Obesity, Insulin Resistance, and Renal Function

REFERENCES

• Asensio C, Cettour-Rose P, Theander-Carrillo C, Rohner-Jeanrenaud F, Muzzin P. Changes in glycemia by leptin administration or high-fat feeding in rodent models of obesity/type 2 diabetes suggest a link between resistin expression and control of glucose homeostasis. Endocrinology 2004; 145: 2206–2213
   Google Scholar
• Axelsson J, Bergsten A, Qureshi A R, Heimburger O, Barany P, Lonnqvist F, Lindholm B, Nordfors L, Alvestrand A, Stenvinkel P. Elevated resistin levels in chronic kidney disease are associated with decreased glomerular filtration rate and inflammation, but not with insulin resistance. Kidney Int 2006; 69: 596–604
   PubMedGoogle Scholar
• Banba N, Nakamura T, Matsumura M, Kuroda H, Hattori Y, Kasai K. Possible relationship of monocyte chemoattractant protein-1 with diabetic nephropathy. Kidney Int 2000; 58: 684–690
   PubMed Web of Science ®Google Scholar
• Banday A A, Marwaha A, Tallam L S, Lokhandwala M F. Tempol reduces oxidative stress, improves insulin sensitivity, decreases renal dopamine D1 receptor hyperphosphorylation, and restores D1 receptor-G-protein coupling and function in obese Zucker rats. Diabetes 2005; 54: 2219–2226
   PubMed Web of Science ®Google Scholar
• Bastard J P, Jardel C, Bruckert E, Blondy P, Capeau J, Laville M, Vidal H, Hainque B. Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab 2000; 85: 3338–3342
   PubMed Web of Science ®Google Scholar
• Baylis C, Atzpodien E A, Freshour G, Engels K. Peroxisome proliferator-activated receptor [gamma] agonist provides superior renal protection versus angiotensin-converting enzyme inhibition in a rat model of type 2 diabetes with obesity. J Pharmacol Exp Ther 2003; 307: 854–860
   PubMed Web of Science ®Google Scholar
• Berger J, Wagner J A. Physiological and therapeutic roles of peroxisome proliferator-activated receptors. Diabetes Technol Ther 2002; 4: 163–174
   PubMedGoogle Scholar
• Bouloumie A, Marumo T, Lafontan M, Busse R. Leptin induces oxidative stress in human endothelial cells. FASEB J 1999; 13: 1231–1238
   PubMed Web of Science ®Google Scholar
• Brennan F M, Chantry D, Jackson A, Maini R, Feldmann M. Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis. Lancet 1989; 2: 244–247
   PubMed Web of Science ®Google Scholar
• Briley L P, Szczech L A. Leptin and renal disease. Semin Dial 2006; 19: 54–59
   PubMed Web of Science ®Google Scholar
• Calkin A C, Giunti S, Jandeleit-Dahm K A, Allen T J, Cooper M E, Thomas M C. PPAR-alpha and -gamma agonists attenuate diabetic kidney disease in the apolipoprotein E knockout mouse. Nephrol Dial Transplant 2006; 21: 2399–2405
   PubMed Web of Science ®Google Scholar
• Chagnac A, Weinstein T, Korzets A, Ramadan E, Hirsch J, Gafter U. Glomerular hemodynamics in severe obesity. Am J Physiol 2000; 278: F817–F822
   PubMed Web of Science ®Google Scholar
• Chan W, Wang M, Martin R J, Trachtman H, Hisano S, Chan J C. mRNA expression for insulin-like growth factor 1, receptors of growth hormone and IGF-1 and transforming growth factor-beta in the kidney and liver of Zucker rats. Nutr Res 2001; 21: 1015–1023
   PubMedGoogle Scholar
• Chang J W, Kim C S, Kim S B, Park S K, Park J S, Lee S K. C-reactive protein induces NF-kappaB activation through intracellular calcium and ROS in human mesangial cells. Nephron 2005; 101: e165–e172
   Google Scholar
• Chen Y M, Lin S L, Chiang W C, Wu K D, Tsai T J. Pentoxifylline ameliorates proteinuria through suppression of renal monocyte chemoattractant protein-1 in patients with proteinuric primary glomerular diseases. Kidney Int 2006; 69: 1410–1415
