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Research Article

Gastrodin causes vasodilation by activating KATP channels in vascular smooth muscles via PKA-dependent signaling pathway

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Pages 543-549 | Received 20 Apr 2017, Accepted 15 Aug 2017, Published online: 25 Aug 2017

References

  • Noma A. ATP-regulated K + channels in cardiac muscle. Nature. 1983;305:147–148.
  • Orie NN, Thomas AM, Perrino BA, et al. Ca2+/calcineurin regulation of cloned vascular KATP channels: crosstalk with the protein kinase A pathway. Br J Pharmacol. 2009;157:554–564.
  • Purves GI, Kamishima T, Davies LM, et al. Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channels. J Physiol (Lond). 2009;587:3639–3650.
  • Matias M, Silvestre S, Falcao A, et al. Gastrodia elata and epilepsy: rationale and therapeutic potential. Phytomedicine. 2016;23:1511–1526.
  • Zhang Q, Yang YM, Yu GY. Effects of gastrodin injection on blood pressure and vasoactive substances in treatment of old patients with refractory hypertension: a randomized controlled trial. J Chin Integr Med. 2008;6:695–699.
  • Zhu D, Medhora M, Campbell WB, et al. Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries. Circ Res. 2003;92:992–1000.
  • Yuan XJ, Goldman WF, Tod ML, et al. Ionic currents in rat pulmonary and mesenteric arterial myocytes in primary culture and subculture. Am J Physiol. 1993;264:L107–L115.
  • Zeng X, Zhang S, Zhang L, et al. A study of the neuroprotective effect of the phenolic glucoside gastrodin during cerebral ischemia in vivo and in vitro. Planta Med. 2006;72:1359–1365.
  • An H, Kim IS, Koppula S, et al. Protective effects of Gastrodia elata Blume on MPP+-induced cytotoxicity in human dopaminergic SH-SY5Y cells. J Ethnopharmacol. 2010;130:290–298.
  • Huang NK, Chern Y, Fang JM, et al. Neuroprotective principles from Gastrodia elata. J Nat Prod. 2007;70:571–574.
  • Kim ST, Kim JD, Lyu YS, et al. Neuroprotective effect of some plant extracts in cultured CT105-induced PC12 cells. Biol Pharm Bull. 2006;29:2021–2024.
  • Ahn EK, Jeon HJ, Lim EJ, et al. Anti-inflammatory and anti-angiogenic activities of Gastrodia elata Blume. J Ethnopharmacol. 2007;110:476–482.
  • Huang NK, Lin YL, Cheng JJ, et al. Gastrodia elata prevents rat pheochromocytoma cells from serum-deprived apoptosis: the role of the MAPK family. Life Sci. 2004;75:1649–1657.
  • Priest BT, McDermott JS. Cardiac ion channels. Channels (Austin). 2015;9:352–359.
  • Quayle JM, Nelson MT, Standen NB. ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiol Rev. 1997;77:1165–1232.
  • Foster MN, Coetzee WA. KATP channels in the cardiovascular system. Physiol Rev. 2016;96:177–252.
  • Brayden JE. Functional roles of KATP channels in vascular smooth muscle. Clin Exp Pharmacol Physiol. 2002;29:312–316.
  • Dzeja PP, Terzic A. Phosphotransfer reactions in the regulation of ATP-sensitive K + channels. FASEB J. 1998;12:523–529.
  • Kleppisch T, Nelson MT. Adenosine activates ATP-sensitive potassium channels in arterial myocytes via A2 receptors and cAMP-dependent protein kinase. Proc Natl Acad Sci USA. 1995;92:12441–12445.
  • Wellman GC, Quayle JM, Standen NB. ATP-sensitive K + channel activation by calcitonin gene-related peptide and protein kinase A in pig coronary arterial smooth muscle. J Physiol. 1998;507(Pt 1):117–129.
  • Kawano H, Kawano T, Tanaka K, et al. Effects of dopamine on ATP-sensitive potassium channels in porcine coronary artery smooth-muscle cells. J Cardiovasc Pharmacol. 2008;51:196–201.
  • Vettorazzi JF, Ribeiro RA, Borck PC, et al. The bile acid TUDCA increases glucose-induced insulin secretion via the cAMP/PKA pathway in pancreatic beta cells. Metabolism. 2016;65:54–63.
  • Salman S, Holloway AC, Nurse CA. Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A. Am J Physiol, Cell Physiol. 2014;307:C266–C277.
  • Nguyen KH, Ta TN, Pham TH, et al. Nuciferine stimulates insulin secretion from beta cells-an in vitro comparison with glibenclamide. J Ethnopharmacol. 2012;142:488–495.
  • Kawano T, Tanaka K, Chi H, et al. Effects of aging on isoflurane-induced and protein kinase A-mediated activation of ATP-sensitive potassium channels in cultured rat aortic vascular smooth muscle cells. J Cardiovasc Pharmacol. 2010;56:676–685.
  • Yang HQ, Subbotina E, Ramasamy R, et al. Cardiovascular KATP channels and advanced aging. Pathobiol Aging Age Relat Dis. 2016;6:32517.

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