Sci. 71: 1633–1642. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Pare G, Krust A, Karas R H, Dupont S, Aronovitz M, Chambon P, Mendelsohn M E.. 2002. Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury. Circ Res. 90: 1087–1092. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Paroo Z, Haist J V, Karmazyn M, Noble E G.. 2002. Exercise improves postischemic cardiac function in males but not females: Consequences of a novel sex-specific heat shock protein 70 response. Circ Res. 90: 911–917. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Pelligrino D A, Santizo R, Baughman V L, Wang Q.. 1998. Cerebral vasodilating capacity during forebrain ischemia: Effects of chronic estrogen depletion and repletion and the role of neuronal nitric oxide synthase. Neuroreport. 9: 3285–3291. [PUBMED], [INFOTRIEVE]
- Pendaries C, Darblade B, Rochaix P, Krust A, Chambon P, Korach K S, Bayard F, Arnal J F.. 2002. The AF-1 activation-function of ERalpha may be dispensable to mediate the effect of estradiol on endothelial NO production in mice. Proc Natl Acad Sci USA. 99: 2205–2210. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Pervin S, Singh R, Rosenfeld M E, Navab M, Chaudhuri G, Nathan L.. 1998. Estradiol suppresses MCP-1 expression in vivo: Implications for atherosclerosis. Arterioscler Thromb Vasc Biol. 18: 1575–1582. [PUBMED], [INFOTRIEVE]
- Phillips G B, Pinkernell B H, Jing T Y.. 1994. The association of hypotestosteronemia with coronary artery disease in men. Arterioscler Thromb. 14: 701–706. [PUBMED], [INFOTRIEVE]
- Pohl U, Holtz J, Busse R, Bassenge E.. 1986. Crucial role of endothelium in the vasodilator response to increased flow in vivo. Hypertension. 8: 37–44. [PUBMED], [INFOTRIEVE]
- Prakash Y S, Togaibayeva A A, Kannan M S, Miller V M, Fitzpatrick L A, Sieck G C.. 1999. Estrogen increases Ca2+ efflux from female porcine coronary arterial smooth muscle. Am J Physiol. 276: H926–H934. [PUBMED], [INFOTRIEVE]
- Randall M D, Alexander S P, Bennett T, Boyd E A, Fry J R, Gardiner S M, Kemp P A, McCulloch A I, Kendall D A.. 1996. An endogenous cannabinoid as an endothelium-derived vasorelaxant. Biochem Biophys Res Commun. 229: 114–120. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Reckelhoff J F, Zhang H, Granger J P.. 1998. Testosterone exacerbates hypertension and reduces pressure-natriuresis in male spontaneously hypertensive rats. Hypertension. 31: 435–439. [PUBMED], [INFOTRIEVE]
- Reckelhoff J F, Zhang H, Srivastava K.. 2000. Gender differences in development of hypertension in spontaneously hypertensive rats: Role of the renin-angiotensin system. Hypertension. 35: 480–483. [PUBMED], [INFOTRIEVE]
- Reckelhoff J F, Zhang H, Srivastava K, Granger J P.. 1999. Gender differences in hypertension in spontaneously hypertensive rats: Role of androgens and androgen receptor. Hypertension. 34: 920–923. [PUBMED], [INFOTRIEVE]
- Reed J C.. 2000. Mechanisms of apoptosis. Am J Pathol. 157: 1415–1430. [PUBMED], [INFOTRIEVE]
- Register T C, Adams M R.. 1998. Coronary artery and cultured aortic smooth muscle cells express mRNA for both the classical estrogen receptor and the newly described estrogen receptor beta. J Steroid Biochem Mol Biol. 64: 187–191. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Reis S E, Gloth S T, Blumenthal R S, Resar J R, Zacur H A, Gerstenblith G, Brinker J A.. 1994. Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women. Circulation. 89: 52–60. [PUBMED], [INFOTRIEVE]
- Rosenfeld C R, Jackson G M.. 1982. Induction and inhibition of uterine vasodilation by catechol estrogen in oophorectomized, nonpregnant ewes. Endocrinology. 110: 1333–1339. [PUBMED], [INFOTRIEVE]