   PubMed Web of Science ®Google Scholar
• Chinen I, Shimabukuro M, Yamakawa K, Higa N, Matsuzaki T, Noguchi K, Ueda S, Sakanashi M, Takasu N. Vascular lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats. Endocrinology 2007; 148: 160–165
   PubMed Web of Science ®Google Scholar
• Chow F Y, Nikolic-Paterson D J, Ma F Y, Ozols E, Rollins B J, Tesch G H. Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice. Diabetologia 2007; 50: 471–480
   PubMed Web of Science ®Google Scholar
• Christ M, Bauersachs J, Liebetrau C, Heck M, Gunther A, Wehling M. Glucose increases endothelial-dependent superoxide formation in coronary arteries by NAD(P)H oxidase activation: attenuation by the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin. Diabetes 2002; 51: 2648–2652
   PubMed Web of Science ®Google Scholar
• Cindik N, Baskin E, Agras P I, Kinik S T, Turan M, Saatci U. Effect of obesity on inflammatory markers and renal functions. Acta Paediatr 2005; 94: 1732–1737
   PubMed Web of Science ®Google Scholar
• Curat C A, Wegner V, Sengenes C, Miranville A, Tonus C, Busse R, Bouloumie A. Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin. Diabetologia 2006; 49: 744–747
   PubMed Web of Science ®Google Scholar
• Datta P K, Sharma M, Duann P, Lianos E A. Effect of nitric oxide synthase inhibition on proteinuria in glomerular immune injury. Exp Biol Med (Maywood, NJ) 2006; 231: 576–584
   Google Scholar
• Delafontaine P. Insulin-like growth factor I and its binding proteins in the cardiovascular system. Cardiovasc Res 1995; 30: 825–834
   PubMed Web of Science ®Google Scholar
• Descamps-Latscha B, Herbelin A, Nguyen A T, Roux-Lombard P, Zingraff J, Moynot A, Verger C, Dahmane D, de Groote D, Jungers P, et al. Balance between IL-1 beta, TNF-alpha, and their specific inhibitors in chronic renal failure and maintenance dialysis: relationships with activation markers of T cells, B cells, and monocytes. J Immunol 1995; 154: 882–892
   PubMed Web of Science ®Google Scholar
• Despres J P, Lemieux I. Abdominal obesity and metabolic syndrome. Nature 2006; 444: 881–887
   PubMed Web of Science ®Google Scholar
• Dey A, Williams R S, Pollock D M, Stepp D W, Newman J W, Hammock B D, Imig J D. Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. Obes Res 2004; 12: 1278–1289
   PubMedGoogle Scholar
• Dobrian A D, Schriver S D, Khraibi A A, Prewitt R L. Pioglitazone prevents hypertension and reduces oxidative stress in diet-induced obesity. Hypertension 2004; 43: 48–56
   PubMed Web of Science ®Google Scholar
• Dominguez H, Storgaard H, Rask-Madsen C, Steffen Hermann T, Ihlemann N, Baunbjerg Nielsen D, Spohr C, Kober L, Vaag A, Torp-Pedersen C. Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes. J Vasc Res 2005; 42: 517–525
   PubMed Web of Science ®Google Scholar
• Eardley K S, Zehnder D, Quinkler M, Lepenies J, Bates R L, Savage C O, Howie A J, Adu D, Cockwell P. The relationship between albuminuria, MCP-1/CCL2, and interstitial macrophages in chronic kidney disease. Kidney Int 2006; 69: 1189–1197
   PubMed Web of Science ®Google Scholar
• Elbatarny H S, Netherton S J, Ovens J D, Ferguson A V, Maurice D H. Adiponectin, ghrelin, and leptin differentially influence human platelet and human vascular endothelial cell functions: implication in obesity-associated cardiovascular diseases. Eur J Pharmacol 2007; 558(1–3)7–13
   Google Scholar
• Elmarakby A A, Quigley J E, Pollock D M, Imig J D. Tumor necrosis factor alpha blockade increases renal Cyp2c23 expression and slows the progression of renal damage in salt-sensitive hypertension. Hypertension 2006; 47: 557–562
