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Review Article

GABAA Receptors in Central Nervous System Disease: Anxiety, Epilepsy, and Insomnia

Pages 731-740 | Published online: 10 Oct 2008

REFERENCES

  • Olsen R W, DeLorey T M, Gordey M, Kang M H. GABA receptor function and epilepsy. Adv Neurol 1999; 79: 499–510
  • Möhler H. Pathophysiological aspects of diversity in neuronal inhibition: A new benzodiazepine pharmacology. Dialog Clin Neurosci 2002; 4: 261–269
  • Möhler H, Fritschy J M, Vogt K, Crestani F, Rudolph U. Pathophysiology and pharmacology of GABAA receptors. Handb Exp Pharmacol 2005; 169: 225–247
  • Feusner J, Richie T, Lawford B, Young R M, Kann B, Noble E P. GABAA receptor beta3 subunit gene and psychiatric morbidity in a post-traumatic stress disorder population. Psychiatry Res 2001; 104: 109–117
  • Taylor M, Bhagwagar Z, Cowen P J, Sharp T. GABA and mood disorders. Psych Med 2003; 33: 3873–3893
  • Loh E W, Ball D. Role of the GABA-Aγ2 receptor subunit genes cluster in drug responses and the development of alcohol dependence. Neurochem Int 2000; 37: 413–423
  • Parsian A, Zhang Z H. Human chromosomes 11p15 and 4p12 and alcohol dependence. Possible association with the GABBR1 gene. Am J Med Genet 1999; 88: 533–538
  • Bianchi M T, Song L, Zhang H, Macdonald R L. Two different mechanisms of disinhibition produced by GABAA receptor mutations linked to epilepsy in humans. J Neurosci 2002; 22: 5321–5327
  • Weiller E, Bisserbe J C, Maier W, Lecrubier Y. Prevalence and recognition of anxiety syndromes in five European primary care settings. A report from the WHO study on Psychological Problems in General Health Care. Br J Psychiatry 1998; 173: 18–23
  • Kalueff A, Nutt D J. Role of GABA in memory and anxiety. Depress Anxiety 1997; 4: 100–110
  • Malizia A L, Cunningham V J, Bell C J, Liddle P F, Jones T, Nutt D J. Decreased brain GABAA-benzodiazepine receptor binding in panic disorders: Preliminary results from a quantitative PET study. Arch Gen Psychiatry 1998; 55: 715–720
  • Malizia A L. What do brain imaging studies tell us about anxiety disorders?. J Psychopharmacol 1999; 13: 372–378
  • Tiihonen J, Kuikka J, Rasanen P, Lepola U, Koponen H, Liuska A, Lehmusvaara A, Vainio P, Kononen M, Bergstrom K, Yu M, Kinnunen I, Akerman K, Karhu J. Cerebral benzodiazepine receptor binding and distribution in generalized anxiety disorders: A fractal analysis. Mol Psychiatry 1997; 6: 463–471
  • Goddard A W, Mason G F, Almai A, Rothman D L, Behar K L, Petroff O A, Chamey D S, Krystal J H. Reductions in occipital cortex GABA levels in panic disorder detected 1H MRS. Arch Gen Psychiatry 2001; 58: 556–561
  • Nutt D J, Malizia A L. New insights into the role of the GABAA receptor in psychiatric disorders. B. J Psychiatry 2001; 179: 390–396
  • Crestani F, Lorez M, Baer K, Essrich C, Benke D, Laurent J P, Belzung C, Fritschy J M, Luscher B, Möhler H. Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues. Nat Neurosci 1999; 2: 833–839
  • Eysenck M W. The nature of anxiety. Handbook of Individual Differences: Biological Perspectives, A Gale, M W Eysenck. Wiley, New York 1992; 157–178
  • Baulac S, Huberfeld G, Gourfinkel-An I, Mitropoulou G, Beranger A, Prud'homme J F, Baulac M, Brice A, Bruzzone R, LeGuern E. First genetic evidence of GABAA receptor dysfunction in epilepsy: A mutation in the γ2-subunit gene. Nat Genet 2001; 28: 46–48
