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Research Article

A Single Mutation at Lysine 241 Alters Expression and Trafficking of the D2 Dopamine Receptor

Pages 453-464 | Published online: 19 Nov 2008

REFERENCES

  • C Jacob, G S Cottrell, D Gehringer, F Schmidlin, E F Grady, and N W Bunnett. 2005. c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2. J Biol Chem 280 (16):16076–16087.
  • A Marchese, and J L Benovic. 2001. Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting. J Biol Chem 276 (49):45509–45512.
  • N P Martin, R J Lefkowitz, and S K Shenoy. 2003. Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination. J Biol Chem 278 (46):45954–45959.
  • S K Shenoy, P H McDonald, T A Kohout, and R J Lefkowitz. 2001. Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science 294 (5545):1307–1313.
  • B L Wolfe, A Marchese, and J Trejo. 2007. Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1. J Cell Biol 177 (5):905–916.
  • C M Pickart, and M J Eddins. 2004. Ubiquitin: structures, functions, mechanisms. Biochim Biophys Acta 1695 (1–3):55–72.
  • A M Weissman. 2001. Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol 2 (3):169–178.
  • L Hicke. 2001. Protein regulation by monoubiquitin. Nat Rev Mol Cell Biol 2 (3):195–201.
  • K Ito, T Haga, J Lameh, and W Sadee. 1999. Sequestration of dopamine D2 receptors depends on coexpression of G-protein-coupled receptor kinases 2 or 5. Eur J Biochem 260 (1):112–119.
  • K M Kim, K J Valenzano, S R Robinson, W D Yao, L S Barak, and M G Caron. 2001. Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins. J Biol Chem 276 (40):37409–37414.
  • Y Namkung, and D R Sibley. 2004. Protein kinase C mediates phosphorylation, desensitization, and trafficking of the D2 dopamine receptor. J Biol Chem 279 (47):49533–49541.
  • O J Kim, M A Ariano, Y Namkung, P Marinec, E Kim, J Han, and D R Sibley. 2008. D2 dopamine receptor expression and trafficking is regulated through direct interactions with ZIP. J Neurochem 106:83–95.
  • C J Beckers, M R Block, B S Glick, J E Rothman, and W E Balch. 1989. Vesicular transport between the endoplasmic reticulum and the Golgi stack requires the NEM-sensitive fusion protein. Nature 339 (6223):397–398.
  • D W Wilson, C A Wilcox, G C Flynn, E Chen, W J Kuang, W J Henzel, M R Block, A Ullrich, and J E Rothman. 1989. A fusion protein required for vesicle-mediated transport inboth mammalian cells and yeast. Nature 339 (6223):355–359.
  • D Armstrong, and P G Strange. 2001. Dopamine D2 receptor dimer formation: evidence from ligand binding. J Biol Chem 276 (25):22621–22629.
  • L Gazi, J F Lopez-Gimenez, M P Rudiger, and P G Strange. 2003. Constitutive oligomerization of human D2 dopamine receptors expressed in Spodoptera frugiperda 9 (Sf9) and in HEK293 cells. Analysis using co-immunoprecipitation and time-resolved fluorescence resonance energy transfer. Eur J Biochem 270 (19):3928–3938.
  • C Missale, S R Nash, S W Robinson, M Jaber, and M G Caron. 1998. Dopamine receptors: from structure to function. Physiol Rev 78 (1):189–225.
  • C M Pickart. 2001. Mechanisms underlying ubiquitination. Annu Rev Biochem 70:503–533.
  • R G Vickery, and M von Zastrow. 1999. Distinct dynamin-dependent and -independent mechanisms target structurally homologous dopamine receptors to different endocytic membranes. J Cell Biol 144 (1):31–43.

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