   PubMed Web of Science ®Google Scholar
• Erdely A, Freshour G, Maddox D A, Olson J L, Samsell L, Baylis C. Renal disease in rats with type 2 diabetes is associated with decreased renal nitric oxide production. Diabetologia 2004; 47: 1672–1676
   PubMed Web of Science ®Google Scholar
• Fajas L, Auboeuf D, Raspe E, Schoonjans K, Lefebvre A M, Saladin R, Najib J, Laville M, Fruchart J C, Deeb S, Vidal-Puig A, Flier J, Briggs M R, Staels B, Vidal H, Auwerx J. The organization, promoter analysis, and expression of the human PPARgamma gene. J Biol Chem 1997; 272: 18779–18789
   PubMed Web of Science ®Google Scholar
• Fan W, Boston B A, Kesterson R A, Hruby V J, Cone R D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 1997; 385: 165–168
   PubMed Web of Science ®Google Scholar
• Fang X, Faraci F M, Kaduce T L, Harmon S, Modrick M L, Hu S, Moore S A, Falck J R, Weintraub N L, Spector A A. 20-Hydroxyeicosatetraenoic acid is a potent dilator of mouse basilar artery: role of cyclooxygenase. Am J Physiol Heart Circ Physiol 2006; 291: H2301–H2307
   Google Scholar
• Futrakul N, Butthep P, Patumraj S, Tipprukmas N, Futrakul P. Enhanced tumor necrosis factor in the serum and renal hypoperfusion in nephrosis associated with focal segmental glomerulosclerosis. Ren Fail 2000; 22: 213–217
   PubMed Web of Science ®Google Scholar
• Galuska D, Ryder J, Kawano Y, Charron M J, Zierath J R. Insulin signaling and glucose transport in insulin resistant skeletal muscle: special reference to GLUT4 transgenic and GLUT4 knockout mice. Adv Exp Med Biology 1998; 441: 73–85
   Google Scholar
• Greenfield J R, Campbell L V. Insulin resistance and obesity. Clin Dermatol 2004; 22: 289–295
   Google Scholar
• Guha P K, Villarreal D, Reams G P, Freeman R H. Role of leptin in the regulation of body fluid volume and pressures. Am J Ther 2003; 10: 211–218
   PubMedGoogle Scholar
• Gum R J, Gaede L L, Koterski S L, Heindel M, Clampit J E, Zinker B A, Trevillyan J M, Ulrich R G, Jirousek M R, Rondinone C M. Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice. Diabetes 2003; 52: 21–28
   PubMed Web of Science ®Google Scholar
• Guo M, Ricardo S D, Deane J A, Shi M, Cullen-McEwen L, Bertram J F. A stereological study of the renal glomerular vasculature in the db/db mouse model of diabetic nephropathy. J Anat 2005; 207: 813–821
   Google Scholar
• Hall J E, Brands M W, Dixon W N, Smith M J, Jr. Obesity-induced hypertension: renal function and systemic hemodynamics. Hypertension 1993; 22: 292–299
   PubMed Web of Science ®Google Scholar
• Han H J, Jeon Y J, Lee Y J. Involvement of NF-kappaB in high glucose-induced alteration of alpha-methyl-D-glucopyranoside (alpha-MG) uptake in renal proximal tubule cells. Cell Physiol Biochem 2003; 13: 375–384
   Google Scholar
• Hayashi K, Kanda T, Homma K, Tokuyama H, Okubo K, Takamatsu I, Tatematsu S, Kumagai H, Saruta T. Altered renal microvascular response in Zucker obese rats. Metab Clin Exp 2002; 51: 1553–1561
   Google Scholar
• Hayden M R, Whaley-Connell A, Sowers J R. Renal redox stress and remodeling in metabolic syndrome, type 2 diabetes mellitus, and diabetic nephropathy: paying homage to the podocyte. Am J Nephrol 2005; 25: 553–569
   PubMed Web of Science ®Google Scholar
• Hotamisligil G S, Shargill N S, Spiegelman B M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993; 259: 87–91
   PubMed Web of Science ®Google Scholar
• Huber S A, Sakkinen P, Conze D, Hardin N, Tracy R. Interleukin-6 exacerbates early atherosclerosis in mice. Arterioscler Throm Vasc Biol 1999; 19: 2364–2367
