Investigation of non-CB₁, non-CB₂ WIN55212-2-sensitive G-protein-coupled receptors in the brains of mammals, birds, and amphibians

References

• Matsuda LA, Lolait SJ, Brownstein MJ, et al. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. 1990;346:561–564.
   PubMed Web of Science ®Google Scholar
• Munro S, Thomas KL, Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature. 1993;365:61–65.
   PubMed Web of Science ®Google Scholar
• Kaminski NE, Abood ME, Kessler FK, et al. Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation. Mol Pharmacol. 1992;42:736–742.
   PubMed Web of Science ®Google Scholar
• Childers SR, Breivogel CS. Cannabis and endogenous cannabinoid systems. Drug Alcohol Depend. 1998;51:173–187.
   PubMed Web of Science ®Google Scholar
• Prather PL, Martin NA, Breivogel CS, et al. Activation of cannabinoid receptors in rat brain by WIN 55212-2 produces coupling to multiple G protein alpha-subunits with different potencies. Mol Pharmacol. 2000;57:1000–1010.
   PubMed Web of Science ®Google Scholar
• Adams IB, Martin BR. Cannabis: pharmacology and toxicology in animals and humans. Addiction. 1996;91:1585–1614.
   PubMed Web of Science ®Google Scholar
• Heyser CJ, Hampson RE, Deadwyler SA. Effects of delta-9-tetrahydrocannabinol on delayed match to sample performance in rats: alterations in short-term memory associated with changes in task specific firing of hippocampal cells. J Pharmacol Exp Ther. 1993;264:294–307.
   PubMed Web of Science ®Google Scholar
• Hilf G, Gierschik P, Jakobs KH. Muscarinic acetylcholine receptor-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to guanine-nucleotide-binding proteins in cardiac membranes. Eur J Biochem. 1989;186:725–731.
   PubMedGoogle Scholar
• Sim-Selley LJ, Daunais JB, Porrino LJ, et al. Mu and kappa1 opioid-stimulated [35S]guanylyl-5′-O-(gamma-thio)-triphosphate binding in cynamologous monkey brain. Neuroscience. 1999;94: 651–662.
   PubMed Web of Science ®Google Scholar
• Breivogel CS, Selley DE, Childers SR. Cannabinoid receptor agonist efficacy for stimulating [35S]GTPgammaS binding to rat cerebellar membranes correlates with agonist-induced decreases in GDP affinity. J Biol Chem. 1998;273:16865–16873.
   PubMed Web of Science ®Google Scholar
• Compton DR, Rice KC, DeCosta BR, et al. Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities. J Pharmacol Exp Ther. 1993;265:218–226.
   PubMed Web of Science ®Google Scholar
• Breivogel CS, Childers SR. The functional neuroanatomy of brain cannabinoid receptors. Neurobiol Dis. 1998;5:417–431.
   PubMed Web of Science ®Google Scholar
• Compton DR, Aceto MD, Lowe J, et al. In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activity. J Pharmacol Exp Ther. 1996;277:586–594.
   PubMed Web of Science ®Google Scholar
• Ledent C, Valverde O, Cossu G, et al. Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science. 1999;283:401–404.
   PubMed Web of Science ®Google Scholar
• Jarai Z, Wagner JA, Varga K, et al. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proc Natl Acad Sci USA. 1999;96:14136–14141.
   PubMed Web of Science ®Google Scholar
• Morales P, Reggio PH. An update on non-CB1, non-CB2 cannabinoid related G-protein-coupled receptors. Cannabis Cannabinoid Res. 2017;2:265–273.
   PubMedGoogle Scholar
• Breivogel CS, Griffin G, Di Marzo V, et al. Evidence for a new G protein-coupled cannabinoid receptor in mouse brain. Mol Pharmacol. 2001;60:155–163.
   PubMed Web of Science ®Google Scholar
• Nguyen PT, Selley DE, Sim-Selley LJ. Statistical parametric mapping reveals ligand and region-specific activation of G-proteins by CB1 receptors and non-CB1 sites in the 3D reconstructed mouse brain. Neuroimage. 2010;52:1243–1251.
   PubMed Web of Science ®Google Scholar
• Fung S, Cherry AE, Xu C, et al. Alkylindole-sensitive receptors modulate microglial cell migration and proliferation. Glia. 2015;63:1797–1808.
   PubMed Web of Science ®Google Scholar
• Fung S, Xu C, Hamel E, et al. Novel indole-based compounds that differentiate alkylindole-sensitive receptors from cannabinoid receptors and microtubules: characterization of their activity on glioma cell migration. Pharmacol Res. 2017;115:233–241.
   PubMed Web of Science ®Google Scholar
• Accorsi-Mendonca D, Almado CE, Dagostin AL, et al. Inhibition of spontaneous neurotransmission in the nucleus of solitary tract of the rat by the cannabinoid agonist WIN 55212-2 is not via CB1 or CB2 receptors. Brain Res. 2008;1200:1–9.
   PubMed Web of Science ®Google Scholar
• Bilsland LG, Dick JR, Pryce G, et al. Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice. FASEB J. 2006;20:1003–1005.
   PubMed Web of Science ®Google Scholar
• Ryberg E, Larsson N, Sjogren S, et al. The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol. 2007;152:1092–1101.
