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Research Article

Synergic prooxidant, apoptotic and TRPV1 channel activator effects of alpha-lipoic acid and cisplatin in MCF-7 breast cancer cells

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Pages 569-577 | Received 10 Jun 2017, Accepted 15 Aug 2017, Published online: 29 Aug 2017

References

  • Jemal A, Siegel R, Xu J, et al. Cancer statistics. CA Cancer J Clin. 2010;60:277–300.
  • Torrens-Mas M, Pons DG, Sastre-Serra J, et al. SIRT3 silencing sensitizes breast cancer cells to cytotoxic treatments through an increment in ROS production. J Cell Biochem. 2017;118:397–406.
  • Nazıroğlu M, Tokat S, Demirci S. Role of melatonin on electromagnetic radiation-induced oxidative stress and Ca2+ signaling molecular pathways in breast cancer. J Recept Signal Transduct Res. 2012;32:290–297.
  • Nazıroğlu M, Karaoğlu A, Aksoy AO. Selenium and high dose vitamin E administration protects cisplatin-induced oxidative damage to renal, liver and lens tissues in rats. Toxicology. 2004;195:221–230.
  • Zhao Y, Jing Z, Li Y, et al. Berberine in combination with cisplatin suppresses breast cancer cell growth through induction of DNA breaks and caspase-3-dependent apoptosis. Oncol Rep. 2016;36:567–572.
  • Lu X, Xiao L, Wang L, et al. Hsp90 inhibitors and drug resistance in cancer: the potential benefits of combination therapies of Hsp90 inhibitors and other anti-cancer drugs. Biochem Pharmacol. 2012;83:995–1004.
  • Sakallı Çetin E, Nazıroğlu M, Çiğ B, et al. Selenium potentiates the anticancer effect of cisplatin against oxidative stress and calcium ion signaling-induced intracellular toxicity in MCF-7 breast cancer cells: involvement of the TRPV1 channel. J Recept Signal Transduct Res. 2017;37:84–93.
  • Uğuz AC, Cig B, Espino J, et al. Melatonin potentiates chemotherapy-induced cytotoxicity and apoptosis in rat pancreatic tumor cells. J Pineal Res. 2012;53:91–98.
  • Rochette L, Ghibu S, Richard C, et al. Direct and indirect antioxidant properties of α-lipoic acid and therapeutic potential. Mol Nutr Food Res. 2013;57:114–125.
  • Moini H, Packer L, Saris NE. Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid. Toxicol Appl Pharmacol. 2002;182:84–90.
  • Bhavsar SK, Bobbala D, Xuan NT, et al. Stimulation of suicidal erythrocyte death by α-lipoic acid. Cell Physiol Biochem. 2010;26:859–868.
  • Puchsaka P, Chaotham C, Chanvorachote P. α-Lipoic acid sensitizes lung cancer cells to chemotherapeutic agents and anoikis via integrin β1/β3 downregulation. Int J Oncol. 2016;49:1445–1456.
  • Kafara P, Icard P, Guillamin M, et al. Lipoic acid decreases Mcl-1, Bcl-xL and up regulates Bim on ovarian carcinoma cells leading to cell death. J Ovarian Res. 2015;8:36.
  • Damnjanovic I, Kocic G, Najman S, et al. Chemopreventive potential of alpha lipoic acid in the treatment of colon and cervix cancer cell lines. Bratisl Lek Listy. 2014;115:611–616.
  • Ohkubo T, Yamazaki J. T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells. Int J Oncol. 2012;41:267–275.
  • Nazıroğlu M. TRPV1 channel: a potential drug target for treating epilepsy. Curr Neuropharmacol. 2015;13:239–247.
  • Caterina MJ, Rosen TA, Tominaga M, et al. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature. 1999;398:436–441.
  • Pecze L, Jósvay K, Blum W, et al. Activation of endogenous TRPV1 fails to induce overstimulation-based cytotoxicity in breast and prostate cancer cells but not in pain-sensing neurons. Biochim Biophys Acta. 2016;1863:2054–2064.
  • Vercelli C, Barbero R, Cuniberti B, et al. Expression and functionality of TRPV1 receptor in human MCF-7 and canine CF.41 cells. Vet Comp Oncol. 2015;13:133–142.
  • Wang H, Zhang Y, Du Y. Ovarian and breast cancer spheres are similar in transcriptomic features and sensitive to fenretinide. Biomed Res Int. 2013;2013:510905.
  • Xing ZG, Yu GD, Qin L, et al. Effects and mechanism of lipoic acid on beta-amyloid-intoxicated C6 glioma cells. Genet Mol Res. 2015;14:13880–13888.
  • Placer ZA, Cushman L, Johnson BC. Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Anal Biochem. 1966;16:359–364.
  • Sedlak J, Lindsay RHC. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem. 1968;25:192–205.
  • Lawrence RA, Burk RF. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun. 1976;71:952–958.
  • Koşar PA, Nazıroğlu M, Övey İS, et al. Synergic effects of doxorubicin and melatonin on apoptosis and mitochondrial oxidative stress in MCF-7 breast cancer cells: Involvement of TRPV1 channels. J Membr Biol. 2016;249:129–140.
  • Grynkiewicz C, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem. 1985;260:3440–3450.
  • Uğuz AC, Nazıroğlu M, Espino J, et al. Selenium modulates oxidative stress induced cell apoptosis in human myeloid HL-60 cells via regulation of caspase-3, -9 and calcium influx. J Membr Biol. 2009;232:15–23.
  • Espino J, Bejarano I, Redondo PC, et al. Melatonin reduces apoptosis induced by calcium signaling in human leukocytes: evidence for the involvement of mitochondria and Bax activation. J Membr Biol. 2010;233:105–118.
  • Zhu H, Sun G, Dong J, et al. The role of PRRX1 in the apoptosis of A549 cells induced by cisplatin. Am J Transl Res. 2017;9:396–402.
  • Schempp CM, Kirkin V, Simon-Haarhaus B, et al. (2002) Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John’s wort that acts by induction of apoptosis. Oncogene. 2002;21:1242–1250.
  • Carrasco C, Rodríguez BA, Pariente JA. Melatonin as a stabilizer of mitochondrial function: Role in diseases and aging. Turk J Biol. 2015;39:822–831.
  • Mukherjea D, Jajoo S, Whitworth C, et al. Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat. J Neurosci. 2008;28:13056–13065.
  • Moini H, Tirosh O, Park YC, et al. R-alpha-lipoic acid action on cell redox status, the insulin receptor, and glucose uptake in 3T3-L1 adipocytes. Arch Biochem Biophys. 2002;397:384–391.
  • Atukeren P, Aydin S, Uslu E, et al. Redox homeostasis of albumin in relation to alpha-lipoic acid and dihydrolipoic acid. Oxid Med Cell Longev. 2010;3:206–213.
  • Ogawa N, Kurokawa T, Fujiwara K, et al. Functional and structural divergence in human TRPV1 channel subunits by oxidative cysteine modification. J Biol Chem. 2016;291:4197–4210.
  • Choi SY, Yu JH, Kim H. Mechanism of alpha-lipoic acid-induced apoptosis of lung cancer cells. Ann N Y Acad Sci. 2009;1171:149–155.
  • Nazıroğlu M. New molecular mechanisms on the activation of TRPM2 channels by oxidative stress and ADP-ribose. Neurochem Res. 2007;32:1990–2001.
  • El-Beshbishy HA, Bahashwan SA, Aly HA, et al. Abrogation of cisplatin-induced nephrotoxicity in mice by alpha lipoic acid through ameliorating oxidative stress and enhancing gene expression of antioxidant enzymes. Eur J Pharmacol. 2011;668:278–284.

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