Therapeutic Intervention in Inflammatory Diseases: A Time and Place for Anti-Adhesion Therapy

REFERENCES

• Abbassi O, Kishimoto T K, McIntire L V, Anderson D C, Smith C W. E-selectin supports neutrophil rolling in vitro under conditions of flow. J Clin Invest 1993; 92: 2719–2730, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Ahrens I, Peter K, Bode C. Use of GPIIb/IIIa inhibitors in cardiovascular medicine. Expert Rev Cardiovasc Ther 2003; 1: 233–242, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMedGoogle Scholar
• Alon R, Kassner P D, Carr M W, Finger E B, Hemler M E, Springer T A. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J Cell Biol 1995; 128: 1243–1253, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Anderson D C. The role of β 2 integrins and intercellular adhesion molecule type 1 in inflammation. Physiology and Pathophysiology of Leukocyte Adhesion, D Granger, G W Schmid-Schonbein. Oxford University Press, New York 1995; 3–42
   Google Scholar
• Arfors K E, Lundberg C, Lindbom L, Lundberg K, Beatty P G, Harlan J M. A monoclonal antibody to the membrane glycoprotein CD18 inhibits polymorphonuclear leukocytes accumulation and plasma leakage in vivo. Blood 1987; 69: 338–340, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Argenbright L W, Letts L G, Rothlein R. Monoclonal antibodies to the leukocyte membrane CD18 glycoprotein complex and to intercellular adhesion molecule-1 inhibit leukocyte-endothelial adhesion in rabbits. J Leukoc Biol 1991; 49: 253–257, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Berg E L, McEvoy L M, Berlin C, Bargatze R F, Butcher E C. L-selectin-mediated lymphocyte rolling on MAdCAM-1. Nature 1993; 366: 695–698, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Bullard D C, Kunkel E J, Kubo H, Hicks M J, Lorenzo I, Doyle N A, Doerschuk C M, Ley K, Beaudet A L. Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J Exp Med 1996; 183: 2329–2336, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Carvalho-Tavares J, Hickey M J, Hutchison J, Michaud J, Sutcliffe I T, Kubes P. A role for platelets and endothelial selectins in tumor necrosis factor- alpha-induced leukocyte recruitment in the brain microvasculature. Circ Res 2000; 87: 1141–1148, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Dalton C M, Miszkiel K A, Barker G J, MacManus D G, Pepple T I, Panzara M, Yang M, Hulme A, O'Connor P, Miller D H. Effect of natalizumab on conversion of gadolinium enhancing lesions to T1 hypointense lesions in relapsing multiple sclerosis. J Neurol 2004; 251: 407–413, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• de Gaetano G, Cerletti C. Aspirin, platelets and prevention of vascular disease. J Lipid Mediat 1989; 1: 289–296, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Doerschuk C M, Winn R K, Coxson H O, Harlan J M. CD18-dependent and -independent mechanisms of neutrophil emigration in the pulmonary and systemic microcirculation of rabbits. J Immunol 1990; 144: 2327–2333, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Essani N A, Bajit S L, Vonderfecht S L, Farhood A, Jaeschke H. Transcriptional activation of vascular cell adhesion molecule-1 (VCAM-1] gene in vivo and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock. J Immunol 1997; 158: 5941–5948, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Faxon D P, Gibbons R J, Chronos N A, Gurbel P A, Sheehan F. The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI study. J Am Coll Cardiol 2002; 40: 1199–1204, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Fox-Robichaud A, Kubes P. Molecular mechanisms of TNFalpha-stimulated leukocyte recruitment into the hepatic circulation. Hepatology 2000; 31: 1123–1127, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Frenette P S, Mayadas T N, Rayburn H, Hynes R O, Wagner D D. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell 1996; 84: 563–574, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ghosh S. Alpha 4 integrin blockade in inflammatory bowel disease. Ann Rheum Dis 2003; 62(Suppl 2)ii70–ii72, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Gidday J M, Park T S, Gonzales E R, Beetsch J W. CD18-dependent leukocyte adherence and vascular injury in pig cerebral circulation after ischemia. Am J Physiol 1997; 272: 2622–2629