  • Wallace R H, Marini C, Petrou S, Harkin L A, Bowser D N, Panchal R G, Williams D A, Sutherland G R, Mulley J C, Scheffer I E, Berkovic S F. Mutant GABAA receptor γ2-subunit in childhood absence epilepsy and febrile seizures. Nat Genet 2001; 28: 49–52
  • Kananura C, Haug K, Sander T, Runge U, Gu W, Hallmann K, Rebstock J, Heils A, Steinlein O K. A splice-site mutation in GABRG2 associated with childhood absence epilepsy and febrile convulsions. Arch Neurol 2002; 59: 1137–1141
  • Cossette P, Liu L, Brisebois K, Dong H, Lortie A, Vanasse M, Saint-Hilaire J M, Carmant L, Verner A, Lu W Y, Wang Y T, Rouleau G A. Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy. Nat Genet 2002; 31: 184–189
  • Coulter D A. Epilepsy-associated plasticity in γ-aminobutyric acid receptor expression, function, and inhibitory synaptic properties. Int Rev Neurobiol 2001; 45: 237–252
  • Treimann D M. GABAergic mechanisms in epilepsy. Epilepsia 2001; 42: 8–12
  • Snead O C, Depaulis A, Vergues M, Marescaux C. Absence epilepsy: Advances in experimental animal models. Adv Neurol 1999; 79: 253–278
  • Loup F, Wieser H G, Yonekawa Y, Aguzzi A, Fritschy J M. Selective alterations in GABAA receptor subtypes in human temporal lobe epilepsy. J Neurosci 2000; 20: 5401–5419
  • Riban V, Bouilleret V, Pham-Lé B T, Fritschy J M, Marescaux C, Depaulis A. Evolution of hippocampal epileptic activity during the development of hippocampal sclerosis in a mouse model of temporal lobe epilepsy. Neurosci 2002; 112: 101–111
  • Bouilleret V, Loup F, Kiener T, Marescaux C, Fritschy J M. Early loss of interneurons and delayed subunit-specific changes in GABAA-receptor expression in a mouse model of mesial temporal lobe epilepsy. Hippocampus 2000; 10: 305–324
  • Arabadzisz D, Antal K, Parpan F, Enri Z, Fritschy J M. Epileptogenesis and chronic seizures in a mouse model of temporal lobe epilepsy are associated with distinct EEG patterns and selective neurochemical changes in the contralateral hippocampus. Exp Neurol 2005; 194: 76–90
  • Cohen I, Navarro V, Clemenceau S, Baulac M, Miles R. On the origin of interictal activity in human temporal lobe epilepsy in vitro. Science 2002; 298: 1418–1421
  • Gulledge A T, Stuart G J. Excitatory actions of GABA in the cortex. Neuron 2003; 37: 299–309
  • Stein V, Nicoll R A. GABA generates excitement. Neuron 2003; 37: 375–378
  • Meldrum B S, Whiting P. Anticonvulsants acting on the GABA system. Pharmacology of GABA and Glycine Neurotransmission, H Möhler. Springer Publishers, New York 2001; 173–194
  • Sohal V S, Keist R, Rudolph U, Huguenard J R. Dynamic GABAA receptor subtype specific modulation of the synchrony and duration of thalamic oscillations. J Neurosci 2003; 23: 3649–3657
  • Woo T U, Whitehead R E, Melchitzky D S, Jewis D A. A subclass of prefrontal GABA axon terminals are selectively altered in schizophrenia. Proc Natl Acad Sci USA 1998; 95: 5341–5346
  • Volk D W, Fritschy J M, Pierri J N, Auh S, Sampson A R, Lewis D A. Reciprocal alterations in pre-and postsynaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophrenia. Cereb Cortex 2002; 12: 1063–1070