- Rosolowsky M, Campbell W B.. 1996. Synthesis of hydroxyeicosatetraenoic (HETEs) and epoxyeicosatrienoic acids (EETs) by cultured bovine coronary artery endothelial cells. Biochim Biophys Acta. 1299: 267–277. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Rosselli M, Imthurn B, Keller P J, Jackson E K, Dubey R K.. 1995. Circulating nitric oxide (nitrite/nitrate) levels in postmenopausal women substituted with 17 beta-estradiol and norethisterone acetate: A two-year follow-up study. Hypertension. 25: 848–853. [PUBMED], [INFOTRIEVE]
- Ruehlmann D O, Steinert J R, Valverde M A, Jacob R, Mann G E.. 1998. Environmental estrogenic pollutants induce acute vascular relaxation by inhibiting L-type Ca2+ channels in smooth muscle cells. FASEB J. 12: 613–619. [PUBMED], [INFOTRIEVE]
- Rupnow H L, Phernetton T M, Modrick M L, Wiltbank M C, Bird I M, Magness R R.. 2002. Endothelial vasodilator production by uterine and systemic arteries. VIII. Estrogen and progesterone effects on cPLA2, COX-1, and PGIS protein expression. Biol Reprod. 66: 468–474. [PUBMED], [INFOTRIEVE]
- Russell K S, Haynes M P, Caulin-Glaser T, Rosneck J, Sessa W C, Bender J R.. 2000. Estrogen stimulates heat shock protein 90 binding to endothelial nitric oxide synthase in human vascular endothelial cells: Effects on calcium sensitivity and NO release. J Biol Chem. 275: 5026–5030. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Russell K S, Haynes M P, Sinha D, Clerisme E, Bender J R.. 2000. Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling. Proc Natl Acad Sci USA. 97: 5930–5935. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Sabbah M, Courilleau D, Mester J, Redeuilh G.. 1999. Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like element. Proc Natl Acad Sci USA. 96: 11217–11222. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Saito S, Aras R S, Lou H, Ramwell P W, Foegh M L.. 1999. Effects of estrogen on nitric oxide synthase expression in rat aorta allograft and smooth muscle cells. J Heart Lung Transplant. 18: 937–945. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Sakuma I, Liu M Y, Sato A, Hayashi T, Iguchi A, Kitabatake A, Hattori Y.. 2002. Endothelium-dependent hyperpolarization and relaxation in mesenteric arteries of middle-aged rats: Influence of oestrogen. Br J Pharmacol. 135: 48–54. [PUBMED], [INFOTRIEVE]
- Salas E, Lopez M G, Villarroya M, Sanchez-Garcia P, De, Pascual R, Dixon W R, Garcia A G.. 1994. Endothelium-independent relaxation by 17-alpha-estradiol of pig coronary arteries. Eur J Pharmacol. 258: 47–55. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Salhab W A, Shaul P W, Cox B E, Rosenfeld C R.. 2000. Regulation of types I and III NOS in ovine uterine arteries by daily and acute estrogen exposure. Am J Physiol Heart Circ Physiol. 278: H2134–H2142. [PUBMED], [INFOTRIEVE]
- Sato T, Michizu H, Hashizume K, Ito A.. 2001. Hormonal regulation of PGE2 and COX-2 production in rabbit uterine cervical fibroblasts. J Appl Physiol. 90: 1227–1231. [PUBMED], [INFOTRIEVE], [CROSSREF]
- Schror K, Morinelli T A, Masuda A, Matsuda K, Mathur R S, Halushka P V.. 1994. Testosterone treatment enhances thromboxane A2 mimetic induced coronary artery vasoconstriction in guinea pigs. Eur J Clin Invest. 24(Suppl 1)50–52. [PUBMED], [INFOTRIEVE]
- Schwartzbauer G, Robbins J.. 2001. Matters of sex: Sex matters. Circulation. 104: 1333–1335. [PUBMED], [INFOTRIEVE]
- Seeger H, Mueck A O, Lippert T H.. 1999. Effect of estradiol metabolites on prostacyclin synthesis in human endothelial cell cultures. Life Sci. 65: L167–L170. [CROSSREF]