   PubMed Web of Science ®Google Scholar
• Grassin-Delyle S, Naline E, Buenestado A, et al. Cannabinoids inhibit cholinergic contraction in human airways through prejunctional CB1 receptors. Br J Pharmacol. 2014;171:2767–2777.
   PubMed Web of Science ®Google Scholar
• McHugh D, Page J, Dunn E, et al. Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. Br J Pharmacol. 2012;165:2414–2424.
   PubMed Web of Science ®Google Scholar
• Song ZH, Modi W, Bonner TI. Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors. Genomics. 1995;28:347–349.
   PubMed Web of Science ®Google Scholar
• McPartland JM, Glass M. Functional mapping of cannabinoid receptor homologs in mammals, other vertebrates, and invertebrates. Gene. 2003;312:297–303.
   PubMed Web of Science ®Google Scholar
• Morales P, Hurst DP, Reggio PH. Methods for the development of in silico GPCR models. Meth Enzymol. 2017;593:405–448.
   PubMed Web of Science ®Google Scholar
• Fredriksson R, Lagerstrom MC, Lundin LG, et al. The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol. 2003;63:1256–1272.
   PubMed Web of Science ®Google Scholar
• Morales P, Isawi I, Reggio PH. Towards a better understanding of the cannabinoid-related orphan receptors GPR3, GPR6, and GPR12. Drug Metab Rev. 2018;50:74–93.
   PubMed Web of Science ®Google Scholar
• Laun AS, Song ZH. GPR3 and GPR6, novel molecular targets for cannabidiol. Biochem Biophys Res Commun. 2017;490:17–21.
   PubMed Web of Science ®Google Scholar
• Brown KJ, Laun AS, Song ZH. Cannabidiol, a novel inverse agonist for GPR12. Biochem Biophys Res Commun. 2017;493:451–454.
   PubMed Web of Science ®Google Scholar
• Herkenham M, Lynn AB, Little MD, et al. Cannabinoid receptor localization in brain. Proc Natl Acad Sci USA.1990;87:1932–1936.
   PubMed Web of Science ®Google Scholar
• Mansbach RS, Rovetti CC, Winston EN, et al. Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats. Psychopharmacology (Berl). 1996;124:315–322.
   PubMed Web of Science ®Google Scholar
• McCoy KL, Gainey D, Cabral GA. delta 9-Tetrahydrocannabinol modulates antigen processing by macrophages. J Pharmacol Exp Ther. 1995;273:1216–1223.
   PubMed Web of Science ®Google Scholar
• Devane WA, Breuer A, Sheskin T, et al. A novel probe for the cannabinoid receptor. J Med Chem. 1992;35:2065–2069.
   PubMed Web of Science ®Google Scholar
• Hollis DM, Coddington EJ, Moore FL. Neuroanatomical distribution of cannabinoid receptor gene expression in the brain of the rough-skinned newt, Taricha granulosa. Brain Behav Evol. 2006;67:135–149.
   PubMed Web of Science ®Google Scholar
• Soderstrom K, Leid M, Moore FL, et al. Behaviroal, pharmacological, and molecular characterization of an amphibian cannabinoid receptor. J Neurochem. 2000;75:413–423.
   PubMed Web of Science ®Google Scholar
• Cesa R, Mackie K, Beltramo M, et al. Cannabinoid receptor CB1-like and glutamic acid decarboxylase-like immunoreactivities in the brain of Xenopus laevis. Cell Tissue Res. 2001;306:391–398.
   PubMed Web of Science ®Google Scholar
• Cottone E, Salio C, Conrath M, et al. Xenopus laevis CB1 cannabinoid receptor: molecular cloning and mRNA distribution in the central nervous system. J Comp Neurol. 2003;464:487–496.
   PubMed Web of Science ®Google Scholar
• Cottone E, Pomatto V, Bovolin P. Role of the endocannabinoid system in the central regulation of nonmammalian vertebrate reproduction. Int J Endocrinol. 2013;2013:941237.
   PubMedGoogle Scholar
• McPartland JM, Glass M, Matias I, et al. A shifted repertoire of endocannabinoid genes in the zebrafish (Danio rerio). Mol Genet Genomics. 2007;277:555–570.
   PubMed Web of Science ®Google Scholar
• Ballesteros J, Weinstein H. Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors. In: Sealfon SC, Conn PM, editors. Methods in neurosciences. Vol. 25. San Diego (CA): Academic Press; 1995. p. 366–428.
   Google Scholar
• Henikoff S, Henikoff JG. Amino acid substitution matrices from protein blocks. Proc Natl Acad Sci USA. U S A1992;89:10915–10919.
   PubMed Web of Science ®Google Scholar
• Breivogel CS, Sim LJ, Childers SR. Regional differences in cannabinoid receptor/G-protein coupling in rat brain. J Pharmacol Exp Ther. 1997;282:1632–1642.
   PubMed Web of Science ®Google Scholar
• Hurst DP, Lynch DL, Barnett-Norris J, et al. N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A) interaction with LYS 3.28(192) is crucial for its inverse agonism at the cannabinoid CB1 receptor. Mol Pharmacol. 2002;62:1274–1287.
   PubMed Web of Science ®Google Scholar
• Breivogel CS, Childers SR. Cannabinoid agonist signal transduction in rat brain: comparison of cannabinoid agonists in receptor binding, G-protein activation, and adenylyl cyclase inhibition. J Pharmacol Exp Ther. 2000;295:328–336.
   PubMed Web of Science ®Google Scholar