Metalloporphyrins, used for HO-1 Inhibition, Themselves Affect Hepatic Microcirculation, Liver Function, and Hepatocellular Integrity

References

• Alpoim MC, Geraldes CF, Oliveira CR, Lima MC. Molecular mechanisms of chromium toxicity: oxidation of haemoglobin. Biochem Soc Trans 1995; 23: S241
   Google Scholar
• Appleton SD, Chretien ML, McLaughlin BE, Vreman HJ, Stevenson DK, Brien JF, Nakatsu K, Maurice DH, Marks GS. Selective inhibition of heme oxygenase without inhibition of nitric oxide synthase or soluble guanyl cyclase by metalloporphyrins at low concentrations. Drug Metab Dispos 1999; 27: 1214–1219
   PubMed Web of Science ®Google Scholar
• Bundock EA, Drummond GS, Kappas A. Tissue distribution of synthetic heme analogues: studies with tin, chromium, and zinc mesoporphyrins. Pharmacology 1996; 52: 187–198
   Google Scholar
• Carter E, Hartsfield C, Miyazono M, Jakkula M, Morris K, McMurtry I. Regulation of heme-oxygenase-1 by nitric oxide during hepatopulmonary syndrome. Am J Physiol 2002; 283: L346–L353
   Google Scholar
• Chen Y, Gines P, Yan J, Summer S, Falk S, Russel N, Schrier R. Increased vascular heme-oxygenase-1 expression contributes to arterial vasodilation in experimental cirrhosis in rats. Hepatology 2004; 39: 1075–1087
   PubMedGoogle Scholar
• Denagel DC, Verity AN, Madden PE, Yang CO, Sangameswaran L, Johnson RM. Identification of a non-propyhrin inhibitor of heme-oxygenase-1. Neuroscience 1998; 24: 2058
   Google Scholar
• Drummond GS, Kappas A. Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation. Proc Natl Acad Sci USA 1981; 78: 6466–6470
   PubMed Web of Science ®Google Scholar
• Farombi EO, Surh YJ. Heme-oxygenase-1 as a potential therapeutic target for hepatoprotection. J Biochem Mol Biol 2006; 39: 479–491
   PubMedGoogle Scholar
• Flores O, Criado M, Sanchez-Rodriguez A, Hidalgo F, Collia F, Lopez-Novoa J, Esteller A. Relationships between NOS2 and HO-1 in liver of rats with chronic bile duct ligation. Hepatol Res 2005; 32: 58–65
   Google Scholar
• Georgiev P, Jochum W, Heinrich S, Jang JH, Nocito A, Dahm F, Clavien PA. Characterization of time-related changes after experimental bile duct ligation. Br J Surg 2008; 95: 646–656
   PubMed Web of Science ®Google Scholar
• Goda N, Suzuki K, Naito M, Takeoka S, Tsuchida E, Ishimura Y, Tamatani T, Suematsu M. Distribution of heme oxygenase isoforms in rat liver. J Clin Invest 1998; 101: 604–612
   PubMed Web of Science ®Google Scholar
• Hamilton JW, Wetterhan KE. Chromium (VI)-induced DNA damage in chick embryo liver and blood cells in vivo. Carcinogenesis 1986; 7: 2085–2088
   PubMed Web of Science ®Google Scholar
• Hinz SR, Vreman HJ, Stevenson DK. Mortality of metalloporphyrin-treated rats after light exposure. Dev Pharmacol Ther 1990; 14: 187–192
   Google Scholar
• Kappas A, Drummond GS, Sardana MK. Sn-protoporpyhrin rapidly and markedly enhances the heme saturation of hepatic tryptophan pyrolase: evidence that this synthetic metalloporphyrin increases the functional content of heme in the liver. J Clin Invest 1985; 75: 302–305
   PubMed Web of Science ®Google Scholar
• Kinobe RT, Dercho RY, Nakatsu K. Inhibition of the heme-oxygenase-carbon monoxide system: on the doorstep of the clinic?. Can J Physiol Pharmacol 2008; 86: 577–599
   Google Scholar
• Kinobe RT, Vlahakis JZ, Vreman HJ, Stevenson DK, Brien JF, Szarek WA, Nakatsu K. Selectivity of imidazole-diaxolane compounds for in vitro inhibition of microsomal haem oxygenase isoforms. Br J Pharmacol 2006; 147: 307–315
   Google Scholar
• Kozma F, Johnson RA, Zhang F, Yu C, Tong X, Nasjletti A. Contribution of endogenous carbon monoxide to regulation of diameter in resistance vessels. Am J Physiol 1999; 276: R1087–R1094
   Google Scholar
• Kubulus D, Rensing H, Paxian M, Thierbach JT, Meisel T, Redl H, Bauer M. Influence of heme-based solutions on stress protein expression and organ failure after hemorrhagic shock. Crit Care Med 2005; 33: 629–637
   PubMed Web of Science ®Google Scholar
• Liu H, Song D, Lee SS. Role of heme-oxygenase-carbon monoxide pathway in pathogenesis of cirrhotic cardiomyopathy in the rat. Am J Physiol 2001; 280: G68–G74
   Web of Science ®Google Scholar
• Luo D, Vincent SR. Metalloporpyhrins inhibit nitric oxide–dependent cGMP formation in vivo. Eur J Pharmacol 1994; 267: 263–267
   Google Scholar
• McCarter SD, Akeyea TG, Lu X, Bihari A, Scott JR, Badhwar A, Dungrey AA, Harris K, Feng Q, Potter RF. Endogenous heme oxygenase induction is a critical mechanism attenuating apoptosis and restoring microvascular perfusion following limb ischemia/reperfusion. Surgery 2004; 136: 67–75
   Google Scholar
• Menger MD, Marzi I, Messmer K. In vivo fluorescence microscopy for quantitative analysis of the hepatic microcirculation in hamsters and rats. Eur Surg Res 1991; 23: 158–169
   PubMedGoogle Scholar
• Misra M, Alcedo JH, Wetterhan KE. Two pathways for chromium (IV)-induced DANN damage in 14-day chick embryos: Cr-DANN binding in liver and 8-oxo-2′-deoxyguanosine in red blood cells. Carcinogenesis 1962; 15: 2911–2917
   Google Scholar
• Nie RG, McCarter SD, Harris KA, Lee PJ, Zhang X, Bihari A, Gray D, Wunder C, Brock RW, Potter RF. The role of endogenous heme oxygenase in the initiation of liver injury following limb ischemia/reperfusion. J Hepatol 2002; 36: 624–630
   PubMed Web of Science ®Google Scholar
• NIH. 1985. Guide for the Care and Use of Laboratory Animals (DHEW Publication No. NIH 86-23. BethesdaMaryland, USA: National Institutes of Health.
