Nitric Oxide and Prostaglandin Inhibition During Acetylcholine-Mediated Cutaneous Vasodilation in Humans

REFERENCES

• Agewall S, Henareh L, Kublickiene K. Endothelial function in conduit and resistance arteries in men with coronary disease. Atherosclerosis 2006; 184: 130–136
   PubMed Web of Science ®Google Scholar
• Anderson C, Andersson T, Wardell K. Changes in skin circulation after insertion of a microdialysis probe visualized by laser Doppler perfusion imaging. J Invest Dermatol 1994; 102: 807–811
   PubMed Web of Science ®Google Scholar
• Bauersachs J, Popp R, Hecker M, Sauer E, Fleming I, Busse R. Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factor. Circulation 1996; 94: 3341–3347
   PubMed Web of Science ®Google Scholar
• Berghoff M, Kathpal M, Kilo S, Hilz M J, Freeman R. Vascular and neural mechanisms of ACh-mediated vasodilation in the forearm cutaneous microcirculation. J Appl Physiol 2002; 92: 780–788
   Google Scholar
• Boutsiouki P, Georgiou S, Clough G F. Recovery of nitric oxide from acetylcholine-mediated vasodilatation in human skin in vivo. Microcirculation 2004; 11: 249–259
   PubMed Web of Science ®Google Scholar
• Bratz I N, Kanagy N L. Nitric oxide synthase-inhibition hypertension is associated with altered endothelial cyclooxygenase function. Am J Physiol Heart Circ Physiol 2004; 287: H2394–H2401
   PubMed Web of Science ®Google Scholar
• Buus N H, Simonsen U, Pilegaard H K, Mulvany M J. Nitric oxide, prostanoid, and non-NO, non-prostanoid involvement in acetylcholine relaxation of isolated human small arteries. Br J Pharmacol 2000; 129: 184–192
   PubMed Web of Science ®Google Scholar
• Buxton I L, Cheek D J, Eckman D, Westfall D P, Sanders K M, Keef K D. NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists. Circ Res 1993; 72: 387–395
   PubMed Web of Science ®Google Scholar
• Celermajer D S, Sorensen K E, Gooch V M, Spiegelhalter D J, Miller O I, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 1111–1115
   PubMed Web of Science ®Google Scholar
• Chang H Y, Chen C W, Hsiue T R. Comparative effects of L-NOARG and L-NAME on basal blood flow and ACh-induced vasodilatation in rat diaphragmatic microcirculation. Br J Pharmacol 1997; 120: 326–332
   Google Scholar
• Clough G F, Boutsiouki P, Church M K, Michel C C. Effects of blood flow on the in vivo recovery of a small diffusible molecule by microdialysis in human skin. J Pharmacol Exp Ther 2002; 302: 681–686
   PubMedGoogle Scholar
• Creager M A, Cooke J P, Mendelsohn M E, Gallagher S J, Coleman S M, et al. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest 1990; 86: 228–234
   PubMed Web of Science ®Google Scholar
• Dalle-Ave A, Kubli S, Golay S, Delachaux A, Liaudet L, et al. Acetylcholine-induced vasodilation and reactive hyperemia are not affected by acute cyclo-oxygenase inhibition in human skin. Microcirculation 2004; 11: 327–336
   Web of Science ®Google Scholar
• de W C, Esser N, Lehr H A, Bolz S S, Pohl U. Pentobarbital-sensitive EDHF comediates ACh-induced arteriolar dilation in the hamster microcirculation. Am J Physiol 1999; 276: H1527–H1534
   Google Scholar
• Drexler H, Hornig B. Endothelial dysfunction in human disease. J Mol Cell Cardiol 1999; 31: 51–60
   PubMed Web of Science ®Google Scholar
• Durand S, Tartas M, Bouye P, Koitka A, Saumet J L, Abraham P. Prostaglandins participate in the late phase of the vascular response to acetylcholine iontophoresis in humans. J Physiol 2004; 561: 811–819
   Google Scholar
• Fleming I, Busse R. Endothelium-derived epoxyeicosatrienoic acids and vascular function. Hypertension 2006; 47: 629–633
   PubMed Web of Science ®Google Scholar
• Fuloria M, Eckman D M, Leach D A, Aschner J L. 20-hydroxyeicosatetraenoic acid is a vasoconstrictor in the newborn piglet pulmonary microcirculation. Am J Physiol Lung Cell Mol Physiol 2004; 287: L360–L365
   Google Scholar
• Fuloria M, Smith T K, Aschner J L. Role of 5,6-epoxyeicosatrienoic acid in the regulation of newborn piglet pulmonary vascular tone. Am J Physiol Lung Cell Mol Physiol 2002; 283: L383–L389
   Google Scholar
• Furchgott R F, Cherry P D, Zawadzki J V, Jothianandan D. Endothelial cells as mediators of vasodilation of arteries. J Cardiovasc Pharmacol 1984; 6(Suppl 2)S336–S343
   Google Scholar
• Hendry R G, Marshall J M. Vasoconstrictor products of cyclo-oxygenase activity limit acetylcholine-induced cutaneous vasodilatation in young men. Clin Sci (Lond) 2004; 107: 323–330
   Google Scholar
• Holowatz L A, Thompson C S, Minson C T, Kenney W L. Mechanisms of acetylcholine-mediated vasodilatation in young and aged human skin. J Physiol 2005; 563: 965–973
   PubMed Web of Science ®Google Scholar