   PubMed Web of Science ®Google Scholar
• Imig J D. Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases. Am J Physiol Renal Physiol 2005; 289: F496–F503
   PubMed Web of Science ®Google Scholar
• Ishiki M, Klip A. Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners. Endocrinology 2005; 146: 5071–5078
   PubMed Web of Science ®Google Scholar
• Iwashima Y, Horio T, Kumada M, Suzuki Y, Kihara S, Rakugi H, Kawano Y, Funahashi T, Ogihara T. Adiponectin and renal function, and implication as a risk of cardiovascular disease. Am J Cardiol 2006; 98: 1603–1608
   PubMed Web of Science ®Google Scholar
• Jiang Z Y, Lin Y W, Clemont A, Feener E P, Hein K D, Igarashi M, Yamauchi T, White M F, King G L. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest 1999; 104: 447–457
   PubMed Web of Science ®Google Scholar
• Kahn S E, Hull R L, Utzschneider K M. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006; 444: 840–846
   PubMed Web of Science ®Google Scholar
• Kamanna V S, Pai R, Ha H, Kirschenbaum M A, Roh D D. Oxidized low-density lipoprotein stimulates monocyte adhesion to glomerular endothelial cells. Kidney Int 1999; 55: 2192–2202
   Google Scholar
• Kamei N, Tobe K, Suzuki R, Ohsugi M, Watanabe T, Kubota N, Ohtsuka-Kowatari N, Kumagai K, Sakamoto K, Kobayashi M, Yamauchi T, Ueki K, Oishi Y, Nishimura S, Manabe I, Hashimoto H, Ohnishi Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Nagai R, Kadowaki T. Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem 2006; 281: 26602–26614
   PubMed Web of Science ®Google Scholar
• Kielar M L, John R, Bennett M, Richardson J A, Shelton J M, Chen L, Jeyarajah D R, Zhou X J, Zhou H, Chiquett B, Nagami G T, Lu C Y. Maladaptive role of IL-6 in ischemic acute renal failure. J Am Soc Nephrol 2005; 16: 3315–3325
   PubMed Web of Science ®Google Scholar
• Kim F, Tysseling K A, Rice J, Pham M, Haji L, Gallis B M, Baas A S, Paramsothy P, Giachelli C M, Corson M A, Raines E W. Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta. Arterioscler Throm Vasc Biol 2005; 25: 989–994
   PubMed Web of Science ®Google Scholar
• Kimmel P L, Phillips T M, Simmens S J, Peterson R A, Weihs K L, Alleyne S, Cruz I, Yanovski J A, Veis J H. Immunologic function and survival in hemodialysis patients. Kidney Int 1998; 54: 236–244
   PubMed Web of Science ®Google Scholar
• Kitagawa K, Wada T, Furuichi K, Hashimoto H, Ishiwata Y, Asano M, Takeya M, Kuziel W A, Matsushima K, Mukaida N, Yokoyama H. Blockade of CCR2 ameliorates progressive fibrosis in kidney. Am J Pathol 2004; 165: 237–246
   PubMed Web of Science ®Google Scholar
• Klahr S, Morrissey J. Progression of chronic renal disease. Am J Kidney Dis 2003; 41: S3–S7
   PubMed Web of Science ®Google Scholar
• Kofler S, Nickel T, Weis M. Role of cytokines in cardiovascular diseases: a focus on endothelial responses to inflammation. Clin Sci (Lond) 2005; 108: 205–213
   PubMed Web of Science ®Google Scholar
• Konukoglu D, Serin O, Turhan M S. Plasma leptin and its relationship with lipid peroxidation and nitric oxide in obese female patients with or without hypertension. Arch Med Res 2006; 37: 602–606
   Google Scholar
• Laflam P F, Garin E H. Effect of tumor necrosis factor alpha and vascular permeability growth factor on albuminuria in rats. Pediatr Nephrol (Berlin) 2006; 21: 177–181
   Google Scholar
• Landau D, Chin E, Bondy C, Domene H, Roberts C T, Jr., Gronbaek H, Flyvbjerg A, Le Roith D. Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes. Endocrinology 1995; 136: 1835–1842
