H4R activation utilizes distinct signaling pathways for the production of RANTES and IL-13 in human mast cells

References

• Hofstra CL, Desai PJ, Thurmond RL, Fung-Leung WP. Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells. J Pharmacol Exp Ther 2003;305:1212–21.
   PubMed Web of Science ®Google Scholar
• Zampeli E, Tiligada E. The role of histamine H4 receptor in immune and inflammatory disorders. Br J Pharmacol 2009;157:24–33.
   PubMed Web of Science ®Google Scholar
• Lim HD, Van RRM, Ling P, et al. Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J Pharmacol Exp Ther 2005;314:1310–21.
   PubMed Web of Science ®Google Scholar
• Haas HL, Sergeeva OA, Selbach O. Histamine in the nervous system. Physiol Rev 2008;88:1183–241.
   PubMed Web of Science ®Google Scholar
• Chan NY, Robador PA, Levi R. Natriuretic peptide-induced catecholamine release from cardiac sympathetic neurons: inhibition by histamine H3 and H4 receptor activation. J Pharmacol Exp Ther 2012;343:568–77.
   PubMed Web of Science ®Google Scholar
• Dijkstra D, Leurs R, Chazot P, et al. Histamine downregulates monocyte CCL2 production through the histamine H4 receptor. J Allergy Clin Immunol 2007;120:300–7.
   PubMed Web of Science ®Google Scholar
• Angel JE, Prema A, Berla TE. Functional characterization of histamine H4 receptor on human mast cells. Mol Immunol 2014;62:19–28.
   PubMed Web of Science ®Google Scholar
• Buckland KF, Williams TJ, Conroy DM. Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor. Br J Pharmacol 2003;140:1117–27.
   PubMed Web of Science ®Google Scholar
• Morse KL, Behan J, Laz TM, et al. Cloning and characterization of a novel human histamine receptor. J Pharmacol Exp Ther 2001;296:1058–66.
   PubMed Web of Science ®Google Scholar
• Desai P, Thurmond RL. Histamine H4 receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation. Eur J Immunol 2011;41:1764–73.
   PubMed Web of Science ®Google Scholar
• Ahmad SF, Mushtaq AA, Khairy MA, et al. Regulation of TNF-α and NFκ-B activation through the JAK/STAT signaling pathway downstream of histamine 4 receptor in a rat model of LPS-induced joint inflammation. Immunobiology 2015;220:889–98.
   PubMed Web of Science ®Google Scholar
• Hinz M, Arslan SC, Scheidereit C. It takes two to tango: IκBs, the multi-functional partners of NFκB. Immunol Rev 2012;246:59–76.
   PubMed Web of Science ®Google Scholar
• Zhang H, Yang H, Wenjing M, Shaoheng H. Induction of IL-13 production and upregulated expression of protease activated receptor-1 by RANTES in a mast cell line. Cytokine 2011;53:231–8.
   PubMed Web of Science ®Google Scholar
• Brightling CE, Symon FA, Holgate ST, et al. Interleukin-4 and -13 expression is co-localized to mast cells within the airway smooth muscle in asthma. Clin Exp Allergy 2003;33:1711–16.
   PubMed Web of Science ®Google Scholar
• Fujikura T, Shimosawa T, Yakuo I. Regulatory effect of histamine H1 receptor antagonist on the expression of messenger RNA encoding CC chemokines in the human nasal mucosa. J Allergy Clin Immunol 2001;107:123–8.
   PubMed Web of Science ®Google Scholar
• Victor A, Sarah LRJ. RANTES: a versatile and controversial chemokine. Trends Immunol 2001;22:83–7.
   PubMed Web of Science ®Google Scholar
• Hershey GK. IL-13 receptors and signaling pathways: an evolving web. J Allergy Clin Immunol 2003;111:677–90.
   PubMed Web of Science ®Google Scholar
• Bhattacharjee A, Shukla M, Yakubenko VP, et al. IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages. Free Radic Biol Med 2013;54:1–16.
   PubMed Web of Science ®Google Scholar
• Radinger M, Kuehn HS, Kim MS, et al. Glycogen synthase kinase 3beta activation is a prerequisite signal for cytokine production and chemotaxis in human mast cells. J Immunol 2010;184:564–72.