• Huang A, Sun D, Smith C J, Connetta J A, Shesely E G, et al. In eNOS knockout mice skeletal muscle arteriolar dilation to acetylcholine is mediated by EDHF. Am J Physiol Heart Circ Physiol 2000; 278: H762–H768
   Google Scholar
• Katz S D, Schwarz M, Yuen J, LeJemtel T H. Impaired acetylcholine-mediated vasodilation in patients with congestive heart failure. Role of endothelium-derived vasodilating and vasoconstricting factors. Circulation 1993; 88: 55–61
   PubMedGoogle Scholar
• Kellogg D L, Jr, Liu Y, Kosiba I F, O'Donnell D. Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol 1999; 86: 1185–1190
   PubMed Web of Science ®Google Scholar
• Kellogg D L, Jr, Zhao J L, Coey U, Green J V. Acetylcholine-induced vasodilation is mediated by nitric oxide and prostaglandins in human skin. J Appl Physiol 2005; 98: 629–632
   PubMed Web of Science ®Google Scholar
• Khan F, Green F C, Forsyth J S, Greene S A, Morris A D, Belch J J. Impaired microvascular function in normal children: effects of adiposity and poor glucose handling. J Physiol 2003; 551: 705–711
   Google Scholar
• Kimura K, Low D A, Keller D M, Davis S L, Crandall C G. Cutaneous blood flow and sweat rate responses to exogenous administration of acetylcholine and methacholine. J Appl Physiol 2007; 102: 1856–1861
   Google Scholar
• Lee K, Mack G W. Role of nitric oxide in methacholine-induced sweating and vasodilation in human skin. J Appl Physiol 2006; 100: 1355–1360
   Google Scholar
• Ludmer P L, Selwyn A P, Shook T L, Wayne R R, Mudge G H, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986; 315: 1046–1051
   PubMed Web of Science ®Google Scholar
• Medow M S, Taneja I, Stewart J M. Cyclo-oxygenase and nitric oxide synthase dependence of cutaneous reactive hyperemia in humans. Am J Physiol Heart Circ Physiol 2007; 293: H425–H432
   PubMed Web of Science ®Google Scholar
• Ming Z, Parent R, Lavallee M. Nitric oxide-independent dilation of conductance coronary arteries to acetylcholine in conscious dogs. Circ Res 1997; 81: 977–987
   Google Scholar
• Mollace V, Muscoli C, Masini E, Cuzzocrea S, Salvemini D. Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors. Pharmacol Rev 2005; 57: 217–252
   PubMed Web of Science ®Google Scholar
• Moncada S, Vane J R. Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin. Pharmacol Rev 1978; 30: 293–331
   PubMed Web of Science ®Google Scholar
• Morgan C J, Friedmann P S, Church M K, Clough G F. Cutaneous microdialysis as a novel means of continuously stimulating eccrine sweat glands in vivo. J Invest Dermatol 2006; 126: 1220–1225
   PubMed Web of Science ®Google Scholar
• Morris S J, Shore A C. Skin blood flow responses to the iontophoresis of acetylcholine and sodium nitroprusside in man: possible mechanisms. J Physiol 1996; 496(Pt 2)531–542
   PubMed Web of Science ®Google Scholar
• Nishikawa Y, Stepp D W, Chilian W M. Nitric oxide exerts feedback inhibition on EDHF-induced coronary arteriolar dilation in vivo. Am J Physiol Heart Circ Physiol 2000; 279: H459–H465
   PubMed Web of Science ®Google Scholar
• Okazaki K, Fu Q, Martini E R, Shook R, Conner C, et al. Vasoconstriction during venous congestion: effects of venoarteriolar response, myogenic reflexes, and hemodynamics of changing perfusion pressure. Am J Physiol Regul Integr Comp Physiol 2005; 289: R1354–R1359
   PubMed Web of Science ®Google Scholar
• Ray C A, Wilson T E. Comparison of skin sympathetic nerve responses to isometric arm and leg exercise. J Appl Physiol 2004; 97: 160–164
   Google Scholar
• Shibasaki M, Crandall C G. Effect of local acetylcholinesterase inhibition on sweat rate in humans. J Appl Physiol 2001; 90: 757–762
   PubMed Web of Science ®Google Scholar
• Shoemaker J K, Pozeg Z I, Hughson R L. Forearm blood flow by Doppler ultrasound during test and exercise: tests of day-to-day repeatability. Med Sci Sports Exerc 1996; 28: 1144–1149
   Google Scholar
• Stewart J M, Medow M S, Minson C T, Taneja I. Cutaneous neuronal nitric oxide is specifically decreased in postural tachycardia syndrome. Am J Physiol Heart Circ Physiol 2007; 113: 449–457
   Google Scholar
• Stoen R, Lossius K, Karlsson J O. Acetylcholine-induced vasodilation may depend entirely upon NO in the femoral artery of young piglets. Br J Pharmacol 2003; 138: 39–46
   PubMedGoogle Scholar
• Vanhoutte P M. Could the absence or malfunction of vascular endothelium precipitate the occurrence of vasospasm?. J Mol Cell Cardiol 1986; 18: 679–689
   PubMedGoogle Scholar
• Zeiher A M, Drexler H, Wollschlager H, Just H. Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis. Circulation 1991; 84: 1984–1992
   PubMed Web of Science ®Google Scholar