   Google Scholar
• Granger D N, Russell J M, Arfors K E, Rothlein R, Anderson D C. Role of CD11/CD18 and ICAM-1 in ischemia/reperfusion-induced leukocyte adherence and emigration in mesenteric venules. FASEB J 1991; 5: A1753
   Web of Science ®Google Scholar
• Harlan J M. Leukocyte adhesion deficiency syndrome: insights into the molecular basis of leukocyte emigration. Clin Immunol Immunopathol 1993; 67: S16–S24, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMedGoogle Scholar
• Harlan J M, Winn R K. Leukocyte-endothelial interactions: clinical trials of anti-adhesion therapy. Crit Care Med 2002; 30: S214–S219, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   Web of Science ®Google Scholar
• Ho M, Hickey M J, Murray A G, Andonegui G, Kubes P. Visualization of Plasmodium falciparum–endothelium interactions in human microvasculature: mimicry of leukocyte recruitment. J Exp Med 2000; 192: 1205–1211, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Horie Y, Wolf R, Anderson D C, Granger D N. Hepatic leukostasis and hypoxic stress in adhesion molecule-deficient mice after gut ischemia/reperfusion. J Clin Invest 1997; 99: 781–788, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Hwang J, Yamanouchi J, Santamaria P, Kubes P. A critical temporal window for selectin-dependent CD4+ lymphocyte homing and initiation of late phase inflammation in contact sensitivity. J Exp Med 2004; 199: 1223–1234, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ibbotson G, Doig C, Kaur J, Gill V, Ostrovsky L, Fairhead T, Kubes P. Functional alpha4-integrin: a newly identified pathway of neutrophil recruitment in critically ill septic patients. Nature Med 2001; 7: 465–470, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Issekutz A C, Ayer L, Miyasaka M, Issekutz T B. Treatment of established adjuvant arthritis in rats with monoclonal antibody to CD18 and very late activation antigen-4 integrins suppresses neutrophil and T-lymphocyte migration to the joints and improves clinical disease. Immunology 1996; 88: 569–576, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Jaeschke H, Farhood A, Bautista A P, Spolarics Z, Spitzer J J, Smith C W. Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18] monoclonal antibody protects against ischemia-reperfusion injury in rat liver. Hepatology 1993; 17: 915–923, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Jaeschke H, Farhood A, Fisher M A, Smith C W. Sequestration of neutrophils in the hepatic vasculature during endotoxemia is independent of β2-integrins and intercellular adhesion molecule-1. Shock 1996; 6: 351–356, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Jones S P, Trocha S D, Strange M B, Granger D N, Kevil C G, Bullard D C, Lefer D J. Leukocyte and endothelial cell adhesion molecules in a chronic murine model of myocardial reperfusion injury. Am J Physiol Heart Circ Physiol 2000; 279: H2196–H2201, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Jullien D, Prinz J C, Langley R G, Caro I, Dummer W, Joshi A, Dedrick R, Natta P. T-Cell Modulation for the treatment of chronic plaque psoriasis with efalizumab (Raptiva trade mark): mechanisms of action. Dermatology 2004; 208: 297–306, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Kansas G S. Selectins and their ligands: current concepts and controversies. Blood 1996; 88: 3259–3287, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Kanwar S, Smith C W, Kubes P. An absolute requirement for P-selectin in ischemia/reperfusion-induced leukocyte recruitment in cremaster muscle. Microcirculation 1998; 5: 281–287, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Kerr K M, Auger W R, Marsh J J, Comito R M, Fedullo R L, Smits G J, Kapelanski D P, Fedullo P F, Channick R N, Jamieson S W, Moser K M. The use of cylexin (CY-1503] in prevention of reperfusion lung injury in patients undergoing pulmonary thromboendarterectomy. Am J Respir Crit Care Med 2000; 162: 14–20, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Kubes P, Jutila M, Payne D. Therapeutic potential of inhibiting leukocyte rolling in ischemia/reperfusion. J Clin Invest 1995; 95: 2510–2519, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Kubes