- Shaul P W.. 1999. Rapid activation of endothelial nitric oxide synthase by estrogen. Steroids. 64: 28–34. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Shaul P W.. 2002. Regulation of endothelial nitric oxide synthase: Location, location, location. Annu Rev Physiol. 64: 749–774. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Shaul P W, Anderson R G.. 1998. Role of plasmalemmal caveolae in signal transduction. Am J Physiol. 275: L843–L851. [PUBMED], [INFOTRIEVE]
- Shaul P W, Smart E J, Robinson L J, German Z, Yuhanna I S, Ying Y, Anderson R G, Michel T.. 1996. Acylation targets emdothelial nitric-oxide synthase to plasmalemmal caveolae. J Biol Chem. 271: 6518–6522. [PUBMED], [INFOTRIEVE], [CROSSREF]
- Sherman T S, Chambliss K L, Gibson L L, Pace M C, Mendelsohn M E, Pfister S L, Shaul P W.. 2002. Estrogen acutely activates prostacyclin synthesis in ovine fetal pulmonary artery endothelium. Am J Respir Cell Mol Biol. 26: 610–616. [PUBMED], [INFOTRIEVE]
- Shibata H, Spencer T E, Onate S A, Jenster G, Tsai S Y, Tsai M J, O'Malley B W.. 1997. Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action. Recent Prog Horm Res. 52: 141–164. [PUBMED], [INFOTRIEVE]
- Shlipak M G, Angeja B G, Go A S, Frederick P D, Canto J G, Grady D.. 2001. Hormone therapy and in-hospital survival after myocardial infarction in postmenopausal women. Circulation. 104: 2300–2304. [PUBMED], [INFOTRIEVE]
- Simoncini T, Hafezi-Moghadam A, Brazil D P, Ley K, Chin W W, Liao J K.. 2000. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature. 407: 538–541. [PUBMED], [INFOTRIEVE], [CROSSREF]
- Simoncini T, Maffei S, Basta G, Barsacchi G, Genazzani A R, Liao J K, De, Caterina R.. 2000. Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms. Circ Res. 87: 19–25. [PUBMED], [INFOTRIEVE]
- Spyridopoulos I, Sullivan A B, Kearney M, Isner J M, Losordo D W.. 1997. Estrogen-receptor-mediated inhibition of human endothelial cell apoptosis. Estradiol as a survival factor. Circulation. 95: 1505–1514. [PUBMED], [INFOTRIEVE]
- Srivastava S, Weitzmann M N, Cenci S, Ross F P, Adler S, Pacifici R.. 1999. Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD. J Clin Invest. 104: 503–513. [PUBMED], [INFOTRIEVE]
- Stallone J N.. 1993. Role of endothelium in sexual dimorphism in vasopressin-induced contraction of rat aorta. Am J Physiol. 265: H2073–H2080. [PUBMED], [INFOTRIEVE]
- Stallone J N, Crofton J T, Share L.. 1991. Sexual dimorphism in vasopressin-induced contraction of rat aorta. Am J Physiol. 260: H453–H458. [PUBMED], [INFOTRIEVE]
- Stallone J N, Salisbury R L, Fulton C T.. 2001. Androgen-receptor defect abolishes sex differences in nitric oxide and reactivity to vasopressin in rat aorta. J Appl Physiol. 91: 2602–2610. [PUBMED], [INFOTRIEVE]
- Stampfer M J, Colditz G A, Willett W C, Manson J E, Rosner B, Speizer F E, Hennekens C H.. 1991. Postmenopausal estrogen therapy and cardiovascular disease: Ten-year follow-up from the nurses' health study. N Engl J Med. 325: 756–762. [PUBMED], [INFOTRIEVE]
- Stampfer M J, Sacks F M, Salvini S, Willett W C, Hennekens C H.. 1991. A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction. N Engl J Med. 325: 373–381. [PUBMED], [INFOTRIEVE]
- Stampfer M J, Willett W C, Colditz G A, Rosner B, Speizer F E, Hennekens C H.. 1985. A prospective study of postmenopausal estrogen therapy and coronary heart disease. N Engl J Med. 313: 1044–1049. [PUBMED], [INFOTRIEVE]
- Stefano G B, Prevot V, Beauvillain J C, Cadet P, Fimiani C, Welters I, Fricchione G L, Breton C, Lassalle P, Salzet M, Bilfinger T V.. 2000. Cell-surface estrogen receptors mediate calcium-dependent nitric oxide release in human endothelia. Circulation. 101: 1594–1597. [PUBMED], [INFOTRIEVE]