   PubMedGoogle Scholar
• Lee F T, Cao Z, Long D M, Panagiotopoulos S, Jerums G, Cooper M E, Forbes J M. Interactions between angiotensin II and NF-kappaB-dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathy. J Am Soc Nephrol 2004; 15: 2139–2151
   PubMed Web of Science ®Google Scholar
• Lee M P, Madani S, Sekula D, Sweeney G. Leptin increases expression and activity of matrix metalloproteinase-2 and does not alter collagen production in rat glomerular mesangial cells. Endocr Res 2005; 31: 27–37
   PubMed Web of Science ®Google Scholar
• Lee S, Kim W, Moon S O, Sung M J, Kim D H, Kang K P, Jang K Y, Lee S Y, Park B H, Koh G Y, Park S K. Renoprotective effect of COMP-angiopoietin-1 in db/db mice with type 2 diabetes. Nephrol Dial Transplant 2007; 22: 396–408
   Google Scholar
• Leibowitz M D, Fievet C, Hennuyer N, Peinado-Onsurbe J, Duez H, Bergera J, Cullinan C A, Sparrow C P, Baffic J, Berger G D, Santini C, Marquis R W, Tolman R L, Smith R G, Moller D E, Auwerx J. Activation of PPARdelta alters lipid metabolism in db/db mice. FEBS Lett 2000; 473: 333–336
   PubMed Web of Science ®Google Scholar
• Leung J C, Chan L Y, Tang S C, Chu K M, Lai K N. Leptin induces TGF-beta synthesis through functional leptin receptor expressed by human peritoneal mesothelial cell. Kidney Int 2006; 69: 2078–2086
   PubMed Web of Science ®Google Scholar
• Levine D Z, Iacovitti M, Robertson S J, Mokhtar G A. Modulation of single-nephron GFR in the db/db mouse model of type 2 diabetes mellitus. Am J Physiol 2006; 290: R975–R981
   Web of Science ®Google Scholar
• Li Z, Rodriguez-Iturbe B, Ni Z, Shahkarami A, Sepassi L, Vaziri N D. Effect of hereditary obesity on renal expressions of NO synthase, caveolin-1, AKt, guanylate cyclase, and calmodulin. Kidney Int 2005; 68: 2766–2772
   PubMed Web of Science ®Google Scholar
• Liberopoulos E N, Mikhailidis D P, Elisaf M S. Diagnosis and management of the metabolic syndrome in obesity. Obes Rev 2005; 6: 283–296
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhang Y, Schmelzer K, Lee T S, Fang X, Zhu Y, Spector A A, Gill S, Morisseau C, Hammock B D, Shyy J Y. The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proc Natl Acad Sci U S A 2005; 102: 16747–16752
   PubMed Web of Science ®Google Scholar
• Lupia E, Elliot S J, Lenz O, Zheng F, Hattori M, Striker G E, Striker L J. IGF-1 decreases collagen degradation in diabetic NOD mesangial cells: implications for diabetic nephropathy. Diabetes 1999; 48: 1638–1644
   PubMed Web of Science ®Google Scholar
• Malyszko J, Malyszko J S, Pawlak K, Mysliwiec M. Resistin, a new adipokine, is related to inflammation and renal function in kidney allograft recipients. Transplant Proc 2006; 38: 3434–3436
   PubMed Web of Science ®Google Scholar
• McCarthy K J, Routh R E, Shaw W, Walsh K, Welbourne T C, Johnson J H. Troglitazone halts diabetic glomerulosclerosis by blockade of mesangial expansion. Kidney Int 2000; 58: 2341–2350
   PubMed Web of Science ®Google Scholar
• McCarty M F, Falahati-Nini A. Neuroprotective potential of the Bahadori leanness program: A “mini-fast with exercise” strategy. Med Hypotheses 2007; 68(5)935–940
   Google Scholar
• Miller A W, Dimitropoulou C, Han G, White R E, Busija D W, Carrier G O. Epoxyeicosatrienoic acid-induced relaxation is impaired in insulin resistance. Am J Physiol Heart Circ Physiol 2001; 281: H1524–H1531
   Google Scholar
• Morrisey K, Evans R A, Wakefield L, Phillips A O. Translational regulation of renal proximal tubular epithelial cell transforming growth factor-beta1 generation by insulin. Am J Pathol 2001; 159: 1905–1915