   PubMed Web of Science ®Google Scholar
• Petit-Bertron AF, Machavoine F, Defresne MP. H4 histamine receptors mediate cell cycle arrest in growth factor induced murine and human hematopoietic progenitor cells. PLoS One 2009;4:e6504.
   Google Scholar
• Kaur D, Hollins F, Woodman L, et al. Mast cells express IL-13R alpha 1: IL-13 promotes human lung mast cell proliferation and Fc epsilon RI expression. Allergy 2006;61:1047–53.
   PubMed Web of Science ®Google Scholar
• Hajoui O, Janani R, Tulic M, et al. Synthesis of IL-13 by human B lymphocytes: regulation and role in IgE production. J Allergy Clin Immunol 2004;114:657–63.
   PubMed Web of Science ®Google Scholar
• Beermann S, Vauth M, Hein R, et al. Distinct signalling pathways of murine histamine H1- and H4-receptors expressed at comparable levels in HEK293 cells. PLoS One 2014;22:e107481–22.
   Google Scholar
• Lessmann E, Leitges M, Huber M. A redundant role for PKC-epsilon in mast cell signaling and effector function. Int Immunol 2006;18:767–73.
   PubMed Web of Science ®Google Scholar
• Rivera J, Gilfillan AM. Molecular regulation of mast cell activation. J Allergy Clin Immunol 2006;117:1214–25.
   PubMed Web of Science ®Google Scholar
• Furumoto Y, Brooks S, Olivera A, et al. Cutting edge: lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival. J Immunol 2006;176:5167–71.
   PubMed Web of Science ®Google Scholar
• Nemeth K, Wilson T, Rada B, et al. Characterization and function of histamine receptors in human bone marrow stromal cells. Stem Cells 2012;30:222–31.
   PubMed Web of Science ®Google Scholar
• Dong H, Zhang W, Zeng X, et al. Histamine induces upregulated expression of histamine receptors and increases release of inflammatory mediators from microglia. Mol Neurobiol 2014;49:1487–500.
   PubMed Web of Science ®Google Scholar
• Lipnik-Stangelj M. Multiple role of histamine H1-receptor-PKCMAPK signalling pathway in histamine-stimulated nerve growth factor synthesis and secretion. Biochem Pharmacol 2006;72:1375–81.
   PubMed Web of Science ®Google Scholar
• Dandekar RD, Khan MM. Regulation of ERK2 phosphorylation by histamine in splenocytes. Immunopharmacol Immunotoxicol 2011;33:250–8.
   PubMed Web of Science ®Google Scholar
• Marinissen MJ, Gutkind JS. G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol Sci 2001;22:368–76.
   PubMed Web of Science ®Google Scholar
• Remko AB, Stefan BJ, Schoonus, et al. Histamine H(1)-receptor activation of nuclear factor-kappa B: roles for G beta gamma- and G alpha(q/11)-subunits in constitutive and agonist-mediated signaling. Mol Pharmacol 2001;60:1133–42.
   PubMed Web of Science ®Google Scholar
• Gutzmer R, Mommert S, Gschwandtner M, et al. The histamine H4 receptor is functionally expressed on T(H)2 cells. J Allergy Clin Immunol 2009;123:619–25.
   PubMed Web of Science ®Google Scholar
• Holgate ST, Bodey KS, Janezic A, et al. Release of RANTES, MIP-1 alpha and MCP-1 into asthmatic airways following endobronchial allergen challenge. Am J Respir Crit Care Med 1997;156:1377–83.
   PubMed Web of Science ®Google Scholar
• Schuh JM, Blease K, Bruhl H, et al. Intrapulmonary targeting of RANTES/CCL5-responsive cells prevents chronic fungal asthma. Eur J Immunol 2003;33:3080–90.
   PubMed Web of Science ®Google Scholar
• Alam R, Stafford S, Forsythe P, et al. RANTES is a chemotactic and activating factor for human eosinophils. J Immunol 1993;150:3442–8.
   PubMed Web of Science ®Google Scholar
• Lukacs NW, Miller AL, Hogaboam CM. Chemokine receptors in asthma: searching for the correct immune targets. J Immunol 2003;171:11–15.
   PubMed Web of Science ®Google Scholar