- Stevis P E, Deecher D C, Suhadolnik L, Mallis L M, Frail D E.. 1999. Differential effects of estradiol and estradiol-BSA conjugates. Endocrinology. 140: 5455–5458. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Stewart K G, Zhang Y, Davidge S T.. 1999. Estrogen decreases prostaglandin H synthase products from endothelial cells. J Soc Gynecol Investig. 6: 322–327. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Strasser A, O'Connor L, Dixit V M.. 2000. Apoptosis signaling. Annu Rev Biochem. 69: 217–245. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Sudhir K, Jennings G L, Funder J W, Komesaroff P A.. 1996. Estrogen enhances basal nitric oxide release in the forearm vasculature in perimenopausal women. Hypertension. 28: 330–334. [PUBMED], [INFOTRIEVE]
- Sudoh N, Toba K, Akishita M, Ako J, Hashimoto M, Iijima K, Kim S, Liang Y Q, Ohike Y, Watanabe T, Yamazaki I, Yoshizumi M, Eto M, Ouchi Y.. 2001. Estrogen prevents oxidative stress-induced endothelial cell apoptosis in rats. Circulation. 103: 724–729. [PUBMED], [INFOTRIEVE]
- Sugden P H, Clerk A.. 1998. “Stress-responsive” mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium. Circ Res. 83: 345–352. [PUBMED], [INFOTRIEVE]
- Sugden P H, Clerk A.. 2001. Akt like a woman: Gender differences in susceptibility to cardiovascular disease. Circ Res. 88: 975–977. [PUBMED], [INFOTRIEVE]
- Sun D, Huang A, Koller A, Kaley G.. 1995. Flow-dependent dilation and myogenic constriction interact to establish the resistance of skeletal muscle arterioles. Microcirculation. 2: 289–295. [PUBMED], [INFOTRIEVE]
- Sun D, Huang A, Smith C J, Stackpole C J, Connetta J A, Shesely E G, Koller A, Kaley G.. 1999. Enhanced release of prostaglandins contributes to flow-induced arteriolar dilation in eNOS knockout mice. Circ Res. 85: 288–293. [PUBMED], [INFOTRIEVE]
- Sun D, Huang A, Zhao G, Bernstein R, Forfia P, Xu X, Koller A, Kaley G, Hintze T H.. 2000. Reduced NO-dependent arteriolar dilation during the development of cardiomyopathy. Am J Physiol Heart Circ Physiol. 278: H461–H468. [PUBMED], [INFOTRIEVE]
- Sun D, Kaley G, Koller A.. 1994. Characteristics and origin of myogenic response in isolated gracilis muscle arterioles. Am J Physiol. 266: H1177–H1183. [PUBMED], [INFOTRIEVE]
- Takamura Y, Shimokawa H, Zhao H, Igarashi H, Egashira K, Takeshita A.. 1999. Important role of endothelium-derived hyperpolarizing factor in shear stress-induced endothelium-dependent relaxations in the rat mesenteric artery. J Cardiovasc Pharmacol. 34: 381–387. [PUBMED], [INFOTRIEVE], [CROSSREF]
- Tamura K, Yamaguchi K, Kogo H.. 2000. 17Beta-estradiol inhibits ovariectomy-induced expression of inducible nitric oxide synthase in rat aorta in vivo. Life Sci. 66: 254–266. [CROSSREF]
- Tang M, Abplanalp W, Ayres S, Subbiah M T.. 1996. Superior and distinct antioxidant effects of selected estrogen metabolites on lipid peroxidation. Metabolism. 45: 411–414. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Teoh H, Man R Y.. 2000. Enhanced relaxation of porcine coronary arteries after acute exposure to a physiological level of 17beta-estradiol involves non-genomic mechanisms and the cyclic AMP cascade. Br J Pharmacol. 129: 1739–1747. [PUBMED], [INFOTRIEVE]
- Thollon C, Bidouard J P, Cambarrat C, Delescluse I, Villeneuve N, Vanhoutte P M, Vilaine J P.. 1999. Alteration of endothelium-dependent hyperpolarizations in porcine coronary arteries with regenerated endothelium. Circ Res. 84: 371–377. [PUBMED], [INFOTRIEVE]
- Thompson L P, Pinkas G, Weiner C P.. 2000. Chronic 17beta-estradiol replacement increases nitric oxide-mediated vasodilation of guinea pig coronary microcirculation. Circulation. 102: 445–451. [PUBMED], [INFOTRIEVE]
- Trepanier-Boulay V, St, Michel C, Tremblay A, Fiset C.. 2001. Gender-based differences in cardiac repolarization in mouse ventricle. Circ Res. 89: 437–444. [PUBMED], [INFOTRIEVE]