   PubMed Web of Science ®Google Scholar
• Mundy A L, Haas E, Bhattacharya I, Widmer C C, Kretz M, Hofmann-Lehmann R, Minotti R, Barton M. Fat intake modifies vascular responsiveness and receptor expression of vasoconstrictors: implications for diet-induced obesity. Cardiovasc Res 2007; 73: 368–375
   PubMed Web of Science ®Google Scholar
• Myers B D, Nelson R G, Williams G W, Bennett P H, Hardy S A, Berg R L, Loon N, Knowler W C, Mitch W E. Glomerular function in Pima Indians with noninsulin-dependent diabetes mellitus of recent onset. J Clin Inves 1991; 88: 524–530
   Google Scholar
• NHANES. CDC, National Center for Health Statistics. NHANES Datasets and Related Documentation (2003–2004). 2004, http://www.cdc.gov/nchs/about/major/nhanes/nhanes2003-2004/nhanes03_04.htm Available at
   Google Scholar
• NIDDK. NIDDK, National Kidney and Urologic Diseases Information Clearing House (NKUDIC). NIH. 2002, http://kidney.niddk.nih.gov/kudiseases/pubs/kdd/index.htm Publication No. 07-3925 October 2006. Available at
   Google Scholar
• Park C W, Kim H W, Ko S H, Chung H W, Lim S W, Yang C W, Chang Y S, Sugawara A, Guan Y, Breyer M D. Accelerated diabetic nephropathy in mice lacking the peroxisome proliferator-activated receptor alpha. Diabetes 2006; 55: 885–893
   PubMed Web of Science ®Google Scholar
• Park C W, Zhang Y, Zhang X, Wu J, Chen L, Cha D R, Su D, Hwang M T, Fan X, Davis L, Striker G, Zheng F, Breyer M, Guan Y. PPARalpha agonist fenofibrate improves diabetic nephropathy in db/db mice. Kidney Int 2006; 69: 1511–1517
   PubMed Web of Science ®Google Scholar
• Patel N S, Chatterjee P K, Di Paola R, Mazzon E, Britti D, De Sarro A, Cuzzocrea S, Thiemermann C. Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia/reperfusion. J Pharmacol Exp Ther 2005; 312: 1170–1178
   PubMed Web of Science ®Google Scholar
• Piqueras L, Reynolds A R, Hodivala-Dilke K M, Alfranca A, Redondo J M, Hatae T, Tanabe T, Warner T D, Bishop-Bailey D. Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis. Arterioscler Throm Vasc Biol 2007; 27: 63–69
   PubMed Web of Science ®Google Scholar
• Plata-Salaman C R. Immunoregulators in the nervous system. Neurosci Biobehav Rev 1991; 15: 185–215
   PubMed Web of Science ®Google Scholar
• Pugliese F, Ferrario R G, Ciavolella A, Tamburin M, Benatti L, Casini A, Patrono C, Salvati P. Growth abnormalities in cultured mesangial cells from rats with spontaneous glomerulosclerosis. Kidney Int 1995; 47: 106–113
   Google Scholar
• Rajala M W, Qi Y, Patel H R, Takahashi N, Banerjee R, Pajvani U B, Sinha M K, Gingerich R L, Scherer P E, Ahima R S. Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting. Diabetes 2004; 53: 1671–1679
   PubMed Web of Science ®Google Scholar
• Randle P J, Priestman D A, Mistry S C, Halsall A. Glucose fatty acid interactions and the regulation of glucose disposal. J Cell Biochem 1994; 55: 1–11, Suppl
   PubMed Web of Science ®Google Scholar
• Raz I, Wexler I, Weiss O, Flyvbjerg A, Segev Y, Rauchwerger A, Raz G, Khamaisi M. Role of insulin and the IGF system in renal hypertrophy in diabetic Psammomys obesus (sand rat). Nephrol Dial Transplant 2003; 18: 1293–1298
   Google Scholar
• Reisin E. Obesity and the kidney connection. Am J Kidney Dis 2001; 38: 1129–1134
   Google Scholar
• Roberts C K, Barnard R J, Sindhu R K, Jurczak M, Ehdaie A, Vaziri N D. Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome. Metab Clin Exp 2006; 55: 928–934
   PubMed Web of Science ®Google Scholar
• Rollins B J. Chemokines. Blood 1997; 90: 909–928