   Google Scholar
• O′Hara K, Nemec AA, Lama J, Klei LR, Mossman BT, Barchowsky A. Chromium (VI) inhibits heme-oxygenase-1 expression in vivo and in arsenic-exosed human airway epithelial cells. J Cell Physiol 2006; 209: 113–121
   PubMed Web of Science ®Google Scholar
• Putzki H, Reichert B. Activity of serum cholinesterase after experimental bile duct ligation in the rat. Z Gesamte Inn Med 1991; 46: 524–525
   Google Scholar
• Rensing H, Bauer I, Datene V, Pätau C, Pannen BH, Bauer M. Differential expression pattern of heme-oxygenase-1/heat shock protein 32 and nitric oxide synthase-II and their impact on liver injury in a rat model of hemorrhage and resuscitation. Crit Care Med 1999; 27: 2766–2775
   PubMed Web of Science ®Google Scholar
• Rensing H, Bauer I, Zhang JX, Paxian M, Pannen BHJ, Yokoyama Y, Clemens MG, Bauer M. Endothelin-1 and heme oxygenase-1 as modulators of sinusoidal tone in the stress-exposed rat liver. Hepatology 2002; 36: 1453–1465
   Google Scholar
• Sass G, Soares MC, Yamashita K, Seyfried S, Zimmermann WH, Eschenhagen T, Kaczmarek E, Ritter T, Volk HD, Tiegs G. Heme-oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice. Hepatology 2003; 38: 909–918
   PubMed Web of Science ®Google Scholar
• Schäfer T, Scheuer C, Römer K, Menger MD, Vollmar B. Inhibition of p53 protects liver tissue against endotoxin-induced apoptotic and necrotic cell death. FASEB J 2003; 17: 660–667
   PubMed Web of Science ®Google Scholar
• Schuster J, Caughman GB. Alteration of cell lipids by metal salts. Biomed Mater Res 2004; 70A: 347–353
   Google Scholar
• Shrivastava R, Upreti RK, Seth PK, Chaturvedi UC. Effects of chromium on the immune system. FEMS Immunol Med Microbiol 2002; 34: 1–7
   PubMed Web of Science ®Google Scholar
• Teran FJ, Johnson RA, Stevenson BK, Peyton KJ, Jackson KE, Appleton SD, Durante W, Johnson FK. Heme-oxygenase–derived carbon monoxide promotes arteriolar endothelial dysfunction and contributes to salt-induced hypertension in Dahl salt-sensitive rats. Am J Physiol 2005; 288: R615–R622
   Google Scholar
• Vlahakis JZ, Kinobe RT, Bowers RJ, Brien JF, Nakatsu K, Szarek WA. Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors. J Med Chem 2006; 49: 4437–4441
   Google Scholar
• Vreman HJ, Ekstrand BC, Stevenson DK. Selection of metalloporphyrin heme oxygenase inhibitors based on potency and photoreactivity. Pediatr Res 1993; 33: 195–200
   PubMed Web of Science ®Google Scholar
• Vreman HJ, Gillaman MJ, Stevenson DK. In vitro inhibition of rat intestinal heme oxygenase by metalloporphyrins. Pediatr Res 1989; 26: 362–365
   PubMed Web of Science ®Google Scholar
• Vreman HJ, Sipkala DA, Stevenson DK. Characterization of porphyrin heme oxygenase inhibitors. Can J Physiol Pharmacol 1996; 74: 278–285
   PubMed Web of Science ®Google Scholar
• Wunder C, Brock RW, McCarter SD, Bihari A, Harris K, Eichelbrönner O, Potter RF. Inhibition of haem oxygenase activity increases leucocyte accumulation in the liver following limb ischaemia-reperfusion in mice. J Physiol 2002; 540: 1013–1021
   Google Scholar
• Yang ZF, Tsui TY, HO DW, Tang TC, Fan ST. Heme-oxygenase-1 potentiates the survival of small for size liver graft. Liver Transpl 2004; 10: 784–793
   Google Scholar