JTC-801 exerts anti-proliferative effects in human osteosarcoma cells by inducing apoptosis

References

• Luetke A, Meyers PA, Lewis I, et al. Osteosarcoma treatment – where do we stand? A state of the art review. Cancer Treat Rev. 2014;40:523–532.
   PubMed Web of Science ®Google Scholar
• Ottaviani G, Jaffe N. The epidemiology of osteosarcoma. Cancer Treat Res. 2009;152:3–13.
   PubMedGoogle Scholar
• Harting MT, Blakely ML. Management of osteosarcoma pulmonary metastases. Semin Pediatr Surg. 2006;15:25–29.
   PubMedGoogle Scholar
• Chou AJ, Geller DS, Gorlick R. Therapy for osteosarcoma: where do we go from here? Paediatr Drugs. 2008;10:315–327.
   PubMedGoogle Scholar
• Hellerstedt-Borjesson S, Nordin K, Fjallskog ML, et al. Women with breast cancer: experience of chemotherapy-induced pain: triangulation of methods. Cancer Nurs. 2015;38:31–39.
   PubMed Web of Science ®Google Scholar
• Köse M. GPCRs and EGFR – cross-talk of membrane receptors in cancer. Bioorg Med Chem Lett. 2017;27:3611–3620.
   PubMed Web of Science ®Google Scholar
• Bedini A, Baiula M, Vincelli G, et al. Nociceptin/orphanin FQ antagonizes lipopolysaccharide-stimulated proliferation, migration and inflammatory signaling in human glioblastoma U87 cells. Biochem Pharmacol. 2017;140:89–104.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Simpson-Durand CD, Standifer KM. Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder. Br J Pharmacol. 2015;172:571–582.
   PubMed Web of Science ®Google Scholar
• Rawls SM, Schroeder JA, Ding Z, et al. NOP receptor antagonist, JTC-801, blocks cannabinoid-evoked hypothermia in rats. Neuropeptides. 2007;41:239–247.
   PubMed Web of Science ®Google Scholar
• Jiang C, Fang X, Zhang H, et al. AMD3100 combined with triptolide inhibit proliferation, invasion and metastasis and induce apoptosis of human U2OS osteosarcoma cells. Biomed Pharmacother. 2017;86:677–685.
   PubMed Web of Science ®Google Scholar
• de Araújo Júnior R, Leitão Oliveira A, de Melo Silveira R, et al. Telmisartan induces apoptosis and regulates Bcl-2 in human renal cancer cells. Exp Biol Med (Maywood). 2015;240:34–44.
   PubMed Web of Science ®Google Scholar
• Niu N, Wang Z, Pan S, et al. Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway. Drug Des Dev Ther. 2015;9:1555–1584.
   PubMed Web of Science ®Google Scholar
• Jiang H, Wang X, Miao W, et al. CXCL8 promotes the invasion of human osteosarcoma cells by regulation of PI3K/Akt signaling pathway. APMIS. 2017;125:773–780.
   PubMed Web of Science ®Google Scholar
• Wang H, Sun N, Li X, et al. Diallyl trisulfide induces osteosarcoma cell apoptosis through reactive oxygen species-mediated downregulation of the PI3K/Akt pathway. Oncol Rep. 2016;35:3648–3658.
   PubMed Web of Science ®Google Scholar
• Schonenbach NS, Hussain S, O’Malley MA. Structure and function of G protein-coupled receptor oligomers: implications for drug discovery. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015;7:408–427.
   PubMed Web of Science ®Google Scholar
• Katritch V, Cherezov V, Stevens RC. Structure–function of the G protein-coupled receptor superfamily. Annu Rev Pharmacol Toxicol. 2013;53:531–556.
   PubMed Web of Science ®Google Scholar
• Lohse MJ, Hein P, Hoffmann C, et al. Kinetics of G-protein-coupled receptor signals in intact cells. Br J Pharmacol. 2008;153 Suppl.1:S125–S132.
   PubMed Web of Science ®Google Scholar
• Moreno JL, Holloway T, Gonzalez-Maeso J. G protein-coupled receptor heterocomplexes in neuropsychiatric disorders. Prog Mol Biol Transl Sci. 2013;117:187–205.
   PubMed Web of Science ®Google Scholar
• Lagerstrom MC, Schioth HB. Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov. 2008;7:339–357.
   PubMed Web of Science ®Google Scholar
• Voisin T, El Firar A, Fasseu M, et al. Aberrant expression of OX1 receptors for orexins in colon cancers and liver metastases: an openable gate to apoptosis. Cancer Res. 2011;71:3341–3351.
   PubMed Web of Science ®Google Scholar
• Steffen JS, Simon E, Warneke V, et al. LGR4 and LGR6 are differentially expressed and of putative tumor biological significance in gastric carcinoma. Virchows Arch. 2012;461:355–365.
   PubMed Web of Science ®Google Scholar
• Dho SH, Lee KP, Jeong D, et al. GPR171 expression enhances proliferation and metastasis of lung cancer cells. Oncotarget. 2016;7:7856–7865.
   PubMedGoogle Scholar
• Ames R, Nuthulaganti P, Fornwald J, et al. Heterologous expression of G protein-coupled receptors in U-2 OS osteosarcoma cells. Receptors Channels. 2004;10:117–124.
   PubMedGoogle Scholar
• Ranjan A, Iyer SV, Iwakuma T. Suppressive roles of A3AR and TMIGD3 i1 in osteosarcoma malignancy. Cell Cycle (Georgetown, TX). 2017;16:903–904.
   PubMed Web of Science ®Google Scholar
• Yamada H, Nakamoto H, Suzuki Y, et al. Pharmacological profiles of a novel opioid receptor-like1 (ORL(1)) receptor antagonist, JTC-801. Br J Pharmacol. 2002;135:323–332.
   PubMed Web of Science ®Google Scholar
• Mabuchi T, Matsumura S, Okuda-Ashitaka E, et al. Attenuation of neuropathic pain by the nociceptin/orphanin FQ antagonist JTC-801 is mediated by inhibition of nitric oxide production. Eur J Neurosci. 2003;17:1384–1392.
   PubMed Web of Science ®Google Scholar
• Koyama T, Fukuda K. Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice. J Anesth. 2009;23:301–303.
   PubMed Web of Science ®Google Scholar
• Choi H, Shin J, Leem D, et al. 6-(3,4-Dihydro-1H-isoquinoline-2-yl)-N-(6-methoxypyridine-2-yl) nicotinamide-26 (DIMN-26) decreases cell proliferation by induction of apoptosis and downregulation of androgen receptor signaling in human prostate cancer cells. Chem Biol Interact. 2016;260:196–207.
   PubMed Web of Science ®Google Scholar
• Ramdani L, Talhi O, Taibi N, et al. Effects of spiro-bisheterocycles on proliferation and apoptosis in human breast cancer cell lines. AR. 2016;36:6399–6408.
   Google Scholar
• Pastor LM, Zuasti A, Ferrer C, et al. Proliferation and apoptosis in aged and photoregressed mammalian seminiferous epithelium, with particular attention to rodents and humans. Reprod Domest Anim. 2011;46:155–164.
   PubMed Web of Science ®Google Scholar
• Mossalam M, Matissek KJ, Okal A, et al. Direct induction of apoptosis using an optimal mitochondrially targeted p53. Mol Pharm. 2012;9:1449–1458.
   PubMedGoogle Scholar
• Kondratskyi A, Kondratska K, Skryma R, et al. Ion channels in the regulation of apoptosis. Biochim Biophys Acta. 2015;1848:2532–2546.
   PubMed Web of Science ®Google Scholar
• Hsu HC, Chen CY, Chiang CH, et al. Eicosapentaenoic acid attenuated oxidative stress-induced cardiomyoblast apoptosis by activating adaptive autophagy. Eur J Nutr. 2014;53:541–547.
   PubMed Web of Science ®Google Scholar
• Milojkovic A, Hemmati PG, Muer A, et al. p14ARF induces apoptosis via an entirely caspase-3-dependent mitochondrial amplification loop. Int J Cancer. 2013;133:2551–2562.
   PubMed Web of Science ®Google Scholar
• Rincheval V, Bergeaud M, Mathieu L, et al. Differential effects of Bcl-2 and caspases on mitochondrial permeabilization during endogenous or exogenous reactive oxygen species-induced cell death: a comparative study of H(2)O(2), paraquat, t-BHP, etoposide and TNF-alpha-induced cell death. Cell Biol Toxicol. 2012;28:239–253.
   PubMed Web of Science ®Google Scholar
• He H, Lam M, McCormick TS, et al. Maintenance of calcium homeostasis in the endoplasmic reticulum by Bcl-2. J Cell Biol. 1997;138:1219.
   PubMed Web of Science ®Google Scholar
• Chang Z, Xing J, Yu X. Curcumin induces osteosarcoma MG63 cells apoptosis via ROS/Cyto-C/Caspase-3 pathway. Tumor Biol. 2014;35:753–758.
   PubMedGoogle Scholar
• Wang Y, Yin RF, Teng JS. Wogonoside induces cell cycle arrest and mitochondrial mediated apoptosis by modulation of Bcl-2 and Bax in osteosarcoma cancer cells. Int J Clin Exp Pathol. 2015;8:63–72.
   PubMed Web of Science ®Google Scholar
• Steelman LS, Chappell WH, Abrams SL, et al. Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging. 2011;3:192–222.
   PubMedGoogle Scholar
• Martini M, De Santis MC, Braccini L, et al. PI3K/AKT signaling pathway and cancer: an updated review. Ann Med. 2014;46:372–383.
   PubMed Web of Science ®Google Scholar
• Slomovitz BM, Coleman RL. The PI3K/AKT/mTOR pathway as a therapeutic target in endometrial cancer. Clin Cancer Res. 2012;18:5856–5864.
   PubMed Web of Science ®Google Scholar
• Choy E, Hornicek F, MacConaill L, et al. High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes. Cancer. 2012;118:2905–2914.
   PubMed Web of Science ®Google Scholar
• Kuijjer ML, van den Akker BE, Hilhorst R, et al. Kinome and mRNA expression profiling of high-grade osteosarcoma cell lines implies Akt signaling as possible target for therapy. BMC Med Genomics. 2014;7:4.
   PubMed Web of Science ®Google Scholar