- Valverde M A, Rojas P, Amigo J, Cosmelli D, Orio P, Bahamonde M I, Mann G E, Vergara C, Latorre R.. 1999. Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit. Science. 285: 1929–1931. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- van, Eickels M, Grohe C, Cleutjens J P, Janssen B J, Wellens H J, Doevendans P A.. 2001. 17beta-estradiol attenuates the development of pressure-overload hypertrophy. Circulation. 104: 1419–1423. [PUBMED], [INFOTRIEVE]
- Vanhaesebroeck B, Alessi D R.. 2000. The PI3K-PDK1 connection: More than just a road to PKB. Biochem J. 346 Pt, 3: 561–576. [CROSSREF]
- Varas-Lorenzo C, Garcia-Rodriguez L A, Perez-Gutthann S, Duque-Oliart A.. 2000. Hormone replacement therapy and incidence of acute myocardial infarction. A population-based nested case-control study. Circulation. 101: 2572–2578. [PUBMED], [INFOTRIEVE]
- Varbiro S, Vajo Z, Nadasy G L, Monos E, Acs N, Szekacs B.. 2001. Hormone replacement reduces elevated in vivo venous tone in hypertensive ovariectomized rats. J Soc Gynecol Investig. 8: 98–103. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Venkov C D, Rankin A B, Vaughan D E.. 1996. Identification of authentic estrogen receptor in cultured endothelial cells. A potential mechanism for steroid hormone regulation of endothelial function. Circulation. 94: 727–733. [PUBMED], [INFOTRIEVE]
- Villablanca A C, Hanley M R.. 1997. 17beta-estradiol stimulates substance P receptor gene expression. Mol Cell Endocrinol. 135: 109–117. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Villablanca A C, Lewis K A, Rutledge J C.. 2002. Time- and dose-dependent differential upregulation of three genes by 17 beta-estradiol in endothelial cells. J Appl Physiol. 92: 1064–1073. [PUBMED], [INFOTRIEVE]
- Wagner A H, Schroeter M R, Hecker M.. 2001. 17beta-estradiol inhibition of NADPH oxidase expression in human endothelial cells. FASEB J. 15: 2121–2130. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Wakatsuki A, Okatani Y, Ikenoue N, Fukaya T.. 2001. Effect of medroxyprogesterone acetate on endothelium-dependent vasodilation in postmenopausal women receiving estrogen. Circulation. 104: 1773–1778. [PUBMED], [INFOTRIEVE]
- Walsh B W, Schiff I, Rosner B, Greenberg L, Ravnikar V, Sacks F M.. 1991. Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N Engl J Med. 325: 1196–1204. [PUBMED], [INFOTRIEVE]
- Waltenberger J.. 1997. Modulation of growth factor action: Implications for the treatment of cardiovascular diseases. Circulation. 96: 4083–4094. [PUBMED], [INFOTRIEVE]
- Walter P, Green S, Greene G, Krust A, Bornert J M, Jeltsch J M, Staub A, Jensen E, Scrace G, Waterfield M.. 1985. Cloning of the human estrogen receptor cDNA. Proc Natl Acad Sci USA. 82: 7889–7893. [PUBMED], [INFOTRIEVE]
- Wang C Y, Guttridge D C, Mayo M W, Baldwin A S, Jr. 1999. NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol Cell Biol. 19: 5923–5929. [PUBMED], [INFOTRIEVE]
- Wang C Y, Mayo M W, Korneluk R G, Goeddel D V, Baldwin A S, Jr.. 1998. NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science. 281: 1680–1683. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Wang X, Abdel-Rahman A A.. 2002. Estrogen modulation of eNOS activity and its association with caveolin-3 and calmodulin in rat hearts. Am J Physiol Heart Circ Physiol. 282: H2309–H2315. [PUBMED], [INFOTRIEVE]
- Wassmann S, Baumer A T, Strehlow K, van, Eickels M, Grohe C, Ahlbory K, Rosen R, Bohm M, Nickenig G.. 2001. Endothelial dysfunction and oxidative stress during estrogen deficiency in spontaneously hypertensive rats. Circulation. 103: 435–441. [PUBMED], [INFOTRIEVE]
- Watanabe Y, Littleton-Kearney M T, Traystman R J, Hurn P D.. 2001. Estrogen restores postischemic pial microvascular dilation. Am J Physiol Heart Circ Physiol. 281: H155–H160. [PUBMED], [INFOTRIEVE]
