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Original

Both ADP and Thrombin Regulate Arteriolar Thrombus Stabilization and Embolization, but Are Not Involved in Initial Hemostasis as Induced by Micropuncture

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Pages 193-205 | Received 03 Aug 2006, Accepted 26 Oct 2006, Published online: 10 Jul 2009

REFERENCES

  • Andre P, Delaney S M, LaRocca T, Vincent D, DeGuzman F, Jurek M, Koller B, Phillips D R, Conley P B. P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries. J Clin Invest 2003; 112: 398–406
  • Broeders M AW, Tangelder G J, Slaaf D W, Reneman R S, oude Egbrink M GA. Endogenous nitric oxide protects against thromboembolism in venules but not in arterioles. Arterioscler Thromb Vasc Biol 1998; 18: 139–145
  • Broeders M AW, Tangelder G J, Slaaf D W, Reneman R S, oude Egbrink M GA. Endogenous nitric oxide and prostaglandins synergistically counteract thromboembolism in arterioles but not in venules. Arterioscler Thromb Vasc Biol 2001; 21: 163–169
  • Broeders M AW, Tangelder G J, Slaaf D W, Reneman R S, oude Egbrink M GA. Hypercholesterolemia enhances thromboembolism in arterioles but not in venules; complete reversal by L-arginine. Arterioscler Thromb Vasc Biol 2002; 22: 680–685
  • Cattaneo M, Canciani M T, Lecchi A, Kinlough-Rathbone R L, Packham M A, Mannucci P M, Mustard J F. Released adenosine diphosphate stabilizes thrombin-induced human platelet aggregates. Blood 1990; 75: 1081–1086
  • Chou J, Mackman N, Merrill-Skoloff G, Pedersen B, Furie B C, Furie B. Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation. Blood 2004; 104: 3190–3197
  • Conley P B, Delaney S M. Scientific and therapeutic insights into the role of the platelet P2Y12 receptor in thrombosis. Curr Opin Hematol 2003; 10: 333–338
  • Day S M, Reeve J L, Pedersen B, Farris D M, Myers D D, Im M, Wakefield T W, Mackman N, Fay W P. Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall. Blood 2005; 105: 192–198
  • Dorsam R T, Kunapuli S P. Central role of the P2Y12 receptor in platelet activation. J Clin Invest 2004; 113: 340–345
  • Dubois C, Panicot-Dubois L, Merrill-Skoloff G, Furie B, Furie B C. Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivo. Blood 2006; 107: 3902–3906
  • Falati S, Gross P, Merrill-Skoloff G, Furie B C, Furie B. Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse. Nat Med 2002; 8: 1175–1181
  • Gachet C. The platelet P2 receptors as molecular targets for old and new antiplatelet drugs. Pharmacol Ther 2005; 108: 180–192
  • Gawaz M. Role of platelets in coronary thrombosis and reperfusion of ischemic myocardium. Cardiovasc Res 2004; 61: 498–511
  • Goto S, Tamura N, Ishida H, Ruggeri Z M. Dependence of platelet thrombus stability on sustained glycoprotein IIb/IIIa activation through adenosine 5′-diphosphate receptor stimulation and cyclic calcium signaling. J Am Coll Cardiol 2006; 47: 155–162
  • Gustafsson D, Elg M. The pharmacodynamics and pharmacokinetics of the oral direct thrombin inhibitor ximelagatran and its active metabolite melagatran: a mini-review. Thromb Res 2003; 109: S9–S15
  • Hatanaka K, Minamiyama M, Takaichi S, Tanaka K, Ishibashi-Ueda H, Imakita M, Yamamoto A. Thrombus formation by the application of thrombin to the outer surface of mouse mesenteric vein: comparison with the application of ADP. Thromb Res 1985; 40: 731–743
  • Heemskerk J WM, Bevers E M, Lindhout T. Platelet activation and blood coagulation. Thromb Haemost 2002; 88: 186–193
  • Hemker H C, Giesen P L, Ramjee M, Wagenvoord R, Beguin S. The thrombogram: monitoring thrombin generation in platelet-rich plasma. Thromb Haemost 2000; 83: 589–591
  • Jin J, Daniel J L, Kunapuli S P. Molecular basis for ADP-induced platelet activation, II: the P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. J Biol Chem 1998; 273: 2030–2034
