VEGF-Mediated Elevated Intracellular Calcium and Angiogenesis in Human Microvascular Endothelial Cells In Vitro are Inhibited by Dominant Negative TRPC6

References

• Ahmmed GU, Malik AB. Functional role of TRPC channels in the regulation of endothelial permeability. Pflugers Arch 2005; 451: 131–142
   PubMedGoogle Scholar
• Bates DO, Curry FE. Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathway. Am J Physiol 1997; 273: H687–H694
   PubMed Web of Science ®Google Scholar
• Bates DO, Harper SJ. Regulation of vascular permeability by vascular endothelial growth factors. Vascul Pharmacol 2002; 39: 225–37
   PubMed Web of Science ®Google Scholar
• Brock TA, Dvorak HF, Senger DR. Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells. Am J Pathol 1991; 138: 213–221
   PubMed Web of Science ®Google Scholar
• Cheng HW, James AF, Foster RR, Hancox JC, Bates DO. VEGF activates receptor-operated cation channels in human microvascular endothelial cells. Arterioscler Thromb Vasc Biol 2006; 26: 1768–1776
   PubMed Web of Science ®Google Scholar
• Clapham DE, Runnels LW, Strubing C. The Trp ion channel family. Nat Rev 2001; 2: 387–396
   Google Scholar
• Eder P, Poteser M, Romanin C, Groschner K. Na(+) entry and modulation of Na+/Ca2 +  exchange as a key mechanism of TRPC signaling. Pflugers Arch 2005; 451: 99–104
   Google Scholar
• Eder P, Probst D, Rosker C, Poteser M, Wolinski H, Kohlwein SD, Romanin C, Groschner K. Phospholipase C-dependent control of cardiac calcium homeostasis involves a TRPC3-NCX1 signaling complex. Cardiovasc Res 2007; 73: 111–119
   Google Scholar
• Garnier-Raveaud S, Usson Y, Cand F, Robert-Nicoud M, Verdetti J, Faury G. Identification of membrane calcium channels essential for cytoplasmic and nuclear calcium elevations induced by vascular endothelial growth factor in human endothelial cells. Growth Fact 2001; 19: 35–48
   Web of Science ®Google Scholar
• Hill AJ, Hinton JM, Cheng H, Gao Z, Bates DO, Hancox JC, Langton PD, James AF. A TRPC-like nonselective cation current activated by alpha 1-adrenoceptors in rat mesenteric artery smooth muscle cells. Cell Cal 2006; 40: 29–40
   PubMedGoogle Scholar
• Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 1999; 397: 259–263
   PubMed Web of Science ®Google Scholar
• Jho D, Mehta D, Ahmmed G, Gao XP, Tiruppathi C, Broman M, Malik AB. Angiopoietin-1 opposes VEGF-induced increase in endothelial permeability by inhibiting TRPC1-dependent Ca2 influx. Circ Res 2005; 96: 1282–1290
   PubMedGoogle Scholar
• Maruyama Y, Nakanishi Y, Walsh EJ, Wilson DP, Welsh DG, Cole WC. Heteromultimeric TRPC6-TRPC7 channels contribute to arginine vasopressin-induced cation current of A7r5 vascular smooth muscle cells. Circ Res 2006; 98: 1520–1527
   Google Scholar
• Morbidelli L, Chang CH, Douglas JG, Granger HJ, Ledda F, Ziche M. Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium. Am J Physiol 1996; 270: H411–H415
   PubMed Web of Science ®Google Scholar
• Nilius B, Droogmans G, Wondergem R. Transient receptor potential channels in endothelium: solving the calcium entry puzzle?. Endothelium 2003; 10: 5–15
   PubMed Web of Science ®Google Scholar
• Paria BC, Vogel SM, Ahmmed GU, Alamgir S, Shroff J, Malik AB, Tiruppathi C. Tumor necrosis factor-alpha-induced TRPC1 expression amplifies store-operated Ca2 +  influx and endothelial permeability. Am J Physiol Lung Cell Mol Physiol 2004; 287: L1303–L1313
   PubMed Web of Science ®Google Scholar
• Pocock TM, Foster RR, Bates DO. Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo. Am J Physiol Heart Circ 2004; 286: H1015–H1026
   Google Scholar
• Pocock TM, Williams B, Curry FE, Bates DO. VEGF and ATP act by different mechanisms to increase microvascular permeability and endothelial [Ca(2+)](i). Am J Physiol Heart Circ 2000; 279: H1625–H1634
   Google Scholar
• Rosker C, Graziani A, Lukas M, Eder P, Zhu MX, Romanin C, Groschner K. Ca(2 + ) signaling by TRPC3 involves Na(+) entry and local coupling to the Na(+)/Ca(2+) exchanger. J Biol Chem 2004; 279: 13696–13704
   PubMedGoogle Scholar
• Sakura H, Ashcroft FM. Identification of four trp1 gene variants murine pancreatic beta-cells. Diabetologia 1997; 40: 528–532
   Google Scholar
• Walker RL, Hume JR, Horowitz B. Differential expression and alternative splicing of TRP channel genes in smooth muscles. Am J Physiol Cell Physiol 2001; 280: C1184–C1192
   Google Scholar
• Wu HM, Yuan Y, Zawieja DC, Tinsley J, Granger HJ. Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability. Am J Physiol 1999; 276: H535–H542
   Google Scholar
• Yuan JP, Zeng W, Huang GN, Worley PF, Muallem S. STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat Cell Biol 2007; 9: 636–645
   PubMed Web of Science ®Google Scholar
• Zagranichnaya TK, Wu X, Villereal ML. Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. J Biol Chem 2005; 280: 29559–29569
   PubMed Web of Science ®Google Scholar