Ascorbate Inhibits Reduced Arteriolar Conducted Vasoconstriction in Septic Mouse Cremaster Muscle

REFERENCES

• Andrew P J, Mayer B. Enzymatic function of nitric oxide synthases. Cardiovasc Res 1999; 43: 521–531
   PubMed Web of Science ®Google Scholar
• Armour J, Tyml K, Lidington D, Wilson J X. Ascorbate prevents microvascular dysfunction in the skeletal muscle of the septic rat. J Appl Physiol 2001; 90: 795–803
   PubMed Web of Science ®Google Scholar
• Bolon M L, Ouellette Y, Li F, Tyml K. Abrupt reoxygenation following hypoxia reduces electrical coupling between endothelial cells of wild-type but not connexin40 null mice in oxidant- and PKA-dependent manner. FASEB J 2005; 19: 1725–1727
   Google Scholar
• Cerwinka W H, Cooper D, Krieglstein C F, Feelisch M, Granger D N. Nitric oxide modulates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules. Am J Physiol Heart Circ Physiol 2002; 282: H1111–H1117
   Google Scholar
• d'Uscio L V, Milstien S, Richardson D, Smith L, Katusic Z S. Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity. Circ Res 2003; 92: 88–95
   PubMed Web of Science ®Google Scholar
• Galley H F, Davies M J, Webster N R. Ascorbyl radical formation in patients with sepsis: effect of ascorbate loading. Free Radic Biol Med 1996; 20: 139–143
   PubMed Web of Science ®Google Scholar
• Gocan N C, Scott J A, Tyml K. Nitric oxide produced via neuronal NOS may impair vasodilatation in septic rat skeletal muscle. Am J Physiol Heart Circ Physiol 2000; 278: H1480–H1489
   Google Scholar
• Gustafsson F, Holstein-Rathlou N. Conducted vasomotor responses in arterioles: characteristics, mechanisms and physiological significance. Acta Physiol Scand 1999; 167: 11–21
   PubMedGoogle Scholar
• Hashiguchi N, Ogura H, Tanaka H, Koh T, Nakamori Y, Noborio M, Shiozaki T, Nishino M, Kuwagata Y, Shimazu T, Sugimoto H. Enhanced expression of heat shock proteins in activated polymorphonuclear leukocytes in patients with sepsis. J Trauma 2001; 51: 1104–1109
   PubMedGoogle Scholar
• Heller R, Unbehaun A, Schellenberg B, Mayer B, Werner-Felmayer G, Werner E R. L-Ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin. J Biol Chem 2001; 276: 40–47
   PubMed Web of Science ®Google Scholar
• Kameritsch P, Khandoga N, Nagel W, Hundhausen C, Lidington D, Pohl U. Nitric oxide specifically reduces the permeability of Cx37-containing gap junctions to small molecules. J Cell Physiol 2005; 203: 233–242
   Google Scholar
• Kavdia M, Popel A S. Contribution of nNOS- and eNOS-derived NO to microvascular smooth muscle NO exposure. J Appl Physiol 2004; 97: 293–301
   PubMed Web of Science ®Google Scholar
• Kurjiaka D T, Segal S S. Conducted vasodilation elevates flow in arteriole networks of hamster striated muscle. Am J Physiol 1995; 269: H1723–H1728
   Google Scholar
• Lidington D, Ouellette Y, Li F, Tyml K. Conducted vasoconstriction is reduced in a mouse model of sepsis. J Vasc Res 2003; 40: 149–158
   Google Scholar
• Marini M, Frabetti F, Musiani D, Franceschi C. Oxygen radicals induce stress proteins and tolerance to oxidative stress in human lymphocytes. Int J Radiat Biol 1996; 70: 337–350
   PubMed Web of Science ®Google Scholar
• McKinnon R L, Lidington D, Bolon M, Ouellette Y, Kidder G M, Tyml K. Reduced arteriolar conducted vasoconstriction in septic mouse cremaster muscle is mediated by nNOS-derived NO. Cardiovasc Res 2006; 69: 236–244
   PubMedGoogle Scholar
• Miles A M, Bohle D S, Glassbrenner P A, Hansert B, Wink D A, Grisham M B. Modulation of superoxide-dependent oxidation and hydroxylation reactions by nitric oxide. J Biol Chem 1996; 271: 40–47
   PubMed Web of Science ®Google Scholar
• Muller M, Gauley J, Heikkila J J. Hydrogen peroxide induces heat shock protein and proto-oncogene mRNA accumulation in Xenopus laevis A6 kidney epithelial cells. Can J Physiol Pharmacol 2004; 82: 523–529
   Google Scholar
• Patel M, Day B J. Metalloporphyrin class of therapeutic catalytic antioxidants. Trends Pharmacol Sci 1999; 20: 359–364
   PubMed Web of Science ®Google Scholar
• Payne G W, Madri J A, Sessa W C, Segal S S. Histamine inhibits conducted vasodilation through endothelium-derived NO production in arterioles of mouse skeletal muscle. FASEB J 2004; 18: 280–286
   PubMed Web of Science ®Google Scholar
• Scott J A, Machoun M, McCormack D G. Inducible nitric oxide synthase and vascular reactivity in rat thoracic aorta: effect of aminoguanidine. J Appl Physiol 1996; 80: 271–277
   Google Scholar
• Scott K C, Hill R C, Lewis D D, Gronwall R, Sundstrom D A, Jones G L, Harper J. Serum ascorbic acid concentrations in previously unsupplemented greyhounds after administration of a single dose of ascorbic acid intravenously or per os. J Anim Physiol Anim Nutr (Berl) 2002; 86: 222–228
   Google Scholar
• Song Y, Zweier J L, Xia Y. Heat-shock protein 90 augments neuronal nitric oxide synthase activity by enhancing Ca2+/calmodulin binding. Biochem J 2001; 355: 357–360
   Google Scholar
• Tyml K, Li F, Wilson J X. Delayed ascorbate bolus protects against maldistribution of microvascular blood flow in septic rat skeletal muscle. Crit Care Med 2005; 33: 1823–1828
   PubMed Web of Science ®Google Scholar
• Tyml K, Wang X, Lidington D, Ouellette Y. Lipopolysaccharide reduces intercellular coupling in vitro and arteriolar conducted response in vivo. Am J Physiol Heart Circ Physiol 2001; 281: H1397–H1406
   PubMed Web of Science ®Google Scholar
• Vasquez-Vivar J, Kalyanaraman B, Martasek P, Hogg N, Masters B S, Karoui H, Tordo P, Pritchard K A, Jr. Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Proc Natl Acad Sci USA 1998; 95: 9220–9225
   PubMed Web of Science ®Google Scholar
• Wilson J X, Dixon S J, Yu J, Nees S, Tyml K. Ascorbate uptake by microvascular endothelial cells of rat skeletal muscle. Microcirculation 1996; 3: 211–221
   Google Scholar
• Wu F, Wilson J X, Tyml K. Ascorbate inhibits iNOS expression and preserves vasoconstrictor responsiveness in skeletal muscle of septic mice. Am J Physiol Regul Integr Comp Physiol 2003; 285: R50–R56
   Google Scholar
• Wu F, Wilson J X, Tyml K. Ascorbate protects against impaired arteriolar constriction in sepsis by inhibiting inducible nitric oxide synthase expression. Free Radic Biol Med 2004; 37: 1282–1289
   PubMed Web of Science ®Google Scholar
• Xia Y, Tsai A L, Berka V, Zweier J L. Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process. J Biol Chem 1998; 273: 25804–25808
   PubMed Web of Science ®Google Scholar