  • Huntsman M M, Tran B V, Potkin S G, Bunney Wejr, Jones E G. Altered ratios of alternatively spliced γ2 subunit of mRNAs of GABAA receptors in prefrontal cortex of schizophrenics. Proc Nat Acad Sci USA 1998; 95: 15066–15071
  • Sarter M, Bruno J P, Berntson G G. Psychotogenic properties of benzodiazepine receptor inverse agonists. Psychopharmacol 2001; 156: 1–13
  • Mrzljak L, Bergson C, Pappy M, Huff R, Levenson R, Goldman-Rakic P S. Localization of D4 receptors in GABAergic neurons in primate brain. Nature 1996; 381: 245–248
  • Carlsson A, Waters N, Holm-Waters S, Tedroff J, Nilsson M, Carlsson M L. Interactions between monoamines, glutamate, and GABA in schizophrenia: New evidence. Annu Rev Pharmacol Toxicol 2001; 41: 237–260
  • Lewis D A, Hashimoto T, Volk D W. Cortical inhibitory neurons and schizophrenia. Nat Rev Neurosci 2005; 6: 312–324
  • Fritschy J M, Möhler H. GABAA receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits. J Comp Neurol 1995; 359: 154–194
  • Pirker S, Schwarzer C, Wieselthaler A, Sieghart W, Sperk G. GABAA receptors: Immunocytochemical distribution of 13 subunits in the adult rat brain. Neurosci 2000; 101: 815–850
  • Yee B K, Keist R, von Boehmer L, Studer R, Benke D, Hagenbuch N, Dong Y, Malenka R C, Fritschy J M, Bluethmann H, Feldon J, Mohler H, Rudolph U. A schizophrenia-related sensorimotor deficit links α3-containing GABAA receptors to a dopamine hyperfunction. Proc Natl Acad Sci USA 2005; 102: 17154–17159
  • Dellini-Stula A, Berdah-Tordjman D. Antipsychotic effects of bretazenil, a partial benzodiazepine agonist in acute schizophrenia—A study group report. J Psychiatry Res 1996; 30: 239–250
  • Crestani F, Keist R, Fritschy J M, Benke D, Vogt K, Prut L, Bluethmann H, Möhler H, Rudolph U. Trace fear conditioning involves hippocampal α5 GABAA receptors. Proc Natl Acad Sci USA 2002; 99: 8980–8985
  • Hauser J, Rudolph U, Keist R, Möhler H, Feldon J, Yee B. Hippocampal α5 subunit containing GABAA receptors modulate expression of prepulse inhibition. Mol Psychiatry 2005; 10: 201–207
  • Spencer K M, Nestor P G, Perlmutter R, Niznikiewicz M A, Klump M C, Frumin M, Shenton M E, Mc Carley R W. Neural synchrony indexes disordered perception and cognition in schizophrenia. Proc Natl Acad Sci USA 2004; 101: 17288–17293
  • Buhr A, Bianchi V, Boulenger J P, Gallati S, Hinkle D J, McDonald R L, Sigel E. Functional characterization of the new human GABA receptor missense mutation β3(R192H). Hum Genet 2002; 111: 154–160
  • Tobler I, Kopp C, Deboer T, Rudolph U. Diazepam-induced changes in sleep: Role of the α1GABAA receptor subtype. Proc Natl Acad Sci USA 2001; 98: 6464–6469
  • Kopp C, Rudolph U, Löw K, Tobler I. Modulation of rhythmic brain activity by diazepam: GABA(A) receptor subtype and state specificity. Proc Natl Acad Sci USA 2004; 101: 3674–3679
  • Brown N, Kerby J, Bonnert T P, Whiting P J, Wafford K A. Pharmacological characterization of a novel cell line expressing human α4β3δ GABAA receptors. Brit J Pharmacol 2002; 136: 965–974
  • Stornstovu S, Ebert B. Gaboxadol: In vitro interaction studies with benzodiazepines and ethanol suggest functional selectivity. Eur J Pharmacol 2003; 467: 49–56
  • Lancel M, Steiger A. Sleep and its modulation by drugs that affect GABAA receptor function. Ang Chem Int Ed 1999; 111: 2852–2864

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