   PubMed Web of Science ®Google Scholar
• Rovin B H, Song H. Chemokine induction by the adipocyte-derived cytokine adiponectin. Clin Immunol (Orlando) 2006; 120: 99–105
   PubMed Web of Science ®Google Scholar
• Sartipy P, Loskutoff D J. Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci USA 2003; 100: 7265–7270
   PubMed Web of Science ®Google Scholar
• Sato K, Sugawara A, Kudo M, Uruno A, Ito S, Takeuchi K. Expression of peroxisome proliferator-activated receptor isoform proteins in the rat kidney. Hypertens Res 2004; 27: 417–425
   PubMed Web of Science ®Google Scholar
• Shoelson S E, Lee J, Yuan M. Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord 2003; 27: S49–52, Suppl 3
   PubMed Web of Science ®Google Scholar
• Shulman G I. Cellular mechanisms of insulin resistance. J Clin Inves 2000; 106: 171–176
   PubMed Web of Science ®Google Scholar
• Staels B, Dallongeville J, Auwerx J, Schoonjans K, Leitersdorf E, Fruchart J C. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 1998; 98: 2088–2093
   PubMed Web of Science ®Google Scholar
• Steinberg H O, Brechtel G, Johnson A, Fineberg N, Baron A D. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent: a novel action of insulin to increase nitric oxide release. J Clin Invest 1994; 94: 1172–1179
   PubMed Web of Science ®Google Scholar
• Steinberg H O, Chaker H, Leaming R, Johnson A, Brechtel G, Baron A D. Obesity/insulin resistance is associated with endothelial dysfunction: implications for the syndrome of insulin resistance. J Clin Invest 1996; 97: 2601–2610
   PubMed Web of Science ®Google Scholar
• Stenvinkel P, Lonnqvist F, Schalling M. Molecular studies of leptin: implications for renal disease. Nephrol Dial Transplant 1999; 14: 1103–1112
   Web of Science ®Google Scholar
• Steppan C M, Bailey S T, Bhat S, Brown E J, Banerjee R R, Wright C M, Patel H R, Ahima R S, Lazar M A. The hormone resistin links obesity to diabetes. Nature 2001; 409: 307–312
   PubMed Web of Science ®Google Scholar
• Susztak K, Raff A C, Schiffer M, Bottinger E P. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes 2006; 55: 225–233
   PubMed Web of Science ®Google Scholar
• Taba Y, Sasaguri T, Miyagi M, Abumiya T, Miwa Y, Ikeda T, Mitsumata M. Fluid shear stress induces lipocalin-type prostaglandin D(2) synthase expression in vascular endothelial cells. Circ Res 2000; 86: 967–973
   PubMed Web of Science ®Google Scholar
• Tanaka T, Yamamoto J, Iwasaki S, Asaba H, Hamura H, Ikeda Y, Watanabe M, Magoori K, Ioka R X, Tachibana K, Watanabe Y, Uchiyama Y, Sumi K, Iguchi H, Ito S, Doi T, Hamakubo T, Naito M, Auwerx J, Yanagisawa M, Kodama T, Sakai J. Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci USA 2003; 100: 15924–15929
   PubMed Web of Science ®Google Scholar
• Tanida M, Iwashita S, Terui N, Ootsuka Y, Shu M, Kang D, Suzuki M. Effect of peripheral administration of leptin on the renal sympathetic nerve activity in high-fat diet-related hypertensive rats. Life Sci 2006; 78: 1149–1154
   Google Scholar
• Trachtman H, Futterweit S, Pine E, Mann J, Valderrama E. Chronic diabetic nephropathy: role of inducible nitric oxide synthase. Pediat Nephrol (Berlin) 2002; 17: 20–29
   Google Scholar
• Uysal K T, Wiesbrock S M, Marino M W, Hotamisligil G S. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997; 389: 610–614
   PubMed Web of Science ®Google Scholar
• Vasylyeva T L, Ferry R J, Jr. Novel roles of the IGF-IGFBP axis in etiopathophysiology of diabetic nephropathy. Diabetes Res Clin Pract 2007; 76(2)177–186
   Google Scholar
