88
Views
12
CrossRef citations to date
0
Altmetric
Research Article

Disruption of the Plasma Membrane Integrity by Cholesterol Depletion Impairs Effectiveness of TRH Receptor-Mediated Signal Transduction via Gq/G11α Proteins

, , , &
Pages 335-352 | Published online: 10 Oct 2008

REFERENCES

  • Golub T, Wacha S, Caroni P. Spatial and temporal control of signaling through lipid rafts. Curr Opin Neurobiol 2004; 14: 542–550
  • Kabouridis P S. Lipid rafts in T cell receptor signalling. Mol Membr Biol 2006; 23: 49–57
  • Lisanti M P, Sargiacomo M, Scherer P E. Purification of caveolae-derived membrane microdomains containing lipid-anchored signaling molecules, such as GPI-anchored proteins, H-Ras, Src-family tyrosine kinases, eNOS, and G-protein alpha-, beta-, and gamma-subunits. Methods Mol Biol 1999; 116: 51–60
  • Rybin V O, Pak E, Alcott S, Steinberg S F. Developmental changes in beta2-adrenergic receptor signaling in ventricular myocytes: The role of Gi proteins and caveolae microdomains. Mol Pharmacol 2003; 63: 1338–1348
  • Chini B, Parenti M. G-protein coupled receptors in lipid rafts and caveolae: How, when and why do they go there?. J Mol Endocrinol 2004; 32: 325–338
  • De Weerd W F, Leeb-Lundberg L M. Bradykinin sequesters B2 bradykinin receptors and the receptor-coupled Galpha subunits Galphaq and Galphai in caveolae in DDT1 MF-2 smooth muscle cells. J Biol Chem 1997; 272: 17858–17866
  • Feron O, Smith T W, Michel T, Kelly R A. Dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. J Biol Chem 1997; 272: 17744–17748
  • Lamb M E, Zhang C, Shea T, Kyle D J, Leeb-Lundberg L M. Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells. Biochemistry 2002; 41: 14340–14347
  • London E, Brown D A. Insolubility of lipids in triton X-100: physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts). Biochim Biophys Acta 2000; 1508: 182–195
  • Sargiacomo M, Sudol M, Tang Z, Lisanti M P. Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells. J Cell Biol 1993; 122: 789–807
  • Stan R V. Structure and function of endothelial caveolae. Microsc Res Tech 2002; 57: 350–364
  • Cheng Z J, Singh R D, Marks D L, Pagano R E. Membrane microdomains, caveolae, and caveolar endocytosis of sphingolipids. Mol Membr Biol 2006; 23: 101–110
  • Kurzchalia T V, Parton R G. Membrane microdomains and caveolae. Curr Opin Cell Biol 1999; 11: 424–431
  • Silvius J R. Role of cholesterol in lipid raft formation: Lessons from lipid model systems. Biochim Biophys Acta 2003; 1610: 174–183
  • Gimpl G, Burger K, Fahrenholz F. Cholesterol as modulator of receptor function. Biochemistry 1997; 36: 10959–10974
  • Pucadyil T J, Chattopadhyay A. Role of cholesterol in the function and organization of G-protein coupled receptors. Prog Lipid Res 2006; 45: 295–333
  • Ilangumaran S, Hoessli D C. Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane. Biochem J 1998; 335: 433–440
  • Allen J A, Yu J Z, Donati R J, Rasenick M M. Beta-adrenergic receptor stimulation promotes G alpha s internalization through lipid rafts: A study in living cells. Mol Pharmacol 2005; 67: 1493–1504
  • Rudajev V, Novotny J, Hejnova L, Milligan G, Svoboda P. Dominant portion of thyrotropin-releasing hormone receptor is excluded from lipid domains. Detergent-resistant and detergent-sensitive pools of TRH receptor and Gqalpha/G11alpha protein. J Biochem (Tokyo) 2005; 138: 111–125
  • Pesanova Z, Novotny J, Cerny J, Milligan G, Svoboda P. Thyrotropin-releasing hormone-induced depletion of G(q)alpha/G(11)alpha proteins from detergent-insensitive membrane domains. FEBS Lett 1999; 464: 35–40