  • Kinlough-Rathbone R L, Rand M L, Packham M A. Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets. Blood 1993; 82: 103–106
  • Lenain N, Freund M, Leon C, Cazenave J P, Gachet C. Inhibition of localized thrombosis in P2Y1-deficient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist. J Thromb Haemost 2003; 1: 1144–1149
  • Leon C, Ravanat C, Freund M, Cazenave J P, Gachet C. Differential involvement of the P2Y1 and P2Y12 receptors in platelet procoagulant activity. Arterioscler Thromb Vasc Biol 2003; 23: 1941–1947
  • Leon C, Alex M, Klocke A, Morgenstern E, Moosbauer C, Eckly A, Spannagl M, Gachet C, Engelmann B. Platelet ADP receptors contribute to the initiation of intravascular coagulation. Blood 2004; 103: 594–600
  • Markus H M. Monitoring embolism in real time. Circulation 2000; 102: 826–828
  • Massberg S, Gawaz M, Gruner S, Schulte V, Konrad I, Zohlnhofer D, Heinzmann U, Nieswandt B. A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. J Exp Med 2003; 197: 41–49
  • Nesbitt W S, Giuliano S, Kulkarni S, Dopheide S M, Harper I S, Jackson S P. Intercellular calcium communication regulates platelet aggregation and thrombus growth. J Cell Biol 2003; 160: 1151–1161
  • oude Egbrink M GA, Tangelder G J, Slaaf D W, Reneman R S. Different roles of prostaglandins in thromboembolic processes in arterioles and venules in vivo. Thromb Haemostas 1993; 70: 826–833
  • oude Egbrink M GA, van Gestel M A, Broeders M AW, Tangelder G J, Heemskerk J WM, Reneman R S, Slaaf D W. Regulation of microvascular thromboembolism in vivo. Microcirculation 2005; 12: 287–300
  • Rosen E D, Raymond S, Zollman A, Noria F, Sandoval-Cooper M, Shulman A, Merz J L, Castellino F J. Laser-induced noninvasive vascular injury models in mice generate platelet- and coagulation-dependent thrombi. Am J Pathol 2001; 158: 1613–1622
  • Ruggeri Z M. Von Willebrand factor, platelets and endothelial cell interactions. J Thromb Haemost 2003; 1: 1335–1342
  • Rumbaut R E, Randhawa J K, Smith C W, Burns A R. Mouse cremaster venules are predisposed to light/dye-induced thrombosis independent of wall shear rate, CD18, ICAM-1, or P-selectin. Microcirculation 2004; 11: 239–247
  • Rumbaut R E, Slaaf D W, Burns A R. Microvascular thrombosis models in venules and arterioles in vivo. Microcirculation 2005; 12: 259–274
  • Slaaf D W, Rood J PSM, Tangelder G J, Jeurens T JM, Alewijnse R, Reneman R S, Arts T. A bidirectional optical (BDO) three-stage prism grating system for on-line measurement of red blood cell velocity in microvessels. Microvasc Res 1981; 22: 110–122
  • Spencer M P. Transcranial Doppler monitoring and causes of stroke from carotid endarterectomy. Stroke 1997; 28: 685–691
  • Tangelder G J, Slaaf D W, Arts T, Reneman R S. Wall shear rate in arterioles in vivo: least estimates from platelet velocity profiles. Am J Physiol 1988; 254: H1059–H1064
  • Turpie A G. State of the art—a journey through the world of antithrombotic therapy. Semin Thromb Hemost 2002; 28: 3–11, (Suppl 3)
  • van d er, Meijden P E, Feijge M A, Giesen P L, Huijberts M, van Raak L P, Heemskerk J W. Platelet P2Y(12) receptors enhance signalling towards procoagulant activity and thrombin generation. Thromb Haemost 2005; 93: 1128–1136
  • van Gestel M A, Heemskerk J WM, Slaaf D W, Heijnen V VT, Sage S O, Reneman R S, oude Egbrink M GA. Real-time detection of activation patterns in individual platelets during thromboembolism in vivo: differences between thrombus growth and embolus formation. J Vasc Res 2002; 39: 534–543
  • van Gestel M A, Heemskerk J W, Slaaf D W, Heijnen V V, Reneman R S, oude Egbrink M G. In vivo blockade of platelet ADP receptor P2Y12 reduces embolus and thrombus formation but not thrombus stability. Arterioscler Thromb Vasc Biol 2003; 23: 518–523

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