P, Payne D, Woodman R C. Molecular mechanisms of leukocyte recruitment in postischemic liver microcirculation. Am J Physiol Gastrointest Liver Physiol 2002; 283: G139–G147, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Kurose I, Anderson D C, Miyasaka M, Tamatani T, Paulson J C, Todd R F, Rusche J R, Granger D N. Molecular determinants of reperfusion-induced leukocyte adhesion and vascular protein leakage. Circ Res 1994; 74: 336–343, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Kurose I, Granger D N, Evans D J, Evans D G, Graham D Y, Anderson D C, Wolf R E, Kvietys P R. Helicobacter pylori induced microvascular protein leakage in rats: role of neutrophils, mast cells and platelets. Gastroenterology 1994; 107: 70–79, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Kurose I, Pothoulakis C, Lamont J T, Anderson D C, Paulson J C, Miyasaka M, Wolf R, Granger D N. Clostridium difficile toxin A-induced microvacular dysfunction: role of histamine. J Clin Invest 1994; 94: 1919–1926, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Labow M A, Norton C R, Rumberger J M, Lombard-Gillooly K M, Shuster D J, Hubbard J, Bertko R, Knaack P A, Terry R W, Harbison M L, Kontgen F, Stewart C L, McIntyre K W, Will P C, Burns D K, Wolitzky B. Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins. Immunity 1994; 1: 709–720, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lawrence M B, Smith C W, Eskin S G, McIntire L V. Effect of venous shear stress on CD18-mediated neutrophil adhesion to cultured endothelium. Blood 1990; 75: 227–237, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Lawrence M B, Springer T A. Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell 1991; 65: 859–873, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ley K, Tedder T F, Kansas G S. L-selectin can mediate leukocyte rolling in untreated mesenteric venules in vivo independent of E- or P-selectin. Blood 1993; 82: 1632–1638, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Li Y, Muruve D A, Collins R G, Lee S S, Kubes P. The role of selectins and integrins in adenovirus vector-induced neutrophil recruitment to the liver. Eur J Immunol 2002; 32: 3443–3452, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lindbom L, Lundberg C, Prieto J, Raud J, Nortamo P, Gahmberg C G, Patarroyo M. Rabbit leukocyte adhesion molecules CD11/CD18 and their participation in acute and delayed inflammatory responses and leukocyte distribution in vivo. Clin Immunol Immunopathol 1990; 57: 105–119, [PUBMED], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Luscinskas F W, Ma S, Nusrat A, Parkos C A, Shaw S K. Leukocyte transendothelial migration: a junctional affair. Semin Immunol 2002; 14: 105–113, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ma X-L, Tsao P S, Lefer A M. Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion. J Clin Invest 1991; 88: 1237–1243, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Mayadas T N, Johnson R C, Rayburn H, Hynes R O, Wagner D D. Leukocyte rolling and extravasation are severely compromised in P-selectin-deficient mice. Cell 1993; 74: 541–554, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Miller D H, Khan O A, Sheremata W A, Blumhardt L D, Rice G P, Libonati M A, Willmer-Hulme A J, Dalton C M, Miszkiel K A, O'Connor P W. A controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 2003; 348: 15–23, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Mizgerd J P, Meek B B, Kutkoski G J, Bullard D C, Beaudet A L, Doerschuk C M. Selectins and neutrophil traffic: margination and Streptococcus pneumoniae-induced emigration in murine lungs. J Exp Med 1996; 184: 639–645, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Nathan C F, Srimal S, Farber C, Sanchez E, Kabbash L, Asch A, Gailit J, Wright S D. Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins. J Cell Biol 1989; 109: 1341–1349, [PUBMED], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ockenhouse C F, Tegoshi T, Maeno Y, Benjamin C, Ho M, Kan K E, Thway Y, Win K, Aikawa M, Lobb R R. Human vascular endothelia cell adhesion receptors for plasmodium falciparum-infected erythrocytes: roles for endothelia leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1. J Exp Med 1997; 176: 1183–1189, [CROSSREF]