- Wehling M.. 1997. Specific, nongenomic actions of steroid hormones. Annu Rev Physiol. 59: 365–393. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Weiner C P, Lizasoain I, Baylis S A, Knowles R G, Charles I G, Moncada S.. 1994. Induction of calcium-dependent nitric oxide synthases by sex hormones. Proc Natl Acad Sci USA. 91: 5212–5216. [PUBMED], [INFOTRIEVE]
- Wellman G C, Bonev A D, Nelson M T, Brayden J E.. 1996. Gender differences in coronary artery diameter involve estrogen, nitric oxide, and Ca(2+)-dependent K+ channels. Circ Res. 79: 1024–1030. [PUBMED], [INFOTRIEVE]
- Wenger N K, Knatterud G L, Canner P L.. 2000. Early risks of hormone therapy in patients with coronary heart disease. JAMA. 284: 41–43. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- White R E, Darkow D J, Lang J L.. 1995. Estrogen relaxes coronary arteries by opening BKCa channels through a cGMP-dependent mechanism. Circ Res. 77: 936–942. [PUBMED], [INFOTRIEVE]
- White R M, Rivera C O, Davison C A.. 2000. Nitric oxide-dependent and -independent mechanisms account for gender differences in vasodilation to acetylcholine. J Pharmacol Exp Ther. 292: 375–380. [PUBMED], [INFOTRIEVE]
- Wiinberg N, Hoegholm A, Christensen H R, Bang L E, Mikkelsen K L, Nielsen P E, Svendsen T L, Kampmann J P, Madsen N H, Bentzon M W.. 1995. 24-h ambulatory blood pressure in 352 normal Danish subjects, related to age and gender. Am J Hypertens. 8: 978–986. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Wu W, Lee W L, Wu Y Y, Chen D, Liu T J, Jang A, Sharma P M, Wang P H.. 2000. Expression of constitutively active phosphatidylinositol 3-kinase inhibits activation of caspase 3 and apoptosis of cardiac muscle cells. J Biol Chem. 275: 40113–40119. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Wu Y, Huang A, Sun D, Falck J R, Koller A, Kaley G.. 2001. Gender-specific compensation for the lack of NO in the mediation of flow-induced arteriolar dilation. Am J Physiol Heart Circ Physiol. 280: H2456–H2461. [PUBMED], [INFOTRIEVE]
- Xiao S, Gillespie D G, Baylis C, Jackson E K, Dubey R K.. 2001. Effects of estradiol and its metabolites on glomerular endothelial nitric oxide synthesis and mesangial cell growth. Hypertension. 37: 645–650. [PUBMED], [INFOTRIEVE]
- Xu H L, Santizo R A, Koenig H M, Pelligrino D A.. 2001. Chronic estrogen depletion alters adenosine diphosphate-induced pial arteriolar dilation in female rats. Am J Physiol Heart Circ Physiol. 281: H2105–H2112. [PUBMED], [INFOTRIEVE]
- Xu R, Morales J A, Muniyappa R, Skafar D F, Ram J L, Sowers J R.. 1999. Interleukin-1beta-induced nitric oxide production in rat aortic endothelial cells: Inhibition by estradiol in normal and high glucose cultures. Life Sci. 64: 2451–2462. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- You H J, Choi C Y, Jeon Y J, Chung Y C, Kang S K, Hahm K S, Jeong H G.. 2002. Suppression of inducible nitric oxide synthase and tumor necrosis factor-alpha expression by 4-nonylphenol in macrophages. Biochem Biophys Res Commun. 294: 753–759. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Zhai P, Eurell T E, Cooke P S, Lubahn D B, Gross D R.. 2000. Myocardial ischemia-reperfusion injury in estrogen receptor-alpha knockout and wild-type mice. Am J Physiol Heart Circ Physiol. 278: H1640–H1647. [PUBMED], [INFOTRIEVE]
- Zhu B T, Conney A H.. 1998. Functional role of estrogen metabolism in target cells: Review and perspectives. Carcinogenesis. 19: 1–27. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]
- Zhu Y, Bian Z, Lu P, Karas R H, Bao L, Cox D, Hodgin J, Shaul P W, Thoren P, Smithies O, Gustafsson J A, Mendelsohn M E.. 2002. Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science. 295: 505–508. [CROSSREF], [PUBMED], [INFOTRIEVE], [CROSSREF]