• Vaziri N D, Ni Z, Oveisi F, Liang K, Pandian R. Enhanced nitric oxide inactivation and protein nitration by reactive oxygen species in renal insufficiency. Hypertension 2002; 39: 135–141
   PubMed Web of Science ®Google Scholar
• Viedt C, Dechend R, Fei J, Hansch G M, Kreuzer J, Orth S R. MCP-1 induces inflammatory activation of human tubular epithelial cells: involvement of the transcription factors, nuclear factor-kappaB and activating protein-1. J Am Soc Nephrol 2002; 13: 1534–1547
   PubMed Web of Science ®Google Scholar
• Villarreal D, Reams G, Freeman R H, Taraben A. Renal effects of leptin in normotensive, hypertensive, and obese rats. Am J Physiol 1998; 275: R2056–R2060
   Google Scholar
• Wallenius V, Wallenius K, Ahren B, Rudling M, Carlsten H, Dickson S L, Ohlsson C, Jansson J O. Interleukin-6-deficient mice develop mature-onset obesity. Nat Med 2002; 8: 75–79
   PubMed Web of Science ®Google Scholar
• Wang M H, Smith A, Zhou Y, Chang H H, Lin S, Zhao X, Imig J D, Dorrance A M. Downregulation of renal CYP-derived eicosanoid synthesis in rats with diet-induced hypertension. Hypertension 2003; 42: 594–599
   PubMed Web of Science ®Google Scholar
• Wang Y, Rangan G K, Tay Y C, Wang Y, Harris D C. Induction of monocyte chemoattractant protein-1 by albumin is mediated by nuclear factor kappaB in proximal tubule cells. J Am Soc Nephrol 1999; 10: 1204–1213
   PubMed Web of Science ®Google Scholar
• Wassmann S, Stumpf M, Strehlow K, Schmid A, Schieffer B, Bohm M, Nickenig G. Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor. Circ Res 2004; 94: 534–541
   PubMed Web of Science ®Google Scholar
• Weisberg S P, Hunter D, Huber R, Lemieux J, Slaymaker S, Vaddi K, Charo I, Leibel R L, Ferrante A W, Jr. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 2006; 116: 115–124
   PubMed Web of Science ®Google Scholar
• Weisberg S P, McCann D, Desai M, Rosenbaum M, Leibel R L, Ferrante A W, Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112: 1796–1808
   PubMed Web of Science ®Google Scholar
• Wilson H M, Chettibi S, Jobin C, Walbaum D, Rees A J, Kluth D C. Inhibition of macrophage nuclear factor-kappaB leads to a dominant anti-inflammatory phenotype that attenuates glomerular inflammation in vivo. Am J Pathol 2005; 167: 27–37
   PubMed Web of Science ®Google Scholar
• Wisse B E. The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol 2004; 15: 2792–2800
   PubMed Web of Science ®Google Scholar
• Xu H, Uysal K T, Becherer J D, Arner P, Hotamisligil G S. Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity. Diabetes 2002; 51: 1876–1883
   PubMed Web of Science ®Google Scholar
• Xu J, Keeton A B, Franklin J L, Li X, Venable D Y, Frank S J, Messina J L. Insulin enhances growth hormone induction of the MEK/ERK signaling pathway. J Biol Chem 2006; 281: 982–992
   PubMedGoogle Scholar
• Yuan M, Konstantopoulos N, Lee J, Hansen L, Li Z W, Karin M, Shoelson S E. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001; 293: 1673–1677
   PubMed Web of Science ®Google Scholar
• Zhao X, Dey A, Romanko O P, Stepp D W, Wang M H, Zhou Y, Jin L, Pollock J S, Webb R C, Imig J D. Decreased epoxygenase and increased epoxide hydrolase expression in the mesenteric artery of obese Zucker rats. Am J Physiol 2005; 288: R188–R196
   PubMed Web of Science ®Google Scholar
• Zhao X, Quigley J E, Yuan J, Wang M H, Zhou Y, Imig J D. PPAR-alpha activator fenofibrate increases renal CYP-derived eicosanoid synthesis and improves endothelial dilator function in obese Zucker rats. Am J Physiol Heart Circ Physiol 2006; 290: H2187–H2195
   PubMed Web of Science ®Google Scholar