   Google Scholar
• Papp K, Bissonnette R, Krueger J G, Carey W, Gratton D, Gulliver W P, Lui H, Lynde C W, Magee A, Minier D, Ouellet J P, Patel P, Shapiro J, Shear N H, Kramer S, Walicke P, Bauer R, Dedrick R L, Kim S S, White M, Garovoy M R. The treatment of moderate to severe psoriasis with a new anti-CD11a monoclonal antibody. J Am Acad Dermatol 2001; 45: 665–674, [PUBMED], [CSA]
   PubMed Web of Science ®Google Scholar
• Richter J, Ng S J, Olsson L, Anderson T. Tumor necrosis factor-induced degranulation in adherent human neutrophils is dependent on CD11b/CD18-integrin-triggered oscillations of cytosolic free Ca2. Proc Natl Acad Sci U S A 1990; 87: 9472–9476, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Ridger V C, Wagner B E, Wallace W A, Hellewell P G. Differential effects of CD18, CD29, and CD49 integrin subunit inhibition on neutrophil migration in pulmonary inflammation. J Immunol 2001; 166: 3484–3490, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Robinson S D, Frenette P S, Rayburn H, Cummiskey M, Ullman-Cullere M, Wagner D D, Hynes R O. Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment. Proc Natl Acad Sci U S A 1999; 96: 11452–11457, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Rose L M, Richards T L, Peterson J, Petersen R, Alvord E C, Jr. Resolution of CNS lesions following treatment of experimental allergic encephalomyelitis in macaques with monoclonal antibody to the CD18 leukocyte integrin. Mult Scler 1997; 2: 259–266, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Sandborn W J, Yednock T A. Novel approaches to treating inflammatory bowel disease: targeting alpha-4 integrin. Am J Gastroenterol 2003; 98: 2372–2382, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Shappell S B, Toman C, Anderson D C, Taylor A A, Entman M L, Smith C W. Mac-1 (CD11b/CD18] mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils. J Immunol 1990; 144: 2702–2711, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Staite N D, Justen J M, Sly L M, Beaudet A L, Bullard D C. Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin. Blood 1996; 88: 2973–2979, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Swerlick R A, Eckman J R, Kumar A, Jeitler M, Wick T M. Alpha(4]beta(1]-integrin expression on sickle reticulocytes—vascular cell-adhesion molecule-1-dependent binding to endothelium. Blood 1993; 82: 1891–1899, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Ulbrich H, Eriksson E E, Lindbom L. Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease. Trends Pharmacol Sci 2003; 24: 640–647, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Vedder N B, Winn R K, Rice C L, Chi E Y, Arfors K E, Harlan J M. A monoclonal antibody to the adherence-promoting leukocyte glycoprotein, CD18, reduces organ injury and improves survival from hemorrhagic shock and resuscitation in rabbits. J Clin Invest 1988; 81: 939–944, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Von Andrian U H, Hansell P, Chambers J D, Berger E M, Filho I T, Butcher E C, Arfors K E. L-selectin function is required for β 2-integrin-mediated neutrophil adhesion at physiological shear rates in vivo. Am J Physiol 1992; 263: H1034–H1044, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Wallace J L, Arfors K E, McKnight G W. A monoclonal antibody against the CD18 leukocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit. Gastroenterology 1991; 100: 878–883, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Warnock R A, Askari S, Butcher E C, Von Andrian U H. Molecular mechanisms of lymphocyte homing to peripheral lymph nodes. J Exp Med 1998; 187: 205–216, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wong J, Johnston B, Lee S S, Bullard D C, Smith C W, Beaudet A L, Kubes P. A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature. J Clin Invest 1997; 99: 2782–2790, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Yadav S S, Howell D N, Steeber D A, Harland R C, Tedder T F, Clavien P A. P-selectin mediates reperfusion injury through neutrophil and platelet sequestration in the warm ischemic mouse liver. Hepatology 1999; 29: 1494–1502, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar