146
Views
12
CrossRef citations to date
0
Altmetric
Research Article

Leptin Receptors and β2-Adrenergic Receptor mRNA Expression in Brain Injury-Related Heterotopic Ossification

, , , , &
Pages 347-359 | Published online: 10 Oct 2008

REFERENCES

  • Pittenger D E. Heterotopic ossification. Orthop Rev 1991; 20: 33–39
  • Sawyer J R, Myers M A, Rosier R N, Puzas J E. Heterotopic ossification: Clinical and cellular aspects. Calcif Tissue Int 1991; 49: 208–215
  • Shehab D, Elgazzar A H, Collier D. Heterotopic ossification. J Nucl Med 2002; 43: 346–353
  • Chauveau C, Devedjian J C, Blary M C, Delecourt C, Hardouin P, Jeanfils J, Broux O. Gene expression in human osteoblastic cells from normal and heterotopic ossification. Exp Mol Pathol 2004; 76: 37–43
  • Rigaux P, Benabid N, Darriet D, Delecourt C, Chieux V, Dudermel A F, Sutter B, Anselme K, Hardouin P. Study of serum factors potentially involved in the pathogenesis of heterotopic bone formation after severe brain injury. Joint Bone Spine 2005; 72: 146–149
  • Ducy P, Amling M, Takeda S, Priemel M, Schilling A F, Beil F T, Shen J, Vinson C, Rueger J M, Karsenty G. Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass. Cell 2000; 100: 197–207
  • Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker K L, Armstrong D, Ducy P, Karsenty G. Leptin regulates bone formation via the sympathetic nervous system. Cell 2002; 111: 305–317
  • Elefteriou F, Ahn J D, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards W G, Bannon T W, Noda M, Clement K, Vaisse G, Karsenty G. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 2005; 434: 514–520
  • Moore R E, Smith C K, Bailey C S, Voelkel E F, Tashjian A H. Characterization of beta-adrenergic receptors on rat and human osteoblast-like cells and demonstration that beta-receptor agonists can stimulate bone resorption in organ culture. Bone Miner 1993; 23: 301–315
  • Togari A, Arai M, Mizutani S, Mizutani S, Koshihara Y, Nagatsu T. Expression of mRNAs for neuropeptide receptors and beta-adrenergic receptors in human osteoblasts and human osteogenic sarcoma cells. Neurosci Lett 1997; 233: 125–128
  • Kellenberger S, Muller K, Richener H, Bilbe G. Formoterol and isoproterenol induce c-fos gene expression in osteoblast-like cells by activating beta2-adrenergic receptors. Bone 1998; 22: 471–478
  • Tartaglia L A, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards G J, Campfield L A, Clark F T, Deeds J, Muir C, Sanker S, Moriarty A, Moore K J, Smutko J S, Mays G G, Wool E A, Monroe C A, Tepper R I. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995; 83: 1263–1271
  • Cioffi J A, Shafer A W, Zupancic T J, Smith-Gbur J, Mikhail A, Platika D, Snodgrass H R. Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction. Nat Med 1996; 2: 585–589
  • Thomas T, Gori F, Khosla S, Jensen M D, Burguera B, Riggs B L. Leptin acts on human marrow stroml cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology 1999; 140: 1630–1638
  • Bjorbaek C, Uotani S, da Silva B, Flier J S. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997; 272: 32686–32695
  • Reseland J E, Syversen U, Bakke I, Qvigstad G, Eide L G, Hjertner O, Gordeladze J O, Drevon C A. Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization. J Bone Miner Res 2001; 16: 1426–1433
  • Gordelaze J O, Drevon C A, Syversen U, Reseland J E. Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization: impact on differentiation markers, apoptosis, and osteoclastic signaling. J Cell Biochem 2002; 85: 825–836
  • Iwamoto I, Fujino T, Douchi T. The leptin receptor in human osteoblasts and the direct effect of leptin on bone metabolism. Gynecol Endocrinol 2004; 19: 97–104
  • Elmquist J K, Ahima R S, Maratos-Flier E, Flier J S, Saper C B. Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 1997; 138: 839–842
  • Marotti G. The osteocyte as a wiring transmission system. J Musculoskel Neuron Interact 2000; 1: 133–136
  • Bonewald L. Osteocytes as multifunctional cells. J Musculoskel Neuron Interact 2006; 6: 331–333
  • Hamrick M W, Pennington C, Newton D, Xie D, Isales C. Leptin deficiency produces contrasting phenotypes in bones of the limb and spine. Bone 2004; 34: 376–383
  • Ghilardi N, Ziegler S, Wiestner A, Stoffel R, Heim M H, Skoda R C. Defective stat signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci USA 1996; 93: 6231–6235
  • Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol 2000; 68: 437–446
  • Leavitt M, Setola V, Fishman P H. Protein kinase C-mediated down-regulation of beta(2)-adrenergic receptor and gene expression in rat C6 glioma cells. J Neurochem 2001; 77: 823–829
  • Tam Y, Regev E, Casap N, Shteyer A, Attar-Namdar M, Alexandrovitch A, Lahat O, Shohami E, Bab I A. Traumatic brain injury stimulates systemic bone formation: Possible role for hypothalamic leptin signaling. J Bone Miner Res 2003; 18: S226

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.