  • Li S, Okamoto T, Chun M, Sargiacomo M, Casanova J E, Hansen S H, Nishimoto I, Lisanti M P. Evidence for a regulated interaction between heterotrimeric G proteins and caveolin. J Biol Chem 1995; 270: 15693–15701
  • Svoboda P, Kim G D, Grassie M A, Eidne K A, Milligan G. Thyrotropin-releasing hormone-induced subcellular redistribution and down-regulation of G11alpha: analysis of agonist regulation of coexpressed G11alpha species variants. Mol Pharmacol 1996; 49: 646–655
  • DeBlasi A, O'Reilly K, Motulsky H J. Calculating receptor number from binding experiments using same compound as radioligand and competitor. Trends Pharmacol Sci 1989; 10: 227–229
  • Bourova L, Kostrnova A, Hejnova L, Moravcova Z, Moon H E, Novotny J, Milligan G, Svoboda P. Delta-Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains. J Neurochem 2003; 85: 34–49
  • Brown D. Structure and function of membrane rafts. Int J Med Microbiol 2002; 291: 433–437
  • Barenholz Y. Sphingomyelin and cholesterol: From membrane biophysics and rafts to potential medical applications. Subcell Biochem 2004; 37: 167–215
  • Lockwich T P, Liu X, Singh B B, Jadlowiec J, Weiland S, Ambudkar I S. Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains. J Biol Chem 2002; 275: 11934–11942
  • Simons K, Toomre D. Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 2000; 1: 31–39
  • Muller G, Hanekop N, Wied S, Frick W. Cholesterol depletion blocks redistribution of lipid raft components and insulin-mimetic signaling by glimepiride and phosphoinositolglycans in rat adipocytes. Mol Med 2002; 8: 120–136
  • Nair B G, Rashed H M, Patel T B. Epidermal growth factor stimulates rat cardiac adenylate cyclase through a GTP-binding regulatory protein. Biochem J 1989; 264: 563–571
  • Langer I, Vertongen P, Perret J, Cnudde J, Gregoire F. De Neef P Robberecht P Waelbroeck M. VPAC(1) receptors have different agonist efficacy profiles on membrane and intact cells. Cell Signal 2002; 14: 689–694
  • Neubig R R. Membrane organization in G-protein mechanisms. FASEB J 1994; 8: 939–946
  • Rodbell M. The role of GTP-binding proteins in signal transduction: from the sublimely simple to the conceptually complex. Curr Top Cell Regul 1992; 32: 1–47
  • Nobles M, Benians A, Tinker A. Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells. Proc Natl Acad Sci USA 2005; 102: 18706–18711
  • Hebert T E, Gales C, Rebois R V. Detecting and imaging protein-protein interactions during G protein-mediated signal transduction in vivo and in situ by using fluorescence-based techniques. Cell Biochem Biophys 2006; 45: 85–109
  • Rebois R V, Robitaille M, Gales C, Dupre D J, Baragli A, Trieu P, Ethier N, Bouvier M, Hebert T E. Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells. J Cell Sci 2006; 119: 2807–2818
  • Tolkovsky A M, Levitzki A. Mode of coupling between the beta-adrenergic receptor and adenylate cyclase in turkey erythrocytes. Biochemistry 1978; 17: 3795–3810
  • Cornea A, Janovick J A, Stanislaus D, Conn P M. Redistribution of G(q/11)alpha in the pituitary gonadotrope in response to a gonadotropin-releasing hormone agonist. Endocrinology 1998; 139: 397–402
  • Oh P, Schnitzer J E. Segregation of heterotrimeric G proteins in cell surface microdomains. G(q) binds caveolin to concentrate in caveolae, whereas G(i) and G(s) target lipid rafts by default. Mol Biol Cell 2001; 12: 685–698

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.