An Imaging Spectroscopy Approach for Measurement of Oxygen Saturation and Hematocrit During Intravital Microscopy

REFERENCES

• Benesch R E, Benesch R, Yung S. Equations for the spectrophotometric analysis of hemoglobin mixtures. Anal Biochem 1973; 55: 245–248
   PubMed Web of Science ®Google Scholar
• Berne R M. Metabolic regulation of blood flow. Circ Res 1964; 14(15)I-261–I-268
   Google Scholar
• Burkhard O, Barnikol W K. Dependence of visible spectrum [epsilon (lambda)] of fully oxygenated hemoglobin on concentration of hemoglobin. J Appl Physiol 1982; 52: 124–130
   PubMed Web of Science ®Google Scholar
• Butler W L, Norris K H. The spectrophotometry of dense light-scattering material. Arch Biochem Biophys 1960; 87: 31–40
   PubMed Web of Science ®Google Scholar
• Butterfield E E. Zur Photometrie des Blutfarbstoffs. Z Physiol Chem 1912; 79: 439–445
   Google Scholar
• Carmeliet P, Jain R K. Angiogenesis in cancer and other diseases. Nature 2000; 407: 249–257
   PubMed Web of Science ®Google Scholar
• Dewhirst M W, Klitzman B, Braun R D, Brizel D M, Haroon Z A, Secomb T W. Review of methods used to study oxygen transport at the microcirculatory level. Int J Cancer 2000; 90: 237–255
   PubMed Web of Science ®Google Scholar
• Ellsworth M L. The red blood cell as an oxygen sensor: what is the evidence?. Acta Physiol Scand 2000; 168: 551–559
   Google Scholar
• Ellsworth M L, Pittman R N, Ellis C G. Measurement of hemoglobin oxygen saturation in capillaries. Am J Physiol 1987; 252: H1031–H1040
   Google Scholar
• Friedland S, Benaron D, Parachikov I, Soetikno R. Measurement of mucosal capillary hemoglobin oxygen saturation in the colon by reflectance spectrophotometry. Gastrointest Endosc 2003; 57: 492–497
   Google Scholar
• Horecker B L. The absorption spectra of hemoglobin and its derivatives in the visible and near infra-red regions. J Biol Chem 1943; 148: 173–183
   Google Scholar
• Japee S A, Pittman R N, Ellis C G. A new video image analysis system to study red blood cell dynamics and oxygenation in capillary networks. Microcirculation 2005; 12: 489–506
   PubMed Web of Science ®Google Scholar
• Khoobehi B, Beach J M, Kawano H. Hyperspectral imaging for measurement of oxygen saturation in the optic nerve head. Invest Ophthalmol Vis Sci 2004; 45: 1464–1472
   PubMed Web of Science ®Google Scholar
• Kobayashi H, Takizawa N. Imaging of oxygen transfer among microvessels of rat cremaster muscle. Circulation 2002; 105: 1713–1719
   PubMed Web of Science ®Google Scholar
• MacRae R A, McClure J A, Latimer P. Spectral transmission and scattering properties of red blood cells. J Opt Soc Am 1961; 51: 1366–1372
   PubMedGoogle Scholar
• McGuire B J, Secomb T W. Theoretical predictions of maximal oxygen consumption in hypoxia: effects of transport limitations. Respir Physiol Neurobiol 2004; 143: 87–97
   Google Scholar
• Nelder J A, Mead R. A simplex method for function minimization. Comput J 1965; 7: 308–313
   Web of Science ®Google Scholar
• Patel S, Pittman R N. Impact of microscope numerical aperture on microspectrophotometric measurements of hemoglobin in microvessels. Microvasc Res 2002; 64: 198–206
   Google Scholar
• Patel S, Pittman R N. Mathematical analysis of hemoglobin spectrophotometry in microvessels. Microvasc Res 2001; 62: 63–73
   Google Scholar
• Pittman R N, Duling B R. Measurement of percent oxyhemoglobin in the microvasculature. J Appl Physiol 1975; 38: 321–327
   PubMed Web of Science ®Google Scholar
• Pittman R N, Duling B R. A new method for the measurement of percent oxyhemoglobin. J Appl Physiol 1975; 38: 315–320
   PubMed Web of Science ®Google Scholar
• Pries A R, Kanzow G, Gaehtgens P. Improvement and calibration of a method for determination of microvessel hematocrit. Bibl Anat 1981; 20: 24–27
   Google Scholar
• Pries A R, Kanzow G, Gaehtgens P. Microphotometric determination of hematocrit in small vessels. Am J Physiol 1983; 245: H167–H177
   Google Scholar
• Pries A R, Ley K, Gaehtgens P. Generalization of the Fahraeus principle for microvessel networks. Am J Physiol 1986; 251: H1324–H1332
   PubMedGoogle Scholar
• Pries A R, Reglin B, Secomb T W. Structural adaptation of microvascular networks: functional roles of adaptive responses. Am J Physiol 2001; 281: H1015–H1025
   Google Scholar
• Rumsey W L, Vanderkooi J M, Wilson D F. Imaging of phosphorescence: a novel method for measuring oxygen distribution in perfused tissue. Science 1988; 241: 1649–1651
   PubMed Web of Science ®Google Scholar
• Shonat R D, Wachman E S, Niu W, Koretsky A P, Farkas D L. Near-simultaneous hemoglobin saturation and oxygen tension maps in mouse brain using an AOTF microscope. Biophys J 1997; 73: 1223–1231
   PubMed Web of Science ®Google Scholar
• Slaaf D W, Tangelder G J, Reneman R S, Jager K, Bollinger A. A versatile incident illuminator for intravital microscopy. Int J Microcirc Clin Exp 1987; 6: 391–397
   Google Scholar
• Sorg B S, Moeller B J, Donovan O, Cao Y, Dewhirst M W. Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development. J Biomed Opt 2005; 10: 44004
   PubMed Web of Science ®Google Scholar
• Stamler J S, Jia L, Eu J P, McMahon T J, Demchenko I T, Bonaventura J, Gernert K, Piantadosi C A. Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science 1997; 276: 2034–2037
   PubMed Web of Science ®Google Scholar
• Torres Filho I P, Terner J, Pittman R N, Somera L G, III, Ward K R. Hemoglobin oxygen saturation measurements using resonance Raman intravital microscopy. Am J Physiol 2005; 289: H488–H495
   Web of Science ®Google Scholar
• Tsukada K, Sekizuka E, Oshio C, Tsujioka K, Minamitani H. Red blood cell velocity and oxygen tension measurement in cerebral microvessels by double-wavelength photoexcitation. J Appl Physiol 2004; 96: 1561–1568
   Google Scholar
• Twersky V. Interface effects in multiple scattering by large, low-refracting, absorbing particles. J Opt Soc Am 1970; 60: 908–914
   Google Scholar
• Zijlstra W G, Buursma A, Zwart A. Molar absorptivities of human hemoglobin in the visible spectral range. J Appl Physiol 1983; 54: 1287–1291
   Google Scholar